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ppsA ppsA mdh mdh APE_0689.1 APE_0689.1 APE_0929.1 APE_0929.1 sdhB sdhB sdhD sdhD sdhC sdhC sdhA sdhA sucC sucC sucD sucD acsA acsA APE_1472 APE_1472 APE_1473.1 APE_1473.1 APE_1484.1 APE_1484.1 citB citB APE_1686.1 APE_1686.1 APE_1687 APE_1687 fumC fumC APE_2108 APE_2108 APE_2126.1 APE_2126.1 APE_2128 APE_2128 APE_2382.1 APE_2382.1 APE_2384 APE_2384 acsA-2 acsA-2 acsA-3 acsA-3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (820 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Can also oxidize tartrate. Can utilize both NAD and NADP. Catalytic efficiency for malate oxidation is 3-fold higher with NADP. Belongs to the LDH/MDH superfamily. (308 aa)
APE_0689.1Isocitrate dehydrogenase [NADP]; NADP-IDH. (432 aa)
APE_0929.1Putative 3-ketoacyl-CoA thiolase. (397 aa)
sdhBSuccinate dehydrogenase subunit B. (305 aa)
sdhDPutative succinate dehydrogenase subunit D. (117 aa)
sdhCSuccinate dehydrogenase subunit C. (119 aa)
sdhASuccinate dehydrogenase subunit A. (583 aa)
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (378 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (292 aa)
acsAAcetyl-coenzyme A synthetase. (656 aa)
APE_14722-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (309 aa)
APE_1473.12-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate, glyoxylate and 2-oxoglutarate to form their CoA derivatives. (642 aa)
APE_1484.13-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA dehydratase. (669 aa)
citBAconitate hydratase; Aconitase. (903 aa)
APE_1686.1Coenzyme B12-dependent mutase. (161 aa)
APE_1687Coenzyme B12-dependent mutase. (565 aa)
fumCFumarate hydratase class II. (444 aa)
APE_2108acetyl-CoA acetyltransferase. (402 aa)
APE_2126.12-oxoacid:ferredoxin oxidoreductase alpha subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (639 aa)
APE_21282-oxoacid:ferredoxin oxidoreductase beta subunit; Catalyzes the coenzyme A-dependent oxidative decarboxylation of different 2-oxoacids such as pyruvate, 2-oxobutyrate and glyoxylate to form their CoA derivatives. (318 aa)
APE_2382.1Conserved hypothetical protein. (385 aa)
APE_2384Conserved hypothetical protein. (394 aa)
acsA-2Acetyl-coenzyme A synthetase. (513 aa)
acsA-3Acetyl-coenzyme A synthetase. (140 aa)
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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