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| | AFZ60923.1 | PFAM: Thymidylate synthase; TIGRFAM: thymidylate synthase, methanogen type; COGs: COG0207 Thymidylate synthase; InterPro IPR000398; KEGG: naz:Aazo_5011 thymidylate synthase; PFAM: Thymidylate synthase; SPTR: Thymidylate synthase. (509 aa) |
| | AFZ55669.1 | Cytidyltransferase-related domain protein; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain; COGs: COG3172 ATPase/kinase involved in NAD metabolism; InterPro IPR004820:IPR004821; KEGG: mbt:JTY_0218 putative transcriptional regulatory protein; PFAM: Cytidylyltransferase; SPTR: Cytidyltransferase-related domain protein; TIGRFAM: Cytidyltransferase-related. (329 aa) |
| | panC/cmk | Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the N-terminal section; belongs to the pantothenate synthetase family. (547 aa) |
| | AFZ55849.1 | PFAM: ATP adenylyltransferase; COGs: COG4360 ATP adenylyltransferase (5' 5'''-P-1 P-4-tetraphosphate phosphorylase II); InterPro IPR019200; KEGG: naz:Aazo_3644 ATP adenylyltransferase-like protein; PFAM: ATP adenylyltransferase, C-terminal; SPTR: ATP adenylyltransferase-like protein. (294 aa) |
| | nadD | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (226 aa) |
| | AFZ55889.1 | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (181 aa) |
| | AFZ55912.1 | InterPro IPR013027; KEGG: naz:Aazo_3719 glucose-inhibited division protein A; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: Glucose-inhibited division protein A. (582 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (305 aa) |
| | AFZ55965.1 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (404 aa) |
| | AFZ56002.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (242 aa) |
| | AFZ56100.1 | PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015795:IPR001697; KEGG: npu:Npun_R0030 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa) |
| | AFZ56101.1 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+); PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR020828:IPR020829:IPR006424; KEGG: npu:Npun_R0031 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde [...] (341 aa) |
| | nadK-2 | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (306 aa) |
| | atpC | ATP synthase F1 subcomplex epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (164 aa) |
| | atpD | ATP synthase F1 subcomplex beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (482 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (202 aa) |
| | AFZ56253.1 | Catalytic domain-containing protein of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: naz:Aazo_1439 hypothetical protein; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; SPTR: Catalytic [...] (434 aa) |
| | AFZ56280.1 | (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (758 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (211 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (142 aa) |
| | AFZ56385.1 | PFAM: Survival protein SurE; TIGRFAM: 5'/3'-nucleotidase SurE; COGs: COG0496 acid phosphatase; InterPro IPR002828; KEGG: npu:Npun_R1763 stationary phase survival protein SurE; PFAM: Survival protein SurE-like phosphatase/nucleotidase; SPTR: Stationary-phase survival protein SurE; TIGRFAM: Survival protein SurE-like phosphatase/nucleotidase. (226 aa) |
| | AFZ56398.1 | PFAM: Amidohydrolase family; TIGRFAM: dihydroorotase, multifunctional complex type; COGs: COG0044 Dihydroorotase and related cyclic amidohydrolase; InterPro IPR004722:IPR006680; KEGG: naz:Aazo_4426 dihydroorotase; PFAM: Amidohydrolase 1; PRIAM: Allantoinase; SPTR: Dihydroorotase; TIGRFAM: Dihydroorotase. (444 aa) |
| | AFZ56405.1 | PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR013650; KEGG: naz:Aazo_1152 ATP-grasp domain-containing protein; PFAM: ATP-grasp fold, succinyl-CoA synthetase-type; PRIAM: Succinate--CoA ligase (ADP-forming); SPTR: ATP-grasp domain protein. (406 aa) |
| | AFZ56527.1 | Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); PFAM: Malic enzyme, NAD binding domain; ACT domain; Malic enzyme, N-terminal domain; COGs: COG0281 Malic enzyme; InterPro IPR012302:IPR002912:IPR012301; KEGG: naz:Aazo_1656 malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Amino acid-binding ACT; PRIAM: Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); SMART: Malic enzyme, NAD-binding; SPTR: Malate dehydrogenase (Oxaloacetate-decarboxylating). (463 aa) |
| | AFZ56553.1 | Hypothetical protein; PFAM: Archaeal ATPase; KEGG: cyc:PCC7424_5277 trypsin-like protein serine protease typically periplasmic contain C-terminal PDZ domain-like protein; SPTR: Trypsin-like protein serine protease typically periplasmic contain C-terminal PDZ domain-like protein. (350 aa) |
| | pdhA | Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (345 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (320 aa) |
| | purD | Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; COGs: COG0151 Phosphoribosylamine-glycine ligase; HAMAP: Phosphoribosylglycinamide synthetase; InterPro IPR020562:IPR020561:IPR020560:IPR000115; KEGG: naz:Aazo_0779 phosphoribosylamine/glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, N-domain; Phosphoribosylglycinamide synthe [...] (427 aa) |
| | AFZ56699.1 | PFAM: NUDIX domain; InterPro IPR000086; KEGG: ava:Ava_3513 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; SPTR: NUDIX hydrolase. (184 aa) |
| | AFZ56925.1 | GCN5-related N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family; InterPro IPR000182; KEGG: naz:Aazo_4968 GCN5-like N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: GCN5-related N-acetyltransferase. (155 aa) |
| | AFZ56930.1 | Pyruvate dehydrogenase (acetyl-transferring); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa) |
| | AFZ56950.1 | UDP-glucose 4-epimerase; PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: cyc:PCC7424_5776 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: UDP-glucose 4-epimerase; SPTR: NAD-dependent epimerase/dehydratase. (319 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | glk | PFAM: Glucokinase; TIGRFAM: glucokinase, proteobacterial type; COGs: COG0837 Glucokinase; HAMAP: Glucokinase; InterPro IPR003836; KEGG: naz:Aazo_0771 glucokinase; PFAM: Glucokinase; PRIAM: Glucokinase; SPTR: Glucokinase; TIGRFAM: Glucokinase; Belongs to the bacterial glucokinase family. (341 aa) |
| | AFZ56987.1 | Nicotinate-nucleotide pyrophosphorylase (carboxylating); PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR004393:IPR022412:IPR002638; KEGG: npu:Npun_F5252 nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate-nucleoti [...] (287 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (184 aa) |
| | fcl | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (314 aa) |
| | gmd | GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (359 aa) |
| | AFZ57168.1 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (465 aa) |
| | nadD-2 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (187 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (564 aa) |
| | atpB | ATP synthase F0 subcomplex A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (252 aa) |
| | atpE | ATP synthase F0 subcomplex C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa) |
| | atpG | ATP synthase F0 subcomplex B' subunit; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria. Belongs to the ATPase B chain family. (163 aa) |
| | atpF | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (183 aa) |
| | atpH | ATP synthase F1 subcomplex delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (184 aa) |
| | atpA | ATP synthase F1 subcomplex alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (506 aa) |
| | atpG-2 | ATP synthase F1 subcomplex gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (315 aa) |
| | pyrE-2 | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (477 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa) |
| | purT | Formate-dependent phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (389 aa) |
| | accD | acetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (316 aa) |
| | AFZ57399.1 | PFAM: Phosphorylase superfamily; InterPro IPR000845; KEGG: npu:Npun_R5283 hypothetical protein; PFAM: Nucleoside phosphorylase domain; SPTR: Putative uncharacterized protein. (221 aa) |
| | AFZ57407.1 | PFAM: Phosphoribulokinase / Uridine kinase family; COGs: COG0572 Uridine kinase; InterPro IPR006083; KEGG: naz:Aazo_0113 phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; SPTR: Phosphoribulokinase. (312 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase; COGs: COG0150 Phosphoribosylaminoimidazole (AIR) synthetase; InterPro IPR000728:IPR010918:IPR004733; KEGG: naz:Aazo_3150 phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein; PRIAM: Phosphoribosylformylglycinamidine cyclo-ligase; SPTR: Phosphoribosylformylglycinamidine cyclo-ligase; TIGRFAM: Phosphoribosylformylglyci [...] (342 aa) |
| | AFZ57520.1 | KEGG: naz:Aazo_0304 hypothetical protein; SPTR: Putative uncharacterized protein. (344 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (405 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (193 aa) |
| | AFZ57779.1 | Adenylate/guanylate cyclase with Chase sensor; PFAM: Adenylate and Guanylate cyclase catalytic domain; CHASE2 domain; COGs: COG4252 transmembrane sensor domain; InterPro IPR007890:IPR001054; KEGG: cyt:cce_2246 adenylate cyclase; PFAM: CHASE2; Adenylyl cyclase class-3/4/guanylyl cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate cyclase. (755 aa) |
| | pgi | PFAM: Phosphoglucose isomerase; COGs: COG0166 Glucose-6-phosphate isomerase; HAMAP: Phosphoglucose isomerase (PGI); InterPro IPR001672; KEGG: naz:Aazo_2767 glucose-6-phosphate isomerase; PFAM: Phosphoglucose isomerase (PGI); SPTR: Glucose-6-phosphate isomerase; Belongs to the GPI family. (528 aa) |
| | AFZ57984.1 | KEGG: npu:Npun_F6540 hypothetical protein; SPTR: Putative uncharacterized protein. (296 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa) |
| | AFZ58025.1 | Adenylate/guanylate cyclase with Chase sensor; PFAM: Adenylate and Guanylate cyclase catalytic domain; CHASE2 domain; COGs: COG4252 transmembrane sensor domain; InterPro IPR007890:IPR001054; KEGG: npu:Npun_R1313 adenylate/guanylate cyclase with CHASE sensor; PFAM: CHASE2; Adenylyl cyclase class-3/4/guanylyl cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with Chase sensor. (737 aa) |
| | coaX | Putative transcriptional acitvator, Baf family; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (253 aa) |
| | AFZ58082.1 | 1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; PFAM: AIR carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: ava:Ava_1809 phosphoribosylaminoimidazole carboxylase catalytic subunit; PFAM: Phosphoribosylaminoimidazole carboxylase, core; SPTR: Probable phosphoribosylaminoimidazole carboxylase catalytic subunit. (264 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | carB | PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit; COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterProIPR006275:IPR005481:IPR005479:IPR005480:IPR 011607; KEGG: ana:alr3809 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-p [...] (1098 aa) |
| | mtnP | Methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (290 aa) |
| | nnrD | YjeF-related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (510 aa) |
| | queG | Iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (323 aa) |
| | AFZ58276.1 | dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase; COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR005888:IPR001509; KEGG: naz:Aazo_0590 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: dTDP-glucose 4,6-dehydratase; SPTR: dTDP-glucose 4,6-dehydratase; TIGRFAM: dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (362 aa) |
| | cugP | Mannose-1-phosphate guanylyltransferase; Catalyzes the formation of UDP-glucose, from UTP and glucose 1-phosphate. (389 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (149 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa) |
| | AFZ58420.1 | PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: 6-pyruvoyl tetrahydropterin synthase/QueD family protein; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: naz:Aazo_4074 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; PFAM: 6-pyruvoyl tetrahydropterin synthase-related; SPTR: Putative uncharacterized protein. (129 aa) |
| | AFZ58429.1 | GCN5-related N-acetyltransferase; PFAM: Acetyltransferase (GNAT) family; InterPro IPR000182; KEGG: ant:Arnit_2046 GCN5-related N-acetyltransferase; PFAM: GCN5-related N-acetyltransferase (GNAT) domain; SPTR: GCN5-related N-acetyltransferase. (164 aa) |
| | AFZ60929.1 | Hypothetical protein; PFAM: Ureidoglycolate hydrolase; KEGG: ava:Ava_0888 hypothetical protein; SPTR: Putative uncharacterized protein. (177 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (248 aa) |
| | AFZ58525.1 | Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (207 aa) |
| | AFZ58526.1 | TIGRFAM: dihydroorotase, multifunctional complex type; COGs: COG0044 Dihydroorotase and related cyclic amidohydrolase; InterPro IPR006680:IPR004722; KEGG: naz:Aazo_4244 dihydroorotase; PFAM: Amidohydrolase 1; SPTR: Dihydroorotase, multifunctional complex type; TIGRFAM: Dihydroorotase. (431 aa) |
| | AFZ58539.1 | PFAM: Adenylate and Guanylate cyclase catalytic domain; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054; KEGG: npu:Npun_R3592 adenylate/guanylate cyclase with integral membrane sensor; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; PRIAM: Guanylate cyclase; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate cyclase with integral membrane sensor; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (435 aa) |
| | AFZ58594.1 | Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; COGs: COG2236 phosphoribosyltransferase; InterPro IPR000836; KEGG: naz:Aazo_3943 phosphoribosyltransferase; PFAM: Phosphoribosyltransferase; SPTR: Phosphoribosyltransferase. (172 aa) |
| | folD | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (292 aa) |
| | AFZ58778.1 | COGs: COG4222 conserved hypothetical protein; KEGG: npu:Npun_R1362 hypothetical protein; SPTR: Putative uncharacterized protein. (394 aa) |
| | AFZ58781.1 | PFAM: Phosphoribulokinase / Uridine kinase family; COGs: COG0572 Uridine kinase; KEGG: cyn:Cyan7425_4433 uridine kinase; SPTR: Uridine kinase. (210 aa) |
| | AFZ58788.1 | PFAM: Isochorismatase family; COGs: COG1335 Amidase related to nicotinamidase; InterPro IPR000868; KEGG: ava:Ava_1578 isochorismatase hydrolase; PFAM: Isochorismatase-like; SPTR: Isochorismatase hydrolase. (257 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (326 aa) |
| | AFZ58865.1 | PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: 6-pyruvoyl tetrahydropterin synthase/QueD family protein; COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: npu:Npun_F2811 putative 6-pyruvoyl tetrahydropterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase-related; SPTR: Putative uncharacterized protein. (290 aa) |
| | comB | PFAM: 2-phosphosulpholactate phosphatase; TIGRFAM: 2-phosphosulfolactate phosphatase; COGs: COG2045 Phosphosulfolactate phosphohydrolase; HAMAP: 2-phosphosulpholactate phosphatase ComB; InterPro IPR022995:IPR005238; KEGG: naz:Aazo_3763 2-phosphosulfolactate phosphatase; PFAM: 2-phosphosulpholactate phosphatase; SPTR: Probable 2-phosphosulfolactate phosphatase; Belongs to the ComB family. (246 aa) |
| | AFZ58941.1 | PFAM: DRTGG domain; COGs: COG0857 BioD-like N-terminal domain of phosphotransacetylase; InterPro IPR010766; KEGG: naz:Aazo_3303 DRTGG domain-containing protein; PFAM: DRTGG; SPTR: DRTGG domain protein. (364 aa) |
| | AFZ58986.1 | KEGG: naz:Aazo_0837 hypothetical protein; SPTR: Putative uncharacterized protein. (129 aa) |
| | AFZ58989.1 | PFAM: DeoC/LacD family aldolase; COGs: COG1830 DhnA-type fructose-1 6-bisphosphate aldolase; InterPro IPR002915; KEGG: ana:all3735 fructose-bisphosphate aldolase; PFAM: Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; SPTR: Fructose-bisphosphate aldolase class I. (360 aa) |
| | carA | PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006274:IPR002474:IPR000991; KEGG: naz:Aazo_2282 carbamoyl-phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase small chain; TIGRFAM: Carbamoyl-phosphate synthase, small subunit; Belo [...] (385 aa) |
| | AFZ59073.1 | PFAM: UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; COGs: COG0381 UDP-N-acetylglucosamine 2-epimerase; InterPro IPR003331; KEGG: naz:Aazo_5189 UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; PRIAM: UDP-N-acetylglucosamine 2-epimerase; SPTR: UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (369 aa) |
| | AFZ59121.1 | InterPro IPR006076; KEGG: naz:Aazo_2159 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: FAD dependent oxidoreductase. (670 aa) |
| | AFZ59147.1 | UDP-glucuronate decarboxylase; PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: naz:Aazo_2627 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; PRIAM: UDP-glucuronate decarboxylase; SPTR: NAD-dependent epimerase/dehydratase. (311 aa) |
| | AFZ59148.1 | Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR017476:IPR001732:IPR014026:IPR014027; KEGG: naz:Aazo_2628 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase, N-terminal; UDP-glucose/GDP-mannose dehydrogenase, dimerisation; UDP-glucose/GDP-mannose dehydrogenase, C-terminal; PRIAM: UDP-gl [...] (463 aa) |
| | AFZ59177.1 | Competence/damage-inducible protein cinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybdenum cofactor synthesis domain; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR008135:IPR008136:IPR001453; KEGG: naz:Aazo_4900 competence/damage-inducible protein CinA; PFAM: CinA, C-terminal; Molybdopterin binding; SMART: Molybdopterin binding; SPTR: CinA-like protein; TIGRFAM: Comp [...] (416 aa) |
| | AFZ59258.1 | PFAM: Adenosine/AMP deaminase; COGs: COG1816 Adenosine deaminase; InterPro IPR001365; KEGG: npu:Npun_F3248 adenosine/AMP deaminase; PFAM: Adenosine/AMP deaminase; SPTR: Adenosine/AMP deaminase. (345 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (445 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, purS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assi [...] (92 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase subunit I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (224 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (228 aa) |
| | adk-2 | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (184 aa) |
| | purC | PFAM: SAICAR synthetase; TIGRFAM: phosphoribosylaminoimidazole-succinocarboxamide synthase; COGs: COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; HAMAP: SAICAR synthetase; InterPro IPR001636; KEGG: npu:Npun_F2927 phosphoribosylaminoimidazole-succinocarboxamide synthase; PFAM: SAICAR synthetase; PRIAM: Phosphoribosylaminoimidazolesuccinocarboxamide synthase; SPTR: Phosphoribosylaminoimidazole-succinocarboxamide synthase; TIGRFAM: SAICAR synthetase. (254 aa) |
| | AFZ59343.1 | Adenylate/guanylate cyclase with GAF and PAS/PAC sensors; PFAM: Adenylate and Guanylate cyclase catalytic domain; GAF domain; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR003018:IPR000014:IPR001054:IPR013656; KEGG: naz:Aazo_3744 GAF/PAS/PAC sensor-containing adenylate/guanylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS fold-4; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; GAF; PAS; SPTR: Adenylate/guanylate cyclase with GAF and PAS/PAC sensors. (851 aa) |
| | queE | Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (265 aa) |
| | guaA | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (540 aa) |
| | pyrB | PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase; COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; HAMAP: Aspartate carbamoyltransferase, eukaryotic; InterPro IPR006132:IPR006131:IPR002082; KEGG: naz:Aazo_1472 aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; PRIAM: Aspartate carbamoyltransferase; SPTR: Aspartate carbamoyltrans [...] (331 aa) |
| | gpmI | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (532 aa) |
| | AFZ59548.1 | PFAM: Cytidine and deoxycytidylate deaminase zinc-binding region; COGs: COG0590 Cytosine/adenosine deaminase; InterPro IPR002125; KEGG: npu:Npun_R2274 CMP/dCMP deaminase, zinc-binding; PFAM: CMP/dCMP deaminase, zinc-binding; SPTR: CMP/dCMP deaminase, zinc-binding. (146 aa) |
| | AFZ59574.1 | Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (339 aa) |
| | queC | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (235 aa) |
| | dacA | Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (332 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (383 aa) |
| | AFZ59744.1 | PFAM: NUDIX domain; InterPro IPR000086; KEGG: naz:Aazo_4700 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; SPTR: NUDIX hydrolase. (182 aa) |
| | AFZ59764.1 | MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR004518:IPR011551; KEGG: naz:Aazo_5032 MazG family protein; PFAM: NTP pyrophosphohydrolase MazG, putative catalytic core; SPTR: MazG family protein; TIGRFAM: NTP pyrophosphohydrolase MazG, bacterial. (267 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (172 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (460 aa) |
| | AFZ59845.1 | Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (197 aa) |
| | purH | PFAM: AICARFT/IMPCHase bienzyme; MGS-like domain; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); HAMAP: AICARFT/IMPCHase bienzyme; InterPro IPR011607:IPR013982:IPR002695; KEGG: naz:Aazo_3178 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase [...] (511 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (225 aa) |
| | AFZ59867.1 | Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (192 aa) |
| | AFZ59926.1 | Metal dependent phosphohydrolase; PFAM: HD domain; COGs: COG0317 Guanosine polyphosphate pyrophosphohydrolase/synthetase; InterPro IPR006674:IPR003607; KEGG: ana:all4671 hypothetical protein; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: All4671 protein. (190 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (352 aa) |
| | purU | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa) |
| | AFZ60048.1 | PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; COGs: COG0015 Adenylosuccinate lyase; InterPro IPR022761:IPR019468:IPR004769; KEGG: naz:Aazo_2094 adenylosuccinate lyase; PFAM: Lyase 1, N-terminal; Adenylosuccinate lyase C-terminal metazoa/fungi; SPTR: Adenylosuccinate lyase; TIGRFAM: Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (431 aa) |
| | purK | 5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (377 aa) |
| | gmd-2 | GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (325 aa) |
| | AFZ60177.1 | PFAM: NUDIX domain; InterPro IPR000086; KEGG: naz:Aazo_2100 NUDIX hydrolase; PFAM: NUDIX hydrolase domain; SPTR: NUDIX hydrolase. (139 aa) |
| | AFZ60219.1 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (555 aa) |
| | AFZ60221.1 | Diguanylate cyclase with PAS/PAC and Chase2 sensors; PFAM: CHASE2 domain; GGDEF domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG4252 transmembrane sensor domain; InterPro IPR000014:IPR000160:IPR007890:IPR013767; KEGG: npu:Npun_R4511 diguanylate cyclase with PAS/PAC and CHASE2 sensors; PFAM: CHASE2; PAS fold; Diguanylate cyclase, predicted; SMART: Diguanylate cyclase, predicted; PAS; SPTR: Diguanylate cyclase with PAS/PAC and Chase2 sensors; TIGRFAM: Diguanylate cyclase, predicted; PAS. (742 aa) |
| | AFZ60227.1 | Putative adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); KEGG: cbl:CLK_A0085 hypothetical protein; SPTR: Predicted protein. (242 aa) |
| | AFZ60257.1 | PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015795:IPR008279; KEGG: naz:Aazo_2208 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PEP-utilising enzyme, mobile domain; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. (589 aa) |
| | AFZ60315.1 | PFAM: 5'-nucleotidase, C-terminal domain; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR008334:IPR001343; KEGG: amr:AM1_1876 5'-nucleotidase/2',3'-cyclic phosphodiesterase, putative; PFAM: 5'-Nucleotidase, C-terminal; Haemolysin-type calcium-binding repeat; PRIAM: 5'-nucleotidase; SPTR: 5'-nucleotidase/2',3'-cyclic phosphodiesterase, putative. (901 aa) |
| | AFZ60384.1 | Glyceraldehyde-3-phosphate dehydrogenase (NAD+); PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR006424:IPR020828:IPR020829; KEGG: ana:alr1095 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphat [...] (338 aa) |
| | surE | Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (265 aa) |
| | AFZ60454.1 | Riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; TIGRFAM: riboflavin kinase/FMN adenylyltransferase; COGs: COG0196 FAD synthase; InterPro IPR015865:IPR002606:IPR015864; KEGG: naz:Aazo_3260 riboflavin biosynthesis protein RibF; PFAM: Riboflavin kinase; FAD synthetase; PRIAM: FAD synthetase., Riboflavin kinase; SMART: Riboflavin kinase; SPTR: Riboflavin biosynthesis protein RibF; TIGRFAM: Riboflavin kinase/FAD synthetase. (367 aa) |
| | AFZ60498.1 | PFAM: IMP dehydrogenase / GMP reductase domain; TIGRFAM: IMP dehydrogenase family protein; COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR005992:IPR001093; KEGG: ava:Ava_2653 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; SPTR: IMP dehydrogenase related 2; TIGRFAM: IMP dehydrogenase-related 2. (387 aa) |
| | pgk | PFAM: Phosphoglycerate kinase; COGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: naz:Aazo_4275 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (400 aa) |
| | queA | S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (372 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | AFZ60715.1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (357 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | AFZ60779.1 | benzoate-CoA ligase family; PFAM: AMP-binding enzyme; TIGRFAM: benzoate-CoA ligase family; COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR000873:IPR011957; KEGG: amr:AM1_A0246 benzoate-CoA ligase; PFAM: AMP-dependent synthetase/ligase; PRIAM: Benzoate--CoA ligase; SPTR: Benzoate-CoA ligase; TIGRFAM: Benzoate-CoA ligase family. (524 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...] (798 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (506 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | glmU | Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (452 aa) |
| | pyrD | Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (377 aa) |
| | AFZ60919.1 | TIGRFAM: deoxycytidine triphosphate deaminase; COGs: COG0717 Deoxycytidine deaminase; InterPro IPR011962; KEGG: npu:Npun_F2524 deoxycytidine triphosphate deaminase; PRIAM: dCTP deaminase; SPTR: Deoxycytidine triphosphate deaminase; TIGRFAM: Deoxycytidine triphosphate deaminase; manually curated. (193 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (146 aa) |
| | AFZ60922.1 | Hypothetical protein; PFAM: dUTPase; TIGRFAM: deoxycytidine triphosphate deaminase; COGs: COG0717 Deoxycytidine deaminase; KEGG: cyt:cce_0383 hypothetical protein; SPTR: Putative uncharacterized protein. (273 aa) |
