STRINGSTRING
AAZ69058.1 AAZ69058.1 rpl10 rpl10 rpl40e rpl40e AAZ69741.1 AAZ69741.1 flpA flpA AAZ69782.1 AAZ69782.1 AAZ69808.1 AAZ69808.1 AAZ69825.1 AAZ69825.1 AAZ69828.1 AAZ69828.1 priL priL AAZ69862.1 AAZ69862.1 rbcL rbcL nth-2 nth-2 dnaG dnaG AAZ69941.1 AAZ69941.1 AAZ69948.1 AAZ69948.1 AAZ69987.1 AAZ69987.1 rps17e rps17e AAZ70139.1 AAZ70139.1 AAZ70167.1 AAZ70167.1 AAZ70203.1 AAZ70203.1 AAZ70233.1 AAZ70233.1 AAZ70327.1 AAZ70327.1 AAZ70355.1 AAZ70355.1 rps2 rps2 rps9 rps9 rpl12 rpl12 AAZ69571.1 AAZ69571.1 nth nth dbh dbh AAZ69529.1 AAZ69529.1 AAZ69466.1 AAZ69466.1 rpl31e rpl31e rps19e rps19e AAZ69380.1 AAZ69380.1 AAZ69363.1 AAZ69363.1 AAZ69351.1 AAZ69351.1 rad50 rad50 mre11 mre11 AAZ69323.1 AAZ69323.1 AAZ69322.1 AAZ69322.1 AAZ69321.1 AAZ69321.1 AAZ69319.1 AAZ69319.1 AAZ69316.1 AAZ69316.1 AAZ69314.1 AAZ69314.1 AAZ69312.1 AAZ69312.1 AAZ69311.1 AAZ69311.1 gvpA gvpA rps24e rps24e AAZ69234.1 AAZ69234.1 AAZ69196.1 AAZ69196.1 rps19 rps19 rps3 rps3 rpl29 rpl29 rps17 rps17 rps4e rps4e rpl6 rpl6 rpl32e rpl32e rpl19e rpl19e rpl18 rpl18 rps5 rps5 truB truB rps4 rps4 AAZ70443.1 AAZ70443.1 AAZ70481.1 AAZ70481.1 nop10 nop10 rpl44e rpl44e priS priS rfcS rfcS AAZ70531.1 AAZ70531.1 AAZ70575.1 AAZ70575.1 AAZ70774.1 AAZ70774.1 AAZ70775.1 AAZ70775.1 AAZ70860.1 AAZ70860.1 AAZ70871.1 AAZ70871.1 rfcL rfcL AAZ71045.1 AAZ71045.1 rps3ae rps3ae AAZ71092.1 AAZ71092.1 AAZ71130.1 AAZ71130.1 AAZ71227.1 AAZ71227.1 AAZ71392.1 AAZ71392.1 rpl15e rpl15e rpl37ae rpl37ae AAZ71439.1 AAZ71439.1 AAZ71555.1 AAZ71555.1 AAZ71558.1 AAZ71558.1 dbh-2 dbh-2 AAZ71668.1 AAZ71668.1 AAZ71674.1 AAZ71674.1 top6A top6A AAZ71843.1 AAZ71843.1 AAZ71863.1 AAZ71863.1 AAZ71873.1 AAZ71873.1 rpl21e rpl21e AAZ72207.1 AAZ72207.1 AAZ72209.1 AAZ72209.1 AAZ72245.1 AAZ72245.1 rps6e rps6e rpl24e rpl24e rps28e rps28e dnaJ dnaJ AAZ72414.1 AAZ72414.1 AAZ72446.1 AAZ72446.1 pdxS pdxS AAZ72512.1 AAZ72512.1 AAZ72533.1 AAZ72533.1 rps10 rps10 rpl30e rpl30e AAZ72571.1 AAZ72571.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AAZ69058.1Phosphoesterase. (422 aa)
rpl10LSU ribosomal protein L10P; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (346 aa)
rpl40eLSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family. (49 aa)
AAZ69741.1Membrane protein. (330 aa)
flpArRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (226 aa)
AAZ69782.1rRNA biogenesis protein Nop56/Nop58. (336 aa)
AAZ69808.1Conserved hypothetical protein. (239 aa)
AAZ69825.1Replication factor C subunit. (340 aa)
AAZ69828.1dCMP deaminase. (159 aa)
priLDNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (413 aa)
AAZ69862.15-methylcytosine-specific restriction enzyme. (306 aa)
rbcLRibulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (428 aa)
nth-2Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (204 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (517 aa)
AAZ69941.1Conserved hypothetical protein. (262 aa)
AAZ69948.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (414 aa)
AAZ69987.1Conserved hypothetical protein. (170 aa)
rps17eSSU ribosomal protein S17E; Belongs to the eukaryotic ribosomal protein eS17 family. (64 aa)
AAZ70139.1ATP-dependent DNA helicase RecQ. (881 aa)
AAZ70167.1ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication. (373 aa)
AAZ70203.1Putative regulatory protein. (506 aa)
AAZ70233.1Transcriptional regulator. (260 aa)
AAZ70327.1Conserved hypothetical protein. (825 aa)
AAZ70355.1snoRNP protein GAR1. (86 aa)
rps2SSU ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family. (247 aa)
rps9SSU ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family. (134 aa)
rpl12LSU ribosomal protein L12AE; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (106 aa)
AAZ69571.1Conserved hypothetical protein. (360 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (235 aa)
dbhDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (365 aa)
AAZ69529.1Adenylate cyclase. (177 aa)
AAZ69466.1Conserved hypothetical protein. (143 aa)
rpl31eLSU ribosomal protein L31E; Belongs to the ribosomal protein L31e family. (89 aa)
rps19eSSU ribosomal protein S19E; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (149 aa)
AAZ69380.1ADP-ribosylglycohydrolase; Dinitrogenase reductase activating glycohydrolase. (315 aa)
AAZ69363.1Conserved hypothetical protein. (417 aa)
AAZ69351.1Conserved hypothetical protein. (488 aa)
rad50DNA repair protein RAD50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (1074 aa)
mre11DNA repair protein; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (776 aa)
AAZ69323.1Hypothetical protein. (181 aa)
AAZ69322.1GvpL. (267 aa)
AAZ69321.1Hypothetical protein. (123 aa)
AAZ69319.1Hypothetical protein; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. (138 aa)
AAZ69316.1GvpF. (219 aa)
AAZ69314.1Hypothetical protein. (437 aa)
AAZ69312.1Hypothetical protein. (76 aa)
AAZ69311.1Hypothetical protein. (76 aa)
gvpAHypothetical protein; Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure. (76 aa)
rps24eSSU ribosomal protein S24E; Belongs to the eukaryotic ribosomal protein eS24 family. (101 aa)
AAZ69234.1Conserved hypothetical protein. (168 aa)
AAZ69196.1Conserved hypothetical protein. (335 aa)
rps19SSU ribosomal protein S19P; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa)
rps3SSU ribosomal protein S3P; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (311 aa)
rpl29LSU ribosomal protein L29P; Belongs to the universal ribosomal protein uL29 family. (67 aa)
rps17SSU ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (109 aa)
rps4eSSU ribosomal protein S4E; Belongs to the eukaryotic ribosomal protein eS4 family. (235 aa)
rpl6LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
rpl32eLSU ribosomal protein L32E; Belongs to the eukaryotic ribosomal protein eL32 family. (145 aa)
rpl19eLSU ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (150 aa)
rpl18LSU ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (174 aa)
rps5SSU ribosomal protein S5P; With S4 and S12 plays an important role in translational accuracy. (208 aa)
truBtRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (338 aa)
rps4SSU ribosomal protein S4P; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (216 aa)
AAZ70443.1Conserved hypothetical protein. (81 aa)
AAZ70481.1Glycosyltransferase. (694 aa)
nop10Conserved hypothetical protein; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (51 aa)
rpl44eLSU ribosomal protein L44E; Binds to the 23S rRNA. (92 aa)
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (414 aa)
rfcSReplication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (334 aa)
AAZ70531.1Archaeal histone. (69 aa)
AAZ70575.1Conserved hypothetical protein. (399 aa)
AAZ70774.1Conserved hypothetical protein. (125 aa)
AAZ70775.1Conserved hypothetical protein. (148 aa)
AAZ70860.1Glucosaminyltransferase. (403 aa)
AAZ70871.1moxR-like ATPase. (324 aa)
rfcLReplication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (642 aa)
AAZ71045.1Conserved hypothetical protein. (91 aa)
rps3aeSSU ribosomal protein S3AE; Belongs to the eukaryotic ribosomal protein eS1 family. (207 aa)
AAZ71092.1GTP-binding protein. (333 aa)
AAZ71130.1Putative magnesium chelatase. (328 aa)
AAZ71227.1DNA replication and repair protein RadC; Belongs to the UPF0758 family. (229 aa)
AAZ71392.1Hypothetical protein. (277 aa)
rpl15eLSU ribosomal protein L15E; Belongs to the eukaryotic ribosomal protein eL15 family. (199 aa)
rpl37aeLSU ribosomal protein L37AE; Binds to the 23S rRNA. (94 aa)
AAZ71439.1Conserved hypothetical protein. (732 aa)
AAZ71555.1moxR-like ATPase. (339 aa)
AAZ71558.1Conserved hypothetical protein. (919 aa)
dbh-2DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis. (367 aa)
AAZ71668.1Cell surface protein. (409 aa)
AAZ71674.1Methyltransferase. (94 aa)
top6AType II DNA topoisomerase VI, subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (369 aa)
AAZ71843.1Conserved hypothetical protein. (413 aa)
AAZ71863.1Kinesin light chain. (493 aa)
AAZ71873.1Conserved hypothetical protein. (561 aa)
rpl21eLSU ribosomal protein L21E; Belongs to the eukaryotic ribosomal protein eL21 family. (97 aa)
AAZ72207.1MoxR-related protein. (498 aa)
AAZ72209.1Conserved hypothetical protein. (119 aa)
AAZ72245.1Cell surface protein. (352 aa)
rps6eSSU ribosomal protein S6E; Belongs to the eukaryotic ribosomal protein eS6 family. (139 aa)
rpl24eLSU ribosomal protein L24E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL24 family. (62 aa)
rps28eSSU ribosomal protein S28E; Belongs to the eukaryotic ribosomal protein eS28 family. (73 aa)
dnaJChaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK a [...] (388 aa)
AAZ72414.1Hypothetical protein. (662 aa)
AAZ72446.1Conserved hypothetical protein. (275 aa)
pdxSPyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa)
AAZ72512.1Hypothetical protein. (365 aa)
AAZ72533.1Conserved hypothetical protein. (273 aa)
rps10SSU ribosomal protein S10P; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rpl30eLSU ribosomal protein L30E; Belongs to the eukaryotic ribosomal protein eL30 family. (98 aa)
AAZ72571.1Hypothetical protein. (1039 aa)
Your Current Organism:
Methanosarcina barkeri Fusaro
NCBI taxonomy Id: 269797
Other names: M. barkeri str. Fusaro, Methanosarcina barkeri DSM 804, Methanosarcina barkeri str. Fusaro, Methanosarcina barkeri strain Fusaro
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