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Meso_0150 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (279 aa) | ||||
Meso_0332 | PFAM: Asp/Glu racemase; KEGG: bur:Bcep18194_A5279 Asp/Glu racemase. (238 aa) | ||||
Meso_0350 | Putative GAF sensor protein; PFAM: GAF pyridoxamine 5'-phosphate oxidase-related, FMN-binding; KEGG: reu:Reut_A0055 GAF:pyridoxamine 5'-phosphate oxidase-related, FMN-binding. (443 aa) | ||||
guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa) | ||||
Meso_0471 | PFAM: Ppx/GppA phosphatase; KEGG: mlo:mlr8346 exopolyphosphatase. (413 aa) | ||||
guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (519 aa) | ||||
Meso_0580 | Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding; KEGG: reu:Reut_B4507 aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead:aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding. (704 aa) | ||||
Meso_0581 | PFAM: molybdopterin dehydrogenase, FAD-binding; KEGG: bja:blr2218 putative xanthine dehydrogenase. (329 aa) | ||||
Meso_0582 | TIGRFAM: Twin-arginine translocation pathway signal; PFAM: ferredoxin [2Fe-2S]-binding; KEGG: mlo:mlr1925 oxidoreductase, iron-sulphur binding subunit. (199 aa) | ||||
purD | TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase protein of unknown function DUF201; KEGG: mlo:mlr7447 phosphoribosylamine-glycine ligase; Belongs to the GARS family. (426 aa) | ||||
Meso_0831 | Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase C terminal phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: pca:Pcar_1779 phosphomannomutase. (451 aa) | ||||
cysD | TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: mlo:mlr7575 sulfate adenylyltransferase subunit 2. (301 aa) | ||||
cysN | Adenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (640 aa) | ||||
amn | AMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (499 aa) | ||||
Meso_0946 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (745 aa) | ||||
purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (490 aa) | ||||
ade | Adenine deaminase; PFAM: amidohydrolase; KEGG: bja:blr3165 putative adenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (600 aa) | ||||
Meso_1120 | PFAM: Ppx/GppA phosphatase; KEGG: mlo:mlr8162 exopolyphosphatase. (506 aa) | ||||
purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (744 aa) | ||||
purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (222 aa) | ||||
purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (80 aa) | ||||
purC | TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; KEGG: mlo:mll0069 phosphoribosylaminoimidazole-succinocarboxamide synthase. (263 aa) | ||||
Meso_1285 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; KEGG: mlo:mll0079 adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (435 aa) | ||||
Meso_1332 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1258 aa) | ||||
gpt | Phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (165 aa) | ||||
Meso_1611 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mlo:mll0404 MazG protein. (267 aa) | ||||
adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (194 aa) | ||||
gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (218 aa) | ||||
surE | 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa) | ||||
Meso_1814 | KEGG: mlo:mll1093 dGTP triphosphohydrolase; TIGRFAM: putative deoxyguanosinetriphosphate triphosphohydrolase; PFAM: metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD region; Belongs to the dGTPase family. Type 2 subfamily. (406 aa) | ||||
purM | TIGRFAM: phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein AIR synthase related protein-like; KEGG: mlo:mll7962 5'-phosphoribosyl-5-aminoimidazole synthetase. (368 aa) | ||||
purN | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (236 aa) | ||||
ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) | ||||
prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) | ||||
apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (181 aa) | ||||
Meso_2239 | TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; KEGG: hch:HCH_05488 carbamate kinase; Belongs to the carbamate kinase family. (305 aa) | ||||
Meso_2544 | PFAM: amidohydrolase; KEGG: ret:RHE_CH00351 probable allantoinase protein. (459 aa) | ||||
Meso_2641 | PFAM: amidohydrolase; KEGG: ret:RHE_CH00351 probable allantoinase protein. (452 aa) | ||||
ureA | TIGRFAM: urease, gamma subunit; PFAM: Urease, gamma subunit region; KEGG: sme:SMc01941 urease gamma subunit protein; Belongs to the urease gamma subunit family. (100 aa) | ||||
ureB | TIGRFAM: urease, beta subunit; PFAM: Urease, beta subunit; KEGG: jan:Jann_1747 urease, beta subunit; Belongs to the urease beta subunit family. (101 aa) | ||||
ureC | Urease. Metallo peptidase. MEROPS family M38; TIGRFAM: urease, alpha subunit; PFAM: amidohydrolase Urease alpha-subunit-like; KEGG: mlo:mll4940 urease alpha subunit; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (570 aa) | ||||
Meso_2702 | Ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (369 aa) | ||||
Meso_2703 | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (954 aa) | ||||
Meso_2725 | 5'-Nucleotidase-like protein; PFAM: Peptidoglycan-binding LysM metallophosphoesterase 5'-Nucleotidase-like; KEGG: ret:RHE_CH03555 probable 5'-nucleotidase protein; Belongs to the 5'-nucleotidase family. (663 aa) | ||||
allA | Ureidoglycolate hydrolase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source. (165 aa) | ||||
Meso_2830 | PFAM: protein of unknown function DUF861, cupin_3 Cupin 2, conserved barrel; KEGG: mlo:mll5131 hypothetical protein. (280 aa) | ||||
Meso_2832 | PFAM: Transthyretin; KEGG: mlo:mlr5133 hypothetical protein; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (121 aa) | ||||
Meso_2833 | PFAM: ferredoxin molybdopterin dehydrogenase, FAD-binding [2Fe-2S]-binding CO dehydrogenase flavoprotein-like; KEGG: mlo:mlr5134 xanthine dehydrogenase, xdhA. (492 aa) | ||||
Meso_2834 | Xanthine dehydrogenase, molybdenum binding subunit apoprotein; PFAM: aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding; KEGG: mlo:mlr5135 xanthine dehydrogenase, xdhB. (781 aa) | ||||
Meso_2838 | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (434 aa) | ||||
Meso_3093 | TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; KEGG: mlo:mll3520 hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa) | ||||
purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) | ||||
Meso_3197 | PFAM: glutamine amidotransferase class-I; KEGG: mlo:mll4216 glutamine amidotransferase. (261 aa) | ||||
Meso_3256 | PFAM: pyruvate kinase; KEGG: mlo:mll3819 pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa) | ||||
purE | 5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (165 aa) | ||||
purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (364 aa) | ||||
purH | IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme MGS-like; KEGG: mlo:mlr4101 phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. (537 aa) | ||||
Meso_3656 | Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (268 aa) | ||||
Meso_3659 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (325 aa) | ||||
Meso_3874 | TIGRFAM: carbamate kinase; PFAM: aspartate/glutamate/uridylate kinase; KEGG: hch:HCH_05488 carbamate kinase; Belongs to the carbamate kinase family. (303 aa) | ||||
Meso_3877 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: hch:HCH_01517 phosphoribosylpyrophosphate synthetase. (326 aa) | ||||
Meso_4014 | Ham1-like protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (215 aa) | ||||
deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (409 aa) |