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fabI fabI zwf zwf gnd gnd panE panE hprA hprA hpnA hpnA ghr ghr Gmet_3144 Gmet_3144 cysG cysG hemA hemA gmd-1 gmd-1 serA serA rmlD rmlD rmlB rmlB Gmet_1655 Gmet_1655 fabG-1 fabG-1 Gmet_1717 Gmet_1717 Gmet_1728 Gmet_1728 gapA gapA Gmet_1972 Gmet_1972 capL capL Gmet_2059 Gmet_2059 sucD-2 sucD-2 Gmet_2072 Gmet_2072 pcmM pcmM bamQ bamQ Gmet_2194 Gmet_2194 Gmet_2203 Gmet_2203 Gmet_2206 Gmet_2206 Gmet_2217 Gmet_2217 Gmet_0832 Gmet_0832 Gmet_0823 Gmet_0823 acuI acuI sucD-1 sucD-1 argC argC asd-1 asd-1 asd-2 asd-2 pseB pseB Gmet_0450 Gmet_0450 Gmet_0422 Gmet_0422 Gmet_0361 Gmet_0361 Gmet_0306 Gmet_0306 folD-1 folD-1 Gmet_0231 Gmet_0231 dapB dapB Gmet_0193 Gmet_0193 Gmet_0106 Gmet_0106 gpsA gpsA Gmet_0063 Gmet_0063 tyrA tyrA arnA arnA proC proC Gmet_0902 Gmet_0902 ald ald Gmet_1105 Gmet_1105 folD-2 folD-2 gdhA gdhA gapB gapB dxr dxr ilvC ilvC ahcY ahcY gnnA gnnA fcl fcl Gmet_1335 Gmet_1335 Gmet_1338 Gmet_1338 mdh mdh aroE aroE ugd ugd uxs uxs galE-2 galE-2 gmd-2 gmd-2 bbsC bbsC bbsD bbsD fabG-2 fabG-2 hom hom maeB maeB Gmet_2226 Gmet_2226 Gmet_2230 Gmet_2230 Gmet_2231 Gmet_2231 Gmet_2235 Gmet_2235 Gmet_2236 Gmet_2236 Gmet_2249 Gmet_2249 sucD-3 sucD-3 Gmet_2269 Gmet_2269 galE-1 galE-1 uge uge
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
fabIEnoyl-(acyl carrier protein) reductase. (256 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (512 aa)
gnd6-phosphogluconate dehydrogenase, decarboxylating. (336 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa)
hprAHydroxypyruvate reductase, putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (330 aa)
hpnANAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase. (328 aa)
ghrGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase. (287 aa)
Gmet_3144NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase. (294 aa)
cysGPrecorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase, putative. (224 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (434 aa)
gmd-1GDP-mannose 4,6-dehydratase and GDP-6-deoxy-D-lyxo-4-hexulose reductase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (360 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (541 aa)
rmlDdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (280 aa)
rmlBdTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (358 aa)
Gmet_1655Rossmann fold nucleotide-binding protein. (134 aa)
fabG-13-oxoacyl-(acyl carrier protein) reductase. (245 aa)
Gmet_17173-hydroxyacyl-CoA dehydrogenase. (281 aa)
Gmet_1728Glu/Leu/Phe/Val dehydrogenase superfamily protein. (992 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
Gmet_1972Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase-related protein. (288 aa)
capLUDP-N-acetyl-D-galactosamine 6-dehydrogenase, putative; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (429 aa)
Gmet_2059Oxidoreductase, short-chain dehydrogenase/reductase family; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa)
sucD-2succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (296 aa)
Gmet_20723-hydroxyacyl-CoA dehydrogenase. (281 aa)
pcmMOxidoreductase, short-chain dehydrogenase/reductase family. (255 aa)
bamQ6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase. (357 aa)
Gmet_2194Oxidoreductase, short-chain dehydrogenase/reductase family. (255 aa)
Gmet_22033-hydroxyacyl-CoA dehydrogenase. (290 aa)
Gmet_2206Oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (254 aa)
Gmet_2217Oxidoreductase, short-chain dehydrogenase/reductase family. (258 aa)
Gmet_0832NADPH:quinone oxidoreductase family protein PIG3. (328 aa)
Gmet_0823NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase. (290 aa)
acuINADP-dependent menaquinol:acrylyl-CoA oxidoreductase. (334 aa)
sucD-1succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
argCN-acetyl-glutamyl-5-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
asd-1Aspartate-4-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa)
asd-2Aspartate-4-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (366 aa)
pseBUDP-N-acetylglucosamine 4,6-dehydratase and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose 5-epimerase. (342 aa)
Gmet_0450Oxidoreductase, putative. (274 aa)
Gmet_0422Oxidoreductase, short-chain dehydrogenase/reductase family. (259 aa)
Gmet_0361Oxidoreductase, short-chain dehydrogenase/reductase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
Gmet_0306Protein of unknown function, coenzyme A-binding and coenzyme A ligase domain-containing. (909 aa)
folD-15,10-methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (290 aa)
Gmet_0231NADPH:quinone oxidoreductase family protein. (320 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (266 aa)
Gmet_0193Phosphoribosylaminoimidazole carboxylase-related protein. (249 aa)
Gmet_0106D-isomer-specific 2-hydroxyacid dehydrogenase, NAD-binding protein. (314 aa)
gpsAGlycerol-3-phosphate dehydrogenase, NAD(P)-dependent; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (335 aa)
Gmet_0063TrkA domain protein. (351 aa)
tyrAPrephenate dehydrogenase. (286 aa)
arnAUDP-glucuronate 4-dehydrogenase, decarboxylating. (346 aa)
proCDelta-1-pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
Gmet_0902Carboxynorspermidine/carboxyspermidine dehydrogenase. (397 aa)
aldAlanine dehydrogenase; Belongs to the AlaDH/PNT family. (365 aa)
Gmet_1105Kef-type potassium transporter, NAD-binding protein; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (672 aa)
folD-25,10-methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
gdhAGlutamate dehydrogenase, NADP-dependent; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (450 aa)
gapBGlyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (481 aa)
dxr1-deoxy-D-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa)
ilvCKetol-acid reductoisomerase, class I; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
ahcYS-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (476 aa)
gnnAUDP-N-acetylglucosamine 3-dehydrogenase, NAD-dependent. (310 aa)
fclGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (321 aa)
Gmet_1335NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase. (338 aa)
Gmet_1338NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase. (639 aa)
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (317 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
ugdUDP-glucose 6-dehydrogenase. (450 aa)
uxsUDP-glucuronate decarboxylase. (313 aa)
galE-2UDP-glucose/UDP-N-acetylglucosamine 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (330 aa)
gmd-2GDP-mannose 4,6-dehydratase and GDP-6-deoxy-D-lyxo-4-hexulose reductase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (349 aa)
bbsC2-[hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase subunit. (248 aa)
bbsD2-[hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase subunit. (249 aa)
fabG-23-oxoacyl-(acyl carrier protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
homHomoserine dehydrogenase. (436 aa)
maeBMalate oxidoreductase, NADP-dependent, phosphate acetyltransferase-like domain-containing. (752 aa)
Gmet_2226Oxidoreductase, short-chain dehydrogenase/reductase family. (261 aa)
Gmet_2230Hypothetical protein. (367 aa)
Gmet_2231Oxidoreductase, short-chain dehydrogenase/reductase family. (257 aa)
Gmet_2235Zinc-dependent alcohol dehydrogenase. (340 aa)
Gmet_2236Oxidoreductase, short-chain dehydrogenase/reductase family. (266 aa)
Gmet_2249Oxidoreductase, short-chain dehydrogenase/reductase family. (260 aa)
sucD-3succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa)
Gmet_22693-hydroxyacyl-CoA dehydrogenase. (296 aa)
galE-1UDP-glucose/UDP-N-acetylglucosamine 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (326 aa)
ugeUDP-galacturonate 4-epimerase. (336 aa)
Your Current Organism:
Geobacter metallireducens
NCBI taxonomy Id: 269799
Other names: G. metallireducens GS-15, Geobacter metallireducens GS-15, Geobacter metallireducens str. GS-15, Geobacter metallireducens strain GS-15
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