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carA carA nadE nadE Tfu_0982 Tfu_0982 Tfu_0947 Tfu_0947 Tfu_0737 Tfu_0737 ddl ddl gatB gatB gatA gatA gatC gatC Tfu_0396 Tfu_0396 Tfu_0372 Tfu_0372 cobB cobB purS purS purL purL purQ purQ Tfu_0108 Tfu_0108 purC purC purD purD purA purA tilS tilS panC panC purM purM Tfu_2714 Tfu_2714 Tfu_2713 Tfu_2713 guaA guaA Tfu_2565 Tfu_2565 Tfu_2557 Tfu_2557 Tfu_2553 Tfu_2553 purK purK Tfu_2518 Tfu_2518 Tfu_2373 Tfu_2373 Tfu_2190 Tfu_2190 argG argG mshC mshC Tfu_1806 Tfu_1806 pafA pafA ddl-2 ddl-2 Tfu_1228 Tfu_1228 pyrG pyrG Tfu_1145 Tfu_1145 murC murC murD murD murF murF murE murE Tfu_1064 Tfu_1064 carB carB Tfu_0988 Tfu_0988
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
carACarbamoyl-phosphate synthase small subunit; Belongs to the CarA family. (416 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (577 aa)
Tfu_0982L-glutamine synthetase. (453 aa)
Tfu_0947Putative acetyl/propionyl CoA carboxylase alpha subunit: biotin carboxylase. (696 aa)
Tfu_0737Hypothetical protein. (385 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (371 aa)
gatBaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (517 aa)
gatAaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (498 aa)
gatCaspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (99 aa)
Tfu_0396Conserved hypothetical protein. (186 aa)
Tfu_0372Conserved hypothetical protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (214 aa)
cobBHydrogenobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (474 aa)
purSPhosphoribosylformylglycinamidine synthetase PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...] (80 aa)
purLPhosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (765 aa)
purQPhosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (235 aa)
Tfu_0108Conserved hypothetical protein. (167 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (307 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (424 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (427 aa)
tilSHelix-turn-helix, Fis-type; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (324 aa)
panCPantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (296 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase. (350 aa)
Tfu_2714Putative ligase. (418 aa)
Tfu_2713Conserved hypothetical protein. (236 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (528 aa)
Tfu_2565Enzymatic protein of unknown function; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (399 aa)
Tfu_2557Putative acyl-CoA carboxylase, alpha subunit. (587 aa)
Tfu_2553biotin--acetyl-CoA-carboxylase ligase. (299 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa)
Tfu_2518Coenzyme F420-0 gamma-glutamyl ligase. (423 aa)
Tfu_2373Nicotinate phosphoribosyltransferase related; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (438 aa)
Tfu_2190Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. (443 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
mshCcysteinyl-tRNA synthetase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (412 aa)
Tfu_1806Conserved hypothetical protein. (316 aa)
pafAConserved hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (452 aa)
ddl-2D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (329 aa)
Tfu_1228Putative acyl-CoA carboxylase complex A subunit. (589 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (581 aa)
Tfu_1145Asparagine synthase (glutamine-hydrolysing). (610 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (472 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (465 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (470 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (534 aa)
Tfu_1064Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (412 aa)
carBCarbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1103 aa)
Tfu_0988L-glutamine synthetase. (474 aa)
Your Current Organism:
Thermobifida fusca
NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX
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