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azf azf Nmlp_1087 Nmlp_1087 maeB1 maeB1 dsa dsa oxdhB oxdhB oxdhA1 oxdhA1 gdh gdh aldH2 aldH2 pykA pykA serA1 serA1 gap gap aldH3 aldH3 ppc ppc sdhC sdhC sdhD sdhD sdhB sdhB sdhA1 sdhA1 fumC fumC mmsA mmsA pgi pgi gabD gabD gpmI gpmI serA3 serA3 lpdA1 lpdA1 oxdhA2 oxdhA2 aceA aceA aceB aceB pgk pgk eno eno acdA acdA deoC1 deoC1 fba1 fba1 fbp fbp icd icd deoC2 deoC2 korB2 korB2 acs1 acs1 maeB2 maeB2 birA birA ppsA ppsA citZ citZ porB porB porA porA tpiA tpiA sucD sucD sucC sucC pccB pccB pccX pccX pccA pccA sdhA2 sdhA2 dadA dadA korA korA korB1 korB1 acs4 acs4 acs3 acs3 korB3 korB3 citB citB Nmlp_3776 Nmlp_3776 mdh mdh
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
azfGlucose-6-phosphate 1-dehydrogenase (NAD); Catalyzes the NAD-dependent oxidation of glucose 6-phosphate to 6-phosphogluconolactone; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (255 aa)
Nmlp_1087Pyridoxal phosphate-dependent aminotransferase. (369 aa)
maeB1Malate dehydrogenase (oxaloacetate-decarboxylating). (752 aa)
dsaDihydrolipoamide S-acyltransferase. (532 aa)
oxdhB2-oxo-3-methylvalerate dehydrogenase E1 component beta subunit. (329 aa)
oxdhA12-oxo-3-methylvalerate dehydrogenase E1 component alpha subunit. (373 aa)
gdhGlucose 1-dehydrogenase; Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway. (353 aa)
aldH2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (478 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (580 aa)
serA1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (338 aa)
aldH3Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (508 aa)
ppcPhosphoenolpyruvate carboxylase. (897 aa)
sdhCSuccinate dehydrogenase subunit C; Deleted EC_number 1.3.99.1. (130 aa)
sdhDSuccinate dehydrogenase subunit D; Deleted EC_number 1.3.99.1. (121 aa)
sdhBSuccinate dehydrogenase subunit B; Deleted EC_number 1.3.99.1. (285 aa)
sdhA1Succinate dehydrogenase subunit A; Deleted EC_number 1.3.99.1. (611 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (471 aa)
mmsAMethylmalonate-semialdehyde dehydrogenase. (493 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (428 aa)
gabDSuccinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (534 aa)
gpmIPhosphoglycerate mutase,2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (513 aa)
serA3Probable D-2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa)
lpdA1Dihydrolipoyl dehydrogenase. (474 aa)
oxdhA2Probable 2-oxoacid dehydrogenase E1 component alpha subunit. (372 aa)
aceAIsocitrate lyase. (355 aa)
aceBMalate synthase. (436 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (398 aa)
acdAacetate--CoA ligase (ADP-forming). (697 aa)
deoC1Deoxyribose-phosphate aldolase. (159 aa)
fba1Fructose-bisphosphate aldolase, class 1. (264 aa)
fbpFructose-1,6-bisphosphatase. (291 aa)
icdIsocitrate dehydrogenase (NADP). (418 aa)
deoC2Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa)
korB2Oxoglutarate--ferredoxin oxidoreductase beta subunit. (289 aa)
acs1acyl-CoA synthetase. (672 aa)
maeB2Malate dehydrogenase (oxaloacetate-decarboxylating). (752 aa)
birAHTH domain protein / biotin--[acetyl-CoA-carboxylase] ligase. (308 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (771 aa)
citZCitrate synthase. (378 aa)
porBPyruvate--ferredoxin oxidoreductase beta subunit. (312 aa)
porAPyruvate--ferredoxin oxidoreductase alpha subunit. (628 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (211 aa)
sucDsuccinate--CoA ligase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
sucCsuccinate--CoA ligase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (382 aa)
pccBpropionyl-CoA carboxylase carboxyltransferase component. (516 aa)
pccXpropionyl-CoA carboxylase small subunit. (83 aa)
pccApropionyl-CoA carboxylase biotin carboxylase component. (614 aa)
sdhA2Succinate dehydrogenase subunit A; Deleted EC_number 1.3.99.1. (596 aa)
dadAHomolog to D-aspartate oxidase. (361 aa)
korAOxoglutarate--ferredoxin oxidoreductase alpha subunit. (587 aa)
korB1Oxoglutarate--ferredoxin oxidoreductase beta subunit. (289 aa)
acs4acyl-CoA synthetase. (654 aa)
acs3acyl-CoA synthetase. (663 aa)
korB3Oxoglutarate--ferredoxin oxidoreductase beta subunit. (287 aa)
citBAconitate hydratase. (661 aa)
Nmlp_3776CobC/GpmA family phosphatase. (203 aa)
mdhMalate dehydrogenase; Belongs to the LDH/MDH superfamily. (303 aa)
Your Current Organism:
Natronomonas moolapensis
NCBI taxonomy Id: 268739
Other names: N. moolapensis 8.8.11, Natronomonas moolapensis 8.8.11, Natronomonas moolapensis DSM 18674, Natronomonas moolapensis JCM 14361, Natronomonas moolapensis str. 8.8.11, Natronomonas moolapensis strain 8.8.11, haloarchaeon CSW8.8.11
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