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BPSL0509 BPSL0509 aroA aroA BPSL0684 BPSL0684 aroC aroC aroA/tyrA aroA/tyrA BPSL2825 BPSL2825 aroE aroE aroQ1 aroQ1 trpE trpE trpG trpG trpD trpD trpC trpC aroB aroB aroK aroK aroQ2 aroQ2 aroE-2 aroE-2 trpA trpA trpB trpB trpF trpF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
BPSL0509Similar to Yersinia pestis putative glycosyl transferase ypo2522 SWALL:Q8ZDN8 (EMBL:AJ414152) (319 aa) fasta scores: E(): 5.8e-38, 43.33% id in 300 aa, and weakly similar Bradyrhizobium japonicum anthranilate phosphoribosyltransferase TrpD SWALL:TRPD_BRAJA (SWALL:P94326) (337 aa) fasta scores: E(): 4.7e-06, 24.41% id in 299 aa. (326 aa)
aroAPutative 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (451 aa)
BPSL0684Putative 3-phosphoskimimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (435 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (369 aa)
aroA/tyrA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (753 aa)
BPSL2825Conserved hypothetical protein; Similar to Ralstonia solanacearum putative para-aminobenzoate synthetase component I protein PabB or rsc2633 or rs05772 SWALL:Q8XW42 (EMBL:AL646071) (626 aa) fasta scores: E(): 1.4e-57, 50.88% id in 676 aa, and to Neisseria meningitidis para-aminobenzoate synthetase component i/4-amino-4-deoxychorismate lyase, putative nmb1970 SWALL:Q9JXM6 (EMBL:AE002545) (593 aa) fasta scores: E(): 1e-42, 41.3% id in 661 aa, and to Neisseria meningitidis putative para-aminobenzoate synthase component I nma0477 SWALL:Q9JW99 (EMBL:AL162753) (598 aa) fasta scores: E(): 1.7 [...] (672 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (292 aa)
aroQ13-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (150 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (497 aa)
trpGSimilar to Pseudomonas aeruginosa anthranilate synthase component II TrpG or Pa0649 SWALL:TRPG_PSEAE (SWALL:P20576) (201 aa) fasta scores: E(): 2.3e-46, 64.58% id in 192 aa. (196 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (343 aa)
trpCSimilar to Pseudomonas aeruginosa indole-3-glycerol phosphate synthase TrpC or Pa0651 SWALL:TRPC_PSEAE (SWALL:P20577) (278 aa) fasta scores: E(): 2.7e-56, 63.07% id in 260 aa; Belongs to the TrpC family. (261 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (359 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (184 aa)
aroQ23-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
aroE-2Similar to Corynebacterium glutamicum shikimate 5-dehydrogenase AroE or cgl0424 SWALL:AROE_CORGL (SWALL:Q9X5C9) (280 aa) fasta scores: E(): 8.9e-36, 48.39% id in 281 aa, and to Ralstonia solanacearum probable shikimate 5-dehydrogenase oxidoreductase protein rsp1398 or rs02060 SWALL:Q8XQ88 (EMBL:AL646084) (315 aa) fasta scores: E(): 3.2e-68, 72.92% id in 277 aa. (284 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (271 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (397 aa)
trpFSimilar to Pseudomonas aeruginosa N-(5'-phosphoribosyl)anthranilate isomerase TrpF or pa3113 SWALL:TRPF_PSEAE (SWALL:Q59649) (211 aa) fasta scores: E(): 9.4e-34, 51.64% id in 213 aa, and to Acinetobacter calcoaceticus N-(5'-phosphoribosyl)anthranilate isomerase TrpF SWALL:TRPF_ACICA (SWALL:P16923) (213 aa) fasta scores: E(): 2.8e-28, 45.41% id in 218 aa. CDS is extended at the N-terminus in comparison to orthologues. (254 aa)
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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