(14 nodes) ATP-grasp fold, subdomain 1 network (Thermobifida fusca)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	purK	Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa)
	purD	Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (424 aa)
	sucC	succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (410 aa)
	Tfu_2557	Putative acyl-CoA carboxylase, alpha subunit. (587 aa)
	Tfu_2128	Conserved hypothetical protein. (907 aa)
	uvrA	Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (945 aa)
	ddl-2	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (329 aa)
	Tfu_1473	Putative pimeloyl-CoA synthetase. (716 aa)
	Tfu_1311	Conserved hypothetical protein. (886 aa)
	Tfu_1302	Probable 6-carboxyhexanoate--COA ligase. (692 aa)
	carB	Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family. (1103 aa)
	Tfu_0863	Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (891 aa)
	Tfu_0737	Hypothetical protein. (385 aa)
	ddl	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (371 aa)

Your Current Organism:

Thermobifida fusca

NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Tfu_1302	Tfu_1473	Tfu_1302	Tfu_1473	Probable 6-carboxyhexanoate--COA ligase.	Putative pimeloyl-CoA synthetase.	0.921
Tfu_1302	Tfu_2557	Tfu_1302	Tfu_2557	Probable 6-carboxyhexanoate--COA ligase.	Putative acyl-CoA carboxylase, alpha subunit.	0.900
Tfu_1302	sucC	Tfu_1302	Tfu_2577	Probable 6-carboxyhexanoate--COA ligase.	succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.805
Tfu_1473	Tfu_1302	Tfu_1473	Tfu_1302	Putative pimeloyl-CoA synthetase.	Probable 6-carboxyhexanoate--COA ligase.	0.921
Tfu_1473	Tfu_2557	Tfu_1473	Tfu_2557	Putative pimeloyl-CoA synthetase.	Putative acyl-CoA carboxylase, alpha subunit.	0.900
Tfu_1473	sucC	Tfu_1473	Tfu_2577	Putative pimeloyl-CoA synthetase.	succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.805
Tfu_2557	Tfu_1302	Tfu_2557	Tfu_1302	Putative acyl-CoA carboxylase, alpha subunit.	Probable 6-carboxyhexanoate--COA ligase.	0.900
Tfu_2557	Tfu_1473	Tfu_2557	Tfu_1473	Putative acyl-CoA carboxylase, alpha subunit.	Putative pimeloyl-CoA synthetase.	0.900
Tfu_2557	sucC	Tfu_2557	Tfu_2577	Putative acyl-CoA carboxylase, alpha subunit.	succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.833
carB	purD	Tfu_1057	Tfu_3013	Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family.	Phosphoribosylamine--glycine ligase; Belongs to the GARS family.	0.574
ddl	ddl-2	Tfu_0633	Tfu_1640	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	0.908
ddl	purK	Tfu_0633	Tfu_2547	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.456
ddl-2	ddl	Tfu_1640	Tfu_0633	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	0.908
purD	carB	Tfu_3013	Tfu_1057	Phosphoribosylamine--glycine ligase; Belongs to the GARS family.	Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family.	0.574
purD	purK	Tfu_3013	Tfu_2547	Phosphoribosylamine--glycine ligase; Belongs to the GARS family.	Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	0.977
purK	ddl	Tfu_2547	Tfu_0633	Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	0.456
purK	purD	Tfu_2547	Tfu_3013	Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).	Phosphoribosylamine--glycine ligase; Belongs to the GARS family.	0.977
sucC	Tfu_1302	Tfu_2577	Tfu_1302	succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	Probable 6-carboxyhexanoate--COA ligase.	0.805
sucC	Tfu_1473	Tfu_2577	Tfu_1473	succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	Putative pimeloyl-CoA synthetase.	0.805
sucC	Tfu_2557	Tfu_2577	Tfu_2557	succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	Putative acyl-CoA carboxylase, alpha subunit.	0.833