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fba fba APE_0012 APE_0012 pckA pckA gap gap pgk pgk pdxT pdxT pdxS pdxS pyk pyk APE_0583 APE_0583 APE_0586.1 APE_0586.1 ppsA ppsA rpiA rpiA APE_0768.1 APE_0768.1 fbpA fbpA tpiA tpiA gapN gapN prs prs glk glk APE_2106.1 APE_2106.1 APE_2433.1 APE_2433.1 deoC deoC eno eno
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fbaFructose-bisphosphate aldolase class I; Belongs to the DeoC/FbaB aldolase family. (272 aa)
APE_0012ATP-dependent 6-phosphofructokinase; ATP-PFK; Belongs to the carbohydrate kinase PfkB family. (310 aa)
pckAPhosphoenolpyruvate carboxykinase [ATP]; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. (489 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; GAPDH. (343 aa)
pgkPhosphoglycerate kinase. (415 aa)
pdxTPyridoxal 5'-phosphate biosynthesis protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (203 aa)
pdxSPyridoxal 5'-phosphate biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (353 aa)
pykPyruvate kinase; PK; Belongs to the pyruvate kinase family. (458 aa)
APE_0583Putative transketolase C-terminal section. (322 aa)
APE_0586.1Putative transketolase N-terminal section. (236 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (820 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (237 aa)
APE_0768.1Bifunctional phosphoglucose / phosphomannose isomerase; Catalyzes the isomerization of both glucose 6-phosphate and epimeric mannose 6-phosphate at a similar catalytic efficiency; Belongs to the PGI/PMI family. (333 aa)
fbpAFructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (387 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa)
gapNNADP-dependent glyceraldehyde-3-phosphate dehydrogenase. (510 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (309 aa)
glkATP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ATP as the phosphate donor. ITP can also serve as an effective phosphoryl donor. According to Hansen et al., the enzyme has a broad hexose specificity, and in addition to glucose, which shows the highest catalytic efficiency, it can also phosphorylate fructose, mannose, glucosamine, N-acetylglucosamine, N- acetylmannosamine and 2-deoxyglucose. However, according to Sakuraba et al., the enzyme shows strict specificity for D-glucose. (320 aa)
APE_2106.1ATP-dependent 6-phosphofructokinase. (306 aa)
APE_2433.1Phospho-sugar mutase; Belongs to the phosphohexose mutase family. (489 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (235 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa)
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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