STRINGSTRING
mdh mdh APE_0392 APE_0392 APE_0193.1 APE_0193.1 aroE aroE APE_2507.1 APE_2507.1 fabG fabG adh adh APE_1963.1 APE_1963.1 hmgA hmgA gyaR gyaR guaB guaB APE_1484.1 APE_1484.1 APE_1279.1 APE_1279.1 APE_1265.1 APE_1265.1 rfbD rfbD hom hom APE_0689.1 APE_0689.1 egsA egsA panE panE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. Can utilize both NAD and NADP. Catalytic efficiency for malate oxidation is 3-fold higher with NADP. Belongs to the LDH/MDH superfamily. (308 aa)
APE_0392Malate dehydrogenase; Malic enzyme. (446 aa)
APE_0193.1L-lysine 6-dehydrogenase. (367 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa)
APE_2507.1Putative glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (333 aa)
fabG3-oxoacyl-[acyl-carrier-protein] reductase. (250 aa)
adhNAD-dependent alcohol dehydrogenase. (344 aa)
APE_1963.1Alcohol dehydrogenase. (390 aa)
hmgA3-hydroxy-3-methylglutaryl-coenzyme A reductase; Converts HMG-CoA to mevalonate. (421 aa)
gyaRGlyoxylate reductase. (335 aa)
guaBInosine-5'-monophosphate dehydrogenase; IMPD. (433 aa)
APE_1484.13-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA dehydratase. (669 aa)
APE_1279.1Pyrimidine nucleotide reductase. (220 aa)
APE_1265.1Putative glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (347 aa)
rfbDdTDP-4-dehydrorhamnose reductase; RmlD. (300 aa)
homHomoserine dehydrogenase; HDH. (332 aa)
APE_0689.1Isocitrate dehydrogenase [NADP]; NADP-IDH. (432 aa)
egsAGlycerol-1-phosphate dehydrogenase [NAD(P)]; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Is also able to catalyze the reverse reaction, i.e. the NAD(+)-dependent oxidation of G1P but not of G3P. Is not active toward glycerol, dihydroxyacetone, glyceraldehyde phosphate, and glycerol-2-phosphate. Belongs to the glycerol-1-phosphate dehydrogenase family. (352 aa)
panE2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (309 aa)
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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