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rpiA rpiA lysC lysC aspC4 aspC4 pabB pabB pabA pabA pabC pabC hisG hisG aroE aroE hisB hisB ilvE1 ilvE1 trpC trpC trpB1 trpB1 trpA trpA fba2 fba2 aroD aroD ilvA ilvA leuA2 leuA2 argF argF argE argE argD argD argB argB argC argC argX argX argH argH argG argG hisE hisE mat mat pykA pykA metX metX serB serB serA1 serA1 gap gap ilvD ilvD asnB asnB aroQ aroQ aroK aroK thrC1 thrC1 aspC3 aspC3 cysE cysE trpG3 trpG3 trpE1 trpE1 trpF trpF trpD1 trpD1 gpmI gpmI serA3 serA3 hisD hisD aroC aroC aroA aroA tyrA tyrA Nmlp_2332 Nmlp_2332 dapD dapD trpD2 trpD2 pgk pgk hisF hisF metE1 metE1 metE2 metE2 eno eno trpB2 trpB2 fba1 fba1 thrC3 thrC3 dapB dapB dapA dapA icd icd lysA lysA glyA glyA cysK cysK ilvB ilvB ilvN ilvN ilvC ilvC leuC leuC leuD leuD leuB leuB hisC hisC citZ citZ hisI hisI tpiA tpiA thrB thrB asd asd aspC2 aspC2 prsA prsA citB citB hisA hisA Nmlp_3776 Nmlp_3776 glnA glnA hisH hisH hom hom pheA pheA proC proC proB proB proA proA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
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rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (235 aa)
lysCAspartate kinase; Belongs to the aspartokinase family. (394 aa)
aspC4Pyridoxal phosphate-dependent aminotransferase. (368 aa)
pabBAminodeoxychorismate synthase component 1. (503 aa)
pabAAminodeoxychorismate synthase component 2. (205 aa)
pabCAminodeoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (288 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (281 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (264 aa)
hisBImidazoleglycerol-phosphate dehydratase. (195 aa)
ilvE1Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (309 aa)
trpCIndole-3-glycerol-phosphate synthase; Belongs to the TrpC family. (257 aa)
trpB1Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa)
trpATryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (292 aa)
fba22-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase. (262 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (231 aa)
ilvAThreonine ammonia-lyase. (402 aa)
leuA22-isopropylmalate synthase / (R)-citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (511 aa)
argFOrnithine carbamoyltransferase. (296 aa)
argEAcetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (365 aa)
argDAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (375 aa)
argBAcetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (277 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (347 aa)
argXProbable glutamate--argW ligase. (287 aa)
argHArgininosuccinate lyase. (508 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
hisEphosphoribosyl-ATP pyrophosphatase. (118 aa)
matS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (401 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (580 aa)
metXHomoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (401 aa)
serBPhosphoserine phosphatase; This gene seems complete but lacks its stop codon so that the reading frame continues into an adjacent ISH element; locus_tag: Nmlp_1419; product: UspA domain protein (nonfunctional); conceptual translation after in silico reconstruction: MSDDRLERPHAAERRHGRGRRVGARRRTDRLCAASRPADRTGT VAGGDRGPGVESAVEAGGPAETTLLYADRHDADRVATGGHGADPNGSFGRLVGAVATT AVAGGPAAVTVTVGR. (239 aa)
serA1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating). (338 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (585 aa)
asnBAsparagine synthase (glutamine-hydrolyzing). (377 aa)
aroQChorismate mutase. (95 aa)
aroKShikimate kinase, archaeal-type. (280 aa)
thrC1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (436 aa)
aspC3Pyridoxal phosphate-dependent aminotransferase. (382 aa)
cysESerine O-acetyltransferase; Gene has a frameshift and is truncated at both termini; locus_tag: Nmlp_1987; product: DNA N-glycosylase (nonfunctional). (188 aa)
trpG3Anthranilate synthase component 2. (194 aa)
trpE1Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (529 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (208 aa)
trpD1Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (333 aa)
gpmIPhosphoglycerate mutase,2,3-biphosphateglycerate-independent type; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (513 aa)
serA3Probable D-2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (422 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (395 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (437 aa)
tyrAPrephenate dehydrogenase. (242 aa)
Nmlp_2332Peptidase M20 family protein (homolog to succinyl-diaminopimelate desuccinylase). (428 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. (278 aa)
trpD2Probable phosphoribosyltransferase (homolog to anthranilate phosphoribosyltransferase). (354 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa)
hisFImidazoleglycerol-phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (271 aa)
metE15-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (356 aa)
metE25-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase (methionine synthase II). (326 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (398 aa)
trpB2Tryptophan synthase beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa)
fba1Fructose-bisphosphate aldolase, class 1. (264 aa)
thrC3Threonine synthase. (391 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (246 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
icdIsocitrate dehydrogenase (NADP). (418 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (414 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
cysKCysteine synthase. (329 aa)
ilvBAcetolactate synthase large subunit. (580 aa)
ilvNAcetolactate synthase small subunit. (211 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (486 aa)
leuD3-isopropylmalate dehydratase small subunit. (201 aa)
leuB3-isopropylmalate dehydrogenase. (326 aa)
hisCHistidinol-phosphate aminotransferase. (355 aa)
citZCitrate synthase. (378 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (120 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (211 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (292 aa)
asdAspartate-semialdehyde dehydrogenase. (344 aa)
aspC2Pyridoxal phosphate-dependent aminotransferase. (373 aa)
prsARibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (277 aa)
citBAconitate hydratase. (661 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (238 aa)
Nmlp_3776CobC/GpmA family phosphatase. (203 aa)
glnAGlutamine synthetase. (456 aa)
hisHImidazoleglycerol-phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (214 aa)
homHomoserine dehydrogenase. (314 aa)
pheAPrephenate dehydratase. (267 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (258 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (286 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (455 aa)
Your Current Organism:
Natronomonas moolapensis
NCBI taxonomy Id: 268739
Other names: N. moolapensis 8.8.11, Natronomonas moolapensis 8.8.11, Natronomonas moolapensis DSM 18674, Natronomonas moolapensis JCM 14361, Natronomonas moolapensis str. 8.8.11, Natronomonas moolapensis strain 8.8.11, haloarchaeon CSW8.8.11
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