STRINGSTRING
CyaB CyaB nop5 nop5 fib fib Nmlp_2210 Nmlp_2210 fen1 fen1 mutS1a mutS1a Nmlp_1719 Nmlp_1719 rad25b rad25b rad3a rad3a metY2 metY2 metY1 metY1 hda1 hda1 rpa2 rpa2 pdxS pdxS nop10 nop10 tbp4 tbp4 rpa3 rpa3 Nmlp_1177 Nmlp_1177 tbp1 tbp1 radA radA Nmlp_1085 Nmlp_1085 orc1 orc1 ligB ligB tfeA tfeA orc5 orc5 Nmlp_2616 Nmlp_2616 Nmlp_2578 Nmlp_2578 orc4 orc4 tbp2 tbp2 tbp3 tbp3 orc3 orc3 top6A top6A orc2 orc2 mutS1b mutS1b rad3b rad3b Nmlp_3759 Nmlp_3759 Nmlp_3729 Nmlp_3729 apn1 apn1 acs5 acs5 rad25a rad25a endA endA cbf5 cbf5 acs2 acs2 rpl40e rpl40e Nmlp_3194 Nmlp_3194 rpa1 rpa1 adk2 adk2 gar1 gar1 menE menE rps8e rps8e radB radB rad25c rad25c dna2 dna2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CyaBAdenylate cyclase domain protein. (177 aa)
nop5rRNA/tRNA 2'-O-methyltransferase complex protein Nop5. (278 aa)
fibFibrillarin-like rRNA/tRNA 2'-O-methyltransferase; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (211 aa)
Nmlp_2210UPF0047 family protein. (130 aa)
fen1Flap endonuclease Fen1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway [...] (327 aa)
mutS1aDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (861 aa)
Nmlp_1719M20 family amidohydrolase (homolog to indole-3-acetyl-aspartate hydrolase). (423 aa)
rad25bDNA repair helicase Rad25. (469 aa)
rad3aDNA repair helicase Rad3. (811 aa)
metY2O-acetylhomoserine aminocarboxypropyltransferase (methionine synthase). (429 aa)
metY1O-acetylhomoserine aminocarboxypropyltransferase (methionine synthase). (425 aa)
hda1HdaI-type histone deacetylase. (336 aa)
rpa2Replication protein A. (471 aa)
pdxSPyridoxal 5'-phosphate synthase subunit PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (301 aa)
nop10tRNA/rRNA pseudouridine synthase complex protein Nop10. (59 aa)
tbp4TATA-binding transcription initiation factor. (184 aa)
rpa3Replication protein A. (309 aa)
Nmlp_1177NMD3 family protein. (381 aa)
tbp1TATA-binding transcription initiation factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (187 aa)
radADNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. (345 aa)
Nmlp_1085Helicase domain protein. (579 aa)
orc1Orc1-type DNA replication protein; Involved in regulation of DNA replication. (519 aa)
ligBDNA ligase (ATP); DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (552 aa)
tfeATranscription initiation factor TFE; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation comp [...] (181 aa)
orc5Orc1-type DNA replication protein; Involved in regulation of DNA replication. (405 aa)
Nmlp_2616Probable DEAD/DEAH box helicase. (817 aa)
Nmlp_2578Probable helicase. (829 aa)
orc4Orc1-type DNA replication protein; Involved in regulation of DNA replication. (315 aa)
tbp2TATA-binding transcription initiation factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (187 aa)
tbp3TATA-binding transcription initiation factor; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (187 aa)
orc3Orc1-type DNA replication protein; Involved in regulation of DNA replication. (418 aa)
top6ADNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (370 aa)
orc2Orc1-type DNA replication protein; Involved in regulation of DNA replication. (374 aa)
mutS1bDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. (922 aa)
rad3bDNA repair helicase Rad3. (722 aa)
Nmlp_3759Beta-lactamase domain protein. (411 aa)
Nmlp_3729Probable GTP-binding protein. (325 aa)
apn1Endonuclease 4; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (277 aa)
acs5acyl-CoA synthetase. (531 aa)
rad25aDNA repair helicase Rad25. (449 aa)
endAtRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (335 aa)
cbf5tRNA-Pro; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (292 aa)
acs2acyl-CoA synthetase. (537 aa)
rpl40e50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa)
Nmlp_3194Probable DEAD/DEAH box helicase. (932 aa)
rpa1Replication protein A. (423 aa)
adk2Probable adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (168 aa)
gar1tRNA/rRNA pseudouridine synthase complex protein Gar1. (75 aa)
menEo-succinylbenzoate--CoA ligase. (488 aa)
rps8e30S ribosomal protein S8e. (123 aa)
radBDNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. (236 aa)
rad25cDNA repair helicase Rad25. (632 aa)
dna2ATP-dependent DNA helicase Dna2. (883 aa)
Your Current Organism:
Natronomonas moolapensis
NCBI taxonomy Id: 268739
Other names: N. moolapensis 8.8.11, Natronomonas moolapensis 8.8.11, Natronomonas moolapensis DSM 18674, Natronomonas moolapensis JCM 14361, Natronomonas moolapensis str. 8.8.11, Natronomonas moolapensis strain 8.8.11, haloarchaeon CSW8.8.11
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