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purK purK purE purE folD folD purU purU ADINL_0227 ADINL_0227 purU-2 purU-2 pyrE pyrE ADINL_0403 ADINL_0403 ADINL_0412 ADINL_0412 purL purL pyrF pyrF ADINL_0729 ADINL_0729 pyrB pyrB ADINL_0731 ADINL_0731 pyrC pyrC purA purA purU-3 purU-3 folD-2 folD-2 ADINL_1982 ADINL_1982 upp upp purH purH purD purD pyrD pyrD ADINL_2519 ADINL_2519 carB carB carA carA purC purC purN purN purM purM ADINL_2892 ADINL_2892 ADINL_2895 ADINL_2895 ADINL_2897 ADINL_2897 ADINL_2898 ADINL_2898 ADINL_2899 ADINL_2899 ADINL_2900 ADINL_2900 ADINL_3063 ADINL_3063 ADINL_3129 ADINL_3129
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (376 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
ADINL_0227ATP-grasp enzyme-like protein. (311 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
ADINL_04032-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; CDP-6-deoxy-delta-3,4-glucoseen reductase-like. (233 aa)
ADINL_04125-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (198 aa)
purLPhosphoribosylformylglycinamidine synthase, synthetase subunit; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1300 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa)
ADINL_0729Dihydroorotase. (427 aa)
pyrBAspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (332 aa)
ADINL_0731Uracil phosphoribosyltransferase; Pyrimidine operon regulatory protein PyrR. (170 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (345 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
purU-3Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
folD-2Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
ADINL_1982Uracil permease. (435 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
purHIMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. (527 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (429 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (333 aa)
ADINL_2519Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa)
carBCarbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1073 aa)
carACarbamoyl-phosphate synthase small chain; Belongs to the CarA family. (379 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (237 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (214 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (353 aa)
ADINL_2892Dihydropyrimidinase. (481 aa)
ADINL_2895Beta-ureidopropionase. (427 aa)
ADINL_2897Pyridine nucleotide-disulfide oxidoreductase associated with reductive pyrimidine catabolism. (448 aa)
ADINL_2898Dihydropyrimidine dehydrogenase [NADP+]. (424 aa)
ADINL_2899Cytosine permease. (417 aa)
ADINL_2900Cytosine deaminase. (416 aa)
ADINL_3063Amidophosphoribosyltransferase. (438 aa)
ADINL_3129Dihydroorotase. (446 aa)
Your Current Organism:
Nitrincola lacisaponensis
NCBI taxonomy Id: 267850
Other names: ATCC BAA-920, DSM 16316, N. lacisaponensis, Nitrincola lacisaponensis Dimitriu et al. 2005, strain 4CA
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