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guaA guaA etfB etfB etfA etfA APE_0140.1 APE_0140.1 lysS lysS ileS ileS APE_0421 APE_0421 thiI thiI nadM nadM APE_0537.1 APE_0537.1 leuS leuS metG metG sat sat queC queC cysS cysS argS argS valS valS nadE nadE nadM-2 nadM-2 APE_2041.1 APE_2041.1 APE_2042.1 APE_2042.1 tyrS tyrS APE_2075 APE_2075 APE_2086 APE_2086 APE_2281.1 APE_2281.1 gltX gltX trpS trpS etfB-2 etfB-2 etfA-2 etfA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
guaAGMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (512 aa)
etfBElectron transfer flavoprotein beta-subunit. (266 aa)
etfAElectron transfer flavoprotein alpha-subunit. (308 aa)
APE_0140.1ATP-dependent universal stress protein. (288 aa)
lysSlysyl-tRNA synthetase; LysRS; lysine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (545 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1064 aa)
APE_0421Conserved hypothetical protein. (238 aa)
thiIThiamine biosynthesis protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (396 aa)
nadMNMN adenylyltransferase. (172 aa)
APE_0537.1Conserved hypothetical protein. (338 aa)
leuSleucyl-tRNA synthetase; LeuRS; leucine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (959 aa)
metGmethionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. (572 aa)
satSulfate adenylyltransferase; ATP-sulfurylase; Belongs to the sulfate adenylyltransferase family. (383 aa)
queCConserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (269 aa)
cysScysteinyl-tRNA synthetase; CysRS; cysteine--tRNA ligase. (472 aa)
argSarginyl-tRNA synthetase; ArgRS; arginine--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (644 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner (By similarity); Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (823 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (286 aa)
nadM-2NMN adenylyltransferase; Belongs to the archaeal NMN adenylyltransferase family. (172 aa)
APE_2041.1Putative asparagine synthetase. (318 aa)
APE_2042.1Conserved hypothetical protein. (232 aa)
tyrStyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (361 aa)
APE_2075Hypothetical protein. (464 aa)
APE_2086Conserved hypothetical protein. (331 aa)
APE_2281.1Putative cytidylyltransferase. (246 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (574 aa)
trpStryptophanyl-tRNA synthetase; TrpRS; tryptophan--tRNA ligase; Belongs to the class-I aminoacyl-tRNA synthetase family. (372 aa)
etfB-2Electron transfer flavoprotein beta-subunit. (280 aa)
etfA-2Electron transfer flavoprotein alpha-subunit. (372 aa)
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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