STRINGSTRING
trpB trpB AFZ56121.1 AFZ56121.1 AFZ56133.1 AFZ56133.1 AFZ56707.1 AFZ56707.1 nth nth mutM mutM gmd gmd AFZ57711.1 AFZ57711.1 pheA pheA hisB hisB eno eno nnrD nnrD AFZ58276.1 AFZ58276.1 AFZ58420.1 AFZ58420.1 AFZ58723.1 AFZ58723.1 aroB aroB AFZ58774.1 AFZ58774.1 AFZ58865.1 AFZ58865.1 AFZ58901.1 AFZ58901.1 AFZ59106.1 AFZ59106.1 fabZ fabZ trpA trpA murQ murQ menC menC AFZ59880.1 AFZ59880.1 gmd-2 gmd-2 aroQ aroQ aroC aroC AFZ60432.1 AFZ60432.1 AFZ60536.1 AFZ60536.1 ilvD ilvD AFZ60618.1 AFZ60618.1 AFZ60694.1 AFZ60694.1 leuC leuC dapA dapA AFZ60909.1 AFZ60909.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (412 aa)
AFZ56121.1TIGRFAM: haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; COGs: COG0546 phosphatase; InterPro IPR006438; KEGG: naz:Aazo_1886 HAD superfamily hydrolase; SPTR: HAD superfamily (Subfamily IA) hydrolase, TIGR01548; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, hypothetical 1. (263 aa)
AFZ56133.1Porphobilinogen synthase; PFAM: Delta-aminolevulinic acid dehydratase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: ava:Ava_3297 delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (325 aa)
AFZ56707.1PFAM: Enoyl-CoA hydratase/isomerase family; COGs: COG1024 Enoyl-CoA hydratase/carnithine racemase; InterPro IPR001753; KEGG: fjo:Fjoh_3100 enoyl-CoA hydratase/isomerase; PFAM: Crotonase, core; SPTR: Enoyl-CoA hydratase/isomerase. (269 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (214 aa)
mutMDNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (277 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (359 aa)
AFZ57711.1L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (364 aa)
pheAPFAM: Prephenate dehydratase; ACT domain; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086:IPR002912; KEGG: npu:Npun_R3887 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT; PRIAM: Prephenate dehydratase; SPTR: Prephenate dehydratase. (290 aa)
hisBPFAM: Imidazoleglycerol-phosphate dehydratase; COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: naz:Aazo_1063 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase. (198 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
nnrDYjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (510 aa)
AFZ58276.1dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase; COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR005888:IPR001509; KEGG: naz:Aazo_0590 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: dTDP-glucose 4,6-dehydratase; SPTR: dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (362 aa)
AFZ58420.1PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: 6-pyruvoyl tetrahydropterin synthase/QueD family protein; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: naz:Aazo_4074 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; PFAM: 6-pyruvoyl tetrahydropterin synthase-related; SPTR: Putative uncharacterized protein. (129 aa)
AFZ58723.1PFAM: VanZ like family; InterPro IPR006976; KEGG: naz:Aazo_3080 hypothetical protein; PFAM: VanZ-like; SPTR: Putative uncharacterized protein. (125 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (365 aa)
AFZ58774.1Protein of unknown function UPF0047; PFAM: Uncharacterised protein family UPF0047; TIGRFAM: secondary thiamine-phosphate synthase enzyme; COGs: COG0432 conserved hypothetical protein; InterPro IPR001602; KEGG: naz:Aazo_2407 hypothetical protein; PFAM: Uncharacterised protein family UPF0047; SPTR: Putative uncharacterized protein; TIGRFAM: Uncharacterised protein family UPF0047. (146 aa)
AFZ58865.1PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: 6-pyruvoyl tetrahydropterin synthase/QueD family protein; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: npu:Npun_F2811 putative 6-pyruvoyl tetrahydropterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase-related; SPTR: Putative uncharacterized protein. (290 aa)
AFZ58901.1PFAM: Pterin 4 alpha carbinolamine dehydratase; COGs: COG2154 Pterin-4a-carbinolamine dehydratase; HAMAP: Transcriptional coactivator/pterin dehydratase; InterPro IPR001533; KEGG: naz:Aazo_3734 transcriptional coactivator/pterin dehydratase; PFAM: Transcriptional coactivator/pterin dehydratase; SPTR: Putative pterin-4-alpha-carbinolamine dehydratase. (100 aa)
AFZ59106.1KEGG: rcu:RCOM_2034660 hypothetical protein; SPTR: Putative uncharacterized protein. (198 aa)
fabZ3-hydroxyacyl-(acyl-carrier-protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (171 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
murQN-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (308 aa)
menCO-succinylbenzoic acid (OSB) synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (319 aa)
AFZ59880.1PFAM: Carbonic anhydrase; COGs: COG0288 Carbonic anhydrase; InterPro IPR001765:IPR006311; KEGG: naz:Aazo_4079 carbonic anhydrase; PFAM: Carbonic anhydrase; SMART: Carbonic anhydrase; SPTR: Carbonic anhydrase. (236 aa)
gmd-2GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (325 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa)
AFZ60432.1Aconitase; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; COGs: COG1049 Aconitase B; InterPro IPR004406:IPR015929:IPR001030; KEGG: ana:all1267 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; PFAM: Aconitase B, N-terminal, bacterial; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; SPTR: Aconitate hydratase 2; TIGRFAM: Aconitase B, bacterial; Belongs to the aconitase/IPM isomerase family. (876 aa)
AFZ60536.1Porphobilinogen synthase; PFAM: Delta-aminolevulinic acid dehydratase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: ana:all4725 delta-aminolevulinic acid dehydratase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (336 aa)
ilvDPFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: naz:Aazo_0368 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (568 aa)
AFZ60618.1Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (264 aa)
AFZ60694.13-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
AFZ60909.1Carbonate dehydratase; PFAM: Eukaryotic-type carbonic anhydrase; COGs: COG3338 Carbonic anhydrase; InterPro IPR001148; KEGG: cyj:Cyan7822_4951 carbonate dehydratase; PFAM: Carbonic anhydrase, alpha-class, catalytic domain; PRIAM: Carbonate dehydratase; SPTR: Carbonic anhydrase. (283 aa)
Your Current Organism:
Anabaena cylindrica
NCBI taxonomy Id: 272123
Other names: A. cylindrica PCC 7122, Anabaena cylindrica IAM M-1, Anabaena cylindrica NIES-19, Anabaena cylindrica PCC 7122, Anabaena cylindrica UTEX B 629, Anabaena sp. ATCC 27899, Anabaena sp. PCC 7122
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