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Meso_2544 | PFAM: amidohydrolase; KEGG: ret:RHE_CH00351 probable allantoinase protein. (459 aa) | ||||
Meso_2563 | TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS; KEGG: mlo:msl5792 thiamin biosynthesis ThiS. (65 aa) | ||||
thiG | Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (258 aa) | ||||
thiE | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (206 aa) | ||||
Meso_2566 | TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: mlo:mll5788 phosphomethylpyrimidine kinase. (256 aa) | ||||
Meso_2641 | PFAM: amidohydrolase; KEGG: ret:RHE_CH00351 probable allantoinase protein. (452 aa) | ||||
Meso_2664 | TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase Amidohydrolase 3; KEGG: bms:BR0278 D-hydantoinase. (485 aa) | ||||
Meso_3182 | PFAM: thiamine monophosphate synthase; KEGG: mlo:mlr3913 thiamine-phosphate pyrophosphorylase. (219 aa) | ||||
Meso_3405 | TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic region; KEGG: mlo:mlr3869 hypothetical protein. (215 aa) | ||||
cmk | TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: sme:SMc00334 putative cytidylate kinase (CMP kinase) protein. (218 aa) | ||||
Meso_3655 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (131 aa) | ||||
deoA | Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (438 aa) | ||||
Meso_4078 | PFAM: alpha/beta hydrolase fold; KEGG: sma:SAV923 putative hydrolase. (267 aa) | ||||
dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (161 aa) | ||||
Meso_3880 | TIGRFAM: putative thymidine phosphorylase; PFAM: glycosyl transferase, family 3 Pyrimidine nucleoside phosphorylase-like; KEGG: hch:HCH_01516 thymidine phosphorylase. (509 aa) | ||||
Meso_3755 | PFAM: flavin reductase-like, FMN-binding; KEGG: reu:Reut_A1544 flavin reductase-like, FMN-binding. (154 aa) | ||||
Meso_3658 | PFAM: phosphoribosyltransferase; KEGG: mlo:mll3162 uracil phosphoribosyltransferase. (148 aa) | ||||
pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa) | ||||
Meso_1472 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: ret:RHE_CH04090 hypothetical protein. (138 aa) | ||||
pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (346 aa) | ||||
pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (234 aa) | ||||
tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (225 aa) | ||||
Meso_1611 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mlo:mll0404 MazG protein. (267 aa) | ||||
pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) | ||||
thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) | ||||
surE | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa) | ||||
Meso_1831 | KEGG: sme:SMa2101 probable nitrilotriacetate monooxygenase component A. (430 aa) | ||||
Meso_1853 | KEGG: ava:Ava_1266 xenobiotic compound monooxygenase, DszA family, A subunit. (456 aa) | ||||
ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) | ||||
Meso_2055 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase 4Fe-4S ferredoxin, iron-sulfur binding; KEGG: sme:SMc01815 dihydropyrimidine dehydrogenase. (437 aa) | ||||
carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I Carbamoyl-phosphate synthase, small chain; KEGG: mlo:mlr2489 carbamoyl-phosphate synthetase small subunit; Belongs to the CarA family. (399 aa) | ||||
carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain, oligomerisation Carbamoyl-phosphate synthetase large chain-like MGS-like; KEGG: mlo:mlr2517 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1162 aa) | ||||
pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (363 aa) | ||||
Meso_0446 | TIGRFAM: 3-oxoadipate enol-lactonase; PFAM: alpha/beta hydrolase fold Ndr; KEGG: sme:SMb20579 putative beta-ketoadipate enol-lactone hydrolase protein. (264 aa) | ||||
pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) | ||||
dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (650 aa) | ||||
Meso_0820 | PFAM: alpha/beta hydrolase fold; KEGG: bte:BTH_II1498 hydrolase, alpha/beta fold family. (282 aa) | ||||
Meso_0958 | PFAM: metal-dependent phosphohydrolase, HD subdomain; KEGG: sme:SMc02559 hypothetical protein. (203 aa) | ||||
Meso_1289 | PFAM: flavin reductase-like, FMN-binding; KEGG: mlo:mlr0087 putative 4-hydroxyphenylacetate 3-monooxygenase. (164 aa) | ||||
Meso_1309 | PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: mlo:mlr1197 hypothetical protein. (155 aa) | ||||
Meso_1358 | TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: mlo:mlr0687 probable noncatalytic chain of dihydroorotase. (428 aa) | ||||
pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: mlo:mlr0686 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (319 aa) | ||||
Meso_2306 | PFAM: isochorismatase hydrolase; KEGG: bpa:BPP3892 putative hydrolase. (246 aa) | ||||
Meso_2361 | KEGG: ava:Ava_1266 xenobiotic compound monooxygenase, DszA family, A subunit. (441 aa) | ||||
Meso_2378 | KEGG: ava:Ava_1266 xenobiotic compound monooxygenase, DszA family, A subunit. (440 aa) | ||||
Meso_2385 | PFAM: flavin reductase-like, FMN-binding; KEGG: reu:Reut_B5770 flavin reductase-like, FMN-binding. (162 aa) | ||||
Meso_2464 | PFAM: flavin reductase-like, FMN-binding; KEGG: psb:Psyr_0995 flavin reductase-like. (170 aa) | ||||
Meso_2480 | PFAM: Endoribonuclease L-PSP; KEGG: mlo:mll5429 hypothetical protein. (131 aa) | ||||
Meso_2526 | 3-oxoadipate enol-lactonase; PFAM: alpha/beta hydrolase fold; KEGG: ret:RHE_PF00194 probable 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase protein. (275 aa) | ||||
thiC | Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (608 aa) |