STRINGSTRING
AFZ55640.1 AFZ55640.1 AFZ55821.1 AFZ55821.1 AFZ55870.1 AFZ55870.1 AFZ55908.1 AFZ55908.1 trpB trpB hisZ hisZ tal tal AFZ56100.1 AFZ56100.1 AFZ56101.1 AFZ56101.1 AFZ56105.1 AFZ56105.1 hisF hisF dapB dapB trpC trpC AFZ56488.1 AFZ56488.1 AFZ56558.1 AFZ56558.1 AFZ56583.1 AFZ56583.1 tal-2 tal-2 AFZ56623.1 AFZ56623.1 AFZ56633.1 AFZ56633.1 dapF dapF AFZ56775.1 AFZ56775.1 AFZ56818.1 AFZ56818.1 hisA hisA AFZ57157.1 AFZ57157.1 trpD trpD AFZ57316.1 AFZ57316.1 leuB leuB AFZ57394.1 AFZ57394.1 AFZ57395.1 AFZ57395.1 AFZ57398.1 AFZ57398.1 ilvC ilvC AFZ57711.1 AFZ57711.1 AFZ57810.1 AFZ57810.1 metK metK AFZ57823.1 AFZ57823.1 pheA pheA tpiA tpiA hisB hisB hisD hisD argH argH eno eno argC argC AFZ58120.1 AFZ58120.1 aroK aroK argB argB proC proC AFZ58527.1 AFZ58527.1 AFZ58550.1 AFZ58550.1 argD argD aroB aroB trpF trpF AFZ58860.1 AFZ58860.1 hisI hisI trpC-2 trpC-2 AFZ58981.1 AFZ58981.1 AFZ58989.1 AFZ58989.1 proB proB AFZ59103.1 AFZ59103.1 glyA glyA argG argG AFZ59241.1 AFZ59241.1 trpE trpE thrB thrB trpA trpA gpmI gpmI AFZ59538.1 AFZ59538.1 lysA lysA AFZ59692.1 AFZ59692.1 proA proA rpiA rpiA prs prs AFZ60021.1 AFZ60021.1 proA-2 proA-2 AFZ60140.1 AFZ60140.1 aroQ aroQ AFZ60188.1 AFZ60188.1 AFZ60257.1 AFZ60257.1 AFZ60263.1 AFZ60263.1 AFZ60273.1 AFZ60273.1 hisG hisG dapL dapL aroE aroE AFZ60384.1 AFZ60384.1 AFZ60389.1 AFZ60389.1 aroC aroC AFZ60432.1 AFZ60432.1 leuA leuA ilvD ilvD ilvA ilvA pgk pgk hisH hisH AFZ60677.1 AFZ60677.1 AFZ60694.1 AFZ60694.1 leuC leuC AFZ60715.1 AFZ60715.1 hisC hisC asd asd dapA dapA argJ argJ aroA aroA
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AFZ55640.1PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; ACT domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase; COGs: COG0111 Phosphoglycerate dehydrogenase and related dehydrogenase; InterPro IPR006139:IPR006140:IPR002912:IPR006236; KEGG: naz:Aazo_2156 D-3-phosphoglycerate dehydrogenase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Amino acid-binding ACT; PRIAM: Phosphoglycerate dehydrogenase; SPTR: D-3-phosphoglycerat [...] (526 aa)
AFZ55821.1PFAM: Serine acetyltransferase, N-terminal; Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451:IPR005881; KEGG: ana:alr1404 serine acetyltransferase; PFAM: Bacterial transferase hexapeptide repeat; PRIAM: Serine O-acetyltransferase; SPTR: Serine acetyltransferase; TIGRFAM: Serine O-acetyltransferase. (242 aa)
AFZ55870.1PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR020828:IPR020829:IPR006424; KEGG: naz:Aazo_0813 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (NADP(+)) (phosphorylating); SM [...] (337 aa)
AFZ55908.1PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I; COGs: COG0174 Glutamine synthetase; InterPro IPR008147:IPR008146:IPR004809; KEGG: naz:Aazo_3715 glutamine synthetase, type I; PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp; PRIAM: Glutamate--ammonia ligase; SPTR: Glutamine synthetase; TIGRFAM: Glutamine synthetase type I. (471 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (412 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (403 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (333 aa)
AFZ56100.1PFAM: Pyruvate kinase, barrel domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR015793:IPR015795:IPR001697; KEGG: npu:Npun_R0030 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PRIAM: Pyruvate kinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. (476 aa)
AFZ56101.1Glyceraldehyde-3-phosphate dehydrogenase (NAD+); PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR020828:IPR020829:IPR006424; KEGG: npu:Npun_R0031 glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde [...] (341 aa)
AFZ56105.1PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterPro IPR002020:IPR011278; KEGG: naz:Aazo_0404 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase type I; Belongs to the citrate synthase family. (378 aa)
hisFImidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (278 aa)
trpCPFAM: Indole-3-glycerol phosphate synthase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013798; KEGG: naz:Aazo_3804 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Indole-3-glycerol phosphate synthase 2; Belongs to the TrpC family. (291 aa)
AFZ56488.12-isopropylmalate synthase; PFAM: HMGL-like; LeuA allosteric (dimerisation) domain; TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR005675:IPR013709:IPR000891; KEGG: naz:Aazo_4800 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; Pyruvate carboxyltransferase; PRIAM: (R)-citramalate synthase; SMART: 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain; SPTR: 2-isopropylmalate synthase/homo [...] (549 aa)
AFZ56558.1PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804:IPR004439; KEGG: ana:alr1827 isocitrate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, prokaryotic. (473 aa)
AFZ56583.1Serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide (three repeats); TIGRFAM: serine O-acetyltransferase; COGs: COG1045 Serine acetyltransferase; InterPro IPR001451:IPR005881; KEGG: naz:Aazo_1129 serine O-acetyltransferase; PFAM: Bacterial transferase hexapeptide repeat; PRIAM: Serine O-acetyltransferase; SPTR: Serine O-acetyltransferase; TIGRFAM: Serine O-acetyltransferase. (250 aa)
tal-2Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (381 aa)
AFZ56623.1PFAM: ACT domain; Small subunit of acetolactate synthase; TIGRFAM: acetolactate synthase, small subunit; COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR002912:IPR019455:IPR004789; KEGG: naz:Aazo_1096 acetolactate synthase small subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase, small subunit; TIGRFAM: Acetolactate synthase, small subunit. (172 aa)
AFZ56633.1PFAM: Transketolase, thiamine diphosphate binding domain; Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain; COGs: COG0021 Transketolase; InterPro IPR005475:IPR005474:IPR005476; KEGG: naz:Aazo_0419 transketolase central region; PFAM: Transketolase, N-terminal; Transketolase-like, pyrimidine-binding domain; Transketolase, C-terminal; PRIAM: Transketolase; SMART: Transketolase-like, pyrimidine-binding domain; SPTR: Transketolase central region. (637 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (279 aa)
AFZ56775.1Cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; COGs: COG0031 Cysteine synthase; InterPro IPR001926:IPR005856:IPR005859; KEGG: npu:Npun_F5408 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; Belongs to the cysteine synthase/cystathionine beta- synthase family. (320 aa)
AFZ56818.1Acetolactate synthase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766; KEGG: npu:Npun_F2094 thiamine pyrophosphate binding domain-containing protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; PRIAM: Acetolactate synthase; SPTR: Thiamine py [...] (598 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; InterPro IPR023016:IPR006062:IPR006063; KEGG: naz:Aazo_2744 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl) [...] (257 aa)
AFZ57157.1Ribulose-5-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase; COGs: COG0036 Pentose-5-phosphate-3-epimerase; InterPro IPR000056; KEGG: naz:Aazo_3229 ribulose-phosphate 3-epimerase; PFAM: Ribulose-phosphate 3-epimerase; PRIAM: Ribulose-phosphate 3-epimerase; SPTR: Ribulose-phosphate 3-epimerase; TIGRFAM: Ribulose-phosphate 3-epimerase. (242 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (350 aa)
AFZ57316.1Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766:IPR012846; KEGG: naz:Aazo_4126 acetolactate synthase large subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, C- [...] (630 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (362 aa)
AFZ57394.1PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962; KEGG: npu:Npun_R1853 asparagine synthase; PFAM: Asparagine synthase; SPTR: Asparagine synthase. (566 aa)
AFZ57395.1PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; TIGRFAM: diaminopimelate decarboxylase; COGs: COG0019 Diaminopimelate decarboxylase; InterPro IPR022644:IPR022643; KEGG: npu:Npun_R1852 Orn/DAP/Arg decarboxylase 2; PFAM: Orn/DAP/Arg decarboxylase 2, C-terminal; Orn/DAP/Arg decarboxylase 2, N-terminal; PRIAM: Diaminopimelate decarboxylase; SPTR: Diaminopimelate decarboxylase. (405 aa)
AFZ57398.1PFAM: Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing); COGs: COG0367 Asparagine synthase (glutamine-hydrolyzing); InterPro IPR001962; KEGG: npu:Npun_R1857 asparagine synthase; PFAM: Asparagine synthase; SPTR: Asparagine synthase. (576 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
AFZ57711.1L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (364 aa)
AFZ57810.1Aspartate transaminase; PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: npu:Npun_R0187 aspartate aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Aspartate transaminase; SPTR: Aminotransferase, class I and II. (388 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (424 aa)
AFZ57823.1PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT domain; COGs: COG0460 Homoserine dehydrogenase; InterPro IPR005106:IPR001342:IPR002912; KEGG: naz:Aazo_4841 homoserine dehydrogenase; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; SPTR: Homoserine dehydrogenase. (429 aa)
pheAPFAM: Prephenate dehydratase; ACT domain; COGs: COG0077 Prephenate dehydratase; InterPro IPR001086:IPR002912; KEGG: npu:Npun_R3887 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT; PRIAM: Prephenate dehydratase; SPTR: Prephenate dehydratase. (290 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa)
hisBPFAM: Imidazoleglycerol-phosphate dehydratase; COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: naz:Aazo_1063 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase. (198 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa)
argHPFAM: Lyase; TIGRFAM: argininosuccinate lyase; COGs: COG0165 Argininosuccinate lyase; HAMAP: Argininosuccinate lyase; InterPro IPR009049:IPR022761; KEGG: naz:Aazo_1169 argininosuccinate lyase; PFAM: Lyase 1, N-terminal; PRIAM: Argininosuccinate lyase; SPTR: Argininosuccinate lyase; TIGRFAM: Argininosuccinate lyase. (461 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (352 aa)
AFZ58120.1Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1176 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (296 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (271 aa)
AFZ58527.1PFAM: Phosphoglycerate mutase family; COGs: COG0406 Fructose-2 6-bisphosphatase; InterPro IPR013078; KEGG: naz:Aazo_4242 phosphoglycerate mutase; PFAM: Histidine phosphatase superfamily, clade-1; SMART: Histidine phosphatase superfamily, clade-1; SPTR: Phosphoglycerate mutase. (447 aa)
AFZ58550.1PFAM: Amino acid kinase family; ACT domain; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; COGs: COG0527 Aspartokinase; InterPro IPR001048:IPR002912:IPR005260:IPR001341; KEGG: naz:Aazo_2221 aspartate kinase; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; SPTR: Aspartokinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class. (599 aa)
argDPFAM: Aminotransferase class-III; TIGRFAM: acetylornithine and succinylornithine transaminases; COGs: COG4992 Ornithine/acetylornithine aminotransferase; HAMAP: Acetylornithine/succinyldiaminopimelate aminotransferase; InterPro IPR005814:IPR004636; KEGG: naz:Aazo_3003 acetylornithine and succinylornithine aminotransferase; PFAM: Aminotransferase class-III; PRIAM: Acetylornithine transaminase; SPTR: Acetylornithine and succinylornithine aminotransferase; TIGRFAM: Acetylornithine/succinylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase f [...] (427 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (365 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; COGs: COG0135 Phosphoribosylanthranilate isomerase; InterPro IPR001240; KEGG: naz:Aazo_3378 phosphoribosylanthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); PRIAM: Phosphoribosylanthranilate isomerase; SPTR: N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (209 aa)
AFZ58860.1Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; COGs: COG0031 Cysteine synthase; InterPro IPR001926:IPR005859:IPR005856; KEGG: naz:Aazo_3782 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; Belongs to the cysteine synthase/cystathionine beta- synthase family. (320 aa)
hisIPFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Phosphoribosyl-ATP pyrophosphohydrolase; Histidine biosynthesis bifunctional protein HisIE; InterPro IPR023019:IPR008179:IPR002496:IPR021130; KEGG: naz:Aazo_2676 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase-like; PRIAM: Phosphoribosyl-AMP cyclohydrolase., Phosphoribosyl-ATP diphosphatase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGR [...] (224 aa)
trpC-2PFAM: Indole-3-glycerol phosphate synthase; COGs: COG0134 Indole-3-glycerol phosphate synthase; InterPro IPR013798; KEGG: naz:Aazo_0100 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; PRIAM: Indole-3-glycerol-phosphate synthase; SPTR: Indole-3-glycerol phosphate synthase 1; Belongs to the TrpC family. (294 aa)
AFZ58981.1Acetolactate synthase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; COGs: COG0028 Thiamine pyrophosphate-requiring protein; InterPro IPR012001:IPR012000:IPR011766; KEGG: naz:Aazo_0840 thiamine pyrophosphate protein domain-containing protein TPP-binding protein; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP-binding; Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain; Thiamine pyrophosphate enzyme, central domain; PRIAM: Acetolactate synthase [...] (547 aa)
AFZ58989.1PFAM: DeoC/LacD family aldolase; COGs: COG1830 DhnA-type fructose-1 6-bisphosphate aldolase; InterPro IPR002915; KEGG: ana:all3735 fructose-bisphosphate aldolase; PFAM: Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; SPTR: Fructose-bisphosphate aldolase class I. (360 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (369 aa)
AFZ59103.1Branched-chain-amino-acid transaminase; PFAM: Aminotransferase class IV; Acetyltransferase (GNAT) family; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544:IPR000182; KEGG: nde:NIDE1103 branched-chain amino acid aminotransferase; PFAM: Aminotransferase, class IV; GCN5-related N-acetyltransferase (GNAT) domain; PRIAM: Branched-chain-amino-acid transaminase; SPTR: Branched-chain-amino-acid transaminase. (471 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (434 aa)
argGPFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; COGs: COG0137 Argininosuccinate synthase; HAMAP: Argininosuccinate synthase; InterPro IPR001518; KEGG: naz:Aazo_4888 argininosuccinate synthase; PFAM: Argininosuccinate synthase; PRIAM: Argininosuccinate synthase; SPTR: Argininosuccinate synthase; TIGRFAM: Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa)
AFZ59241.1Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: ava:Ava_1347 cysteine synthase A; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase. (324 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (504 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (304 aa)
trpATryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
gpmIPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (532 aa)
AFZ59538.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (670 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa)
AFZ59692.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (347 aa)
proAGlutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (435 aa)
rpiARibose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (236 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (352 aa)
AFZ60021.1PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterPro IPR000991:IPR006221; KEGG: naz:Aazo_4993 anthranilate synthase glutamine amidotransferase; PFAM: Glutamine amidotransferase class-I, C-terminal; PRIAM: Anthranilate synthase; SPTR: Glutamine amidotransferase of anthranilate synthase; TIGRFAM: Anthranilate synthase, glutamine amidotransferase domain. (199 aa)
proA-2Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa)
AFZ60140.13-deoxy-D-arabinoheptulosonate-7-phosphate synthase; PFAM: DAHP synthetase I family; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR006268:IPR006218; KEGG: naz:Aazo_3904 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SPTR: Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2. (352 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
AFZ60188.1Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (306 aa)
AFZ60257.1PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; COGs: COG0469 Pyruvate kinase; InterPro IPR001697:IPR015793:IPR015795:IPR008279; KEGG: naz:Aazo_2208 pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, C-terminal-like; PEP-utilising enzyme, mobile domain; PRIAM: Pyruvate kinase., Pyruvate, water dikinase; SPTR: Pyruvate kinase; TIGRFAM: Pyruvate kinase; Belongs to the pyruvate kinase family. (589 aa)
AFZ60263.1Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis. (133 aa)
AFZ60273.1Cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001926; KEGG: ava:Ava_0452 cysteine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Cysteine synthase; SPTR: Cysteine synthase; TIGRFAM: Cysteine synthase A; Cysteine synthase K/M; Belongs to the cysteine synthase/cystathionine beta- synthase family. (313 aa)
hisGATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)
dapLLL-diaminopimelate aminotransferase apoenzyme; Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. (411 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (288 aa)
AFZ60384.1Glyceraldehyde-3-phosphate dehydrogenase (NAD+); PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterPro IPR006424:IPR020828:IPR020829; KEGG: ana:alr1095 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphat [...] (338 aa)
AFZ60389.1LL-diaminopimelate aminotransferase apoenzyme; PFAM: Aminotransferase class I and II; COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: naz:Aazo_3357 class I/II aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: LL-diaminopimelate aminotransferase; SPTR: Aminotransferase class I and II. (401 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (362 aa)
AFZ60432.1Aconitase; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; COGs: COG1049 Aconitase B; InterPro IPR004406:IPR015929:IPR001030; KEGG: ana:all1267 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; PFAM: Aconitase B, N-terminal, bacterial; Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha; SPTR: Aconitate hydratase 2; TIGRFAM: Aconitase B, bacterial; Belongs to the aconitase/IPM isomerase family. (876 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (530 aa)
ilvDPFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; COGs: COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; HAMAP: Dihydroxy-acid dehydratase; InterPro IPR004404:IPR000581; KEGG: naz:Aazo_0368 dihydroxy-acid dehydratase; PFAM: Dihydroxy-acid/6-phosphogluconate dehydratase; PRIAM: Dihydroxy-acid dehydratase; SPTR: Dihydroxy-acid dehydratase; TIGRFAM: Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (568 aa)
ilvAThreonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (503 aa)
pgkPFAM: Phosphoglycerate kinase; COGs: COG0126 3-phosphoglycerate kinase; HAMAP: Phosphoglycerate kinase; InterPro IPR001576; KEGG: naz:Aazo_4275 phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (400 aa)
hisHImidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (211 aa)
AFZ60677.1L-threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase; COGs: COG0498 Threonine synthase; InterPro IPR004450:IPR001926; KEGG: naz:Aazo_2960 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; PRIAM: Threonine synthase; SPTR: Threonine synthase; TIGRFAM: Threonine synthase. (434 aa)
AFZ60694.13-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (202 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
AFZ60715.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (357 aa)
hisCPFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HAMAP: Histidinol-phosphate aminotransferase; InterPro IPR004839:IPR005861; KEGG: naz:Aazo_2341 class I/II aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (383 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (345 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
argJN-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa)
Your Current Organism:
Anabaena cylindrica
NCBI taxonomy Id: 272123
Other names: A. cylindrica PCC 7122, Anabaena cylindrica IAM M-1, Anabaena cylindrica NIES-19, Anabaena cylindrica PCC 7122, Anabaena cylindrica UTEX B 629, Anabaena sp. ATCC 27899, Anabaena sp. PCC 7122
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