STRINGSTRING
purK purK purE purE ADINL_0071 ADINL_0071 ADINL_0311 ADINL_0311 ADINL_0323 ADINL_0323 ADINL_0332 ADINL_0332 ADINL_0350 ADINL_0350 rph rph gmk gmk ADINL_0367 ADINL_0367 ADINL_0377 ADINL_0377 ADINL_0393 ADINL_0393 ADINL_0398 ADINL_0398 purL purL ihfB ihfB ADINL_0721 ADINL_0721 ADINL_0733 ADINL_0733 ADINL_0756 ADINL_0756 ADINL_0757 ADINL_0757 ADINL_0759 ADINL_0759 ADINL_0760 ADINL_0760 gpt gpt alc alc ADINL_0776 ADINL_0776 ADINL_0777 ADINL_0777 ADINL_0784 ADINL_0784 ureC ureC ureB ureB ureA ureA ADINL_0838 ADINL_0838 ADINL_0929 ADINL_0929 cpdA cpdA ADINL_0956 ADINL_0956 ADINL_0968 ADINL_0968 ychF ychF prs prs ADINL_1012 ADINL_1012 ADINL_1017 ADINL_1017 ADINL_1067 ADINL_1067 tilS tilS surE surE purA purA ADINL_1218 ADINL_1218 ADINL_1252 ADINL_1252 ADINL_1274 ADINL_1274 ADINL_1278 ADINL_1278 ihfA ihfA ADINL_1334 ADINL_1334 ADINL_1341 ADINL_1341 ADINL_1350 ADINL_1350 ADINL_1475 ADINL_1475 ADINL_1517 ADINL_1517 dgt dgt ADINL_1530 ADINL_1530 ppnP ppnP ADINL_1691 ADINL_1691 nrdR nrdR ndk ndk ADINL_1901 ADINL_1901 ADINL_1903 ADINL_1903 guaA guaA guaB guaB ADINL_1957 ADINL_1957 ADINL_1984 ADINL_1984 purH purH purD purD ADINL_1995 ADINL_1995 adk adk ADINL_2008 ADINL_2008 ADINL_2009 ADINL_2009 ADINL_2032 ADINL_2032 ADINL_2135 ADINL_2135 ttcA ttcA ADINL_2226 ADINL_2226 ADINL_2281 ADINL_2281 ADINL_2301 ADINL_2301 ADINL_2349 ADINL_2349 ADINL_2383 ADINL_2383 ADINL_2519 ADINL_2519 ADINL_2666 ADINL_2666 ADINL_2855 ADINL_2855 purC purC ADINL_2866 ADINL_2866 purN purN purM purM ADINL_2885 ADINL_2885 apt apt ADINL_3032 ADINL_3032 truA truA ADINL_3063 ADINL_3063 ADINL_3089 ADINL_3089 ADINL_3096 ADINL_3096 ADINL_3097 ADINL_3097 cysN cysN cysD cysD
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purKPhosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (376 aa)
purEPhosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
ADINL_0071Hypothetical protein. (344 aa)
ADINL_0311Putative transport protein. (343 aa)
ADINL_0323Electron transfer flavoprotein, beta subunit. (276 aa)
ADINL_0332Putative membrane protein. (270 aa)
ADINL_0350Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase. (148 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (226 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (205 aa)
ADINL_0367GTP pyrophosphokinase, (p)ppGpp synthetase II; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (704 aa)
ADINL_0377Pyruvate kinase; Belongs to the pyruvate kinase family. (478 aa)
ADINL_0393Putative hydrolase. (219 aa)
ADINL_0398Exopolyphosphatase; Belongs to the GppA/Ppx family. (508 aa)
purLPhosphoribosylformylglycinamidine synthase, synthetase subunit; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1300 aa)
ihfBIntegration host factor beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (100 aa)
ADINL_0721Nucleoside 5-triphosphatase RdgB (dHAPTP, dITP, XTP-specific); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa)
ADINL_0733UPF0301 protein YqgE; Belongs to the UPF0301 (AlgH) family. (188 aa)
ADINL_0756Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (431 aa)
ADINL_07572-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) decarboxylase. (284 aa)
ADINL_0759Xanthine dehydrogenase, molybdenum binding subunit. (780 aa)
ADINL_0760Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A. (488 aa)
gptXanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (169 aa)
alcAllantoicase; Belongs to the allantoicase family. (334 aa)
ADINL_0776Ureidoglycolate hydrolase. (168 aa)
ADINL_0777Uricase (urate oxidase). (308 aa)
ADINL_0784Hydantoin racemase. (243 aa)
ureCUrease alpha subunit. (567 aa)
ureBUrease beta subunit; Belongs to the urease beta subunit family. (101 aa)
ureAUrease gamma subunit; Belongs to the urease gamma subunit family. (100 aa)
ADINL_08385'-nucleotidase; Belongs to the 5'-nucleotidase family. (511 aa)
ADINL_0929ADP-ribose pyrophosphatase. (214 aa)
cpdA3',5'-cyclic-nucleotide phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (265 aa)
ADINL_0956Hypothetical protein. (548 aa)
ADINL_0968CBS domain protein. (128 aa)
ychFGTP-binding and nucleic acid-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (384 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (334 aa)
ADINL_1012Electron transfer flavoprotein, beta subunit. (250 aa)
ADINL_1017Hypothetical protein. (257 aa)
ADINL_1067Hypothetical protein. (156 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (444 aa)
surE5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (251 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
ADINL_1218Adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (341 aa)
ADINL_1252Bis(5'-nucleosyl)-tetraphosphatase, symmetrical; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (275 aa)
ADINL_1274Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (295 aa)
ADINL_1278CBS domain protein. (137 aa)
ihfAIntegration host factor alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (103 aa)
ADINL_1334Type I restriction-modification system, restriction subunit R. (1125 aa)
ADINL_13415'-nucleotidase. (316 aa)
ADINL_1350Adenylate cyclase. (656 aa)
ADINL_1475Type I restriction-modification system, restriction subunit R. (72 aa)
ADINL_1517Polynucleotide kinase. (150 aa)
dgtDeoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs. (494 aa)
ADINL_1530Mg/Co/Ni transporter MgtE; Acts as a magnesium transporter. (458 aa)
ppnPPutative cytoplasmic protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (93 aa)
ADINL_1691Hypothetical protein. (37 aa)
nrdRRibonucleotide reductase transcriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (158 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (135 aa)
ADINL_1901Magnesium and cobalt efflux protein CorC. (280 aa)
ADINL_1903Hypothetical protein. (183 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (526 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa)
ADINL_1957Lysine decarboxylase family; Belongs to the LOG family. (186 aa)
ADINL_1984Hypoxanthine-guanine phosphoribosyltransferase. (186 aa)
purHIMP cyclohydrolase; Phosphoribosylaminoimidazolecarboxamide formyltransferase. (527 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (429 aa)
ADINL_1995Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical). (123 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa)
ADINL_2008Nucleoside triphosphate pyrophosphohydrolase MazG. (275 aa)
ADINL_2009GTP pyrophosphokinase, (p)ppGpp synthetase I; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (756 aa)
ADINL_2032Electron transfer flavoprotein, beta subunit. (249 aa)
ADINL_2135Cell division protein BolA; Belongs to the BolA/IbaG family. (103 aa)
ttcAtRNA(Cytosine32)-2-thiocytidine synthetase; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (301 aa)
ADINL_2226Decarboxylase family protein. (458 aa)
ADINL_2281Deoxyguanosinetriphosphate triphosphohydrolase. (447 aa)
ADINL_2301Diadenosine tetraphosphatase and related serine/threonine protein phosphatase. (325 aa)
ADINL_2349Transcriptional activator domain. (1120 aa)
ADINL_2383Phosphoglucomutase. (533 aa)
ADINL_2519Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (454 aa)
ADINL_2666Putative toxin to DivIC. (169 aa)
ADINL_2855Putative permease PerM. (364 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (237 aa)
ADINL_2866DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (214 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (353 aa)
ADINL_2885Mg/Co/Ni transporter MgtE; Acts as a magnesium transporter. (447 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (180 aa)
ADINL_3032Membrane protein. (177 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (280 aa)
ADINL_3063Amidophosphoribosyltransferase. (438 aa)
ADINL_3089Purine nucleoside phosphorylase. (158 aa)
ADINL_3096Ribonucleotide reductase of class Ia (aerobic), alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (754 aa)
ADINL_3097Ribonucleotide reductase of class Ia (aerobic), beta subunit. (376 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (560 aa)
cysDSulfate adenylyltransferase subunit 2. (305 aa)
Your Current Organism:
Nitrincola lacisaponensis
NCBI taxonomy Id: 267850
Other names: ATCC BAA-920, DSM 16316, N. lacisaponensis, Nitrincola lacisaponensis Dimitriu et al. 2005, strain 4CA
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