(14 nodes) Pyruvate metabolism network (Aeropyrum pernix)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	acsA	Acetyl-coenzyme A synthetase. (656 aa)
	APE_1458	Mercuric reductase; MerA; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (461 aa)
	APE_1472	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (309 aa)
	APE_1473.1	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (642 aa)
	pdhD	Dihydrolipoyl dehydrogenase; Glycine cleavage system L protein; pyruvate dehydrogenase complex, E3 component. (464 aa)
	pdhC	Pyruvate dehydrogenase complex, E2 component; Dihydrolipoyllysine-residue acetyltransferase component. (412 aa)
	pdhB	Pyruvate dehydrogenase E1 component, beta subunit. (325 aa)
	pdhA	Pyruvate dehydrogenase E1 component, alpha subunit. (377 aa)
	APE_2126.1	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (639 aa)
	APE_2128	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (318 aa)
	APE_2468.1	Putative propionate CoA-transferase. (554 aa)
	APE_2581	Hypothetical protein. (405 aa)
	acsA-2	Acetyl-coenzyme A synthetase. (513 aa)
	acsA-3	Acetyl-coenzyme A synthetase. (140 aa)

Your Current Organism:

Aeropyrum pernix

NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APE_1458	APE_2581	APE_1458	APE_2581	Mercuric reductase; MerA; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Hypothetical protein.	0.648
APE_1458	pdhA	APE_1458	APE_1677.1	Mercuric reductase; MerA; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyruvate dehydrogenase E1 component, alpha subunit.	0.937
APE_1458	pdhB	APE_1458	APE_1674	Mercuric reductase; MerA; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyruvate dehydrogenase E1 component, beta subunit.	0.981
APE_1458	pdhC	APE_1458	APE_1671	Mercuric reductase; MerA; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Pyruvate dehydrogenase complex, E2 component; Dihydrolipoyllysine-residue acetyltransferase component.	0.996
APE_1472	APE_1473.1	APE_1472	APE_1473.1	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	0.999
APE_1472	APE_2126.1	APE_1472	APE_2126.1	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives.	0.997
APE_1472	APE_2128	APE_1472	APE_2128	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives.	0.906
APE_1472	APE_2468.1	APE_1472	APE_2468.1	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Putative propionate CoA-transferase.	0.900
APE_1472	acsA	APE_1472	APE_1346.1	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Acetyl-coenzyme A synthetase.	0.919
APE_1472	acsA-2	APE_1472	APE_2604	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Acetyl-coenzyme A synthetase.	0.919
APE_1472	acsA-3	APE_1472	APE_2604a.1	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Acetyl-coenzyme A synthetase.	0.919
APE_1472	pdhA	APE_1472	APE_1677.1	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Pyruvate dehydrogenase E1 component, alpha subunit.	0.919
APE_1472	pdhB	APE_1472	APE_1674	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Pyruvate dehydrogenase E1 component, beta subunit.	0.917
APE_1472	pdhC	APE_1472	APE_1671	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Pyruvate dehydrogenase complex, E2 component; Dihydrolipoyllysine-residue acetyltransferase component.	0.925
APE_1472	pdhD	APE_1472	APE_1669.1	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Dihydrolipoyl dehydrogenase; Glycine cleavage system L protein; pyruvate dehydrogenase complex, E3 component.	0.916
APE_1473.1	APE_1472	APE_1473.1	APE_1472	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	0.999
APE_1473.1	APE_2126.1	APE_1473.1	APE_2126.1	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives.	0.906
APE_1473.1	APE_2128	APE_1473.1	APE_2128	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	2-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives.	0.997
APE_1473.1	APE_2468.1	APE_1473.1	APE_2468.1	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Putative propionate CoA-transferase.	0.900
APE_1473.1	acsA	APE_1473.1	APE_1346.1	2-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives.	Acetyl-coenzyme A synthetase.	0.921