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| | Bxe_B2374 | Pyruvate dehydrogenase (cytochrome); Belongs to the TPP enzyme family. (573 aa) |
| | Bxe_A0931 | Putative AMP-dependent synthetase and ligase. (615 aa) |
| | Bxe_A0937 | 3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (393 aa) |
| | Bxe_A0940 | 3-oxoacyl-(acyl-carrier-protein) synthase II; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (408 aa) |
| | Bxe_A0941 | 3-oxoacyl-[acyl-carrier-protein] synthase I; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (413 aa) |
| | serC | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (348 aa) |
| | Bxe_A0977 | Chorismate mutase. (360 aa) |
| | hisC-2 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa) |
| | Bxe_A0979 | Prephenate dehydrogenase. (310 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (434 aa) |
| | Bxe_A0986 | UDP-glucose 6-dehydrogenase. (467 aa) |
| | Bxe_A0990 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa) |
| | Bxe_A1020 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (166 aa) |
| | plsX | Phosphate:acyl-[acyl carrier protein] acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (368 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (329 aa) |
| | Bxe_A1073 | [Acyl-carrier-protein] S-malonyltransferase. (311 aa) |
| | acpP-2 | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (79 aa) |
| | Bxe_A1076 | 3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (428 aa) |
| | acpS | Holo-acyl carrier protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (158 aa) |
| | carA | Carbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (391 aa) |
| | carB | Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1084 aa) |
| | Bxe_A1263 | Dihydropteroate synthase. (270 aa) |
| | Bxe_A1338 | Methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (272 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (572 aa) |
| | argA | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. (462 aa) |
| | Bxe_A1518 | Putative membrane protein. (277 aa) |
| | Bxe_A1522 | L-glutamine synthetase. (471 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Belongs to the KdsA family. (284 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (320 aa) |
| | Bxe_A1587 | Putative metallo-beta-lactamase family protein. (257 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (383 aa) |
| | Bxe_A1621 | Serine O-acetyltransferase. (281 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa) |
| | Bxe_A1630 | Aspartate kinase; Belongs to the aspartokinase family. (416 aa) |
| | Bxe_A1635 | Enoyl-[acyl-carrier-protein] reductase (NADH). (263 aa) |
| | Bxe_A1660 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (356 aa) |
| | dapE | Succinyldiaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (401 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (275 aa) |
| | Bxe_A1671 | Succinyldiaminopimelate aminotransferase apoenzyme. (405 aa) |
| | fabZ | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (154 aa) |
| | Bxe_A1825 | Conserved hypothetical protein; Weak similarity to coenzyme PQQ synthesis proteinC. (243 aa) |
| | Bxe_A1836 | Pyruvate oxidase; Belongs to the TPP enzyme family. (613 aa) |
| | argF-2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (332 aa) |
| | Bxe_A1925 | Putative hydantoin racemase. (288 aa) |
| | Bxe_A1957 | Transcriptional regulator, TetR family. (229 aa) |
| | Bxe_A2037 | Putative acyl carrier protein AcpP, PP-binding protein. (86 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (524 aa) |
| | Bxe_A2133 | Putative nonspecific acid phosphatase, NapD-like protein. (352 aa) |
| | fabV | Hypothetical short-chain alcohol dehydrogenase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (398 aa) |
| | Bxe_A2245 | UDP-glucose 6-dehydrogenase. (482 aa) |
| | Bxe_A2314 | Acetylornithine deacetylase / acetylornithine deacetylase ArgE, Metallo peptidase, MEROPS family M20A. (416 aa) |
| | Bxe_A2315 | Putative amino-acid dehydratase. (344 aa) |
| | Bxe_A2331 | Phosphoserine phosphatase. (279 aa) |
| | Bxe_A2380 | L-threonine synthase. (483 aa) |
| | Bxe_A2381 | Homoserine dehydrogenase. (443 aa) |
| | Bxe_A2525 | Putative acyl-carrier, MmcB like protein; Citation: Mao,Y., Varoglu,M. and Sherman, D.H.Chem.Biol. 6 (4), 251-263 (1999). (83 aa) |
| | Bxe_A2527 | Putative seryl-tRNA synthetase, SerRS-like protein. (354 aa) |
| | Bxe_A2627 | Gentisate pathway; Citation: Microbiol. Res. 160 (1), 53-59 (2005).Gene 312, 239-248 (2003). Appl Environ Microbiol. 1999Mar; 65(3): 946-950. J. Bacteriol. 183 (2), 700- 708(2001). (348 aa) |
| | Bxe_A2687 | Similar to Drosophila yellow-related protein. (377 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (212 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (477 aa) |
| | Bxe_A2761 | Propionyl-CoA carboxylase. (532 aa) |
| | Bxe_A2776 | Putative (R)-specific enoyl-CoA hydratase, MaoC- like protein. (311 aa) |
| | argD-2 | Succinylornithine aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (411 aa) |
| | Bxe_A3217 | Putative NADPH quinone oxidoreductase. (338 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa) |
| | Bxe_A3230 | Acetolactate synthase, small subunit. (163 aa) |
| | Bxe_A3231 | Acetolactate synthase, large subunit. (587 aa) |
| | Bxe_A3298 | Putative acetolactate synthase; Belongs to the TPP enzyme family. (550 aa) |
| | ubiC | Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (227 aa) |
| | argH | Argininosuccinate lyase. (468 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (431 aa) |
| | Bxe_A3463 | Acetylornithine deacetylase ArgE, Metallo peptidase, MEROPS family M20A. (388 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (277 aa) |
| | panD | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa) |
| | ilvD | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (557 aa) |
| | Bxe_A3662 | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. (248 aa) |
| | Bxe_A3664 | Sulfite reductase (NADPH) beta subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (559 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa) |
| | Bxe_A3956 | 7,8-Dihydro-6-hydroxymethylpterin- pyrophosphokinase, HPPK. (182 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa) |
| | Bxe_A3973 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (357 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (271 aa) |
| | Bxe_A4011 | Glutamate synthase (NADPH); Belongs to the glutamate synthase family. (536 aa) |
| | Bxe_A4042 | Dihydroneopterin triphosphate pyrophosphatase. (192 aa) |
| | ilvA-2 | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (535 aa) |
| | hisC-3 | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (359 aa) |
| | Bxe_A4143 | Putative glycosyl transferase. (323 aa) |
| | bioC | Conserved hypothetical protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (338 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (334 aa) |
| | Bxe_A4243 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (905 aa) |
| | Bxe_A4263 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa) |
| | bioF | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (394 aa) |
| | bioD | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (245 aa) |
| | bioB | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (360 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (287 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (299 aa) |
| | metXS | Homoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (381 aa) |
| | Bxe_A4479 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (577 aa) |
| | Bxe_A4526 | Gentisate pathway; Citation: Microbiol. Res. 160 (1), 53-59 (2005).Gene 312, 239-248 (2003). Appl Environ Microbiol. 1999Mar; 65(3): 946-950. J. Bacteriol. 183 (2), 700- 708(2001). (348 aa) |
| | Bxe_B0017 | MoaA/NifB/PqqE family protein. (384 aa) |
| | Bxe_B0029 | Putative dihydrodipicolinate synthase; Belongs to the DapA family. (294 aa) |
| | Bxe_B0137 | Benzoylformate decarboxylase (MdlC); Mandelate pathway; Citation: Biochemistry 37 (28), 9918-9930 (1998); Belongs to the TPP enzyme family. (525 aa) |
| | Bxe_B0181 | Putative thiamine pyrophosphate enzyme; Belongs to the TPP enzyme family. (552 aa) |
| | Bxe_B0239 | Putative zinc-containing alcohol dehydrogenase. (321 aa) |
| | Bxe_B0308 | Putative coenzyme PQQ synthesis protein D. (93 aa) |
| | lipA-2 | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa) |
| | fabZ-2 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (155 aa) |
| | Bxe_B0355 | Enoyl-[acyl-carrier-protein] reductase (NADH). (257 aa) |
| | ilvE-2 | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (310 aa) |
| | Bxe_B0373 | Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (390 aa) |
| | Bxe_B0458 | 2,3-dimethylmalate lyase. (296 aa) |
| | Bxe_B0459 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa) |
| | Bxe_B0460 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (206 aa) |
| | Bxe_B0461 | 2,3-dimethylmalate lyase. (301 aa) |
| | Bxe_B0525 | Non-ribosomal peptide synthase. (3180 aa) |
| | Bxe_B0598 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (338 aa) |
| | Bxe_B0616 | Serine O-acetyltransferase. (308 aa) |
| | Bxe_B0667 | Hypothetical protein. (126 aa) |
| | Bxe_B0670 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa) |
| | Bxe_B0677 | Conserved hypothetical protein. (314 aa) |
| | xsc | Sulfoacetaldehyde acetyltransferase; Citation: Biochem J. 2003 Jan 15;369(Pt 2):275-85; Belongs to the TPP enzyme family. (610 aa) |
| | Bxe_B0743 | Ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (311 aa) |
| | Bxe_B0882 | 4-hydroxyphenylpyruvate dioxygenase. (627 aa) |
| | aroQ-2 | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (160 aa) |
| | aroE-2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (296 aa) |
| | Bxe_B0922 | Putative nitrite/sulfite reductase. (595 aa) |
| | Bxe_B0941 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (481 aa) |
| | Bxe_B0942 | L-glutamine synthetase. (444 aa) |
| | Bxe_B0957 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (372 aa) |
| | Bxe_B0961 | Propionyl-CoA carboxylase. (535 aa) |
| | Bxe_B1112 | Conserved hypothetical protein. (262 aa) |
| | Bxe_B1115 | Putative acetolactate synthase large subunit; Belongs to the TPP enzyme family. (586 aa) |
| | Bxe_B1142 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa) |
| | Bxe_B1203 | 2,3-dimethylmalate lyase. (293 aa) |
| | Bxe_B1224 | Ketopantoate reductase. (327 aa) |
| | Bxe_B1245 | Putative oxidoreductase. (510 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (764 aa) |
| | Bxe_B1266 | Aldo/keto reductase. (331 aa) |
| | Bxe_B1422 | Pyrroline-5-carboxylate reductase. (264 aa) |
| | Bxe_B1438 | Putative homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (378 aa) |
| | Bxe_B1486 | Tartrate dehydrogenase. (360 aa) |
| | Bxe_B1489 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (465 aa) |
| | ilvD-2 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (588 aa) |
| | Bxe_B1533 | Aconitase; Belongs to the aconitase/IPM isomerase family. (861 aa) |
| | Bxe_B1555 | Serine O-acetyltransferase. (325 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa) |
| | Bxe_B1620 | Tartrate dehydrogenase. (368 aa) |
| | Bxe_B1799 | Gluconolactonase. (309 aa) |
| | Bxe_B1846 | Putative malonate decarboxylase delta subunit. (104 aa) |
| | Bxe_B1847 | Malonate decarboxylase, beta subunit. (300 aa) |
| | Bxe_B1850 | Putative acyl transferase. (310 aa) |
| | Bxe_B1926 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (171 aa) |
| | dapA-2 | Dihydrodipicolinate synthase family; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (307 aa) |
| | Bxe_B2140 | Gluconolactonase. (296 aa) |
| | Bxe_B2143 | Conserved hypothetical protein. (291 aa) |
| | Bxe_B2147 | 2,3-dimethylmalate lyase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family. (299 aa) |
| | Bxe_B2247 | Putative hexapeptide transferase family protein. (136 aa) |
| | Bxe_B2259 | Ketopantoate reductase. (325 aa) |
| | acpP | Putative acyl-carrier-protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (83 aa) |
| | orf20 | Tetrahydromethanopterin biosynthesis protein. (460 aa) |
| | orf17 | Putative phosphoribosylformimino-5-aminoimidazole carboxamideribotide isomerase; Required for methylotrophy; Belongs to the HisA/HisF family. (256 aa) |
| | pqqB | Pyrroloquinoline quinone biosynthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm; Belongs to the PqqB family. (306 aa) |
| | pqqC | Pyrroloquinoline quinone synthesis C; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (250 aa) |
| | pqqD | Pyrroloquinoline quinone synthesis D. (96 aa) |
| | pqqE | Pyrroloquinoline quinone synthesis E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (407 aa) |
| | gph-2 | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (228 aa) |
| | leuD-2 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (210 aa) |
| | leuC-2 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (477 aa) |
| | selD | Selenophosphate synthase; Synthesizes selenophosphate from selenide and ATP. (354 aa) |
| | ilvD-3 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (620 aa) |
| | Bxe_B2677 | Putative zinc-binding dehydrogenase. (319 aa) |
| | Bxe_B2759 | Putative oxalyl-CoA decarboxylase; Belongs to the TPP enzyme family. (580 aa) |
| | Bxe_B2768 | Conserved hypothetical protein. (246 aa) |
| | Bxe_B2813 | Putative dihydrodipicolinate synthetase; Belongs to the DapA family. (311 aa) |
| | thrB | Homoserine kinase; Belongs to the pseudomonas-type ThrB family. (331 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (396 aa) |
| | Bxe_B2877 | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. (436 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (281 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (237 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (373 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa) |
| | leuD-3 | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (217 aa) |
| | leuC-3 | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (399 aa) |
| | Bxe_C0016 | Putative aminotransferase. (429 aa) |
| | Bxe_C0050 | Enoyl-[acyl-carrier-protein] reductase (NADH). (257 aa) |
| | Bxe_C0056 | L-threonine ammonia-lyase. (344 aa) |
| | Bxe_C0061 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (465 aa) |
| | Bxe_C0062 | Putative Zinc-binding dehydrogenase. (364 aa) |
| | Bxe_C0121 | Serine O-acetyltransferase. (327 aa) |
| | Bxe_C0241 | Cysteine synthase. (315 aa) |
| | Bxe_C0294 | Putative pyruvate decarboxylase; Belongs to the TPP enzyme family. (590 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (443 aa) |
| | Bxe_C0353 | Putative senescence marker protein-30 (SMP-30). (295 aa) |
| | Bxe_C0387 | Putative acetyltransferase. (182 aa) |
| | Bxe_C0403 | Putative acetyltransferase. (175 aa) |
| | Bxe_C0417 | Conserved hypothetical protein. (308 aa) |
| | Bxe_C0418 | Hypothetical protein. (330 aa) |
| | Bxe_C0421 | Putative Orn/DAP/Arg decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (402 aa) |
| | Bxe_C0423 | Conserved hypothetical protein. (315 aa) |
| | Bxe_C0424 | Conserved hypothetical protein. (344 aa) |
| | Bxe_C0425 | Hypothetical protein. (92 aa) |
| | Bxe_C0659 | 2,3-dimethylmalate lyase. (322 aa) |
| | Bxe_C0661 | 2,3-dimethylmalate lyase. (310 aa) |
| | Bxe_C0664 | Putative pyruvate decarboxylase; Belongs to the TPP enzyme family. (561 aa) |
| | Bxe_C0665 | Isocitrate dehydrogenase (NAD+). (344 aa) |
| | Bxe_C0681 | Hypothetical protein. (119 aa) |
| | Bxe_C0738 | Putative hydantoin racemase. (254 aa) |
| | argF-3 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (333 aa) |
| | Bxe_C0769 | Tartrate dehydrogenase. (362 aa) |
| | Bxe_C0784 | Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (466 aa) |
| | dapD-2 | Putative tetrahydrodipicolinate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (299 aa) |
| | Bxe_C0879 | Shikimate dehydrogenase. (281 aa) |
| | ilvD-4 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (588 aa) |
| | Bxe_C1072 | UDP-glucose 6-dehydrogenase. (457 aa) |
| | Bxe_C1114 | Putative pyruvate decarboxylase; Belongs to the TPP enzyme family. (587 aa) |
| | Bxe_C1117 | Conserved hypothetical protein. (262 aa) |
| | Bxe_C1163 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. (568 aa) |
| | Bxe_C1169 | Conserved hypothetical protein. (253 aa) |
| | Bxe_C1229 | Tartrate dehydrogenase. (364 aa) |
| | Bxe_C1238 | Putative racemase. (236 aa) |
| | Bxe_C1284 | Putative thiamine pyrophosphate requiring enzyme; Belongs to the TPP enzyme family. (635 aa) |
| | Bxe_C1302 | Putative deaminase-reductase. (213 aa) |
| | Bxe_C1312 | Acetylornithine deacetylase. (398 aa) |
| | Bxe_C1359 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (594 aa) |
| | Bxe_C1362 | Xylono-1,4-lactonase. (294 aa) |
| | Bxe_A0365 | Glutamate synthase (NADH) large subunit. (1567 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (361 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (183 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (420 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (315 aa) |
| | Bxe_A0180 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (276 aa) |
| | Bxe_A0152 | Hypothetical protein. (107 aa) |
| | Bxe_A0098 | 3-oxoacyl-(acyl-carrier protein) synthase. (346 aa) |
| | Bxe_A0097 | Putative acyl carrier protein. (88 aa) |
| | Bxe_A0096 | 3-oxoacyl-(acyl-carrier protein) synthase. (354 aa) |
| | Bxe_A0090 | Nonspecific acid phosphatase precursor. (358 aa) |
| | Bxe_A0051 | Acetolactate synthase, large subunit, putative; Belongs to the TPP enzyme family. (574 aa) |
| | Bxe_A0049 | Delta-1-pyrroline-5-carboxylate dehydrogenase / L-proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1309 aa) |
| | Bxe_A0011 | Phenylalanine degradation; Citation: J. Mol. Biol. 320 (3), 645-661 (2002). (336 aa) |
| | hisG | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (232 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (440 aa) |
| | hisC | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (195 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (250 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (136 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase. (131 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (261 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (349 aa) |
| | trpE | Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...] (497 aa) |
| | gph | Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (238 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (437 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (372 aa) |
| | Bxe_A0531 | Acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (461 aa) |
| | Bxe_A0532 | Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (287 aa) |
| | Bxe_A0550 | L-arabinonolactonase. (304 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (254 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (423 aa) |
| | ilvE | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa) |
| | kynU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (416 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (408 aa) |
| | argF | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (309 aa) |
| | nadA | Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (379 aa) |
| | argD | Acetylornithine aminotransferase apoenzyme; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (394 aa) |
| | Bxe_A0886 | Serine/threonine dehydratase. (321 aa) |
| | Bxe_A0926 | Conserved hypothetical protein. (248 aa) |
| | Bxe_A0928 | Putative acyl-carrier protein. (99 aa) |
