STRINGSTRING
APE_0084.1 APE_0084.1 APE_0085a APE_0085a APE_0086 APE_0086 APE_0101.1 APE_0101.1 etfB etfB etfA etfA proC proC APE_0158.1 APE_0158.1 APE_0163.1 APE_0163.1 gap gap APE_0193.1 APE_0193.1 APE_0237.1 APE_0237.1 APE_0243 APE_0243 APE_0257a APE_0257a pyrD pyrD aor aor APE_0290a APE_0290a APE_0291 APE_0291 eapA eapA APE_0309.1 APE_0309.1 APE_0320.1 APE_0320.1 APE_0385.1 APE_0385.1 APE_0392 APE_0392 APE_0481.1 APE_0481.1 loxD loxD APE_0492.1 APE_0492.1 egsA egsA APE_0562.1 APE_0562.1 aroE aroE APE_0583 APE_0583 APE_0586.1 APE_0586.1 APE_0595.1 APE_0595.1 APE_0641 APE_0641 mdh mdh panE panE APE_0689.1 APE_0689.1 APE_0708.1 APE_0708.1 APE_0739 APE_0739 sod sod APE_0756.1 APE_0756.1 APE_0775 APE_0775 aoxA aoxA aoxB aoxB aoxC aoxC APE_0796.1 APE_0796.1 APE_0800.1 APE_0800.1 APE_0807.1 APE_0807.1 APE_0935 APE_0935 sdhB sdhB sdhD sdhD sdhC sdhC sdhA sdhA APE_1043.1 APE_1043.1 APE_1044 APE_1044 APE_1061.1 APE_1061.1 APE_1119.1 APE_1119.1 asd asd hom hom rfbD rfbD APE_1209a APE_1209a APE_1209e APE_1209e APE_1209f APE_1209f APE_1265.1 APE_1265.1 APE_1267.1 APE_1267.1 APE_1279.1 APE_1279.1 narG narG narH narH APE_1297 APE_1297 narJ narJ APE_1336.1 APE_1336.1 gdhA gdhA APE_1411.1 APE_1411.1 APE_1415 APE_1415 APE_1418.1 APE_1418.1 APE_1419.1 APE_1419.1 APE_1422 APE_1422 APE_1426 APE_1426 APE_1428.1 APE_1428.1 APE_1457 APE_1457 APE_1458 APE_1458 lysY lysY APE_1471.1 APE_1471.1 APE_1472 APE_1472 APE_1473.1 APE_1473.1 APE_1484.1 APE_1484.1 sirC sirC guaB guaB APE_1557.1 APE_1557.1 APE_1586a APE_1586a APE_1586b APE_1586b APE_1622.1 APE_1622.1 APE_1623 APE_1623 pdhD pdhD pdhB pdhB pdhA pdhA APE_1681.1 APE_1681.1 APE_1694.1 APE_1694.1 APE_1719.1 APE_1719.1 APE_1720 APE_1720 APE_1721 APE_1721 APE_1722 APE_1722 soxC soxC APE_1727.1 APE_1727.1 fni fni gapN gapN APE_1814.1 APE_1814.1 gyaR gyaR hmgA hmgA APE_1952.1 APE_1952.1 APE_1961 APE_1961 APE_1963.1 APE_1963.1 APE_2062.1 APE_2062.1 gcvPB gcvPB gcvPA gcvPA bcp bcp APE_2126.1 APE_2126.1 APE_2128 APE_2128 APE_2158.1 APE_2158.1 APE_2213 APE_2213 APE_2216.1 APE_2216.1 APE_2219 APE_2219 adh adh APE_2273.1 APE_2273.1 APE_2278 APE_2278 APE_2284a APE_2284a hemA hemA APE_2354 APE_2354 etfB-2 etfB-2 etfA-2 etfA-2 APE_2421 APE_2421 APE_2430.1 APE_2430.1 APE_2462.1 APE_2462.1 trxA trxA fabG fabG APE_2507.1 APE_2507.1 APE_2509 APE_2509 APE_2533.1 APE_2533.1 APE_2556.1 APE_2556.1 APE_2563 APE_2563 APE_2568.1 APE_2568.1 APE_2580 APE_2580 APE_2605.1 APE_2605.1 APE_2610 APE_2610
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APE_0084.1NADH dehydrogenase. (237 aa)
APE_0085aHypothetical protein. (148 aa)
APE_0086Thiol peroxidase. (163 aa)
APE_0101.1Putative iron-sulfur protein. (672 aa)
etfBElectron transfer flavoprotein beta-subunit. (266 aa)
etfAElectron transfer flavoprotein alpha-subunit. (308 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (279 aa)
APE_0158.1Hypothetical protein. (236 aa)
APE_0163.1Conserved hypothetical protein. (442 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; GAPDH. (343 aa)
APE_0193.1L-lysine 6-dehydrogenase. (367 aa)
APE_0237.1Hypothetical protein. (211 aa)
APE_0243Hypothetical protein. (148 aa)
APE_0257aHypothetical protein. (56 aa)
pyrDProbable dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (306 aa)
aorTungsten-containing aldehyde ferredoxin oxidoreductase. (609 aa)
APE_0290aHypothetical protein. (71 aa)
APE_0291Truncated thiol peroxidase. (110 aa)
eapAAlkyldihydroxyacetonephosphate synthase. (476 aa)
APE_0309.1Putative oxidoreductase. (367 aa)
APE_0320.1Ferredoxin. (110 aa)
APE_0385.1acyl-CoA dehydrogenase. (543 aa)
APE_0392Malate dehydrogenase; Malic enzyme. (446 aa)
APE_0481.1Hypothetical protein. (98 aa)
loxDD-lactate dehydrogenase. (473 aa)
APE_0492.1Conserved hypothetical protein. (201 aa)
egsAGlycerol-1-phosphate dehydrogenase [NAD(P)]; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Is also able to catalyze the reverse reaction, i.e. the NAD(+)-dependent oxidation of G1P but not of G3P. Is not active toward glycerol, dihydroxyacetone, glyceraldehyde phosphate, and glycerol-2-phosphate. Belongs to the glycerol-1-phosphate dehydrogenase family. (352 aa)
APE_0562.1Putative prephenate dehydrogenase. (268 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa)
APE_0583Putative transketolase C-terminal section. (322 aa)
APE_0586.1Putative transketolase N-terminal section. (236 aa)
APE_0595.1Putative dehydrogenase. (383 aa)
APE_0641Thioredoxin; ApTrx. (349 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. Can utilize both NAD and NADP. Catalytic efficiency for malate oxidation is 3-fold higher with NADP. Belongs to the LDH/MDH superfamily. (308 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa)
APE_0689.1Isocitrate dehydrogenase [NADP]; NADP-IDH. (432 aa)
APE_0708.1Aldehyde dehydrogenase, large subunit. (764 aa)
APE_0739acyl-CoA dehydrogenase. (345 aa)
sodSuperoxide dismutase [Mn/Fe]; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (214 aa)
APE_0756.1Putative dehydrogenase. (291 aa)
APE_0775Protein-disulfide oxidoreductase; Thioredoxin-like protein. (243 aa)
aoxACytochrome c oxidase (aa3-type) subunit II. (236 aa)
aoxBCytochrome c oxidase (aa3-type) subunit I+III; In the C-terminal section; belongs to the cytochrome c oxidase subunit 3 family. (815 aa)
aoxCCytochrome c oxidase (aa3-type) subunit IV. (103 aa)
APE_0796.1Putative SCO1 protein. (230 aa)
APE_0800.1Hypothetical protein. (360 aa)
APE_0807.1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (540 aa)
APE_0935Hypothetical protein. (337 aa)
sdhBSuccinate dehydrogenase subunit B. (305 aa)
sdhDPutative succinate dehydrogenase subunit D. (117 aa)
sdhCSuccinate dehydrogenase subunit C. (119 aa)
sdhASuccinate dehydrogenase subunit A. (583 aa)
APE_1043.1Putative dehydrogenase. (381 aa)
APE_1044NADH dehydrogenase. (249 aa)
APE_1061.1Thioredoxin reductase; ApTR. (337 aa)
APE_1119.1ABCE1 homolog. (614 aa)
asdAspartate-semialdehyde dehydrogenase; ASADH. (349 aa)
homHomoserine dehydrogenase; HDH. (332 aa)
rfbDdTDP-4-dehydrorhamnose reductase; RmlD. (300 aa)
APE_1209aTruncated acyl-CoA dehydrogenase. (65 aa)
APE_1209eTruncated acyl-CoA dehydrogenase. (91 aa)
APE_1209fTruncated acyl-CoA dehydrogenase. (32 aa)
APE_1265.1Putative glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (347 aa)
APE_1267.1Putative oxidoreductase. (428 aa)
APE_1279.1Pyrimidine nucleotide reductase. (220 aa)
narGNitrate reductase, alpha subunit. (1283 aa)
narHNitrate reductase, beta subunit. (464 aa)
APE_1297Putative nitrate reductase, gamma subunit. (321 aa)
narJNitrate reductase delta subunit. (178 aa)
APE_1336.1Putative phytoene dehydrogenase. (549 aa)
gdhANADP-dependent glutamate dehydrogenase; GDH; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (418 aa)
APE_1411.1NuoL homolog. (701 aa)
APE_1415NuoM homolog. (513 aa)
APE_1418.1NuoJ homolog. (160 aa)
APE_1419.1NuoI homolog. (186 aa)
APE_1422NuoD homolog. (414 aa)
APE_1426NuoC homolog. (189 aa)
APE_1428.1NuoB homolog; Belongs to the complex I 20 kDa subunit family. (199 aa)
APE_1457Conserved hypothetical protein; Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction. Belongs to the Dps family. (173 aa)
APE_1458Mercuric reductase; MerA; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (461 aa)
lysYN-acetyl-gamma-aminoadipyl-phosphate reductase/N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (355 aa)
APE_1471.1Putative GTP cyclohydrolase I. (101 aa)
APE_14722-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (309 aa)
APE_1473.12-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (642 aa)
APE_1484.13-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA dehydratase. (669 aa)
sirCPrecorrin-2 dehydrogenase. (220 aa)
guaBInosine-5'-monophosphate dehydrogenase; IMPD. (433 aa)
APE_1557.1Putative alcohol dehydrogenase. (312 aa)
APE_1586aTruncated acyl-CoA dehydrogenase. (48 aa)
APE_1586bTruncated acyl-CoA dehydrogenase. (35 aa)
APE_1622.1Conserved hypothetical protein. (389 aa)
APE_1623Cytochrome c oxidase (ba3-type) subunit I; Belongs to the heme-copper respiratory oxidase family. (548 aa)
pdhDDihydrolipoyl dehydrogenase; Glycine cleavage system L protein; pyruvate dehydrogenase complex, E3 component. (464 aa)
pdhBPyruvate dehydrogenase E1 component, beta subunit. (325 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit. (377 aa)
APE_1681.1acyl-CoA dehydrogenase. (389 aa)
APE_1694.1Cytochrome AA3 controlling protein. (150 aa)
APE_1719.1Hypothetical protein. (190 aa)
APE_1720Cytochrome c oxidase (ba3-type) subunit II. (196 aa)
APE_1721Putative SCO1 protein. (254 aa)
APE_1722Thioredoxin. (389 aa)
soxCCytochrome b. (571 aa)
APE_1727.1Conserved hypothetical protein. (147 aa)
fniIsopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (375 aa)
gapNNADP-dependent glyceraldehyde-3-phosphate dehydrogenase. (510 aa)
APE_1814.1Conserved hypothetical protein. (301 aa)
gyaRGlyoxylate reductase. (335 aa)
hmgA3-hydroxy-3-methylglutaryl-coenzyme A reductase; Converts HMG-CoA to mevalonate. (421 aa)
APE_1952.1Conserved hypothetical protein. (463 aa)
APE_1961Putative oxidoreductase, aldo/keto reductase family. (272 aa)
APE_1963.1Alcohol dehydrogenase. (390 aa)
APE_2062.1Ribonucleotide reductase, B12-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (979 aa)
gcvPBGlycine cleavage system P-protein subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (520 aa)
gcvPAGlycine cleavage system P-protein subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (465 aa)
bcpThiol peroxidase; Bacterioferritin comigratory protein. (161 aa)
APE_2126.12-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (639 aa)
APE_21282-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (318 aa)
APE_2158.1acyl-CoA dehydrogenase. (399 aa)
APE_2213Aldehyde dehydrogenase, small subunit; Iron-sulfur subunit. (163 aa)
APE_2216.1Aldehyde dehydrogenase, large subunit. (785 aa)
APE_2219Aldehyde dehydrogenase, middle subunit. (292 aa)
adhNAD-dependent alcohol dehydrogenase. (344 aa)
APE_2273.1Thioredoxin. (394 aa)
APE_2278Thioredoxin peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (250 aa)
APE_2284aConserved hypothetical protein. (78 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (416 aa)
APE_2354acyl-CoA dehydrogenase. (405 aa)
etfB-2Electron transfer flavoprotein beta-subunit. (280 aa)
etfA-2Electron transfer flavoprotein alpha-subunit. (372 aa)
APE_2421FixC protein. (436 aa)
APE_2430.1Thioredoxin. (159 aa)
APE_2462.1Conserved hypothetical protein. (145 aa)
trxAThioredoxin. (143 aa)
fabG3-oxoacyl-[acyl-carrier-protein] reductase. (250 aa)
APE_2507.1Putative glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa)
APE_2509Putative acetolactate synthase; Belongs to the TPP enzyme family. (556 aa)
APE_2533.1Conserved hypothetical protein. (688 aa)
APE_2556.1Probable arsenite oxidase large subunit. (1006 aa)
APE_2563Probable arsenite oxidase small subunit precursor. (210 aa)
APE_2568.1Conserved hypothetical protein. (190 aa)
APE_2580Putative flavoredoxin. (263 aa)
APE_2605.1Molybdopterin oxidoreductase, iron-sulfur binding subunit. (233 aa)
APE_2610Molybdopterin oxidoreductase, molybdopterin binding subunit. (1165 aa)
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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