(13 nodes) AMP-binding enzyme, C-terminal domain superfamily network (Thermobifida fusca)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	Tfu_1866	Amino acid adenylation. (1074 aa)
	Tfu_1865	Amino acid adenylation. (1344 aa)
	Tfu_1546	Putative acyl-CoA synthetase. (510 aa)
	Tfu_1408	Putative ortho-succinylbenzoate-CoA synthetase. (391 aa)
	Tfu_1300	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism. (547 aa)
	Tfu_2808	Putative acetyl-coenzyme A synthetase. (581 aa)
	Tfu_1867	Non-ribosomal peptide synthase:Amino acid adenylation. (3629 aa)
	Tfu_1871	2,3-dihydroxybenzoate-AMP ligase. (543 aa)
	Tfu_1998	Putative acyl-CoA synthetase, long-chain fatty acid:CoA ligase. (508 aa)
	Tfu_2158	Putative long-chain-fatty-acid-CoA ligase. (515 aa)
	Tfu_2245	acetoacetyl-CoA synthase. (654 aa)
	Tfu_2248	Putative acyl-CoA synthetase, long-chain fatty acid:CoA ligase. (550 aa)
	acsA	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)

Your Current Organism:

Thermobifida fusca

NCBI taxonomy Id: 269800
Other names: T. fusca YX, Thermobifida fusca YX, Thermobifida fusca str. YX, Thermobifida fusca strain YX

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Tfu_1300	Tfu_1408	Tfu_1300	Tfu_1408	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	Putative ortho-succinylbenzoate-CoA synthetase.	0.727
Tfu_1300	Tfu_1546	Tfu_1300	Tfu_1546	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	Putative acyl-CoA synthetase.	0.573
Tfu_1300	Tfu_1865	Tfu_1300	Tfu_1865	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	Amino acid adenylation.	0.684
Tfu_1300	Tfu_1866	Tfu_1300	Tfu_1866	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	Amino acid adenylation.	0.585
Tfu_1300	Tfu_2245	Tfu_1300	Tfu_2245	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	acetoacetyl-CoA synthase.	0.518
Tfu_1300	Tfu_2808	Tfu_1300	Tfu_2808	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	Putative acetyl-coenzyme A synthetase.	0.541
Tfu_1300	acsA	Tfu_1300	Tfu_2856	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.485
Tfu_1408	Tfu_1300	Tfu_1408	Tfu_1300	Putative ortho-succinylbenzoate-CoA synthetase.	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	0.727
Tfu_1408	Tfu_1546	Tfu_1408	Tfu_1546	Putative ortho-succinylbenzoate-CoA synthetase.	Putative acyl-CoA synthetase.	0.584
Tfu_1408	Tfu_1865	Tfu_1408	Tfu_1865	Putative ortho-succinylbenzoate-CoA synthetase.	Amino acid adenylation.	0.914
Tfu_1408	Tfu_1866	Tfu_1408	Tfu_1866	Putative ortho-succinylbenzoate-CoA synthetase.	Amino acid adenylation.	0.892
Tfu_1408	Tfu_1867	Tfu_1408	Tfu_1867	Putative ortho-succinylbenzoate-CoA synthetase.	Non-ribosomal peptide synthase:Amino acid adenylation.	0.417
Tfu_1408	Tfu_2245	Tfu_1408	Tfu_2245	Putative ortho-succinylbenzoate-CoA synthetase.	acetoacetyl-CoA synthase.	0.496
Tfu_1408	Tfu_2808	Tfu_1408	Tfu_2808	Putative ortho-succinylbenzoate-CoA synthetase.	Putative acetyl-coenzyme A synthetase.	0.546
Tfu_1408	acsA	Tfu_1408	Tfu_2856	Putative ortho-succinylbenzoate-CoA synthetase.	Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.	0.522
Tfu_1546	Tfu_1300	Tfu_1546	Tfu_1300	Putative acyl-CoA synthetase.	DitJ-like CoA ligase (AMP forming), possibly related to diterpenoid metabolism.	0.573
Tfu_1546	Tfu_1408	Tfu_1546	Tfu_1408	Putative acyl-CoA synthetase.	Putative ortho-succinylbenzoate-CoA synthetase.	0.584
Tfu_1546	Tfu_1998	Tfu_1546	Tfu_1998	Putative acyl-CoA synthetase.	Putative acyl-CoA synthetase, long-chain fatty acid:CoA ligase.	0.576
Tfu_1546	Tfu_2158	Tfu_1546	Tfu_2158	Putative acyl-CoA synthetase.	Putative long-chain-fatty-acid-CoA ligase.	0.580
Tfu_1546	Tfu_2248	Tfu_1546	Tfu_2248	Putative acyl-CoA synthetase.	Putative acyl-CoA synthetase, long-chain fatty acid:CoA ligase.	0.583