STRINGSTRING
gmk gmk ADINL_0367 ADINL_0367 ADINL_0393 ADINL_0393 tadA tadA ADINL_0602 ADINL_0602 ADINL_0733 ADINL_0733 gpt gpt ADINL_0828 ADINL_0828 nudJ nudJ ADINL_0909 ADINL_0909 ADINL_0910 ADINL_0910 tilS tilS pyrG pyrG surE surE pcm pcm ADINL_1094 ADINL_1094 ADINL_1095 ADINL_1095 ADINL_1098 ADINL_1098 nnrE nnrE ADINL_1199 ADINL_1199 ADINL_1218 ADINL_1218 ppnP ppnP sthA sthA ADINL_1690 ADINL_1690 nadE nadE guaA guaA guaB guaB ADINL_1984 ADINL_1984 adk adk ADINL_2008 ADINL_2008 ADINL_2009 ADINL_2009 ADINL_2024 ADINL_2024 ADINL_2226 ADINL_2226 nadK nadK dcd dcd ADINL_2499 ADINL_2499 ADINL_2742 ADINL_2742 ADINL_2852 ADINL_2852 apt apt ADINL_3096 ADINL_3096 ADINL_3144 ADINL_3144
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa)
ADINL_0367GTP pyrophosphokinase, (p)ppGpp synthetase II; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (704 aa)
ADINL_0393Putative hydrolase. (219 aa)
tadAtRNA-specific adenosine-34 deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (164 aa)
ADINL_0602Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase); Thiamin-phosphate pyrophosphorylase-like protein. (140 aa)
ADINL_0733UPF0301 protein YqgE; Belongs to the UPF0301 (AlgH) family. (188 aa)
gptXanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (169 aa)
ADINL_0828ATP-dependent 23S rRNA helicase DbpA; Belongs to the DEAD box helicase family. (433 aa)
nudJNudix-like NDP and NTP phosphohydrolase YmfB; Belongs to the Nudix hydrolase family. NudJ subfamily. (151 aa)
ADINL_0909MutT/nudix family protein; Belongs to the Nudix hydrolase family. (145 aa)
ADINL_0910Putative nudix hydrolase YeaB. (197 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (444 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (542 aa)
surE5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (251 aa)
pcmProtein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (221 aa)
ADINL_1094Arginine/ornithine antiporter ArcD. (305 aa)
ADINL_1095Lipoprotein NlpD. (287 aa)
ADINL_1098C-terminal domain of CinA type S; Protein Implicated in DNA repair function with RecA and MutS; Belongs to the CinA family. (164 aa)
nnrENAD(P)HX epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epime [...] (505 aa)
ADINL_1199Quinolinate phosphoribosyltransferase; Belongs to the NadC/ModD family. (280 aa)
ADINL_1218Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (341 aa)
ppnPPutative cytoplasmic protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (93 aa)
sthASoluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (466 aa)
ADINL_1690ATPase involved in DNA repair. (889 aa)
nadENAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (542 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
ADINL_1984Hypoxanthine-guanine phosphoribosyltransferase. (186 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa)
ADINL_2008Nucleoside triphosphate pyrophosphohydrolase MazG. (275 aa)
ADINL_2009GTP pyrophosphokinase, (p)ppGpp synthetase I; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (756 aa)
ADINL_2024L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (560 aa)
ADINL_2226Decarboxylase family protein. (458 aa)
nadKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (292 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (177 aa)
ADINL_2499NADH pyrophosphatase; Belongs to the Nudix hydrolase family. (194 aa)
ADINL_2742Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s). (574 aa)
ADINL_2852Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (348 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)
ADINL_3096Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (754 aa)
ADINL_3144ATPase involved in DNA repair. (966 aa)
Your Current Organism:
Nitrincola lacisaponensis
NCBI taxonomy Id: 267850
Other names: ATCC BAA-920, DSM 16316, N. lacisaponensis, Nitrincola lacisaponensis Dimitriu et al. 2005, strain 4CA
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