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fba fba ilvD ilvD proC proC gap gap pgk pgk pyk pyk APE_0562.1 APE_0562.1 aroC aroC aroA aroA aroK aroK aroE aroE aroD aroD aroB aroB aroG aroG APE_0583 APE_0583 APE_0586.1 APE_0586.1 APE_0632.1 APE_0632.1 rpiA rpiA aspC aspC APE_0683 APE_0683 APE_0689.1 APE_0689.1 APE_0935 APE_0935 hxlA hxlA dapA dapA fbpA fbpA lysC lysC asd asd hom hom APE_1223.1 APE_1223.1 metC metC aroA-2 aroA-2 lysZ lysZ lysY lysY lysX lysX lysJ lysJ lysK lysK thrC thrC APE_1498.1 APE_1498.1 tpiA tpiA cysK cysK mat mat apgM apgM citB citB gltA gltA prs prs APE_1917 APE_1917 hxlB hxlB glyA glyA argF argF cobD cobD APE_2041.1 APE_2041.1 metE metE APE_2050.1 APE_2050.1 thrB thrB metB metB glnA glnA aspC-2 aspC-2 thrC-2 thrC-2 trpB trpB eno eno APE_2509 APE_2509 trpC trpC trpF trpF trpB-2 trpB-2 trpA trpA trpD trpD trpE trpE trpG trpG
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fbaFructose-bisphosphate aldolase class I; Belongs to the DeoC/FbaB aldolase family. (272 aa)
ilvDDihydroxy-acid dehydratase; DAD; Belongs to the IlvD/Edd family. (553 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (279 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; GAPDH. (343 aa)
pgkPhosphoglycerate kinase. (415 aa)
pykPyruvate kinase; PK; Belongs to the pyruvate kinase family. (458 aa)
APE_0562.1Putative prephenate dehydrogenase. (268 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (380 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa)
aroKShikimate kinase. (280 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (222 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (358 aa)
aroGPhospho-2-dehydro-3-deoxyheptonate aldolase. (270 aa)
APE_0583Putative transketolase C-terminal section. (322 aa)
APE_0586.1Putative transketolase N-terminal section. (236 aa)
APE_0632.1Conserved hypothetical protein. (419 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (237 aa)
aspCAspartate aminotransferase; Transaminase A. (401 aa)
APE_0683Phosphoserine phosphatase. (222 aa)
APE_0689.1Isocitrate dehydrogenase [NADP]; NADP-IDH. (432 aa)
APE_0935Hypothetical protein. (337 aa)
hxlAHexulose-6-phosphate synthase. (240 aa)
dapAPutative dihydrodipicolinate synthase. (303 aa)
fbpAFructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (387 aa)
lysCAspartate kinase; Belongs to the aspartokinase family. (454 aa)
asdAspartate-semialdehyde dehydrogenase; ASADH. (349 aa)
homHomoserine dehydrogenase; HDH. (332 aa)
APE_1223.1Cystathionine beta-synthase; CBS. (389 aa)
metCCystathionine gamma-lyase. (384 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase. (419 aa)
lysZAcetylaminoadipate kinase/acetylglutamate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (270 aa)
lysYN-acetyl-gamma-aminoadipyl-phosphate reductase/N-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (355 aa)
lysXLysine biosynthesis protein LysX/ribosomal protein S6 modification protein RimK; Alternative gene symbol: rimK. (286 aa)
lysJAcetyl-lysine aminotransferase/acetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (388 aa)
lysKAcetyl-lysine deacetylase/acetylornithine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (350 aa)
thrCThreonine synthase. (340 aa)
APE_1498.1Threonine dehydratase. (411 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (223 aa)
cysKCysteine synthase; Cysteine synthase that can also catalyze the synthesis of S- sulfo-L-cysteine from thiosulfate and O(3)-acetyl-L-serine, as well as the sulfhydrylation of L-serine by sulfide. Belongs to the cysteine synthase/cystathionine beta- synthase family. (389 aa)
matS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (406 aa)
apgM2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (424 aa)
citBAconitate hydratase; Aconitase. (903 aa)
gltACitrate synthase. (394 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (309 aa)
APE_1917Hypothetical protein. (441 aa)
hxlB6-phospho-3-hexuloisomerase; Belongs to the SIS family. PHI subfamily. (212 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity). (439 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (314 aa)
cobDThreonine-phosphate decarboxylase. (354 aa)
APE_2041.1Putative asparagine synthetase. (318 aa)
metEMethylcobalamin:homocysteine methyltransferase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown (By similarity). (332 aa)
APE_2050.1Putative methylcobalamin:homocysteine methyltransferase; Putative methionine synthase. (336 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (313 aa)
metBCystathionine gamma-synthase. (389 aa)
glnAGlutamine synthetase; Glutamate--ammonia ligase; Belongs to the glutamine synthetase family. (458 aa)
aspC-2Aspartate aminotransferase; Transaminase A. (405 aa)
thrC-2Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (393 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (449 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa)
APE_2509Putative acetolactate synthase; Belongs to the TPP enzyme family. (556 aa)
trpCIndole-3-glycerol phosphate synthase; IGPS; Belongs to the TrpC family. (261 aa)
trpFN-(5'-phosphoribosyl) anthranilate isomerase; Belongs to the TrpF family. (215 aa)
trpB-2Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (252 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (438 aa)
trpGAnthranilate synthase component II. (196 aa)
Your Current Organism:
Aeropyrum pernix
NCBI taxonomy Id: 272557
Other names: A. pernix K1, Aeropyrum pernix K1, Aeropyrum pernix str. K1, Aeropyrum pernix strain K1
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