STRINGSTRING
pyrD pyrD Meso_0097 Meso_0097 Meso_0150 Meso_0150 pyrF pyrF Meso_1264 Meso_1264 psuG psuG Meso_1332 Meso_1332 Meso_1358 Meso_1358 pyrB pyrB pyrH pyrH pyrC pyrC pyrE pyrE tmk tmk Meso_1611 Meso_1611 pyrG pyrG thyA thyA surE surE ndk ndk Meso_2043 Meso_2043 Meso_2055 Meso_2055 Meso_2057 Meso_2057 carA carA carB carB Meso_2306 Meso_2306 Meso_2385 Meso_2385 Meso_2464 Meso_2464 Meso_2546 Meso_2546 Meso_2640 Meso_2640 Meso_2664 Meso_2664 Meso_2702 Meso_2702 Meso_2703 Meso_2703 Meso_2725 Meso_2725 cmk cmk Meso_3655 Meso_3655 Meso_3656 Meso_3656 deoA deoA Meso_3658 Meso_3658 Meso_3880 Meso_3880 dut dut
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrDDihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (363 aa)
Meso_0097dCTP deaminase; PFAM: 2-deoxycytidine 5-triphosphate deaminase; KEGG: bmb:BruAb1_0332 dCTP deaminase. (361 aa)
Meso_0150Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (279 aa)
pyrFOrotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa)
Meso_1264PfkB; PFAM: PfkB; KEGG: mlo:mll0029 carbohydrate kinase. (313 aa)
psuGIndigoidine synthase A like protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (304 aa)
Meso_1332Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1258 aa)
Meso_1358TIGRFAM: dihydroorotase, multifunctional complex type; PFAM: amidohydrolase; KEGG: mlo:mlr0687 probable noncatalytic chain of dihydroorotase. (428 aa)
pyrBTIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; KEGG: mlo:mlr0686 aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (319 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (346 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (234 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (225 aa)
Meso_1611TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: mlo:mll0404 MazG protein. (267 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
surE3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
Meso_2043TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: peptidase M20; KEGG: mlo:mll1631 N-carbamoyl-beta-alanine amidohydrolase. (416 aa)
Meso_2055Dihydrouracil dehydrogenase (NAD+) / dihydropyrimidine dehydrogenase (NADP+); TIGRFAM: dihydroorotate dehydrogenase family protein; PFAM: dihydroorotate dehydrogenase 4Fe-4S ferredoxin, iron-sulfur binding; KEGG: sme:SMc01815 dihydropyrimidine dehydrogenase. (437 aa)
Meso_2057PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mlo:mll1646 glutamate synthase beta subunit. (450 aa)
carATIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I Carbamoyl-phosphate synthase, small chain; KEGG: mlo:mlr2489 carbamoyl-phosphate synthetase small subunit; Belongs to the CarA family. (399 aa)
carBTIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain, oligomerisation Carbamoyl-phosphate synthetase large chain-like MGS-like; KEGG: mlo:mlr2517 carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1162 aa)
Meso_2306PFAM: isochorismatase hydrolase; KEGG: bpa:BPP3892 putative hydrolase. (246 aa)
Meso_2385PFAM: flavin reductase-like, FMN-binding; KEGG: reu:Reut_B5770 flavin reductase-like, FMN-binding. (162 aa)
Meso_2464PFAM: flavin reductase-like, FMN-binding; KEGG: psb:Psyr_0995 flavin reductase-like. (170 aa)
Meso_2546TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: peptidase M20; KEGG: ret:RHE_CH00350 probable N-carbamoyl-L-amino acid amidohydrolase protein. (422 aa)
Meso_2640TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: peptidase M20 peptidase dimerisation; KEGG: ret:RHE_CH00350 probable N-carbamoyl-L-amino acid amidohydrolase protein. (422 aa)
Meso_2664TIGRFAM: dihydropyrimidinase; PFAM: amidohydrolase Amidohydrolase 3; KEGG: bms:BR0278 D-hydantoinase. (485 aa)
Meso_2702Ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (369 aa)
Meso_2703Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (954 aa)
Meso_27255'-Nucleotidase-like protein; PFAM: Peptidoglycan-binding LysM metallophosphoesterase 5'-Nucleotidase-like; KEGG: ret:RHE_CH03555 probable 5'-nucleotidase protein; Belongs to the 5'-nucleotidase family. (663 aa)
cmkTIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region; KEGG: sme:SMc00334 putative cytidylate kinase (CMP kinase) protein. (218 aa)
Meso_3655Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (131 aa)
Meso_3656Inosine guanosine and xanthosine phosphorylase family; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (268 aa)
deoAThymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (438 aa)
Meso_3658PFAM: phosphoribosyltransferase; KEGG: mlo:mll3162 uracil phosphoribosyltransferase. (148 aa)
Meso_3880TIGRFAM: putative thymidine phosphorylase; PFAM: glycosyl transferase, family 3 Pyrimidine nucleoside phosphorylase-like; KEGG: hch:HCH_01516 thymidine phosphorylase. (509 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (161 aa)
Your Current Organism:
Chelativorans sp. BNC1
NCBI taxonomy Id: 266779
Other names: C. sp. BNC1, Mesorhizobium sp. BNC1
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.