STRINGSTRING
Nmlp_2646 Nmlp_2646 rps19 rps19 rpl2 rpl2 rpl23 rpl23 rpl4 rpl4 rpl3 rpl3 Nmlp_1621 Nmlp_1621 Nmlp_1635 Nmlp_1635 Nmlp_1642 Nmlp_1642 Nmlp_1646 Nmlp_1646 Nmlp_1647 Nmlp_1647 Nmlp_1649 Nmlp_1649 gatC gatC gatA gatA nfi nfi smc smc hisS hisS Nmlp_1673 Nmlp_1673 Nmlp_1678 Nmlp_1678 Nmlp_1689 Nmlp_1689 polB polB rad50 rad50 mre11 mre11 pan2 pan2 cna cna rps10b rps10b Nmlp_1726 Nmlp_1726 Nmlp_1728 Nmlp_1728 Nmlp_1738 Nmlp_1738 Nmlp_1751 Nmlp_1751 priS priS Tif2Bd Tif2Bd lhr1 lhr1 mutS5b mutS5b Nmlp_1793 Nmlp_1793 pelA pelA lhr2 lhr2 uvrD uvrD Nmlp_1809 Nmlp_1809 rpl37e rpl37e rpl15e rpl15e mutS1a mutS1a nucS nucS Nmlp_1842 Nmlp_1842 Nmlp_1847 Nmlp_1847 Nmlp_1853 Nmlp_1853 thrS thrS gth1 gth1 gtl3 gtl3 Nmlp_1886 Nmlp_1886 rpl43e rpl43e pth pth Nmlp_1905 Nmlp_1905 Nmlp_1910 Nmlp_1910 Nmlp_1923 Nmlp_1923 Nmlp_1924 Nmlp_1924 Nmlp_1933 Nmlp_1933 trm56 trm56 rpl11 rpl11 drg drg Nmlp_1976 Nmlp_1976 fen1 fen1 gatE gatE tef5A tef5A topA topA gatB gatB serS serS Nmlp_2138 Nmlp_2138 Nmlp_2142 Nmlp_2142 rps15 rps15 rps1e rps1e Nmlp_2167 Nmlp_2167 zim zim Nmlp_2213 Nmlp_2213 Nmlp_2296 Nmlp_2296 tif1A2 tif1A2 Nmlp_2306 Nmlp_2306 mutY mutY nosD2 nosD2 nosD1 nosD1 Nmlp_2321 Nmlp_2321 dnaG dnaG rpl42e rpl42e rps27e rps27e tif2a tif2a aglB aglB Nmlp_2364 Nmlp_2364 psmA psmA top6A top6A gyrB gyrB gyrA gyrA tif2b1 tif2b1 orc3 orc3 Nmlp_2491 Nmlp_2491 Nmlp_2492 Nmlp_2492 Nmlp_2495 Nmlp_2495 polY2 polY2 Nmlp_2509 Nmlp_2509 orc4 orc4 Nmlp_2525 Nmlp_2525 Nmlp_2565 Nmlp_2565 Nmlp_2572 Nmlp_2572 Nmlp_2579 Nmlp_2579 Nmlp_2584 Nmlp_2584 Nmlp_2586 Nmlp_2586 Nmlp_2590 Nmlp_2590 Nmlp_2597 Nmlp_2597 Nmlp_2605 Nmlp_2605 Nmlp_2611 Nmlp_2611 Nmlp_2616 Nmlp_2616 rpl22 rpl22 Nmlp_2651 Nmlp_2651 Nmlp_2656 Nmlp_2656 orc5 orc5 Nmlp_2665 Nmlp_2665 Nmlp_2666 Nmlp_2666 phr3 phr3 cheR cheR Nmlp_2698 Nmlp_2698 rpl8e rpl8e rps28e rps28e rpl24e rpl24e prmC prmC ksgA ksgA rpl21e rpl21e tef1b tef1b gltS gltS rnj rnj rps2 rps2 rps9 rps9 rpl13 rpl13 rpl18e rpl18e rps11 rps11 rps4 rps4 rps13 rps13 rps6e rps6e Nmlp_2780 Nmlp_2780 tyrS tyrS Nmlp_2857 Nmlp_2857 ligB ligB dna2 dna2 Nmlp_2921 Nmlp_2921 Nmlp_2929 Nmlp_2929 Nmlp_2974 Nmlp_2974 proS proS Nmlp_2986 Nmlp_2986 Tif2Ba Tif2Ba trmY trmY nthA nthA radB radB rps8e rps8e rpl1 rpl1 rpl10 rpl10 rpl12 rpl12 cysS cysS rpc34 rpc34 ansB ansB trm5 trm5 Nmlp_3090 Nmlp_3090 rfcB rfcB Nmlp_3148 Nmlp_3148 rpa1 rpa1 Nmlp_3194 Nmlp_3194 Nmlp_3206 Nmlp_3206 phr4 phr4 Nmlp_3219 Nmlp_3219 rpl40e rpl40e metS metS phr2 phr2 polY1 polY1 rnhB rnhB Nmlp_3321 Nmlp_3321 nthB nthB Nmlp_3332 Nmlp_3332 rps17e rps17e aspS aspS rfcC rfcC trmG10 trmG10 alaS alaS trpS trpS ileS ileS dnaJ dnaJ Nmlp_3610 Nmlp_3610 Nmlp_3611 Nmlp_3611 Nmlp_3639 Nmlp_3639 Nmlp_3653 Nmlp_3653 Nmlp_3676 Nmlp_3676 Nmlp_3686 Nmlp_3686 apn1 apn1 trmI trmI tfs1 tfs1 hjc hjc Nmlp_3732 Nmlp_3732 valS valS tif2b2 tif2b2 cbiT cbiT tif5B tif5B Nmlp_3809 Nmlp_3809 udg udg rps10a rps10a tef1a tef1a tef2 tef2 rps7 rps7 rps12 rps12 uvrB uvrB rlmE rlmE gatD gatD mutS1b mutS1b mutL mutL pheT pheT pheS pheS ogt ogt hel308a hel308a uvrA uvrA polD1 polD1 polD2 polD2 Nmlp_3946 Nmlp_3946 mutS5a mutS5a orc2 orc2 orc1 orc1 Nmlp_1012 Nmlp_1012 Nmlp_1019 Nmlp_1019 Nmlp_1028 Nmlp_1028 Nmlp_1031 Nmlp_1031 cbiE cbiE polX polX rfcA rfcA ligA ligA radA radA Nmlp_1096 Nmlp_1096 Nmlp_1103 Nmlp_1103 trm1 trm1 Nmlp_1149 Nmlp_1149 spt5 spt5 Nmlp_1156 Nmlp_1156 lysS lysS rps19e rps19e taw2 taw2 pan1 pan1 aglD aglD pcn pcn priL priL rpa3 rpa3 leuS leuS uvrC uvrC Nmlp_1276 Nmlp_1276 Nmlp_1285 Nmlp_1285 Nmlp_1286 Nmlp_1286 rpl16 rpl16 atpH atpH tif6 tif6 rpl31e rpl31e rpl39e rpl39e Nmlp_1336 Nmlp_1336 nosD3 nosD3 Nmlp_1349 Nmlp_1349 nreA nreA Nmlp_1360 Nmlp_1360 argS argS rpa2 rpa2 glyS glyS hef hef Nmlp_1382 Nmlp_1382 Nmlp_1402 Nmlp_1402 arf1 arf1 tif1 tif1 Nmlp_1437 Nmlp_1437 Nmlp_1438 Nmlp_1438 rpl20e rpl20e ashA ashA pimT2 pimT2 pimT1 pimT1 Nmlp_1500 Nmlp_1500 Nmlp_1510 Nmlp_1510 CCT61390.1 CCT61390.1 Nmlp_1512 Nmlp_1512 tif1A1 tif1A1 rps31e rps31e rps24e rps24e spt4 spt4 tif2c tif2c rpl15 rpl15 rpl30 rpl30 rps5 rps5 rpl18 rpl18 rpl19e rpl19e rpl32e rpl32e rpl6 rpl6 rps8 rps8 rps14 rps14 rpl5 rpl5 rps4e rps4e rpl24 rpl24 rpl14 rpl14 rps17 rps17 rpl29 rpl29 rps3 rps3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Nmlp_2646Homolog to restriction system mrr N-terminal region. (71 aa)
rps1930S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (140 aa)
rpl250S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (243 aa)
rpl2350S ribosomal protein L23; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (82 aa)
rpl450S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (248 aa)
rpl350S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (336 aa)
Nmlp_1621Integrase family protein. (400 aa)
Nmlp_1635ISH9-type transposase ISNamo2; Gene has been targetted by a transposon; locus_tag: Nmlp_1634; product: sensor box histidine kinase (nonfunctional); conceptual translation after in silico reconstruction: MASEHERIDSHAVLDSLPDALFVVDRQRTISYANQRLCNVLNI SRIDLLDEPLAFLDQFVYEGFENLVSAIDEVLSGRQDDLRTEIETTLPEAAPVQQHIT VDARVTAADGNGISGALVVLRNVEEYHERQAQPRHEAQRFRTMFERHSAPMLLIDPDS GRIENANRSAVDFYGYDADRLYGMPIERINCHSPEEVSRKHKCAHRGDQNCFEFEHRL ASGETRAVEVHSSPIEIEGRTLLFSIVHDVTDRKESRRELRVFREAVAQAGHSVIITD VDGAIEYVNPAFEEVTGYDGDEIAGETPEVLNSGRRDPQFYEQLWETIRSGNVWEAEL VNQTKSGELYYAEHTIAPIVGDDGEITNFVAVQKDITERKLKQKRLSELH [...] (276 aa)
Nmlp_1642DUF790 family protein. (450 aa)
Nmlp_1646XerC/D-like integrase. (337 aa)
Nmlp_1647ISH14-type transposase ISNamo13. (226 aa)
Nmlp_1649PHP domain protein. (225 aa)
gatCaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (89 aa)
gatAaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (426 aa)
nfiEndonuclease 5; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (245 aa)
smcChromosome segregation protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1192 aa)
hisShistidine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (432 aa)
Nmlp_1673ISH14-type transposase ISNamo7. (211 aa)
Nmlp_1678ISH14-type transposase ISNamo8. (211 aa)
Nmlp_1689ISH14-type transposase ISNamo11. (211 aa)
polBDNA-directed DNA polymerase B (intein-containing). (1376 aa)
rad50DNA double-strand break repair ATPase Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex. Belongs to the SMC family. RAD50 subfamily. (887 aa)
mre11DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity; Belongs to the MRE11/RAD32 family. (465 aa)
pan2Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (404 aa)
cnatRNA/rRNA cytosine-C5-methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (303 aa)
rps10b30S ribosomal protein S10b; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (108 aa)
Nmlp_1726ISH14-type transposase ISNamo9. (211 aa)
Nmlp_1728ISH11-type transposase ISNamo4. (330 aa)
Nmlp_1738Homolog to phage integrase. (336 aa)
Nmlp_1751IS1341-type transposase ISNamo23. (411 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (393 aa)
Tif2BdeIF-2B domain protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (284 aa)
lhr1ATP-dependent DNA helicase. (950 aa)
mutS5bDNA mismatch repair protein MutS. (582 aa)
Nmlp_1793DUF814 domain protein. (703 aa)
pelAmRNA surveillance protein pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (355 aa)
lhr2ATP-dependent DNA helicase; Gene has a frameshift; locus_tag: Nmlp_1797; product: uncharacterized protein (nonfunctional); conceptual translation after in silico reconstruction: MVPDSPPSTLRDRLPAETESNALIYGFVGGVVGIVLSAVPLST LLGGIVAGYGGRFEDGLKAGAVAGVVTFVPFVVLFFLLLAFLGFGGAPIALGVFGAVA LVFVAAYTVGLAVLGGYLGIYIRHEL. (946 aa)
uvrDRepair helicase UvrD. (614 aa)
Nmlp_1809ISH14-type transposase ISNamo8. (211 aa)
rpl37e50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. (57 aa)
rpl15e50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. (196 aa)
mutS1aDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (861 aa)
nucSEndonuclease NucS; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (248 aa)
Nmlp_1842Product: thioredoxin domain protein (nonfunctional). (211 aa)
Nmlp_1847ISH14-type transposase ISNamo9. (211 aa)
Nmlp_1853IS1341-type transposase ISNamo21; Gene has been targetted by a transposon; locus_tag: Nmlp_1855; conceptual translation after in silico reconstruction: MSTDNSDDTTEHHAHEHRDVGGPGYPTPAAMRTESGREQTAYV MAPRVGMQNDGPGFVGVVDLDPASDTYSELIDTVEMPNKGDELHHFGWNACSSSCHAE GLSRQYLIVPGQRSSRIHVIDAEEPRDPEIVTVIEPEELFEYDLSAPHTVHCVPGGKI VISMLGDADGELPGGFLQLDQEDFSIDGRWEADRGAMEMNYDYWYQPRYDVLISSEWA APNTYYPGFDLDDVEAGNYGDSIHIWSWDDREHVQTLEFGDAGRIPLEVRMSHNPEET QGYVGAALSSNIIRFYESTDGAWEWDVVIDEDPREHEDWDMPVPPLIIDILLSLDDQY LFFSNWLHGDVRMYDVSDAANPRLVDRVWAGGLFGDRQEIQDKEIRGAPQMLQLSRDG TRLYWTTSLFSSWDNQFFPEMAEEGSLMFKADVFPDEGRLDL [...] (459 aa)
thrSthreonine--tRNA ligase; Belongs to the class-II aminoacyl-tRNA synthetase family. (642 aa)
gth1Probable glycosyltransferase, type 1. (366 aa)
gtl3Probable glycosyltransferase, type 2. (255 aa)
Nmlp_1886DUF2298 family protein. (754 aa)
rpl43e50S ribosomal protein L43e. (86 aa)
pthpeptidyl-tRNA hydrolase. (112 aa)
Nmlp_1905IS1341-type transposase ISNamo23. (411 aa)
Nmlp_1910Gene has been targetted by a transposon; locus_tag: Nmlp_1911; product: IS1341-type transposase ISNamo20 (nonfunctional); conceptual translation after in silico reconstruction: MLEIHRTHRAKILNHSQVEDPLDRHGWSASKLWNVANYHSRQK WDDTGEIPDHSDLKDELKGHSKYKGLHSQSSQRVLEELAEAFNSWYEKRKSDNRANPP GYRKKNYYDDHGNRVHEEHPRSTVTWKQNGIKHDTKNNRVRLSKGSNHKEHPKAWEYI LVEYETRPGVTVENLQQVRAVYDKAKRRWELHLVCKDEIETPTAPGNETAGIDLGICN FAAVAYSTEQADLYPGNRLKQDGYYFPKEIAKCDDSGGKEAPRLHAKWSERRTHFFHS LSKHIVQRCIERGVGRINIGKLAGVREDDNGEAKNWGRHGNLDLHGWAFDRFTSILEY KAEVEGVEVVEVSERDTSKTCCVCGREDESQRVERGLYVCEPCDAVFNADVNGAENIR LELKQSNSESAPDLGGD [...] (211 aa)
Nmlp_1923YfiH family protein. (263 aa)
Nmlp_1924HAD superfamily hydrolase. (217 aa)
Nmlp_1933ISH9-type transposase ISNamo1. (271 aa)
trm56tRNA (cytidine(56)-2'-O)-methyltransferase; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. (215 aa)
rpl1150S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (163 aa)
drgGTP-binding protein Drg. (371 aa)
Nmlp_1976RimK family protein. (448 aa)
fen1Flap endonuclease Fen1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway [...] (327 aa)
gatEglutamyl-tRNA(Gln) amidotransferase subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (617 aa)
tef5ATranslation elongation factor aEF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (124 aa)
topADNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (849 aa)
gatBaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (496 aa)
serSserine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (458 aa)
Nmlp_2138PaaI family protein. (146 aa)
Nmlp_2142Uncharacterized protein. (296 aa)
rps1530S ribosomal protein S15. (154 aa)
rps1e30S ribosomal protein S1e; Belongs to the eukaryotic ribosomal protein eS1 family. (208 aa)
Nmlp_2167Integrase family protein. (368 aa)
zimCTAG modification methylase. (367 aa)
Nmlp_2213tRNA (cytidine/uridine-2'-O-)-methyltransferase. (258 aa)
Nmlp_2296Homolog to translation elongation factor aEF-1 alpha subunit. (541 aa)
tif1A2Translation initiation factor aIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (94 aa)
Nmlp_2306DHH/RecJ family phosphoesterase. (733 aa)
mutYA/G-specific adenine glycosylase. (339 aa)
nosD2ABC-type transport system periplasmic substrate-binding protein (probable substrate copper). (703 aa)
nosD1ABC-type transport system periplasmic substrate-binding protein (probable substrate copper). (629 aa)
Nmlp_2321TRAM domain protein. (151 aa)
dnaGDNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (514 aa)
rpl42e50S ribosomal protein L42e; Binds to the 23S rRNA. (93 aa)
rps27e30S ribosomal protein S27e. (57 aa)
tif2aTranslation initiation factor aIF-2 alpha subunit. (266 aa)
aglBDolichyl-monophosphooligosaccharide--protein glycotransferase AglB. (957 aa)
Nmlp_2364DUF368 family protein. (314 aa)
psmAProteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (249 aa)
top6ADNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (370 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (639 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (848 aa)
tif2b1Translation initiation factor aIF-2 beta subunit. (135 aa)
orc3Orc1-type DNA replication protein; Involved in regulation of DNA replication. (418 aa)
Nmlp_2491IS1341-type transposase ISNamo20. (439 aa)
Nmlp_2492KaiC domain protein. (485 aa)
Nmlp_2495Integrase family protein; Product: ABC-type transport system permease protein (nonfunctional). (428 aa)
polY2DNA-directed DNA polymerase Y; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (421 aa)
Nmlp_2509ISH9-type transposase NmIRS1. (287 aa)
orc4Orc1-type DNA replication protein; Involved in regulation of DNA replication. (315 aa)
Nmlp_2525UPF0066 family protein; Gene has a frameshift; locus_tag: Nmlp_2524; product: ISH9-type transposase NmIRS2 (nonfunctional); conceptual translation after in silico reconstruction: MQALPESRLLRFVEQAYHLARRAVARYSSKFSKRRYTLHQHIV LLYLKIRKNTTYRTLLDELIEMPRIRSAIGLEEIPSPSTLCKAFNRLDMAVWRGLLNL SVTLLPTNGVVGIDASGFDRSHASKHYTKRTKLTIQRLKVTLLVDTKANAILNLHVTT TRKHDSQIAPSLIKRNTDEVTILLGDKGYDDQKVRALAREDGVRPVIKYREFSSLNKA WNARLDADLYGQRSQNETVNSSLKRKYGFVRSRHWWKQFRELVVGCLTHNIDTSL. (163 aa)
Nmlp_2565Uncharacterized protein. (96 aa)
Nmlp_2572IS1341-type transposase ISNamo24; Gene has been targetted by a transposon; locus_tag: Nmlp_2571; product: small CPxCG-related zinc finger protein (nonfunctional); conceptual translation after in silico reconstruction: MSTTDLSTLGDCPRCSASVTSIDVLIEYKIDGQPAVYAVHAEC PGCQAVIKPA. (434 aa)
Nmlp_2579ISH14-type transposase ISNamo8. (211 aa)
Nmlp_2584Homolog to 5-methylcytosine restriction system protein McrC. (400 aa)
Nmlp_2586ISH14-type transposase ISNamo7. (211 aa)
Nmlp_2590ISH14-type transposase ISNamo13. (226 aa)
Nmlp_2597Integrase family protein. (424 aa)
Nmlp_2605ISH9-type transposase ISNamo1. (271 aa)
Nmlp_2611ISH14-type transposase ISNamo13. (226 aa)
Nmlp_2616Probable DEAD/DEAH box helicase. (817 aa)
rpl2250S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. (154 aa)
Nmlp_2651IS1341-type transposase ISNamo25. (410 aa)
Nmlp_2656ISH14-type transposase ISNamo8. (211 aa)
orc5Orc1-type DNA replication protein; Involved in regulation of DNA replication. (405 aa)
Nmlp_2665IS200-type transposase ISNamo17. (129 aa)
Nmlp_2666IS1341-type transposase ISNamo17. (411 aa)
phr3Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (526 aa)
cheRProtein-glutamate O-methyltransferase CheR. (271 aa)
Nmlp_2698XerC/D-like integrase. (345 aa)
rpl8e50S ribosomal protein L8e; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (120 aa)
rps28e30S ribosomal protein S28e; Belongs to the eukaryotic ribosomal protein eS28 family. (74 aa)
rpl24e50S ribosomal protein L24e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL24 family. (123 aa)
prmCProbable S-adenosylmethionine-dependent methyltransferase PrmC. (191 aa)
ksgARibosome biogenesis protein KsgA, 16S rRNA-methylating; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (273 aa)
rpl21e50S ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family. (97 aa)
tef1bTranslation elongation factor aEF-1 beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (88 aa)
gltSglutamate--tRNA(Glu/Gln) ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (571 aa)
rnjRibonuclease J; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily. (446 aa)
rps230S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (268 aa)
rps930S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (132 aa)
rpl1350S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (149 aa)
rpl18e50S ribosomal protein L18e; Belongs to the eukaryotic ribosomal protein eL18 family. (117 aa)
rps1130S ribosomal protein S11; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (127 aa)
rps430S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (174 aa)
rps1330S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (171 aa)
rps6e30S ribosomal protein S6e; Belongs to the eukaryotic ribosomal protein eS6 family. (129 aa)
Nmlp_2780IS1341-type transposase ISNamo26. (423 aa)
tyrStyrosine--tRNA ligase. (345 aa)
Nmlp_2857DNA N-glycosylase. (306 aa)
ligBDNA ligase (ATP); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (552 aa)
dna2ATP-dependent DNA helicase Dna2. (883 aa)
Nmlp_2921Uncharacterized protein. (588 aa)
Nmlp_2929XerC/D-like integrase. (336 aa)
Nmlp_2974Probable phosphoesterase. (230 aa)
proSproline--tRNA ligase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (482 aa)
Nmlp_2986Uncharacterized protein. (168 aa)
Tif2BaNUDIX family hydrolase / eIF-2B domain protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (425 aa)
trmYtRNA (pseudouridine(54)-N(1))-methyltransferase; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family. (196 aa)
nthAEndonuclease 3; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (227 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (236 aa)
rps8e30S ribosomal protein S8e. (123 aa)
rpl150S ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (212 aa)
rpl1050S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (352 aa)
rpl1250S ribosomal protein L12; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (112 aa)
cysScysteine--tRNA ligase. (497 aa)
rpc34Probable transcription factor (homolog to RNA polymerase III subunit RPC34). (118 aa)
ansBAsparaginase/glutaminase family protein. (316 aa)
trm5tRNA (guanine(37)-N(1))-methyltransferase. (330 aa)
Nmlp_3090DUF2298 family protein. (789 aa)
rfcBReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (492 aa)
Nmlp_3148IS1341-type transposase ISNamo20. (439 aa)
rpa1Replication protein A. (423 aa)
Nmlp_3194Probable DEAD/DEAH box helicase. (932 aa)
Nmlp_3206ISH14-type transposase ISNamo8. (206 aa)
phr4Cryptochrome/photolyase-related protein. (509 aa)
Nmlp_3219uracil-DNA glycosylase superfamily protein. (195 aa)
rpl40e50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa)
metSmethionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (705 aa)
phr2Deoxyribodipyrimidine photolyase; Belongs to the DNA photolyase family. (466 aa)
polY1DNA-directed DNA polymerase Y; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (400 aa)
rnhBRibonuclease H, type 2; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (210 aa)
Nmlp_3321DUF790 family protein. (500 aa)
nthBEndonuclease 3. (271 aa)
Nmlp_3332HD family hydrolase. (233 aa)
rps17e30S ribosomal protein S17e; Belongs to the eukaryotic ribosomal protein eS17 family. (63 aa)
aspSaspartate--tRNA(Asp/Asn) ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn). (434 aa)
rfcCReplication factor C small subunit. (341 aa)
trmG10tRNA (guanine(10),N(2))-dimethyltransferase. (318 aa)
alaSalanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (928 aa)
trpStryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). (536 aa)
ileSisoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1070 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (385 aa)
Nmlp_3610IS200-type transposase ISNamo19; Gene is interrupted (frameshift,in-frame stop) and is truncated at the N-terminus; locus_tag: Nmlp_3609; product: ISH14-type transposase NmIRS15 (nonfunctional). (129 aa)
Nmlp_3611IS1341-type transposase ISNamo19. (419 aa)
Nmlp_3639ISH14-type transposase ISNamo7. (211 aa)
Nmlp_3653ISH14-type transposase ISNamo9. (211 aa)
Nmlp_3676ISH9-type transposase ISNamo1. (271 aa)
Nmlp_3686Integrase family protein / sensor/bat box HTH-10 family transcription regulator. (837 aa)
apn1Endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (277 aa)
trmItRNA (adenine-N(1))-methyltransferase TrmI. (243 aa)
tfs1Transcription elongation factor TFS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (108 aa)
hjcHolliday junction resolvase Hjc; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (173 aa)
Nmlp_3732ABCE1 family ribosome recycling factor. (612 aa)
valSvaline--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (887 aa)
tif2b2Translation initiation factor aIF-2 beta subunit. (203 aa)
cbiTcobalt-precorrin-6B C15-methyltransferase (decarboxylating); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. (179 aa)
tif5BTranslation initiation factor aIF-5B (bacterial-type IF2); Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (603 aa)
Nmlp_3809arNOG05511 family protein (AAA-type ATPase core domain protein); Belongs to the AAA ATPase family. (436 aa)
udguracil-DNA glycosylase. (193 aa)
rps10a30S ribosomal protein S10a; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
tef1aTranslation elongation factor aEF-1 alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (421 aa)
tef2Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (729 aa)
rps730S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (203 aa)
rps1230S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (142 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (683 aa)
rlmE23S rRNA (uridine-2'-O-) methyltransferase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (252 aa)
gatDglutamyl-tRNA(Gln) amidotransferase subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (414 aa)
mutS1bDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. (922 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (700 aa)
pheTphenylalanine--tRNA ligase beta subunit. (634 aa)
pheSphenylalanine--tRNA ligase alpha subunit. (504 aa)
ogtProbable methylated-DNA--protein-cysteine methyltransferase. (153 aa)
hel308aATP-dependent DNA helicase Hel308; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (769 aa)
uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (977 aa)
polD1DNA-directed DNA polymerase D exonuclease subunit DP1; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (642 aa)
polD2DNA-directed DNA polymerase D large subunit (intein-containing); Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1486 aa)
Nmlp_3946Integrase family protein. (287 aa)
mutS5aDNA mismatch repair protein MutS; Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily. (678 aa)
orc2Orc1-type DNA replication protein; Involved in regulation of DNA replication. (374 aa)
orc1Orc1-type DNA replication protein; Involved in regulation of DNA replication. (519 aa)
Nmlp_1012IS1341-type transposase ISNamo20. (439 aa)
Nmlp_1019HAD superfamily hydrolase. (289 aa)
Nmlp_1028Nonhistone chromosomal protein. (103 aa)
Nmlp_1031DEAD/DEAH box helicase. (794 aa)
cbiECobalt-precorrin-7 C5-methyltransferase. (247 aa)
polXDNA-directed DNA polymerase X. (580 aa)
rfcAReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (324 aa)
ligADNA ligase (NAD); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (690 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (345 aa)
Nmlp_1096IS1341-type transposase ISNamo20. (439 aa)
Nmlp_1103TRAM domain protein. (129 aa)
trm1tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (366 aa)
Nmlp_1149Uncharacterized protein. (729 aa)
spt5Transcription elongation factor Spt5; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (146 aa)
Nmlp_1156PHP domain protein. (251 aa)
lysSlysine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (546 aa)
rps19e30S ribosomal protein S19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (151 aa)
taw2tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7- aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe). (342 aa)
pan1Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (405 aa)
aglDGlycosyltransferase AglD. (608 aa)
pcnDNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. (247 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (360 aa)
rpa3Replication protein A. (309 aa)
leuSleucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (900 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (576 aa)
Nmlp_1276Probable restriction/modification enzyme. (1194 aa)
Nmlp_1285IS1341-type transposase ISNamo19. (419 aa)
Nmlp_1286IS200-type transposase ISNamo19. (130 aa)
rpl1650S ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family. (177 aa)
atpHA-type ATP synthase subunit H. (112 aa)
tif6Translation initiation factor aIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (221 aa)
rpl31e50S ribosomal protein L31e; Belongs to the ribosomal protein L31e family. (90 aa)
rpl39e50S ribosomal protein L39e; Belongs to the eukaryotic ribosomal protein eL39 family. (50 aa)
Nmlp_1336PHP domain protein. (256 aa)
nosD3ABC-type transport system periplasmic substrate-binding protein (probable substrate copper). (665 aa)
Nmlp_1349Probable S-adenosylmethionine-dependent methyltransferase. (210 aa)
nreADNA repair protein NreA; Involved in DNA damage repair. (426 aa)
Nmlp_1360Probable amidase. (489 aa)
argSarginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (580 aa)
rpa2Replication protein A. (471 aa)
glySglycine--tRNA ligase. (578 aa)
hefATP-dependent RNA helicase/nuclease Hef; Product: Kef-type transport system (probable substrate potassium) (nonfunctional). (835 aa)
Nmlp_1382PUA domain protein. (159 aa)
Nmlp_1402HAD superfamily hydrolase. (208 aa)
arf1Peptide chain release factor aRF-1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (412 aa)
tif1Translation initiation factor aIF-1 (SUI1 protein, bacterial-type IF3); Belongs to the SUI1 family. (97 aa)
Nmlp_1437ISH14-type transposase ISNamo12. (211 aa)
Nmlp_1438IS1341-type transposase ISNamo22; Product: nitroreductase family protein (nonfunctional); part of the region does not belong to this CDS as coordinates speficy only the outer boundaries; gene has been targetted by a transposon. (445 aa)
rpl20e50S ribosomal protein L20e. (57 aa)
ashAArchaea-specific helicase AshA. (675 aa)
pimT2protein-L-isoaspartate O-methyltransferase. (244 aa)
pimT1protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. (240 aa)
Nmlp_1500UCP015877 family protein. (216 aa)
Nmlp_1510IS1341-type transposase ISNamo18. (411 aa)
CCT61390.1IS200-type transposase ISNamo18. (127 aa)
Nmlp_1512ISH14-type transposase ISNamo10. (211 aa)
tif1A1Translation initiation factor aIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (97 aa)
rps31e30S ribosomal protein S31e; Belongs to the eukaryotic ribosomal protein eS31 family. (44 aa)
rps24e30S ribosomal protein S24e; Belongs to the eukaryotic ribosomal protein eS24 family. (103 aa)
spt4Transcription elongation factor Spt4; Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (65 aa)
tif2cTranslation initiation factor aIF-2 gamma subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. (409 aa)
rpl1550S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (166 aa)
rpl3050S ribosomal protein L30. (154 aa)
rps530S ribosomal protein S5; Belongs to the universal ribosomal protein uS5 family. (211 aa)
rpl1850S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (184 aa)
rpl19e50S ribosomal protein L19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (149 aa)
rpl32e50S ribosomal protein L32e; Belongs to the eukaryotic ribosomal protein eL32 family. (239 aa)
rpl650S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rps830S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa)
rps1430S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles. (59 aa)
rpl550S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rps4e30S ribosomal protein S4e; Belongs to the eukaryotic ribosomal protein eS4 family. (269 aa)
rpl2450S ribosomal protein L24; Located at the polypeptide exit tunnel on the outside of the subunit. (120 aa)
rpl1450S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (132 aa)
rps1730S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (114 aa)
rpl2950S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (69 aa)
rps330S ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (301 aa)
Your Current Organism:
Natronomonas moolapensis
NCBI taxonomy Id: 268739
Other names: N. moolapensis 8.8.11, Natronomonas moolapensis 8.8.11, Natronomonas moolapensis DSM 18674, Natronomonas moolapensis JCM 14361, Natronomonas moolapensis str. 8.8.11, Natronomonas moolapensis strain 8.8.11, haloarchaeon CSW8.8.11
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