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fba fba APE_0012 APE_0012 pckA pckA gap gap pgk pgk prpB prpB pdxT pdxT pdxS pdxS APE_0392 APE_0392 pyk pyk APE_0583 APE_0583 APE_0586.1 APE_0586.1 ppsA ppsA rpiA rpiA mdh mdh aspC aspC APE_0689.1 APE_0689.1 APE_0768.1 APE_0768.1 APE_0807.1 APE_0807.1 APE_0935 APE_0935 sdhB sdhB sdhD sdhD sdhC sdhC sdhA sdhA gcvH gcvH sucC sucC sucD sucD fbpA fbpA acsA acsA gdhA gdhA APE_1458 APE_1458 APE_1472 APE_1472 APE_1473.1 APE_1473.1 tpiA tpiA citB citB pdhD pdhD pdhC pdhC pdhB pdhB pdhA pdhA gcvT gcvT gltA gltA gapN gapN fumC fumC prs prs glyA glyA glk glk APE_2106.1 APE_2106.1 gcvPB gcvPB gcvPA gcvPA APE_2126.1 APE_2126.1 APE_2128 APE_2128 glnA glnA prpD prpD aspC-2 aspC-2 APE_2433.1 APE_2433.1 deoC deoC eno eno APE_2468.1 APE_2468.1 APE_2581 APE_2581 acsA-2 acsA-2 acsA-3 acsA-3
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fbaFructose-bisphosphate aldolase class I; Belongs to the DeoC/FbaB aldolase family. (272 aa)
APE_0012ATP-dependent 6-phosphofructokinase; ATP-PFK; Belongs to the carbohydrate kinase PfkB family. (310 aa)
pckAPhosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (489 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; GAPDH. (343 aa)
pgkPhosphoglycerate kinase. (415 aa)
prpBPutative carboxyvinyl-carboxyphosphonate phosphorylmutase; Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2- methylisocitrate to yield pyruvate and succinate via an alpha-carboxy- carbanion intermediate. (308 aa)
pdxTPyridoxal 5'-phosphate biosynthesis protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (203 aa)
pdxSPyridoxal 5'-phosphate biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (353 aa)
APE_0392Malate dehydrogenase; Malic enzyme. (446 aa)
pykPyruvate kinase; PK; Belongs to the pyruvate kinase family. (458 aa)
APE_0583Putative transketolase C-terminal section. (322 aa)
APE_0586.1Putative transketolase N-terminal section. (236 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (820 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (237 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. Can utilize both NAD and NADP. Catalytic efficiency for malate oxidation is 3-fold higher with NADP. Belongs to the LDH/MDH superfamily. (308 aa)
aspCAspartate aminotransferase; Transaminase A. (401 aa)
APE_0689.1Isocitrate dehydrogenase [NADP]; NADP-IDH. (432 aa)
APE_0768.1Bifunctional phosphoglucose / phosphomannose isomerase; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency; Belongs to the PGI/PMI family. (333 aa)
APE_0807.1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (540 aa)
APE_0935Hypothetical protein. (337 aa)
sdhBSuccinate dehydrogenase subunit B. (305 aa)
sdhDPutative succinate dehydrogenase subunit D. (117 aa)
sdhCSuccinate dehydrogenase subunit C. (119 aa)
sdhASuccinate dehydrogenase subunit A. (583 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (143 aa)
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (378 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
fbpAFructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (387 aa)
acsAAcetyl-coenzyme A synthetase. (656 aa)
gdhANADP-dependent glutamate dehydrogenase; GDH; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (418 aa)
APE_1458Mercuric reductase; MerA; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (461 aa)
APE_14722-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (309 aa)
APE_1473.12-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (642 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa)
citBAconitate hydratase; Aconitase. (903 aa)
pdhDDihydrolipoyl dehydrogenase; Glycine cleavage system L protein; pyruvate dehydrogenase complex, E3 component. (464 aa)
pdhCPyruvate dehydrogenase complex, E2 component; Dihydrolipoyllysine-residue acetyltransferase component. (412 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit. (325 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit. (377 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
gltACitrate synthase. (394 aa)
gapNNADP-dependent glyceraldehyde-3-phosphate dehydrogenase. (510 aa)
fumCFumarate hydratase class II. (444 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (309 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). (439 aa)
glkATP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ATP as the phosphate donor. ITP can also serve as an effective phosphoryl donor. According to Hansen et al., the enzyme has a broad hexose specificity, and in addition to glucose, which shows the highest catalytic efficiency, it can also phosphorylate fructose, mannose, glucosamine, N-acetylglucosamine, N- acetylmannosamine and 2-deoxyglucose. However, according to Sakuraba et al., the enzyme shows strict specificity for D-glucose. (320 aa)
APE_2106.1ATP-dependent 6-phosphofructokinase. (306 aa)
gcvPBGlycine cleavage system P-protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (520 aa)
gcvPAGlycine cleavage system P-protein subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (465 aa)
APE_2126.12-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (639 aa)
APE_21282-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (318 aa)
glnAGlutamine synthetase; Glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (458 aa)
prpD2-methylcitrate dehydratase. (458 aa)
aspC-2Aspartate aminotransferase; Transaminase A. (405 aa)
APE_2433.1Phospho-sugar mutase; Belongs to the phosphohexose mutase family. (489 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (235 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa)
APE_2468.1Putative propionate CoA-transferase. (554 aa)
APE_2581Hypothetical protein. (405 aa)
acsA-2Acetyl-coenzyme A synthetase. (513 aa)
acsA-3Acetyl-coenzyme A synthetase. (140 aa)
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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