STRINGSTRING
Tfu_2067 Tfu_2067 Tfu_2350 Tfu_2350 Tfu_2390 Tfu_2390 lysA lysA Tfu_2437 Tfu_2437 Tfu_2481 Tfu_2481 ppc ppc Tfu_2564 Tfu_2564 Tfu_2890 Tfu_2890 Tfu_2893 Tfu_2893 Tfu_2891 Tfu_2891 asd asd Tfu_0043 Tfu_0043 mdh mdh Tfu_0434 Tfu_0434 fumC fumC Tfu_0494 Tfu_0494 Tfu_0495 Tfu_0495 Tfu_0526 Tfu_0526 aroA aroA Tfu_0562 Tfu_0562 nadA nadA dapB dapB dapA dapA dapF dapF Tfu_0821 Tfu_0821 kynU kynU aroC aroC aroK aroK aroB aroB Tfu_1173 Tfu_1173 Tfu_1174 Tfu_1174 Tfu_1207 Tfu_1207 Tfu_1313 Tfu_1313 aroQ aroQ Tfu_1715 Tfu_1715 Tfu_1718 Tfu_1718 Tfu_1720 Tfu_1720 Tfu_2012 Tfu_2012
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Tfu_2067Shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family. (282 aa)
Tfu_23503-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (353 aa)
Tfu_2390Malate dehydrogenase (oxaloacetate decarboxylating). (470 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (461 aa)
Tfu_2437Peptidase M20D, amidohydrolase. (653 aa)
Tfu_2481Glutamate dehydrogenase (NAD). (1617 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (875 aa)
Tfu_2564Peptidase M20D, amidohydrolase. (410 aa)
Tfu_28907, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. (174 aa)
Tfu_2893Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (302 aa)
Tfu_2891Dihydroneopterin aldolase family:Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (126 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (352 aa)
Tfu_0043Aspartate kinase; Belongs to the aspartokinase family. (423 aa)
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (330 aa)
Tfu_0434L-proline dehydrogenase. (311 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
Tfu_04942,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (278 aa)
Tfu_0495Succinyl-diaminopimelate desuccinylase. (354 aa)
Tfu_0526Putative peptidase. (464 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (424 aa)
Tfu_0562Malate dehydrogenase (oxaloacetate decarboxylating). (428 aa)
nadAQuinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (332 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (246 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (325 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (274 aa)
Tfu_0821Imidazolonepropionase. (401 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (413 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (406 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (368 aa)
Tfu_1173Glutamate synthase (NADH) large subunit. (1520 aa)
Tfu_1174Glutamate synthase (NADH) small subunit. (485 aa)
Tfu_1207Chorismate mutase. (120 aa)
Tfu_1313Putative citrate lyase beta subunit; Belongs to the HpcH/HpaI aldolase family. (275 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
Tfu_1715Dihydrodipicolinate synthase. (288 aa)
Tfu_1718Putative dihydrodipicolinate synthase; Belongs to the DapA family. (301 aa)
Tfu_1720Conserved hypothetical protein. (388 aa)
Tfu_2012Amidase, hydantoinase/carbamoylase. (407 aa)
Your Current Organism:
Thermobifida fusca
NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX
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