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MMP0028 MMP0028 gtrA gtrA MMP0089 MMP0089 MMP0107 MMP0107 cbiX(s) cbiX(s) hemL hemL cbiL cbiL cbiC cbiC MMP0338 MMP0338 hemD hemD cbiJ cbiJ hemC hemC MMP0886 MMP0886 MMP0888 MMP0888 MMP0889 MMP0889 cobY/cofC cobY/cofC cobS cobS chiB chiB cbiH cbiH cobA cobA cbiD cbiD cobQ cobQ cbiT cbiT cbiE cbiE hemB hemB cbiA cbiA cbiA-2 cbiA-2 cbiM cbiM cbiN cbiN cbiQ cbiQ cbiO cbiO cbiG cbiG MMP1630 MMP1630 cbiF cbiF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP0028Cobyric acid synthase related protein. (483 aa)
gtrAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (382 aa)
MMP0089Conserved hypothetical protein. (201 aa)
MMP0107Hypothetical protein. (174 aa)
cbiX(s)Sirohydrochlorin cobaltochelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. (144 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (427 aa)
cbiLPrecorrin-2 C-20 methyltransferase; Belongs to the precorrin methyltransferase family. (228 aa)
cbiCPrecorrin-8X methylmutase CbiC/CobH. (210 aa)
MMP0338Phosphoribosyltransferase related protein; Belongs to the UPF0284 family. (350 aa)
hemDUroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (244 aa)
cbiJPrecorrin-6x reductase CbiJ/CobK. (248 aa)
hemCPorphobilinogen deaminase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82. (304 aa)
MMP0886Cobalt transport system permease related protein. (255 aa)
MMP0888Putative cobalt transport protein. (108 aa)
MMP0889Cobalamin (vitamin B12) biosynthesis CbiM protein. (212 aa)
cobY/cofCNucleoside triphosphate: 5'-deoxyadenosylcobinamide phosphate nucleotidyltransferase; Appears to catalyze the guanylation of both (S)-2-phospholactate and adenosylcobinamide phosphate; Citation: M. G. Thomas and J. C. Escalante-Semerena, J. Bacteriol., 2000, 182, 4227; Nat. Prod. Rep., 2002, 19(2), 133 - 147. (202 aa)
cobSCobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (257 aa)
chiBCobalamin biosynthesis protein B; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (306 aa)
cbiHprecorrin-3B C17-methyltransferase; Citation: J. Bacteriol. 175:3303-3316(1993). (250 aa)
cobAuroporphyrin-III C-methyltransferase; Citation: J Bacteriol. 1991 Aug;173(15):4637-45; Belongs to the precorrin methyltransferase family. (239 aa)
cbiDCobalamin (vitamin B12) biosynthesis CbiD protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (365 aa)
cobQCobyrinic acid a,c-diamide synthase:Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (492 aa)
cbiTSAM (and some other nucleotide) binding motif; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (181 aa)
cbiEUroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase. (246 aa)
hemBDelta-aminolevulinic acid dehydratase; Citation: Microbiology. 2002 Aug;148(Pt 8):2273-82; Belongs to the ALAD family. (322 aa)
cbiACobyrinic acid a,c-diamide synthase. (131 aa)
cbiA-2Cobyrinic acid a,c-diamide synthase:Cobyrinic acid a,c-diamide synthase CbiA. (349 aa)
cbiMCobalamin biosynthesis protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (225 aa)
cbiNConserved hypothetical protein; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (98 aa)
cbiQCobalt transport protein Q. (257 aa)
cbiOCobalt transport protein O; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (278 aa)
cbiGCobalamin (vitamin B12) biosynthesis CbiG protein. (323 aa)
MMP1630ATP/GTP-binding site motif A (P-loop):ABC transporter:AAA ATPase. (549 aa)
cbiFPrecorrin-4 C11-methyltransferase; Citation: Eur J Biochem 1998 Jun 1; 254(2):341-6. (254 aa)
Your Current Organism:
Methanococcus maripaludis S2
NCBI taxonomy Id: 267377
Other names: M. maripaludis S2, Methanococcus maripaludis LL, Methanococcus maripaludis str. S2, Methanococcus maripaludis strain S2
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