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| | Krad_0061 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aau:AAur_3725 pyridoxal-phosphate dependent enzyme. (313 aa) |
| | Krad_0462 | TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (357 aa) |
| | Krad_0463 | TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (446 aa) |
| | Krad_0513 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mkm:Mkms_1225 O-acetylhomoserine/O-acetylserine sulfhydrylase. (480 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (416 aa) |
| | Krad_0561 | PFAM: transferase hexapeptide repeat containing protein; KEGG: cdi:DIP1891 serine acetyltransferase. (204 aa) |
| | Krad_0596 | PFAM: GCN5-related N-acetyltransferase; KEGG: ace:Acel_0217 GCN5-related N-acetyltransferase. (188 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: sco:SCO7036 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (470 aa) |
| | Krad_0937 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (777 aa) |
| | Krad_0956 | PFAM: GCN5-related N-acetyltransferase; KEGG: sma:SAV5596 acetyltransferase. (251 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | Krad_1082 | TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: msm:MSMEG_5270 cystathionine beta-synthase. (454 aa) |
| | Krad_1092 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: nca:Noca_0976 cystathionine gamma-synthase. (393 aa) |
| | Krad_1137 | PFAM: GCN5-related N-acetyltransferase; KEGG: sco:SCO5134 hypothetical protein. (350 aa) |
| | Krad_1138 | 4Fe-4S ferredoxin iron-sulfur binding domain protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (136 aa) |
| | Krad_1139 | PFAM: aminotransferase class I and II; KEGG: art:Arth_2812 aminotransferase, class I and II. (389 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (330 aa) |
| | Krad_1143 | TIGRFAM: succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: art:Arth_2805 succinyl-diaminopimelate desuccinylase. (378 aa) |
| | Krad_1199 | PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; KEGG: sma:SAV6084 anthranilate/para-aminobenzoate synthase component I. (704 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa) |
| | Krad_1252 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: sma:SAV2918 putative homoserine dehydrogenase. (450 aa) |
| | Krad_1253 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (363 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (328 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: rha:RHA1_ro05087 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (563 aa) |
| | Krad_1335 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: nca:Noca_3392 acetolactate synthase, large subunit, biosynthetic type. (611 aa) |
| | Krad_1336 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: fal:FRAAL5850 acetolactate synthase III, valine-sensitive, small subunit. (170 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa) |
| | Krad_1344 | O-acetylhomoserine aminocarboxypropyltransferase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: mbo:Mb3372 O-acetylhomoserine sulfhydrylase. (441 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (362 aa) |
| | Krad_1353 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; KEGG: nca:Noca_3367 branched-chain amino acid aminotransferase. (374 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (477 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | Krad_1362 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: aau:AAur_0889 cystathionine gamma-synthase. (406 aa) |
| | Krad_1414 | Aminotransferase class I and II; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: sma:SAV4517 putative aminotransferase. (413 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (246 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (319 aa) |
| | Krad_1513 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (425 aa) |
| | murE | UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (548 aa) |
| | ilvD-2 | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: rha:RHA1_ro06484 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (619 aa) |
| | Krad_1922 | PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: art:Arth_2162 peptidase M20. (446 aa) |
| | Krad_2014 | PFAM: dihydrodipicolinate synthetase; KEGG: rha:RHA1_ro07087 dihydrodipicolinate synthase; Belongs to the DapA family. (306 aa) |
| | Krad_2177 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: nca:Noca_4506 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (441 aa) |
| | Krad_2488 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rha:RHA1_ro00984 3-isopropylmalate dehydrogenase. (377 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (439 aa) |
| | Krad_2903 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: nca:Noca_2574 phosphoserine phosphatase SerB. (410 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (276 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: sco:SCO2039 indoleglycerol phosphate synthase; Belongs to the TrpC family. (274 aa) |
| | Krad_2967 | KEGG: lxx:Lxx11270 mambrane protein. (109 aa) |
| | Krad_2968 | KEGG: sma:SAV6172 hypothetical protein. (199 aa) |
| | Krad_2969 | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (102 aa) |
| | Krad_2970 | KEGG: nfa:nfa38650 hypothetical protein. (238 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | Krad_2976 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tfu:Tfu_0175 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. (63 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (366 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (203 aa) |
| | Krad_3029 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: sma:SAV6853 putative shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (286 aa) |
| | tyrS | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (422 aa) |
| | Krad_3154 | TIGRFAM: DNA-3-methyladenine glycosylase; PFAM: methylpurine-DNA glycosylase (MPG); KEGG: sma:SAV6486 putative 3-methyladenine DNA glycosylase; Belongs to the DNA glycosylase MPG family. (215 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: art:Arth_1503 argininosuccinate lyase. (481 aa) |
| | argR | Arginine repressor, ArgR; Regulates arginine biosynthesis genes. (184 aa) |
| | Krad_3157 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: aau:AAur_1634 acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (416 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (300 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (364 aa) |
| | pheT | TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: art:Arth_1490 phenylalanyl-tRNA synthetase, beta subunit. (854 aa) |
| | pheS | TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; KEGG: aau:AAur_1623 phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (388 aa) |
| | hisA | TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein; KEGG: art:Arth_1473 bifunctional HisA/TrpF protein. (267 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: art:Arth_1471 imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: nca:Noca_3044 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (378 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (443 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (356 aa) |
| | Krad_3301 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: nfa:nfa51510 cysteine synthase. (366 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (431 aa) |
| | Krad_3362 | TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: art:Arth_0531 O-acetylhomoserine/O-acetylserine sulfhydrylase. (445 aa) |
| | Krad_3363 | PFAM: CoA-binding domain protein; KEGG: art:Arth_0530 CoA-binding domain protein. (199 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (575 aa) |
| | Krad_3391 | TIGRFAM: para-aminobenzoate synthase, subunit I; glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein; KEGG: sma:SAV1178 putative para-aminobenzoic acid synthase. (637 aa) |
| | Krad_3445 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: rha:RHA1_ro01564 shikimate 5-dehydrogenase. (271 aa) |
| | Krad_3475 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: cef:CE2028 putative epoxyalkane:coenzyme M transferase. (406 aa) |
| | metZ | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (399 aa) |
| | Krad_3591 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (385 aa) |
| | Krad_3601 | PFAM: aminotransferase class I and II; KEGG: pen:PSEEN1583 aminotransferase. (405 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (487 aa) |
| | Krad_4045 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: art:Arth_3700 L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. (471 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (418 aa) |
| | pat | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (376 aa) |
