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| | Meso_0492 | PFAM: glycosyl transferase, group 1; KEGG: pmi:PMT9312_1301 glycosyltransferase-like. (410 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (519 aa) |
| | Meso_0580 | Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding; KEGG: reu:Reut_B4507 aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead:aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding. (704 aa) |
| | Meso_0634 | PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; KEGG: mlo:mlr4960 penicillin-binding protein; Belongs to the peptidase S11 family. (287 aa) |
| | Meso_0645 | PFAM: NUDIX hydrolase; KEGG: sme:SMb20988 hypothetical protein. (155 aa) |
| | Meso_0649 | PFAM: polysaccharide biosynthesis protein; KEGG: ret:RHE_PE00198 putative succinoglycan biosynthesis transport protein. (498 aa) |
| | Meso_0651 | PFAM: O-antigen polymerase; KEGG: rsp:RSP_2549 putative polysaccharide polymerase. (428 aa) |
| | Meso_0660 | TIGRFAM: exopolysaccharide transport protein family; PFAM: lipopolysaccharide biosynthesis; KEGG: mlo:mlr5276 exopolysaccharide polymerization protein, succinoglycan biosynthesis transport protein ExoP. (776 aa) |
| | Meso_0662 | TIGRFAM: FolC bifunctional protein; PFAM: Mur ligase, middle region; KEGG: mlo:mlr5076 folylpolyglutamate synthase / dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family. (440 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (307 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) |
| | atpB | ATP synthase F0 subcomplex A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (249 aa) |
| | atpE | ATP synthase F0 subcomplex C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (75 aa) |
| | atpF1 | H+-transporting two-sector ATPase, B/B' subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (193 aa) |
| | atpF2 | ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (159 aa) |
| | purD | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase protein of unknown function DUF201; KEGG: mlo:mlr7447 phosphoribosylamine-glycine ligase; Belongs to the GARS family. (426 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (650 aa) |
| | Meso_0753 | PFAM: protein of unknown function DUF179; KEGG: mlo:mlr7511 putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. (202 aa) |
| | Meso_0769 | KEGG: sme:SMc01535 hypothetical protein. (177 aa) |
| | Meso_0779 | Polysaccharide biosynthesis protein CapD; PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR 3-beta hydroxysteroid dehydrogenase/isomerase polysaccharide biosynthesis protein CapD Male sterility-like; KEGG: bms:BR0510 epimerase/dehydratase, putative. (644 aa) |
| | Meso_0785 | PFAM: NAD-dependent epimerase/dehydratase 3-beta hydroxysteroid dehydrogenase/isomerase polysaccharide biosynthesis protein CapD dTDP-4-dehydrorhamnose reductase Male sterility-like; KEGG: bja:blr3666 nucleoside-diphosphate-sugar epimerase. (300 aa) |
| | Meso_0832 | PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; KEGG: mlo:mll7579 probable aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (393 aa) |
| | murJ | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (528 aa) |
| | Meso_4038 | PFAM: ErfK/YbiS/YcfS/YnhG; KEGG: bms:BR0139 lipoprotein, putative. (206 aa) |
| | queE | preQ(0) biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (246 aa) |
| | Meso_4052 | PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ret:RHE_CH03712 6-pyruvoyl tetrahydropterin synthase protein. (118 aa) |
| | queC | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (232 aa) |
| | Meso_4055 | Phosphopantothenoylcysteine decarboxylase / Phosphopantothenate-cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (411 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (161 aa) |
| | kdsB | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (251 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (409 aa) |
| | Meso_0859 | PFAM: ErfK/YbiS/YcfS/YnhG; KEGG: bmb:BruAb1_0586 hypothetical protein. (247 aa) |
| | Meso_0883 | TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51 penicillin-binding protein, transpeptidase; KEGG: mlo:mll7657 penicillin-binding protein. (714 aa) |
| | Meso_0907 | Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding; KEGG: mlo:mlr7702 putative dehydrogenase. (770 aa) |
| | amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (499 aa) |
| | Meso_0958 | PFAM: metal-dependent phosphohydrolase, HD subdomain; KEGG: sme:SMc02559 hypothetical protein. (203 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (490 aa) |
| | Meso_1133 | TIGRFAM: Twin-arginine translocation pathway signal; PFAM: Peptidoglycan-binding domain 1; KEGG: mlo:mlr8397 hypothetical protein. (419 aa) |
| | Meso_1153 | KEGG: mlo:mll8434 hypothetical protein. (421 aa) |
| | Meso_1157 | TIGRFAM: exopolysaccharide transport protein family; PFAM: lipopolysaccharide biosynthesis; KEGG: mlo:mlr8439 succinoglycan transport protein ExoP. (720 aa) |
| | Meso_1158 | KEGG: mlo:mll8447 hypothetical protein. (400 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (274 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (744 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) |
| | purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: mlo:mll0069 phosphoribosylaminoimidazole-succinocarboxamide synthase. (263 aa) |
| | Meso_1285 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) |
| | Meso_1314 | PFAM: ErfK/YbiS/YcfS/YnhG; KEGG: mlo:mll1184 hypothetical protein. (139 aa) |
| | Meso_1315 | PFAM: lipid A biosynthesis acyltransferase; KEGG: mlo:mlr1179 lipid A biosynthesis lauroyl acyltransferase. (306 aa) |
| | Meso_1320 | PFAM: phosphopantetheine-binding; KEGG: ret:RHE_CH02478 acyl carrier protein. (94 aa) |
| | gpt | Phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa) |
| | pyrB | TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: mlo:mlr0686 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (319 aa) |
| | Meso_1371 | PFAM: beta-lactamase peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 Sporulation related; KEGG: mlo:mlr0666 penicillin-binding protein; Belongs to the peptidase S11 family. (465 aa) |
| | Meso_1374 | PFAM: O-antigen polymerase; KEGG: ret:RHE_CH00790 hypothetical protein. (426 aa) |
| | Meso_1375 | PFAM: glycosyl transferase, family 25; KEGG: atc:AGR_C_3310 glycosyl transferase, family 25. (241 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa) |
| | lpxD | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (365 aa) |
| | fabZ | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (156 aa) |
| | lpxA | acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (277 aa) |
| | Meso_1392 | PFAM: protein of unknown function DUF1009; KEGG: mlo:mll0631 hypothetical protein. (297 aa) |
| | Meso_1393 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (392 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa) |
| | queA | Queuosine biosynthesis protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (358 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (376 aa) |
| | Meso_1431 | PFAM: glycosyl transferase, family 51; KEGG: sme:SMa1905 putative MrcB penicillin binding protein B. (300 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (346 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (234 aa) |
| | Meso_1538 | PFAM: metallophosphoesterase; KEGG: mlo:mll0806 hypothetical protein. (273 aa) |
| | Meso_1556 | KEGG: mlo:mll0533 hypothetical protein. (661 aa) |
| | Meso_1580 | PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 Penicillin-binding protein 5-like; KEGG: mlo:mll0426 penicillin binding protein; Belongs to the peptidase S11 family. (382 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (225 aa) |
| | Meso_1629 | Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (466 aa) |
| | kdsA | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: bme:BMEI0850 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase). (276 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (194 aa) |
| | glmS | Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (607 aa) |
| | Meso_1708 | TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51 penicillin-binding protein, transpeptidase; KEGG: mlo:mlr0215 penicillin-binding protein. (818 aa) |
| | Meso_1716 | acetyl-CoA carboxylase carboxyltransferase subunit alpha; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (391 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (454 aa) |
| | purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein AIR synthase related protein-like; KEGG: mlo:mll7962 5'-phosphoribosyl-5-aminoimidazole synthetase. (368 aa) |
| | purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (236 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | lpxC | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (327 aa) |
| | ddl | D-alanine--D-alanine ligase; Cell wall formation. (308 aa) |
| | murB | UDP-N-acetylmuramate dehydrogenase; Cell wall formation. (321 aa) |
| | murC | UDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (465 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (375 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (467 aa) |
| | mraY | Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (477 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (483 aa) |
| | Meso_2055 | Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase 4Fe-4S ferredoxin, iron-sulfur binding; KEGG: sme:SMc01815 dihydropyrimidine dehydrogenase. (437 aa) |
| | carA | TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I Carbamoyl-phosphate synthase, small chain; KEGG: mlo:mlr2489 carbamoyl-phosphate synthetase small subunit; Belongs to the CarA family. (399 aa) |
| | Meso_2094 | PFAM: MltA-interacting MipA; KEGG: ret:RHE_CH00894 hypothetical conserved membrane protein. (270 aa) |
| | carB | TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain, oligomerisation Carbamoyl-phosphate synthetase large chain-like MGS-like; KEGG: mlo:mlr2517 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1162 aa) |
| | Meso_2114 | PFAM: glycosyl transferase, family 25; KEGG: bmb:BruAb1_1592 glycosyl transferase, family 25. (258 aa) |
| | Meso_2115 | KEGG: ath:At1g64980 expressed protein. (455 aa) |
| | Meso_2116 | PFAM: glycosyl transferase, family 25; KEGG: bms:BR0321 glycosyl transferase, family 25. (250 aa) |
| | Meso_2126 | PFAM: NAD-dependent epimerase/dehydratase 3-beta hydroxysteroid dehydrogenase/isomerase Male sterility-like; KEGG: sme:SMc03963 sulfolipid biosynthesis protein. (301 aa) |
| | Meso_2128 | UDP-sulfoquinovose synthase; PFAM: NAD-dependent epimerase/dehydratase; KEGG: ret:RHE_CH03468 sulfolipid (UDP-sulfoquinovose) biosynthesis protein. (406 aa) |
| | Meso_2143 | PFAM: SPW repeat; KEGG: ret:RHE_CH01246 hypothetical protein. (120 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (390 aa) |
| | Meso_2262 | PFAM: NUDIX hydrolase; KEGG: sme:SMb20988 hypothetical protein. (155 aa) |
| | Meso_2266 | TIGRFAM: Twin-arginine translocation pathway signal; PFAM: dehydrogenase, E1 component; KEGG: tte:TTE0186 Thiamine pyrophosphate-dependent dehydrogenases, E1 component alpha subunit. (375 aa) |
| | Meso_2349 | Xanthosine triphosphate pyrophosphatase-like protein; KEGG: pto:PTO0809 hypothetical protein. (531 aa) |
| | Meso_2393 | PFAM: NAD/NADP octopine/nopaline dehydrogenase NAD-dependent glycerol-3-phosphate dehydrogenase-like Ketopantoate reductase ApbA/PanE-like; KEGG: sth:STH257 NAD/NADP octopine/nopaline dehydrogenase. (359 aa) |
| | Meso_2403 | Methylthioadenosine phosphorylase; Purine nucleoside phosphorylase involved in purine salvage. (276 aa) |
| | Meso_2584 | PFAM: DegT/DnrJ/EryC1/StrS aminotransferase aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: rpa:RPA3350 putative aminotransferase; Belongs to the DegT/DnrJ/EryC1 family. (392 aa) |
| | Meso_2587 | PFAM: polysaccharide biosynthesis protein; KEGG: gvi:gll1781 probable polysaccharide transport protein. (508 aa) |
| | Meso_2592 | PFAM: lipopolysaccharide biosynthesis; KEGG: ret:RHE_CH03233 exopolysaccharide polymerization protein. (790 aa) |
| | Meso_2661 | KEGG: rpa:RPA2648 hypothetical protein. (261 aa) |
| | Meso_2696 | KEGG: ade:Adeh_1016 glycosyl transferase, group 1. (311 aa) |
| | Meso_2702 | Ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (369 aa) |
| | Meso_2734 | PFAM: Peptidoglycan-binding domain 1; KEGG: bmf:BAB2_0084 hypothetical protein. (300 aa) |
| | Meso_2761 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (189 aa) |
| | Meso_2763 | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (295 aa) |
| | Meso_2774 | PFAM: NAD-dependent epimerase/dehydratase 3-beta hydroxysteroid dehydrogenase/isomerase dTDP-4-dehydrorhamnose reductase Male sterility-like; KEGG: ret:RHE_PB00058 dTDP-glucose 4,6-dehydratase protein. (330 aa) |
| | Meso_2779 | PFAM: NAD-dependent epimerase/dehydratase short-chain dehydrogenase/reductase SDR 3-beta hydroxysteroid dehydrogenase/isomerase polysaccharide biosynthesis protein CapD dTDP-4-dehydrorhamnose reductase Male sterility-like; KEGG: ret:RHE_PB00053 probable nucleoside diphosphate epimerase protein. (367 aa) |
| | Meso_2780 | PFAM: NAD-dependent epimerase/dehydratase 3-beta hydroxysteroid dehydrogenase/isomerase polysaccharide biosynthesis protein CapD dTDP-4-dehydrorhamnose reductase Male sterility-like; KEGG: ret:RHE_PB00052 probable NDP-glucose dehydratase epimerase protein. (369 aa) |
| | Meso_2782 | PFAM: UDP-glucose/GDP-mannose dehydrogenase NAD-dependent glycerol-3-phosphate dehydrogenase-like; KEGG: sme:SMc02641 UDP-glucose 6-dehydrogenase protein. (457 aa) |
| | Meso_2872 | KEGG: sme:SMb21513 putative cell-surface polysaccharide exporter protein, PST family. (437 aa) |
| | Meso_2875 | PFAM: O-antigen polymerase; KEGG: sme:SMb21505 putative membrane protein, similar to Wzy-like polysaccharide polymerase ExoQ. (440 aa) |
| | Meso_2994 | PFAM: ErfK/YbiS/YcfS/YnhG; KEGG: mlo:mll3427 hypothetical protein. (490 aa) |
| | Meso_3019 | KEGG: mlo:mlr3471 hypothetical protein. (426 aa) |
| | Meso_3057 | PFAM: beta-lactamase peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; KEGG: bme:BMEI0035 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (382 aa) |
| | Meso_3060 | PFAM: protein of unknown function DUF949; KEGG: mlo:mlr3577 hypothetical protein. (439 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa) |
| | Meso_3073 | Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (208 aa) |
| | Meso_3093 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: mlo:mll3520 hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | Meso_3186 | PFAM: NAD-dependent epimerase/dehydratase 3-beta hydroxysteroid dehydrogenase/isomerase polysaccharide biosynthesis protein CapD dTDP-4-dehydrorhamnose reductase NmrA-like Male sterility-like; KEGG: mca:MCA0612 UDP-glucose 4-epimerase. (305 aa) |
| | mtgA | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (243 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (194 aa) |
| | coaA | TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase; KEGG: mlo:mlr5019 pantothenate kinase. (330 aa) |
| | Meso_3518 | PFAM: ErfK/YbiS/YcfS/YnhG; KEGG: sme:SMc01200 hypothetical protein. (195 aa) |
| | Meso_3554 | PFAM: sugar isomerase (SIS); KEGG: rsp:RSP_1447 possible glucosamine--fructose-6-phosphate aminotransferase (isomerizing). (330 aa) |
| | Meso_3565 | Gentisate 1,2-dioxygenase; PFAM: Cupin 2, conserved barrel; KEGG: jan:Jann_2910 cupin 2 protein. (367 aa) |
| | Meso_3597 | PFAM: NAD-dependent epimerase/dehydratase; KEGG: mlo:mlr4637 hypothetical protein. (291 aa) |
| | queG | Domain of unknown function DUF1730; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (383 aa) |
| | uppP | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (268 aa) |
| | Meso_3656 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (268 aa) |
| | Meso_3658 | PFAM: phosphoribosyltransferase; KEGG: mlo:mll3162 uracil phosphoribosyltransferase. (148 aa) |
| | phnN | Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (209 aa) |
| | Meso_3784 | TIGRFAM: FGGY-family pentulose kinase; PFAM: carbohydrate kinase, FGGY; KEGG: mlo:mll4918 ribitol kinase. (529 aa) |
| | Meso_3877 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. (326 aa) |
| | Meso_3973 | PFAM: DegT/DnrJ/EryC1/StrS aminotransferase aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: mst:Msp_0290 predicted pyridoxal phosphate-dependent enzyme; Belongs to the DegT/DnrJ/EryC1 family. (417 aa) |
| | Meso_3986 | TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51 penicillin-binding protein, transpeptidase; KEGG: mlo:mll3238 penicillin-binding protein. (723 aa) |
| | gpsA | PFAM: UBA/THIF-type NAD/FAD binding fold NADP oxidoreductase, coenzyme F420-dependent NAD-dependent glycerol-3-phosphate dehydrogenase-like Ketopantoate reductase ApbA/PanE-like; KEGG: mlo:mlr4225 glycerol-3-phosphate dehydrogenase. (327 aa) |
| | atpH | ATP synthase F1 subcomplex delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (180 aa) |
| | atpA | ATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (509 aa) |
| | atpG | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (519 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (135 aa) |
| | Meso_3276 | Gentisate 1,2-dioxygenase; PFAM: Cupin 2, conserved barrel; KEGG: eba:ebA5613 putative gentisate 1,2-dioxygenase oxidoreductase protein. (324 aa) |
| | purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (364 aa) |
| | purH | IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like; KEGG: mlo:mlr4101 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (537 aa) |
| | Meso_3423 | KEGG: mlo:mll4235 hypothetical protein. (204 aa) |
| | Meso_0013 | PFAM: protein of unknown function DUF344; KEGG: mlo:mll5641 hypothetical protein. (299 aa) |
| | Meso_0053 | TIGRFAM: gentisate 1,2-dioxygenase; PFAM: Cupin 2, conserved barrel; KEGG: pae:PA2470 gentisate 1,2-dioxygenase. (353 aa) |
| | Meso_0059 | Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding; KEGG: mlo:mll1128 carbon-monoxide dehydrogenase large subunit. (781 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (363 aa) |
| | Meso_0107 | KEGG: dvu:DVUA0119 type III secretion system ATPase; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region H+-transporting two-sector ATPase, alpha/beta subunit-like; SMART: ATPase. (429 aa) |
| | Meso_0150 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (279 aa) |
| | Meso_0168 | TIGRFAM: acetoacetyl-CoA synthase; PFAM: AMP-dependent synthetase and ligase; KEGG: mlo:mlr6539 acetoacetyl-CoA synthetase. (652 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (429 aa) |
| | Meso_0248 | Hypothetical protein. (329 aa) |
| | Meso_0258 | TIGRFAM: penicillin-binding protein 1C; PFAM: glycosyl transferase, family 51 penicillin-binding protein, transpeptidase Penicillin-binding-like; KEGG: sme:SMb21297 probable bifunctional penicillin-binding protein. (699 aa) |
| | Meso_0300 | ATPase, FliI/YscN family; KEGG: mlo:mlr2909 flagella-specific ATPase fliI; TIGRFAM: ATPase, FliI/YscN family; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; SMART: ATPase. (465 aa) |
| | Meso_0360 | PFAM: ErfK/YbiS/YcfS/YnhG; KEGG: mlo:mll6923 hypothetical protein. (266 aa) |
| | Meso_0424 | FMN adenylyltransferase; TIGRFAM: riboflavin biosynthesis protein RibF cytidyltransferase-related domain; PFAM: Riboflavin kinase / FAD synthetase; KEGG: mlo:mlr8243 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. (330 aa) |
| | Meso_0438 | Three-deoxy-D-manno-octulosonic-acid transferase-like protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (439 aa) |
| | lpxK | lipid-A-disaccharide kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (343 aa) |
| | queF | GTP cyclohydrolase I; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (153 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (286 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa) |
| | Meso_0474 | Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding; KEGG: mbo:Mb0380c probable carbon monoxyde dehydrogenase (large chain). (793 aa) |
| | Meso_0484 | PFAM: UDP-glucose/GDP-mannose dehydrogenase NAD-dependent glycerol-3-phosphate dehydrogenase-like; KEGG: mlo:mlr5265 UDP-glucose dehydrogenase. (446 aa) |
