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APE_0392 APE_0392 mdh mdh aspC aspC APE_0689.1 APE_0689.1 APE_0807.1 APE_0807.1 APE_0935 APE_0935 sdhB sdhB sdhD sdhD sdhC sdhC sdhA sdhA gcvH gcvH sucC sucC sucD sucD acsA acsA gdhA gdhA APE_1458 APE_1458 APE_1472 APE_1472 APE_1473.1 APE_1473.1 citB citB pdhD pdhD pdhC pdhC pdhB pdhB pdhA pdhA gcvT gcvT gltA gltA fumC fumC glyA glyA gcvPB gcvPB gcvPA gcvPA APE_2126.1 APE_2126.1 APE_2128 APE_2128 glnA glnA aspC-2 aspC-2 APE_2468.1 APE_2468.1 APE_2581 APE_2581 acsA-2 acsA-2 acsA-3 acsA-3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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APE_0392Malate dehydrogenase; Malic enzyme. (446 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. Can utilize both NAD and NADP. Catalytic efficiency for malate oxidation is 3-fold higher with NADP. Belongs to the LDH/MDH superfamily. (308 aa)
aspCAspartate aminotransferase; Transaminase A. (401 aa)
APE_0689.1Isocitrate dehydrogenase [NADP]; NADP-IDH. (432 aa)
APE_0807.1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (540 aa)
APE_0935Hypothetical protein. (337 aa)
sdhBSuccinate dehydrogenase subunit B. (305 aa)
sdhDPutative succinate dehydrogenase subunit D. (117 aa)
sdhCSuccinate dehydrogenase subunit C. (119 aa)
sdhASuccinate dehydrogenase subunit A. (583 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (143 aa)
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (378 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
acsAAcetyl-coenzyme A synthetase. (656 aa)
gdhANADP-dependent glutamate dehydrogenase; GDH; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (418 aa)
APE_1458Mercuric reductase; MerA; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (461 aa)
APE_14722-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (309 aa)
APE_1473.12-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (642 aa)
citBAconitate hydratase; Aconitase. (903 aa)
pdhDDihydrolipoyl dehydrogenase; Glycine cleavage system L protein; pyruvate dehydrogenase complex, E3 component. (464 aa)
pdhCPyruvate dehydrogenase complex, E2 component; Dihydrolipoyllysine-residue acetyltransferase component. (412 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit. (325 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit. (377 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
gltACitrate synthase. (394 aa)
fumCFumarate hydratase class II. (444 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). (439 aa)
gcvPBGlycine cleavage system P-protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (520 aa)
gcvPAGlycine cleavage system P-protein subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (465 aa)
APE_2126.12-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (639 aa)
APE_21282-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (318 aa)
glnAGlutamine synthetase; Glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (458 aa)
aspC-2Aspartate aminotransferase; Transaminase A. (405 aa)
APE_2468.1Putative propionate CoA-transferase. (554 aa)
APE_2581Hypothetical protein. (405 aa)
acsA-2Acetyl-coenzyme A synthetase. (513 aa)
acsA-3Acetyl-coenzyme A synthetase. (140 aa)
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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