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hisD hisD Meso_0313 Meso_0313 hisG hisG hisZ hisZ Meso_0804 Meso_0804 Meso_0933 Meso_0933 hisI hisI Meso_2540 Meso_2540 Meso_2545 Meso_2545 Meso_2628 Meso_2628 Meso_2632 Meso_2632 hutU hutU Meso_2978 Meso_2978 hutU-2 hutU-2 Meso_2984 Meso_2984 hutH hutH hutI hutI Meso_2987 Meso_2987 hisC hisC hisB hisB hisH hisH hisA hisA hisF hisF hisE hisE Meso_3627 Meso_3627
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
Meso_0313PFAM: aldehyde dehydrogenase; KEGG: atc:AGR_L_75 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (792 aa)
hisGATP phosphoribosyltransferase catalytic subunit; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (230 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (373 aa)
Meso_0804PFAM: aldehyde dehydrogenase; KEGG: pfo:Pfl_3233 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (500 aa)
Meso_0933PFAM: aminotransferase, class I and II; KEGG: mlo:mll7737 histidinol-phosphate aminotransferase. (371 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (139 aa)
Meso_2540PFAM: phenylalanine/histidine ammonia-lyase; KEGG: sth:STH3194 histidine ammonia-lyase. (514 aa)
Meso_2545TIGRFAM: urocanate hydratase; PFAM: Urocanase; KEGG: sth:STH3193 urocanase. (547 aa)
Meso_2628PFAM: phenylalanine/histidine ammonia-lyase; KEGG: ret:RHE_CH00352 histidine ammonia-lyase protein. (516 aa)
Meso_2632PFAM: phenylalanine/histidine ammonia-lyase; KEGG: sme:SMa0306 putative histidine ammonia-lyase. (535 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (554 aa)
Meso_2978PFAM: phenylalanine/histidine ammonia-lyase; KEGG: mlo:mll7124 histidine ammonia-lyase. (504 aa)
hutU-2Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (562 aa)
Meso_2984PFAM: N-formylglutamate amidohydrolase; KEGG: ret:RHE_PE00071 formiminoglutamase protein. (266 aa)
hutHTIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase; KEGG: ret:RHE_PE00072 histidine ammonia-lyase protein; Belongs to the PAL/histidase family. (511 aa)
hutITIGRFAM: imidazolonepropionase; PFAM: amidohydrolase Amidohydrolase 3; KEGG: ret:RHE_PE00073 imidazolonepropionase protein; Belongs to the metallo-dependent hydrolases superfamily. HutI family. (417 aa)
Meso_2987TIGRFAM: formiminoglutamate deiminase; PFAM: amidohydrolase; KEGG: ret:RHE_PE00074 probable cytosine deaminase protein. (450 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mlo:mll3536 imidazole acetol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa)
hisBPFAM: imidazoleglycerol-phosphate dehydratase; KEGG: mlo:mlr5008 imidazoleglycerol-phosphate dehydratase. (202 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis; KEGG: sme:SMc02570 probable phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase protein. (247 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (268 aa)
hisEPFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: mlo:mlr5018 phosphoribosyl-ATP pyrophosphatase. (112 aa)
Meso_3627PFAM: aldehyde dehydrogenase; KEGG: mlo:mll2867 aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (503 aa)
Your Current Organism:
Chelativorans sp. BNC1
NCBI taxonomy Id: 266779
Other names: C. sp. BNC1, Mesorhizobium sp. BNC1
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