(41 nodes) Vitamin binding network (Thermobifida fusca)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	Tfu_1741	L-threonine ammonia-lyase. (310 aa)
	Tfu_0206	Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (431 aa)
	Tfu_0226	L-threonine synthase. (428 aa)
	serC	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (373 aa)
	Tfu_0686	Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)
	Tfu_0278	Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (462 aa)
	Tfu_0301	Aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
	Tfu_0690	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (448 aa)
	Tfu_0440	Cystathionine gamma-lyase. (381 aa)
	Tfu_0492	Aminotransferase. (370 aa)
	Tfu_0553	Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (553 aa)
	Tfu_0566	2-oxoglutarate dehydrogenase E1 component. (1214 aa)
	Tfu_0568	Succinyldiaminopimelate aminotransferase. (391 aa)
	Tfu_0586	Alpha-glucan phosphorylase. (873 aa)
	Tfu_0595	Putative pyridoxal-phosphate-dependent aminotransferase. (390 aa)
	Tfu_0611	Acetolactate synthase, large subunit. (589 aa)
	Tfu_0632	Cystathionine gamma-synthase. (406 aa)
	pat	Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
	Tfu_2823	o-acetylhomoserine/O-acetylserine sulfhydrylase. (443 aa)
	icmF	methylmalonyl-CoA mutase, N-terminal; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1080 aa)
	Tfu_2762	methylmalonyl-CoA mutase. (740 aa)
	Tfu_2761	methylmalonyl-CoA mutase. (630 aa)
	hemL	Glutamate-1-semialdehyde 2,1-aminomutase. (430 aa)
	Tfu_2675	Putative oxidoreductase. (352 aa)
	Tfu_2661	L-aspartate aminotransferase. (402 aa)
	alr	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (374 aa)
	lysA	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (461 aa)
	Tfu_2423	L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (354 aa)
	glyA	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
	Tfu_2253	Aminotransferase. (430 aa)
	Tfu_2247	Aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (418 aa)
	Tfu_2223	L-threonine O-3-phosphate decarboxylase. (336 aa)
	argD	Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (403 aa)
	dxs	1-Deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (637 aa)
	Tfu_1865	Amino acid adenylation. (1344 aa)
	Tfu_1825	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1158 aa)
	Tfu_1641	Valine-pyruvate aminotransferase. (440 aa)
	menD	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (553 aa)
	hisC	Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa)
	Tfu_1115	Protein of unknown function UPF0001; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (240 aa)
	kynU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (413 aa)

Your Current Organism:

Thermobifida fusca

NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Tfu_0226	Tfu_1741	Tfu_0226	Tfu_1741	L-threonine synthase.	L-threonine ammonia-lyase.	0.943
Tfu_0226	Tfu_1825	Tfu_0226	Tfu_1825	L-threonine synthase.	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.435
Tfu_0226	Tfu_2423	Tfu_0226	Tfu_2423	L-threonine synthase.	L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.	0.921
Tfu_0226	serC	Tfu_0226	Tfu_0246	L-threonine synthase.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.	0.932
Tfu_0301	Tfu_1865	Tfu_0301	Tfu_1865	Aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Amino acid adenylation.	0.411
Tfu_0440	Tfu_1741	Tfu_0440	Tfu_1741	Cystathionine gamma-lyase.	L-threonine ammonia-lyase.	0.863
Tfu_0440	Tfu_1825	Tfu_0440	Tfu_1825	Cystathionine gamma-lyase.	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.980
Tfu_0440	Tfu_2823	Tfu_0440	Tfu_2823	Cystathionine gamma-lyase.	o-acetylhomoserine/O-acetylserine sulfhydrylase.	0.932
Tfu_0492	lysA	Tfu_0492	Tfu_2425	Aminotransferase.	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.	0.771
Tfu_0492	serC	Tfu_0492	Tfu_0246	Aminotransferase.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.	0.503
Tfu_0553	Tfu_0611	Tfu_0553	Tfu_0611	Acetolactate synthase large subunit; Belongs to the TPP enzyme family.	Acetolactate synthase, large subunit.	0.926
Tfu_0553	Tfu_1741	Tfu_0553	Tfu_1741	Acetolactate synthase large subunit; Belongs to the TPP enzyme family.	L-threonine ammonia-lyase.	0.953
Tfu_0553	Tfu_2675	Tfu_0553	Tfu_2675	Acetolactate synthase large subunit; Belongs to the TPP enzyme family.	Putative oxidoreductase.	0.913
Tfu_0566	Tfu_1825	Tfu_0566	Tfu_1825	2-oxoglutarate dehydrogenase E1 component.	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.437
Tfu_0566	Tfu_2253	Tfu_0566	Tfu_2253	2-oxoglutarate dehydrogenase E1 component.	Aminotransferase.	0.856
Tfu_0566	Tfu_2661	Tfu_0566	Tfu_2661	2-oxoglutarate dehydrogenase E1 component.	L-aspartate aminotransferase.	0.856
Tfu_0566	Tfu_2675	Tfu_0566	Tfu_2675	2-oxoglutarate dehydrogenase E1 component.	Putative oxidoreductase.	0.915
Tfu_0566	Tfu_2761	Tfu_0566	Tfu_2761	2-oxoglutarate dehydrogenase E1 component.	methylmalonyl-CoA mutase.	0.462
Tfu_0566	Tfu_2762	Tfu_0566	Tfu_2762	2-oxoglutarate dehydrogenase E1 component.	methylmalonyl-CoA mutase.	0.462
Tfu_0566	glyA	Tfu_0566	Tfu_2353	2-oxoglutarate dehydrogenase E1 component.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.767