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| | Meso_0008 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (302 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferases; PFAM: aminotransferase, class I and II aminotransferase class-III; KEGG: mlo:mlr5646 acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa) |
| | Meso_0088 | TIGRFAM: 5-aminolevulinic acid synthase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II aminotransferase class-III; KEGG: bmb:BruAb1_0345 HemA, 5-aminolevulinic acid synthase. (425 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (363 aa) |
| | Meso_0097 | dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: bmb:BruAb1_0332 dCTP deaminase. (361 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (396 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase / 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa) |
| | Meso_0161 | PFAM: glutamine synthetase, catalytic region; KEGG: bms:BRA0768 glutamine synthetase family protein. (475 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | Meso_0309 | L-threonine ammonia-lyase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: ret:RHE_CH03537 probable threonine dehydratase protein. (324 aa) |
| | Meso_0328 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1264 aa) |
| | Meso_0373 | Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (457 aa) |
| | argB | N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (312 aa) |
| | Meso_0398 | PFAM: Hydantoinase/oxoprolinase Hydantoinase B/oxoprolinase Hydantoinaseoxoprolinase-like; KEGG: bja:blr3621 probable hydantoin utilization protein. (1277 aa) |
| | Meso_0405 | PFAM: Rhodanese-like; KEGG: rpa:RPA3613 putative thiosulfate sulfurtransferase. (284 aa) |
| | Meso_0409 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: psp:PSPPH_2974 D-isomer specific 2-hydroxyacid dehydrogenase family protein. (312 aa) |
| | hisG | ATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (230 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (373 aa) |
| | Meso_0421 | KEGG: atu:Atu1660 hypothetical protein. (70 aa) |
| | hisS | TIGRFAM: histidyl-tRNA synthetase; PFAM: tRNA synthetase, class II (G, H, P and S) Anticodon-binding; KEGG: bms:BRA0187 histidyl-tRNA synthetase. (503 aa) |
| | Meso_0423 | TIGRFAM: HAD-superfamily subfamily IIA hydrolase like protein HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase-like hydrolase; KEGG: bmb:BruAb2_0194 hydrolase, haloacid dehalogenase-like family. (286 aa) |
| | Meso_0424 | FMN adenylyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF cytidyltransferase-related domain; PFAM: Riboflavin kinase / FAD synthetase; KEGG: mlo:mlr8243 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (330 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (395 aa) |
| | tdh | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (344 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (519 aa) |
| | Meso_0590 | Transcriptional regulator, AraC family with amidase-like domain; PFAM: helix-turn-helix, AraC type ThiJ/PfpI; KEGG: atc:AGR_L_1109 hypothetical protein. (347 aa) |
| | Meso_0591 | TIGRFAM: sarcosine oxidase, beta subunit family; PFAM: FAD dependent oxidoreductase; KEGG: atc:AGR_L_1106 sarcosine oxidase beta subunit. (417 aa) |
| | Meso_0592 | TIGRFAM: sarcosine oxidase, delta subunit family; PFAM: Sarcosine oxidase, delta subunit, heterotetrameric; KEGG: atc:AGR_L_1105 sarcosine oxidase, subunit delta. (100 aa) |
| | Meso_0593 | TIGRFAM: sarcosine oxidase, alpha subunit family; PFAM: glycine cleavage T protein (aminomethyl transferase) FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: atc:AGR_L_1103 sarcosine oxidase alpha subunit. (997 aa) |
| | Meso_0594 | PFAM: Sarcosine oxidase, gamma subunit; KEGG: atc:AGR_L_1101 sarcosine oxidase gamma subunit. (182 aa) |
| | Meso_0624 | PFAM: homocysteine S-methyltransferase; KEGG: jan:Jann_3671 homocysteine S-methyltransferase. (312 aa) |
| | katG | Catalase/peroxidase HPI; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (726 aa) |
| | Meso_0662 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle region; KEGG: mlo:mlr5076 folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (440 aa) |
| | trpA | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (281 aa) |
| | trpB | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpF | PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); KEGG: bmb:BruAb1_2086 TrpF, N-(5phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (218 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) |
| | purD | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase protein of unknown function DUF201; KEGG: mlo:mlr7447 phosphoribosylamine-glycine ligase; Belongs to the GARS family. (426 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa) |
| | thrB | TIGRFAM: homoserine kinase; PFAM: aminoglycoside phosphotransferase; KEGG: mlo:mlr7503 homoserine kinase; Belongs to the pseudomonas-type ThrB family. (322 aa) |
| | Meso_0760 | TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mll7517 threonine synthase. (467 aa) |
| | cysD | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: mlo:mlr7575 sulfate adenylyltransferase subunit 2. (301 aa) |
| | cysN | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (640 aa) |
| | cysQ | 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (274 aa) |
| | Meso_0933 | PFAM: aminotransferase, class I and II; KEGG: mlo:mll7737 histidinol-phosphate aminotransferase. (371 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | cysS | TIGRFAM: cysteinyl-tRNA synthetase; PFAM: cysteinyl-tRNA synthetase, class Ia; KEGG: mlo:mlr7799 cysteine-tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (506 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (490 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (139 aa) |
| | gcvP | Glycine dehydrogenase (decarboxylating) alpha subunit; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (931 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (122 aa) |
| | Meso_1018 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); KEGG: mlo:mlr0883 glycine cleavage system protein T. (364 aa) |
| | Meso_1112 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mlo:mll8145 cystathionine beta-lyase. (388 aa) |
| | Meso_1129 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: mlo:mll8390 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (343 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (437 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa) |
| | Meso_1167 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mlo:mlr8465 O-acetylhomoserine (thiol)-lyase. (427 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (744 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: mlo:mll0069 phosphoribosylaminoimidazole-succinocarboxamide synthase. (263 aa) |
| | Meso_1285 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | Meso_1325 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1204 aa) |
| | Meso_1332 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1258 aa) |
| | gpt | Phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa) |
| | Meso_1358 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: mlo:mlr0687 probable noncatalytic chain of dihydroorotase. (428 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: mlo:mlr0686 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (319 aa) |
| | Meso_1367 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain serine dehydratase beta chain; KEGG: mlo:mll0670 L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (466 aa) |
| | ilvA | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (418 aa) |
| | Meso_1424 | PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; KEGG: mlo:mlr0353 O-acetylserine (thiol) lyase. (346 aa) |
| | Meso_1426 | PFAM: Rhodanese-like; KEGG: mlo:mlr0355 thiosulfate sulfurtransferase. (281 aa) |
| | Meso_1462 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase, class II; KEGG: mlo:mll0826 phospho-2-dehydro-3-deoxyheptonate aldolase. (458 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (346 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (234 aa) |
| | Meso_1479 | Aminotransferase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase aminotransferase, class I and II; KEGG: mlo:mlr1282 aspartate transaminase. (397 aa) |
| | Meso_1544 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region glutamine synthetase, beta-Grasp; KEGG: sme:SMc00948 glutamine synthetase I protein. (469 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (225 aa) |
| | Meso_1614 | PFAM: aminotransferase, class IV; KEGG: mlo:mlr0401 D-alanine aminotransferase. (288 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: bme:BMEI0843 indole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (271 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (194 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa) |
| | Meso_1729 | TIGRFAM: serine O-acetyltransferase; PFAM: transferase hexapeptide repeat serine acetyltransferase-like; KEGG: mlo:mlr0175 serine acetyltransferase. (272 aa) |
| | Meso_1744 | TIGRFAM: phosphoserine phosphatase SerB HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase-like hydrolase; KEGG: mlo:mlr1449 probable phosphoserine phosphatase. (295 aa) |
| | Meso_1750 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (167 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (218 aa) |
| | Meso_1828 | PFAM: FAD dependent oxidoreductase; KEGG: bcl:ABC0532 glycine/D-amino acid oxidase. (371 aa) |
| | Meso_1830 | PFAM: NADPH-dependent FMN reductase; KEGG: bbr:BB0642 NADPH-dependent FMN reductase. (197 aa) |
| | Meso_1852 | PFAM: NADPH-dependent FMN reductase; KEGG: ret:RHE_PC00012 probable NAD(P)H-dependent FMN reductase protein. (190 aa) |
| | Meso_1870 | PFAM: glutamine synthetase, catalytic region; KEGG: sme:SMc01594 probable glutamine synthetase. (455 aa) |
| | Meso_1922 | PFAM: homoserine dehydrogenase amino acid-binding ACT homoserine dehydrogenase, NAD-binding; KEGG: mlo:mll0934 homoserine dehydrogenase. (436 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein AIR synthase related protein-like; KEGG: mlo:mll7962 5'-phosphoribosyl-5-aminoimidazole synthetase. (368 aa) |
| | purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (236 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | Meso_2020 | PFAM: Hydantoinase/oxoprolinase Hydantoinase B/oxoprolinase Hydantoinaseoxoprolinase-like; KEGG: mlo:mlr1573 5-oxoprolinase. (1218 aa) |
| | Meso_2028 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: mlo:mll1587 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (305 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I Carbamoyl-phosphate synthase, small chain; KEGG: mlo:mlr2489 carbamoyl-phosphate synthetase small subunit; Belongs to the CarA family. (399 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain, oligomerisation Carbamoyl-phosphate synthetase large chain-like MGS-like; KEGG: mlo:mlr2517 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1162 aa) |
| | Meso_2107 | PFAM: aminotransferase, class I and II; KEGG: mlo:mlr2541 aspartate aminotransferase A. (400 aa) |
| | Meso_2108 | PFAM: amidinotransferase; KEGG: efa:EF2972 amidinotransferase family protein. (323 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) |
| | Meso_2199 | TIGRFAM: glutamine amidotransferase of anthranilate synthase anthranilate synthase; PFAM: glutamine amidotransferase class-I Anthranilate synthase component I and chorismate binding protein Anthranilate synthase component I-like; KEGG: mlo:mlr2774 anthranilate synthase. (729 aa) |
| | fhs | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: mlo:mlr2763 formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (559 aa) |
| | Meso_2239 | TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; KEGG: hch:HCH_05488 carbamate kinase; Belongs to the carbamate kinase family. (305 aa) |
| | Meso_2240 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (333 aa) |
| | arcA | TIGRFAM: arginine deiminase; PFAM: amidinotransferase; KEGG: hch:HCH_05490 arginine deiminase. (408 aa) |
| | Meso_2242 | PFAM: C4-dicarboxylate anaerobic carrier; KEGG: ppr:PBPRA0478 putative membrane protein. (478 aa) |
| | Meso_2294 | PFAM: Shikimate/quinate 5-dehydrogenase Shikimate dehydrogenase substrate binding-like; KEGG: ppu:PP2608 shikimate dehydrogenase family protein. (288 aa) |
| | Meso_2359 | PFAM: aminotransferase, class IV; KEGG: bms:BRA0934 D-alanine aminotransferase, putative. (285 aa) |
| | Meso_2364 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: rru:Rru_A1613 cystathionine beta-lyase. (398 aa) |
| | Meso_2378 | KEGG: ava:Ava_1266 xenobiotic compound monooxygenase, DszA family, A subunit. (440 aa) |
| | Meso_2390 | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: reu:Reut_B3820 argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (499 aa) |
| | Meso_2392 | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: reu:Reut_B3820 argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. (499 aa) |
| | Meso_2416 | PFAM: aminotransferase class-III; KEGG: mlo:mll7127 putative aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa) |
| | Meso_2417 | PFAM: aldehyde dehydrogenase; KEGG: mlo:mll7128 succinic semialdehyde dehydrogenase. (525 aa) |
| | Meso_2629 | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: mth:MTH269 argininosuccinate lyase. (499 aa) |
| | Meso_2642 | PFAM: Rhodanese-like; KEGG: mag:amb1299 rhodanese-related sulfurtransferase. (286 aa) |
| | Meso_2643 | PFAM: aminotransferase, class I and II Thioredoxin domain; KEGG: bcl:ABC2888 aminotransferase. (514 aa) |
| | Meso_2644 | PFAM: FAD dependent oxidoreductase; KEGG: sme:SMc03200 putative amino acid deaminase transmembrane protein. (396 aa) |
| | Meso_2645 | PFAM: molybdopterin oxidoreductase molydopterin dinucleotide-binding region; KEGG: rpa:RPA4653 biotin sulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (771 aa) |
| | Meso_2698 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: rpb:RPB_1584 methionine synthase, vitamin-B12 independent. (373 aa) |
| | metE | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (769 aa) |
| | Meso_2702 | Ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (369 aa) |
| | Meso_2703 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (954 aa) |
| | Meso_2729 | TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: bmb:BruAb2_0080 para-aminobenzoate synthase, component I. (385 aa) |
| | Meso_2743 | TIGRFAM: glutamate synthases, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mlo:mll3029 glutamate synthase (NADPH) small chain. (484 aa) |
| | Meso_2744 | PFAM: glutamine amidotransferase, class-II glutamate synthase, alpha subunit-like ferredoxin-dependent glutamate synthase glutamate synthase; KEGG: mlo:mll3030 glutamate synthase (NADPH) large chain. (1574 aa) |
| | Meso_2745 | L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (352 aa) |
| | Meso_2891 | PFAM: cytochrome c, class I. (201 aa) |
| | Meso_2920 | DoxX; PFAM: DoxX; KEGG: sco:SCO0201 integral membrane protein SCJ1213c. (160 aa) |
| | Meso_3001 | TIGRFAM: aspartate kinase aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase amino acid-binding ACT; KEGG: bmb:BruAb1_1850 aspartate kinase, monofunctional class; Belongs to the aspartokinase family. (424 aa) |
| | argJ | N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mlr3506 argininosuccinate lyase, (ASAL). (473 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (195 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (375 aa) |
| | metAA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (312 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mlo:mll3536 imidazole acetol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa) |
| | Meso_3085 | PFAM: Prephenate dehydrogenase NADP oxidoreductase, coenzyme F420-dependent 6-phosphogluconate dehydrogenase, NAD-binding NAD-dependent glycerol-3-phosphate dehydrogenase-like; KEGG: mlo:mll3535 cyclohexadienyl dehydrogenase / prephenate dehydrogenase. (319 aa) |
| | Meso_3093 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: mlo:mll3520 hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa) |
| | Meso_3139 | PFAM: dihydrodipicolinate synthetase; KEGG: rpa:RPA3190 possible dihydrodipicoline synthase related protein; Belongs to the DapA family. (308 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | Meso_3161 | TIGRFAM: D-3-phosphoglycerate dehydrogenase; PFAM: amino acid-binding ACT D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; KEGG: mlo:mll3875 phosphoglycerate dehydrogenase. (532 aa) |
| | Meso_3162 | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (390 aa) |
| | Meso_3197 | PFAM: glutamine amidotransferase class-I; KEGG: mlo:mll4216 glutamine amidotransferase. (261 aa) |
| | Meso_3308 | Serine-glyoxylate aminotransferase apoenzyme; PFAM: aminotransferase, class V; KEGG: sil:SPOA0144 serine--glyoxylate transaminase, putative. (398 aa) |
| | Meso_3322 | PFAM: FAD dependent oxidoreductase; KEGG: mlo:mll3980 D-amino-acid dehydrogenase. (435 aa) |
| | Meso_3340 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; KEGG: mlo:mlr4380 chorismate mutase. (108 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: mlo:mlr4366 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (419 aa) |
| | asd | Aspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (293 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (364 aa) |
| | purH | IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like; KEGG: mlo:mlr4101 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (537 aa) |
| | Meso_3422 | PFAM: NAD-glutamate dehydrogenase; KEGG: mlo:mll4104 hypothetical protein. (1586 aa) |
| | proA | Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (428 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (390 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (279 aa) |
| | Meso_3491 | PFAM: GCN5-related N-acetyltransferase; KEGG: sme:SMc02576 hypothetical acetyltransferase protein. (179 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mlo:mlr5008 imidazoleglycerol-phosphate dehydratase. (202 aa) |
| | Meso_3494 | KEGG: mlo:mlr5010 hypothetical protein. (161 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. (247 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (268 aa) |
| | hisE | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mlo:mlr5018 phosphoribosyl-ATP pyrophosphatase. (112 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (465 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (277 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa) |
| | Meso_3626 | PFAM: aminotransferase, class I and II; KEGG: sme:SMc04386 aspartate aminotransferase B protein. (411 aa) |
| | Meso_3628 | PFAM: protein of unknown function DUF1338; KEGG: sme:SMc04383 hypothetical protein. (482 aa) |
| | Meso_3629 | TIGRFAM: cystathionine beta-lyase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: mag:amb1294 cystathionine beta-lyase/cystathionine gamma-synthase. (388 aa) |
| | Meso_3630 | PFAM: Rhodanese-like; KEGG: cfa:474515 similar to 3-mercaptopyruvate sulfurtransferase. (282 aa) |
| | Meso_3711 | PFAM: NADPH-dependent FMN reductase; KEGG: sma:SAV3813 putative NADPH-dependent FMN reductase. (202 aa) |
| | Meso_3736 | PFAM: aminotransferase, class I and II; KEGG: dde:Dde_0276 aminotransferase, classes I and II. (392 aa) |
| | Meso_3758 | PFAM: dihydrodipicolinate synthetase; KEGG: jan:Jann_3748 dihydrodipicolinate synthetase; Belongs to the DapA family. (295 aa) |
| | Meso_3874 | TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; KEGG: hch:HCH_05488 carbamate kinase; Belongs to the carbamate kinase family. (303 aa) |
| | Meso_3924 | PFAM: S-adenosylmethionine synthetase; KEGG: atc:AGR_C_632 S-adenosylmethionine synthetase; Belongs to the AdoMet synthase family. (443 aa) |
| | Meso_3972 | PFAM: Shikimate/quinate 5-dehydrogenase Shikimate dehydrogenase substrate binding-like; KEGG: bme:BMEII0871 shikimate 5-dehydrogenase. (269 aa) |
| | Meso_3989 | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (480 aa) |
| | Meso_3990 | KEGG: mlo:msl3231 hypothetical protein. (102 aa) |
| | Meso_3991 | PFAM: nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like nitrite and sulphite reductase 4Fe-4S region; KEGG: mlo:mll3230 sulfite reductase hemoprotein subunit. (556 aa) |
| | cysH | Phosphoadenylylsulfate reductase (thioredoxin); Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (245 aa) |
| | Meso_3993 | PFAM: Uncharacterised conserved protein UCP030820; KEGG: mlo:mll3227 hypothetical protein. (178 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (161 aa) |
| | Meso_4087 | PFAM: prephenate dehydratase amino acid-binding ACT; KEGG: bmb:BruAb1_0037 PheA, prephenate dehydratase. (290 aa) |
