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| | Krad_0061 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: aau:AAur_3725 pyridoxal-phosphate dependent enzyme. (313 aa) |
| | Krad_0165 | TIGRFAM: ribose-phosphate pyrophosphokinase; PFAM: phosphoribosyltransferase; KEGG: sma:SAV7451 putative ribose-phosphate pyrophosphokinase. (312 aa) |
| | pheA | PFAM: prephenate dehydratase; amino acid-binding ACT domain protein; KEGG: tfu:Tfu_3053 prephenate dehydratase. (314 aa) |
| | Krad_0462 | TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase NAD - binding; Semialdehyde dehydrogenase dimerisation region; Belongs to the aspartate-semialdehyde dehydrogenase family. (357 aa) |
| | Krad_0463 | TIGRFAM: aspartate kinase; aspartate kinase, monofunctional class; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. (446 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (416 aa) |
| | Krad_0561 | PFAM: transferase hexapeptide repeat containing protein; KEGG: cdi:DIP1891 serine acetyltransferase. (204 aa) |
| | Krad_0596 | PFAM: GCN5-related N-acetyltransferase; KEGG: ace:Acel_0217 GCN5-related N-acetyltransferase. (188 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | Krad_0673 | Aminotransferase class I and II; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: sco:SCO4645 aspartate aminotransferase. (415 aa) |
| | argG | PFAM: argininosuccinate synthase; KEGG: sco:SCO7036 argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (470 aa) |
| | gpmA | Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (250 aa) |
| | Krad_0937 | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (777 aa) |
| | Krad_0956 | PFAM: GCN5-related N-acetyltransferase; KEGG: sma:SAV5596 acetyltransferase. (251 aa) |
| | aroQ | 3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | Krad_1082 | TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: msm:MSMEG_5270 cystathionine beta-synthase. (454 aa) |
| | Krad_1092 | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: nca:Noca_0976 cystathionine gamma-synthase. (393 aa) |
| | Krad_1137 | PFAM: GCN5-related N-acetyltransferase; KEGG: sco:SCO5134 hypothetical protein. (350 aa) |
| | Krad_1140 | TIGRFAM: citrate synthase I; PFAM: Citrate synthase; KEGG: mpa:MAP0829 citrate synthase; Belongs to the citrate synthase family. (441 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (330 aa) |
| | Krad_1143 | TIGRFAM: succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: art:Arth_2805 succinyl-diaminopimelate desuccinylase. (378 aa) |
| | Krad_1206 | TIGRFAM: histidinol-phosphate phosphatase, putative; PFAM: inositol monophosphatase; KEGG: art:Arth_2655 histidinol-phosphate phosphatase, putative. (275 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa) |
| | Krad_1252 | PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding; KEGG: sma:SAV2918 putative homoserine dehydrogenase. (450 aa) |
| | Krad_1253 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (363 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (328 aa) |
| | Krad_1277 | Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: ace:Acel_0686 threonine aldolase. (357 aa) |
| | ilvD | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: rha:RHA1_ro05087 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (563 aa) |
| | Krad_1335 | TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: nca:Noca_3392 acetolactate synthase, large subunit, biosynthetic type. (611 aa) |
| | Krad_1336 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: fal:FRAAL5850 acetolactate synthase III, valine-sensitive, small subunit. (170 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (342 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (362 aa) |
| | Krad_1353 | TIGRFAM: branched-chain amino acid aminotransferase; PFAM: aminotransferase class IV; KEGG: nca:Noca_3367 branched-chain amino acid aminotransferase. (374 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (477 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | Krad_1362 | PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: aau:AAur_0889 cystathionine gamma-synthase. (406 aa) |
| | Krad_1414 | Aminotransferase class I and II; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase class I and II; KEGG: sma:SAV4517 putative aminotransferase. (413 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (246 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (308 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (319 aa) |
| | Krad_1513 | D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (425 aa) |
| | Krad_1566 | TIGRFAM: aconitate hydratase 1; PFAM: aconitate hydratase domain protein; KEGG: art:Arth_1644 aconitate hydratase 1. (949 aa) |
| | Krad_1637 | Glutamate--putrescine ligase; PFAM: glutamine synthetase catalytic region; KEGG: sco:SCO1613 putative glutamine synthetase. (483 aa) |
| | ilvD-2 | TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; KEGG: rha:RHA1_ro06484 dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (619 aa) |
| | Krad_1918 | Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase; PFAM: Ribose/galactose isomerase; KEGG: msm:MSMEG_3272 ribose 5-phosphate isomerase. (167 aa) |
| | Krad_2014 | PFAM: dihydrodipicolinate synthetase; KEGG: rha:RHA1_ro07087 dihydrodipicolinate synthase; Belongs to the DapA family. (306 aa) |
| | Krad_2157 | TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; KEGG: aau:AAur_1469 putative fructose/tagatose bisphosphate aldolase. (281 aa) |
| | Krad_2177 | TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; PFAM: peptidase M20; peptidase dimerisation domain protein; KEGG: nca:Noca_4506 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase. (441 aa) |
| | Krad_2488 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rha:RHA1_ro00984 3-isopropylmalate dehydrogenase. (377 aa) |
| | Krad_2903 | TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: nca:Noca_2574 phosphoserine phosphatase SerB. (410 aa) |
| | Krad_2922 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (697 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (373 aa) |
| | tpiA | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (261 aa) |
| | pgk | PFAM: phosphoglycerate kinase; KEGG: nca:Noca_2531 phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa) |
| | Krad_2931 | TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase; KEGG: art:Arth_2087 glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | Krad_2959 | TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; KEGG: art:Arth_1693 pyruvate kinase; Belongs to the pyruvate kinase family. (505 aa) |
| | Krad_2960 | TIGRFAM: glutamate synthase, NADH/NADPH, small subunit; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: aau:AAur_1843 putative NADH/NADPH dependent glutamate synthases, small subunit. (485 aa) |
| | Krad_2961 | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: nca:Noca_3022 glutamate synthase (ferredoxin). (1536 aa) |
| | trpA | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (276 aa) |
| | trpB | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (433 aa) |
| | trpC | PFAM: Indole-3-glycerol phosphate synthase; KEGG: sco:SCO2039 indoleglycerol phosphate synthase; Belongs to the TrpC family. (274 aa) |
| | Krad_2969 | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. (102 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (285 aa) |
| | Krad_2976 | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: tfu:Tfu_0175 phosphoribosyl-ATP pyrophosphatase; Belongs to the PRA-PH family. (63 aa) |
| | Krad_2980 | PFAM: ribulose-phosphate 3-epimerase; KEGG: aau:AAur_1824 ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (221 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (399 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (366 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (203 aa) |
| | Krad_3029 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: sma:SAV6853 putative shikimate 5-dehydrogenase; Belongs to the shikimate dehydrogenase family. (286 aa) |
| | Krad_3118 | Prephenate dehydrogenase; PFAM: amino acid-binding ACT domain protein; Prephenate dehydrogenase; KEGG: art:Arth_1535 prephenate dehydrogenase. (370 aa) |
| | Krad_3119 | TIGRFAM: chorismate mutase; PFAM: Chorismate mutase of the AroH class; KEGG: nca:Noca_2499 chorismate mutase. (126 aa) |
| | argH | TIGRFAM: argininosuccinate lyase; PFAM: fumarate lyase; KEGG: art:Arth_1503 argininosuccinate lyase. (481 aa) |
| | Krad_3157 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa) |
| | argD | TIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: aau:AAur_1634 acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (416 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (300 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (383 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (364 aa) |
| | hisA | TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis protein; KEGG: art:Arth_1473 bifunctional HisA/TrpF protein. (267 aa) |
| | hisH | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (213 aa) |
| | hisB | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: art:Arth_1471 imidazoleglycerol-phosphate dehydratase. (199 aa) |
| | hisC | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: nca:Noca_3044 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (378 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (443 aa) |
| | Krad_3233 | TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase class II; KEGG: art:Arth_1553 phospho-2-dehydro-3-deoxyheptonate aldolase; Belongs to the class-II DAHP synthase family. (466 aa) |
| | Krad_3234 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (343 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (356 aa) |
| | Krad_3291 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ace:Acel_0923 glutamine synthetase, type I. (474 aa) |
| | Krad_3296 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: tfu:Tfu_0982 glutamine synthetase type I. (447 aa) |
| | Krad_3301 | PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: nfa:nfa51510 cysteine synthase. (366 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (431 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (575 aa) |
| | Krad_3398 | TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: mva:Mvan_2276 asparagine synthase (glutamine-hydrolyzing). (594 aa) |
| | Krad_3445 | PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding domain protein; KEGG: rha:RHA1_ro01564 shikimate 5-dehydrogenase. (271 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (432 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (382 aa) |
| | Krad_3475 | PFAM: Methionine synthase vitamin-B12 independent; KEGG: cef:CE2028 putative epoxyalkane:coenzyme M transferase. (406 aa) |
| | Krad_3522 | Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase; PFAM: Ribose/galactose isomerase; KEGG: tfu:Tfu_2202 ribose/galactose isomerase:ribose 5-phosphate isomerase, actinobacteria. (162 aa) |
| | Krad_3591 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (385 aa) |
| | Krad_3601 | PFAM: aminotransferase class I and II; KEGG: pen:PSEEN1583 aminotransferase. (405 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa) |
| | Krad_3988 | TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: tfu:Tfu_2568 isocitrate dehydrogenase; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa) |
| | Krad_4045 | TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; KEGG: art:Arth_3700 L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. (471 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (418 aa) |
| | Krad_4124 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa) |
| | Krad_4226 | Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase; PFAM: Ribose/galactose isomerase; KEGG: msm:MSMEG_3272 ribose 5-phosphate isomerase. (167 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (461 aa) |
| | pat | Histidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (376 aa) |
| | Krad_4424 | PFAM: glutamine synthetase catalytic region; KEGG: mva:Mvan_4030 glutamine synthetase, catalytic region. (721 aa) |
