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| | pgsA | Phosphatidylglycerophosphate synthase; BH2386; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (192 aa) |
| | ribC | Riboflavin kinase / FAD synthase; BH2409; Belongs to the ribF family. (313 aa) |
| | BH2421 | 1-deoxy-d-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (365 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; BH2422; Belongs to the CDS family. (264 aa) |
| | smbA | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa) |
| | fliI | Flagellar-specific ATP synthase; BH2455. (437 aa) |
| | plsX | Involved in fatty acid/phospholipid synthesis; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (337 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; BH2502; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | dfp | Flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (404 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa) |
| | narA | Molybdopterin cofactor biosynthesis; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (338 aa) |
| | narQ | Required for formate dehydrogenase activity; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (270 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (234 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (305 aa) |
| | pyrDII | Dihydroorotate dehydrogenase (electron transfer subunit); Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (259 aa) |
| | pyrAB | Carbamoyl-phosphate synthetase (catalytic subunit); BH2536; Belongs to the CarB family. (1062 aa) |
| | pyrAA | Carbamoyl-phosphate synthetase (glutaminase subunit); BH2537. (362 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa) |
| | pyrB | Aspartate carbamoyltransferase; BH2539; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (305 aa) |
| | BH2587 | BH2587; unknown conserved protein. (275 aa) |
| | coaD | Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa) |
| | BH2635 | Myo-inositol-1(or 4)-monophosphatase. (267 aa) |
| | pdhA | Pyruvate dehydrogenase E1 (lipoamide) alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (361 aa) |
| | BH2674 | 6-phosphogluconate dehydrogenase. (298 aa) |
| | BH2678 | Acetylornithine deacetylase; Catalyzes the deformylation of the formylaminopyrimidine N- formyl-4-amino-5-aminomethyl-2-methylpyrimidine (FAMP) to give the corresponding aminopyrimidine. (427 aa) |
| | tenA | Transcriptional regulator of extracellular enzyme genes; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway. Thus, catalyzes the conversion of 4- amino-5-aminomethyl-2-methylpyrimidine to 4-amino-5-hydroxymethyl-2- methylpyrimidine (HMP). To a lesser extent, is also able to catalyze the hydrolytic cleavage of thiamine; however, this thiaminase activity is unlikely to be physiologically relevant. Therefore, is involved in the regeneration of the thiamine pyrimidine from thiami [...] (224 aa) |
| | BH2680 | ABC transporter (ATP-binding protein); Participates in a thiamine pyrimidine salvage pathway as part of the ABC transporter complex ThiXYZ involved in the import of thiamine degradation products such as the formylaminopyrimidine N- formyl-4-amino-5-aminomethyl-2-methylpyrimidine (FAMP). Is likely responsible for energy coupling to the transport system. (249 aa) |
| | BH2681 | ABC transporter (permease); Participates in a thiamine pyrimidine salvage pathway as part of the ABC transporter complex ThiXYZ involved in the import of thiamine degradation products such as the formylaminopyrimidine N- formyl-4-amino-5-aminomethyl-2-methylpyrimidine (FAMP). Is probably responsible for the translocation of the substrate across the membrane. Belongs to the binding-protein-dependent transport system permease family. (250 aa) |
| | BH2682 | Thiamine biosynthesis; Participates in a thiamine pyrimidine salvage pathway as part of the ABC transporter complex ThiXYZ involved in the import of thiamine degradation products. Binds the formylaminopyrimidine N- formyl-4-amino-5-aminomethyl-2-methylpyrimidine (FAMP). Does not bind thiamine; Belongs to the NMT1 family. (330 aa) |
| | BH2771 | BH2771; unknown conserved protein in others. (379 aa) |
| | BH2779 | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (629 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase(NADP+)/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (279 aa) |
| | accC | acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa) |
| | BH2848 | NAD kinase 1; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (265 aa) |
| | BH2849 | GTP pyrophosphokinase. (211 aa) |
| | BH2858 | Cardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (503 aa) |
| | BH2875 | Pantothenate kinase. (316 aa) |
| | carB | Arginine specific carbamoyl-phosphate synthase large chain; BH2895; Belongs to the CarB family. (1047 aa) |
| | carA | Arginine specific carbamoyl-phosphate synthase small chain; BH2896. (359 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (198 aa) |
| | moaD | Molybdopterin converting factor (subunit 1); BH3018. (78 aa) |
| | moaE | Molybdopterin converting factor (subunit 2); Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity); Belongs to the MoaE family. (156 aa) |
| | mobB | Molybdopterin-guanine dinucleotide biosynthesis; BH3020. (169 aa) |
| | moeA | Molybdopterin biosynthesis; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (423 aa) |
| | moaB | Molybdopterin precursor biosynthesis; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family. (170 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (165 aa) |
| | maf | Septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (190 aa) |
| | BH3067 | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (194 aa) |
| | BH3150 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (201 aa) |
| | pykA | Pyruvate kinase; BH3163; Belongs to the pyruvate kinase family. (584 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | accA | acetyl-CoA carboxylase carboxyltransferase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa) |
| | accD | acetyl-CoA carboxylase transferase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (282 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (391 aa) |
| | BH3199 | NAD kinase 2; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (265 aa) |
| | BH3203 | Thiamin biosynthesis; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (382 aa) |
| | BH3210 | BH3210; unknown. (134 aa) |
| | BH3249 | Nicotinate phosphoribosyltransferase; BH3249; unknown conserved protein in others; Belongs to the NAPRTase family. (365 aa) |
| | BH3256 | Probable inosine/xanthosine triphosphatase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (177 aa) |
| | BH3265 | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa) |
| | pgi | Glucose-6-phosphate isomerase; BH3343. (450 aa) |
| | thiK | Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (261 aa) |
| | thyB | Thymidylate synthase B; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | BH3453 | BH3453; unknown conserved protein; Belongs to the 5'-nucleotidase family. (462 aa) |
| | eno | Enolase (2-phosphoglycerate dehydratase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa) |
| | pgm | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. (510 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | pgk | Phosphoglycerate kinase; BH3559; Belongs to the phosphoglycerate kinase family. (394 aa) |
| | BH3735 | Hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa) |
| | atpC | ATP synthase epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa) |
| | atpD | ATP synthase beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (470 aa) |
| | atpG | ATP synthase gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (285 aa) |
| | atpA | ATP synthase alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (502 aa) |
| | atpH | ATP synthase delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (183 aa) |
| | atpF | ATP synthase subunit b; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (162 aa) |
| | atpE | ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (70 aa) |
| | atpB | ATP synthase subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (237 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | tdk | Thymidine kinase; BH3779. (204 aa) |
| | BH3785 | Transaldolase (pentose phosphate); Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (212 aa) |
| | fbaA | Fructose-1,6-bisphosphate aldolase; BH3786. (287 aa) |
| | ctrA | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa) |
| | BH3796 | Fused isobutyryl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1087 aa) |
| | BH3803 | Cardiolipin synthetase; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (398 aa) |
| | lctE | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (310 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | BH3997 | BH3997; unknown conserved protein in others. (101 aa) |
| | guaB | Inositol-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa) |
| | BH0022 | Superoxide-inducible protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (298 aa) |
| | BH0023 | Amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (196 aa) |
| | BH0026 | Nucleotidase precursor; Belongs to the 5'-nucleotidase family. (641 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | BH0061 | Isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (287 aa) |
| | gcaD | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (455 aa) |
| | prs | Phosphoribosyl pyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | hprT | Hypoxanthine-guanine phosphoribosyltransferase; BH0084; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | BH0086 | Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (254 aa) |
| | BH0102 | Creatine kinase; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. (356 aa) |
| | BH0107 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (228 aa) |
| | BH0108 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | BH0213 | Pyruvate dehydrogenase E1 (lipoamide) alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (367 aa) |
| | BH0265 | Diadenylate cyclase; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (274 aa) |
| | BH0368 | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (177 aa) |
| | nrdB | Ribonucleoside-diphosphate reductase beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (345 aa) |
| | BH0544 | Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (328 aa) |
| | BH0592 | BH0592; unknown conserved protein in others. (397 aa) |
| | guaA | GMP synthetase; Catalyzes the synthesis of GMP from XMP. (513 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase I; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase II; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (379 aa) |
| | purB | Adenylosuccinate lyase; BH0625; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (433 aa) |
| | purC | Phosphoribosylaminoimidazole succinocarboxamide synthetase; BH0626; Belongs to the SAICAR synthetase family. (237 aa) |
| | BH0627 | Phosphoribosylformylglycinamidine synthase subunit PurS; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (84 aa) |
| | purL | Phosphoribosylformylglycinamidine synthetase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assis [...] (227 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthetase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (743 aa) |
| | purF | Phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (473 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; BH0631. (345 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (188 aa) |
| | purH | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; BH0633. (511 aa) |
| | purD | Phosphoribosylglycinamide synthetase; BH0634. (428 aa) |
| | BH0647 | Heptaprenylglyceryl phosphate synthase; Prenyltransferase that catalyzes in vivo the transfer of the heptaprenyl moiety of heptaprenyl pyrophosphate (HepPP; 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond- formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales. (229 aa) |
| | BH0676 | BH0676; unknown conserved protein. (295 aa) |
| | BH0776 | Acetoin dehydrogenase (TPP-dependent) alpha chain; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (326 aa) |
| | fruB | Fructose 1-phosphate kinase; BH0827; Belongs to the carbohydrate kinase PfkB family. (306 aa) |
| | BH0998 | GTP cyclohydrolase FolE2; Converts GTP to 7,8-dihydroneopterin triphosphate. (299 aa) |
| | BH1015 | BH1015; unknown conserved protein. (1137 aa) |
| | glpK | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (497 aa) |
| | glpD | Glycerol-3-phosphate dehydrogenase; BH1095; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (553 aa) |
| | BH1132 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa) |
| | BH1160 | Non-canonical purine NTP pyrophosphatase homolog; BH1160; unknown conserved protein; Belongs to the HAM1 NTPase family. (193 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (509 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; BH1219; Belongs to the NadC/ModD family. (281 aa) |
| | nadA | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (367 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa) |
| | relA | GTP pyrophosphokinase (stringent response); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (728 aa) |
| | udk | Uridine kinase; BH1275. (211 aa) |
| | pssA | Phosphatidylserine synthase; BH1310; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (179 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (259 aa) |
| | BH1326 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (207 aa) |
| | dra | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (224 aa) |
| | BH1364 | Diacylglycerol kinase. (130 aa) |
| | BH1382 | Penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (314 aa) |
| | BH1399 | Putative nucleotidase BH1399; BH1399; unknown conserved protein in B. subtilis; Belongs to the 5'(3')-deoxyribonucleotidase family. (195 aa) |
| | gcpE | Peptidoglycan acetylation; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (367 aa) |
| | glk | Glucose kinase; BH1425; Belongs to the ROK (NagC/XylR) family. (330 aa) |
| | BH1431 | Thiamine phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | BH1433 | Thiamin biosynthesis; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (261 aa) |
| | BH1434 | Glycine oxidase (sarcosine oxidase). (365 aa) |
| | BH1514 | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (198 aa) |
| | BH1530 | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (393 aa) |
| | cmk | Cytidylate kinase; BH1634. (222 aa) |
| | BH1639 | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (206 aa) |
| | gpsA | NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; BH1640; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (345 aa) |
| | mtrA | GTP cyclohydrolase I; BH1646. (188 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (147 aa) |
| | bmrU | Multidrug resistance protein; BH1774. (311 aa) |
| | acoC | Acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase); BH1824. (410 aa) |
| | BH1862 | L-arabinose utilization protein; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species. Belongs to the glycerol-1-phosphate dehydrogenase family. (399 aa) |
| | araD | L-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (231 aa) |
| | araB | L-ribulokinase; BH1872. (563 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (497 aa) |
| | BH1885 | BH1885; unknown conserved protein. (251 aa) |
| | thiC | Thiamin biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (595 aa) |
| | BH1953 | BH1953; unknown conserved protein. (295 aa) |
| | BH2041 | BH2041; unknown conserved protein. (376 aa) |
| | BH2205 | Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (411 aa) |
| | BH2206 | Oxoglutarate dehydrogenase; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (945 aa) |
| | nadE | NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (272 aa) |
| | BH2314 | Fructose bisphosphate aldolase; Produces dihydroxyacetone phosphate (DHAP or glycerone phosphate) and malonic semialdehyde (MSA or 3-oxopropanoate) from 6- phospho-5-dehydro-2-deoxy-D-gluconate (DKGP); Belongs to the class II fructose-bisphosphate aldolase family. IolJ subfamily. (288 aa) |
