STRINGSTRING
Tfu_0067 Tfu_0067 Tfu_0068 Tfu_0068 Tfu_0069 Tfu_0069 Tfu_0072 Tfu_0072 pckG pckG mdh mdh Tfu_0180 Tfu_0180 Tfu_0181 Tfu_0181 Tfu_0182 Tfu_0182 Tfu_0247 Tfu_0247 Tfu_0253 Tfu_0253 Tfu_0276 Tfu_0276 Tfu_0353 Tfu_0353 Tfu_0360 Tfu_0360 Tfu_0361 Tfu_0361 Tfu_0436 Tfu_0436 fumC fumC Tfu_0501 Tfu_0501 Tfu_0507 Tfu_0507 Tfu_0562 Tfu_0562 Tfu_0566 Tfu_0566 Tfu_0593 Tfu_0593 Tfu_0594 Tfu_0594 Tfu_0686 Tfu_0686 Tfu_0687 Tfu_0687 Tfu_0690 Tfu_0690 Tfu_0744 Tfu_0744 Tfu_0819 Tfu_0819 Tfu_0863 Tfu_0863 Tfu_0875 Tfu_0875 Tfu_0946 Tfu_0946 Tfu_0947 Tfu_0947 Tfu_0948 Tfu_0948 Tfu_0958 Tfu_0958 Tfu_0982 Tfu_0982 Tfu_0988 Tfu_0988 Tfu_0993 Tfu_0993 Tfu_0994 Tfu_0994 Tfu_1031 Tfu_1031 Tfu_1068 Tfu_1068 Tfu_1173 Tfu_1173 Tfu_1174 Tfu_1174 Tfu_1215 Tfu_1215 Tfu_1228 Tfu_1228 Tfu_1229 Tfu_1229 Tfu_1259 Tfu_1259 Tfu_1277 Tfu_1277 Tfu_1278 Tfu_1278 Tfu_1280 Tfu_1280 Tfu_1281 Tfu_1281 Tfu_1282 Tfu_1282 Tfu_1284 Tfu_1284 Tfu_1295 Tfu_1295 Tfu_1296 Tfu_1296 Tfu_1297 Tfu_1297 Tfu_1299 Tfu_1299 Tfu_1300 Tfu_1300 Tfu_1301 Tfu_1301 Tfu_1302 Tfu_1302 Tfu_1371 Tfu_1371 Tfu_1376 Tfu_1376 Tfu_1377 Tfu_1377 Tfu_1379 Tfu_1379 gcvP gcvP Tfu_1467 Tfu_1467 Tfu_1468 Tfu_1468 Tfu_1469 Tfu_1469 Tfu_1470 Tfu_1470 Tfu_1471 Tfu_1471 Tfu_1472 Tfu_1472 Tfu_1473 Tfu_1473 Tfu_1474 Tfu_1474 Tfu_1475 Tfu_1475 Tfu_1476 Tfu_1476 Tfu_1477 Tfu_1477 Tfu_1478 Tfu_1478 Tfu_1479 Tfu_1479 Tfu_1480 Tfu_1480 Tfu_1481 Tfu_1481 Tfu_1482 Tfu_1482 Tfu_1483 Tfu_1483 Tfu_1484 Tfu_1484 Tfu_1485 Tfu_1485 Tfu_1486 Tfu_1486 Tfu_1488 Tfu_1488 Tfu_1512 Tfu_1512 Tfu_1513 Tfu_1513 Tfu_1520 Tfu_1520 Tfu_1530 Tfu_1530 Tfu_1544 Tfu_1544 Tfu_1546 Tfu_1546 Tfu_1647 Tfu_1647 Tfu_1649 Tfu_1649 Tfu_1682 Tfu_1682 Tfu_1733 Tfu_1733 Tfu_1777 Tfu_1777 Tfu_1844 Tfu_1844 Tfu_1878 Tfu_1878 Tfu_1903 Tfu_1903 Tfu_1904 Tfu_1904 Tfu_1925 Tfu_1925 Tfu_1972 Tfu_1972 Tfu_1998 Tfu_1998 Tfu_1999 Tfu_1999 Tfu_2158 Tfu_2158 Tfu_2239 Tfu_2239 Tfu_2248 Tfu_2248 Tfu_2309 Tfu_2309 Tfu_2310 Tfu_2310 gcvT gcvT gcvH gcvH glyA glyA purU purU Tfu_2390 Tfu_2390 Tfu_2394 Tfu_2394 Tfu_2395 Tfu_2395 Tfu_2399 Tfu_2399 Tfu_2451 Tfu_2451 Tfu_2452 Tfu_2452 Tfu_2453 Tfu_2453 Tfu_2481 Tfu_2481 Tfu_2485 Tfu_2485 ppc ppc Tfu_2555 Tfu_2555 Tfu_2556 Tfu_2556 Tfu_2557 Tfu_2557 Tfu_2559 Tfu_2559 Tfu_2568 Tfu_2568 folD folD sucD sucD sucC sucC Tfu_2590 Tfu_2590 Tfu_2665 Tfu_2665 Tfu_2666 Tfu_2666 Tfu_2674 Tfu_2674 Tfu_2675 Tfu_2675 Tfu_2759 Tfu_2759 Tfu_2760 Tfu_2760 Tfu_2761 Tfu_2761 Tfu_2762 Tfu_2762 Tfu_2763 Tfu_2763 Tfu_2808 Tfu_2808 icmF icmF Tfu_2844 Tfu_2844 acsA acsA Tfu_2949 Tfu_2949 Tfu_2980 Tfu_2980 pdhA pdhA Tfu_3050 Tfu_3050 Tfu_3051 Tfu_3051
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tfu_0067Short chain enoyl-CoA hydratase / Enoyl-CoA hydratase. (256 aa)
Tfu_0068Putative acyl-CoA dehydrogenase. (391 aa)
Tfu_0069Putative transcriptional regulator. (202 aa)
Tfu_0072Putative quinone oxidoreductase. (328 aa)
pckGPhosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (604 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa)
Tfu_0180Pyruvate dehydrogenase (lipoamide). (405 aa)
Tfu_0181Putative branched-chain alpha keto acid dehydrogenase E1 beta subunit. (327 aa)
Tfu_0182Putative dihydrolipoamide acyltransferase component. (446 aa)
Tfu_0247Citrate synthase; Belongs to the citrate synthase family. (401 aa)
Tfu_0253Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (380 aa)
Tfu_0276Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (254 aa)
Tfu_0353Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain. (583 aa)
Tfu_0360Putative oxidoreductase. (331 aa)
Tfu_0361Oxidoreductase, short chain dehydrogenase/reductase family. (264 aa)
Tfu_0436Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (407 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
Tfu_0501Enoyl-CoA hydratase. (263 aa)
Tfu_0507Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain. (489 aa)
Tfu_0562Malate dehydrogenase (oxaloacetate decarboxylating). (428 aa)
Tfu_05662-oxoglutarate dehydrogenase E1 component. (1214 aa)
Tfu_0593Electron transfer flavoprotein, beta subunit. (259 aa)
Tfu_0594Electron transfer flavoprotein, alpha subunit. (313 aa)
Tfu_0686Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
Tfu_0687Methylmalonate-semialdehyde dehydrogenase (acylating). (500 aa)
Tfu_06904-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa)
Tfu_0744Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (496 aa)
Tfu_0819Malate synthase A; Belongs to the malate synthase family. (532 aa)
Tfu_0863Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (891 aa)
Tfu_0875Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
Tfu_0946butyryl-CoA dehydrogenase. (384 aa)
Tfu_0947Putative acetyl/propionyl CoA carboxylase alpha subunit: biotin carboxylase. (696 aa)
Tfu_0948propionyl-CoA carboxylase. (541 aa)
Tfu_0958Conserved hypothetical protein. (151 aa)
Tfu_0982L-glutamine synthetase. (453 aa)
Tfu_0988L-glutamine synthetase. (474 aa)
Tfu_09932-oxoglutarate dehydrogenase E2 component. (580 aa)
Tfu_0994Dihydrolipoamide dehydrogenase. (459 aa)
Tfu_1031Long-chain fatty-acid-CoA ligase. (598 aa)
Tfu_1068glutaryl-CoA dehydrogenase. (396 aa)
Tfu_1173Glutamate synthase (NADH) large subunit. (1520 aa)
Tfu_1174Glutamate synthase (NADH) small subunit. (485 aa)
Tfu_1215methylmalonyl-CoA decarboxylase alpha chain. (519 aa)
Tfu_1228Putative acyl-CoA carboxylase complex A subunit. (589 aa)
Tfu_1229Putative 3-oxoacyl-ACP synthase III. (344 aa)
Tfu_1259Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (250 aa)
Tfu_1277Transcriptional regulator, GntR family. (244 aa)
Tfu_1278Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
Tfu_1280Short chain enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (260 aa)
Tfu_1281butyryl-CoA dehydrogenase. (387 aa)
Tfu_1282Putative acyl-CoA dehydrogenase. (392 aa)
Tfu_1284Putative acyl-CoA dehydrogenase. (388 aa)
Tfu_1295Putative membrane transport protein. (500 aa)
Tfu_1296Hypothetical protein. (165 aa)
Tfu_1297Amidohydrolase family protein. (262 aa)
Tfu_1299Dihydroxynaphthoic acid synthase; Belongs to the enoyl-CoA hydratase/isomerase family. (270 aa)
Tfu_1300DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism. (547 aa)
Tfu_1301Similar to Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases. (336 aa)
Tfu_1302Probable 6-carboxyhexanoate--COA ligase. (692 aa)
Tfu_1371Glutamate dehydrogenase (NADP); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (452 aa)
Tfu_1376Hypothetical protein. (437 aa)
Tfu_1377Isocitrate lyase. (429 aa)
Tfu_1379Putative acyl-CoA dehydrogenase. (409 aa)
gcvPGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (957 aa)
Tfu_1467Hypothetical protein. (213 aa)
Tfu_1468Similar to Acyl-CoA dehydrogenases. (716 aa)
Tfu_1469Conserved hypothetical protein. (378 aa)
Tfu_1470Hypothetical protein. (153 aa)
Tfu_1471Betaine-aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
Tfu_1472Short-chain dehydrogenase/reductase (SDR) family protein. (282 aa)
Tfu_1473Putative pimeloyl-CoA synthetase. (716 aa)
Tfu_1474Short chain dehydrogenase. (262 aa)
Tfu_1475Similar to TRAP-type C4-dicarboxylate transport system periplasmic component. (431 aa)
Tfu_1476Hypothetical protein. (178 aa)
Tfu_1477TrapT family, DctM subunit, C4-dicarboxylate transport. (506 aa)
Tfu_1478Conserved hypothetical protein; Belongs to the cytochrome P450 family. (403 aa)
Tfu_1479Putative ferredoxin. (71 aa)
Tfu_1480Subunit of CoA-transferase of family III; Belongs to the CoA-transferase III family. (409 aa)
Tfu_1481Putative subunit of succinyl-CoA:benzylsuccinate CoA-transferase; Belongs to the CoA-transferase III family. (406 aa)
Tfu_1482Hypothetical protein. (198 aa)
Tfu_1483Conserved hypothetical protein. (152 aa)
Tfu_1484Putative exported protein. (389 aa)
Tfu_1485Conserved hypothetical protein. (134 aa)
Tfu_1486Similar to TRAP-type C4-dicarboxylate transport system periplasmic component. (431 aa)
Tfu_1488NADH:flavin oxidoreductases, Old Yellow enzyme family. (656 aa)
Tfu_1512Putative acyl-CoA dehydrogenase. (382 aa)
Tfu_1513Biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (120 aa)
Tfu_1520Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
Tfu_1530Similar to Acetyl/propionyl-CoA carboxylase alpha subunit. (1849 aa)
Tfu_1544Putative enoyl-CoA hydratase/isomerase family protein. (223 aa)
Tfu_1546Putative acyl-CoA synthetase. (510 aa)
Tfu_1647acyl-CoA dehydrogenase. (385 aa)
Tfu_1649Catalase; Belongs to the catalase family. (555 aa)
Tfu_1682Putative short chain dehydrogenase. (252 aa)
Tfu_1733Putative acyl-CoA synthetase, long-chain-fatty acid:CoA ligase. (614 aa)
Tfu_1777Putative acyl-CoA dehydrogenase. (383 aa)
Tfu_1844Conserved hypothetical protein. (339 aa)
Tfu_1878Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (275 aa)
Tfu_1903Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
Tfu_1904Short chain enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase. (697 aa)
Tfu_1925Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (916 aa)
Tfu_1972Conserved hypothetical protein. (373 aa)
Tfu_1998Putative acyl-CoA synthetase, long-chain fatty acid:CoA ligase. (508 aa)
Tfu_1999acyl-CoA dehydrogenase. (391 aa)
Tfu_2158Putative long-chain-fatty-acid-CoA ligase. (515 aa)
Tfu_2239Conserved hypothetical protein. (659 aa)
Tfu_2248Putative acyl-CoA synthetase, long-chain fatty acid:CoA ligase. (550 aa)
Tfu_2309Putative acyl-CoA dehydrogenase. (411 aa)
Tfu_2310Putative acyl-CoA dehydrogenase. (377 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
Tfu_2390Malate dehydrogenase (oxaloacetate decarboxylating). (470 aa)
Tfu_2394Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
Tfu_2395methylmalonyl-CoA epimerase. (147 aa)
Tfu_23993-hydroxyacyl-CoA dehydrogenase. (398 aa)
Tfu_2451Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (248 aa)
Tfu_2452Succinate dehydrogenase subunit A. (646 aa)
Tfu_2453Succinate dehydrogenase subunit C. (238 aa)
Tfu_2481Glutamate dehydrogenase (NAD). (1617 aa)
Tfu_2485acyl-CoA dehydrogenase. (398 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (875 aa)
Tfu_2555propionyl-CoA carboxylase complex B subunit. (534 aa)
Tfu_2556Conserved hypothetical protein. (81 aa)
Tfu_2557Putative acyl-CoA carboxylase, alpha subunit. (587 aa)
Tfu_2559Dihydrolipoamide dehydrogenase. (460 aa)
Tfu_2568Isocitrate dehydrogenase (NADP); Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
sucCsuccinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (410 aa)
Tfu_2590Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (525 aa)
Tfu_2665Conserved hypothetical protein. (141 aa)
Tfu_2666Conserved hypothetical protein; Belongs to the UPF0336 family. (152 aa)
Tfu_26742-oxoglutarate ferredoxin oxidoreductase, alpha subunit. (617 aa)
Tfu_2675Putative oxidoreductase. (352 aa)
Tfu_2759Similar to Glutathione peroxidase. (210 aa)
Tfu_2760Hypothetical protein. (470 aa)
Tfu_2761methylmalonyl-CoA mutase. (630 aa)
Tfu_2762methylmalonyl-CoA mutase. (740 aa)
Tfu_2763ArgK protein. (332 aa)
Tfu_2808Putative acetyl-coenzyme A synthetase. (581 aa)
icmFmethylmalonyl-CoA mutase, N-terminal; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1080 aa)
Tfu_2844Putative oxidoreductase. (949 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
Tfu_2949Succinate semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
Tfu_2980(S)-2-hydroxy-acid oxidase. (402 aa)
pdhAPyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (365 aa)
Tfu_3050Dehydrogenase complex, E1 component, beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (331 aa)
Tfu_3051Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase. (431 aa)
Your Current Organism:
Thermobifida fusca
NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX
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