STRINGSTRING
murA murA mrcA mrcA BPSS0238 BPSS0238 murI murI BPSS0451 BPSS0451 mreB-2 mreB-2 amj amj BPSS0984 BPSS0984 ftsI-3 ftsI-3 BPSS1239 BPSS1239 BPSS2304 BPSS2304 ftsI-2 ftsI-2 rodA rodA mrdA mrdA BPSL0184 BPSL0184 BPSL0185 BPSL0185 mreB mreB glmU glmU BPSL0408 BPSL0408 BPSL0657 BPSL0657 murB murB murJ murJ BPSL1055 BPSL1055 uppP1 uppP1 BPSL1512 BPSL1512 BPSL2015 BPSL2015 BPSL2104 BPSL2104 BPSL2297 BPSL2297 nagZ nagZ uppP2 uppP2 wbiH wbiH mtgA mtgA mpl mpl ddlB ddlB murC murC murG murG ftsW ftsW murD murD mraY mraY murF murF murE murE ftsI ftsI
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (449 aa)
mrcASimilar to Escherichia coli penicillin-binding protein 1A MrcA or PonA or b3396 SWALL:PBPA_ECOLI (SWALL:P02918) (850 aa) fasta scores: E(): 1.9e-88, 38.63% id in 818 aa. (773 aa)
BPSS0238Similar to Bacillus subtilis penicillin-binding protein 1A/1B PonA SWALL:PBPA_BACSU (SWALL:P39793) (914 aa) fasta scores: E(): 8.7e-44, 30.94% id in 685 aa, and to Escherichia coli penicillin-binding protein 1B MrcB or PonB or PbpF or b0149 SWALL:PBPB_ECOLI (SWALL:P02919) (844 aa) fasta scores: E(): 9.3e-43, 31.98% id in 591 aa. (720 aa)
murIPutative glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (290 aa)
BPSS0451Family S11 unassigned peptidase; C-terminal region is similar to Escherichia coli, and Shigella flexneri penicillin-binding protein 7 precursor PbpG or b2134 or sf2219 or s2348 SWALL:PBP7_ECOLI (SWALL:P33364) (313 aa) fasta scores: E(): 2.9e-36, 46.69% id in 272 aa. Full length CDS is similar to Ralstonia solanacearum putative D-alanyl-D-alanine-endopeptidase rsc1609 or rs03972 SWALL:Q8XYZ7 (EMBL:AL646065) (375 aa) fasta scores: E(): 1.2e-51, 47.82% id in 345 aa; Belongs to the peptidase S11 family. (362 aa)
mreB-2Rod shape-determining protein; Similar to Escherichia coli, Salmonella typhimurium, Salmonella typhi, and Shigella flexneri rod shape-determining protein MreB SWALL:MREB_ECOLI (SWALL:P13519) (347 aa) fasta scores: E(): 3.8e-57, 51.43% id in 348 aa, and to Ralstonia solanacearum probable rod shape-determining protein rsc0059 or rs01882 SWALL:Q8Y3C1 (EMBL:AL646057) (347 aa) fasta scores: E(): 3.5e-63, 54.95% id in 333 aa. Similar to BPSL0186, 54.955% identity (54.955% ungapped) in 333 aa overlap. (354 aa)
amjPutative membrane protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (267 aa)
BPSS0984Similar to Escherichia coli, and Shigella flexneri UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA or MurZ SWALL:MURA_ECOLI (SWALL:P28909) (419 aa) fasta scores: E(): 3.9e-30, 31.79% id in 434 aa, and to Borrelia burgdorferi UDP-N-acetylglucosamine 1-carboxyvinyltransferase bb0472 SWALL:MURA_BORBU (SWALL:O51428) (427 aa) fasta scores: E(): 9.1e-49, 33.95% id in 430 aa. (433 aa)
ftsI-3Putative penicillin-binding protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (594 aa)
BPSS1239Family S11 unassigned peptidase; Similar to Pseudomonas putida D-alanyl-D-alanine carboxypeptidase DacA or pp4803 SWALL:AAN70372 (EMBL:AE016792) (386 aa) fasta scores: E(): 3.1e-33, 42.75% id in 276 aa, and to Ralstonia solanacearum probable penicillin-binding Dac or rsc0327 or rs03294 SWALL:Q8Y2K8 (EMBL:AL646058) (397 aa) fasta scores: E(): 4.4e-45, 44.87% id in 312 aa, and to Xanthomonas axonopodis penicillin-binding protein 6 DacC or xac0664 SWALL:Q8PPM2 (EMBL:AE011695) (401 aa) fasta scores: E(): 1.2e-33, 38.8% id in 268 aa; Belongs to the peptidase S11 family. (333 aa)
BPSS2304Penicillin-binding protein; Internal region is similar to an internal region of Escherichia coli penicillin-binding protein 1A MrcA or PonA SWALL:PBPA_ECOLI (SWALL:P02918) (850 aa) fasta scores: E(): 1.4e-21, 30.8% id in 737 aa. C-terminal region is similar to Chlorobium tepidum penicillin-binding protein 1 CT0176 SWALL:AAM71424 (EMBL:AE012797) (763 aa) fasta scores: E(): 1.5e-58, 36.31% id in 771 aa. (839 aa)
ftsI-2Similar to Neisseria gonorrhoeae penicillin-binding protein 2 PenA SWALL:PBP2_NEIGO (SWALL:P08149) (581 aa) fasta scores: E(): 1.9e-65, 37.97% id in 574 aa, and to Ralstonia solanacearum probable penicillin-binding 3 precursor pbp-3 transmembrane protein FtsI or rsc2850 or rs00255 SWALL:Q8XVI1 (EMBL:AL646072) (595 aa) fasta scores: E(): 1e-84, 46.4% id in 556 aa, and to Xanthomonas axonopodis penicillin-binding protein 3 FtsI or xac0774 SWALL:AAM35662 (EMBL:AE011708) (622 aa) fasta scores: E(): 2.7e-68, 40.76% id in 547 aa. (570 aa)
rodARod shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (382 aa)
mrdAPenicillin-binding protein; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (818 aa)
BPSL0184Similar to Escherichia coli rod shape-determining protein MreD SWALL:MRED_ECOLI (SWALL:P16927) (162 aa) fasta scores: E(): 1.4e-06, 29.41% id in 153 aa, and to Ralstonia solanacearum probable rod shape-determining mred transmembrane protein rsc0061 or rs01884 SWALL:Q8Y3B9 (EMBL:AL646057) (170 aa) fasta scores: E(): 2.7e-43, 65.29% id in 170 aa. (170 aa)
BPSL0185Similar to Escherichia coli rod shape-determining protein MreC SWALL:MREC_ECOLI (SWALL:P16926) (367 aa) fasta scores: E(): 4e-23, 32.77% id in 357 aa, and to Ralstonia solanacearum probable rod shape-determining MreC transmembrane protein rsc0060 or rs01883 SWALL:Q8Y3C0 (EMBL:AL646057) (346 aa) fasta scores: E(): 2.1e-44, 46.62% id in 356 aa. (357 aa)
mreBPutative rod shape-determining protein; Similar to Escherichia coli, Salmonella typhimurium, and Salmonella typhi rod shape-determining protein MreB or EnvB or RodY SWALL:MREB_ECOLI (SWALL:P13519) (347 aa) fasta scores: E(): 1.7e-87, 71.14% id in 350 aa, and to Ralstonia solanacearum probable rod shape-determining protein rsc0059 or rs01882 SWALL:Q8Y3C1 (EMBL:AL646057) (347 aa) fasta scores: E(): 1.9e-114, 93.66% id in 347 aa. Similar to BPSS0633, 54.955% identity (54.955% ungapped) in 333 aa overlap. (347 aa)
glmUBifunctional glmU protein [includes: UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferas [...] (453 aa)
BPSL0408Similar to Escherichia coli penicillin-binding protein 6 precursor DacC SWALL:DACC_ECOLI (SWALL:P08506) (400 aa) fasta scores: E(): 5.8e-48, 42.21% id in 379 aa, and to Ralstonia solanacearum probable penicillin-binding rsc0327 or rs03294 SWALL:Q8Y2K8 (EMBL:AL646058) (397 aa) fasta scores: E(): 1.8e-79, 58.8% id in 403 aa; Belongs to the peptidase S11 family. (403 aa)
BPSL0657Similar to Ralstonia solanacearum hypothetical protein rsc0514 or rs04986 SWALL:Q8Y222 (EMBL:AL646059) (352 aa) fasta scores: E(): 3.9e-76, 59.3% id in 344 aa, and to Pseudomonas aeruginosa hypothetical protein SWALL:Q9X4N9 (EMBL:AF116284) (338 aa) fasta scores: E(): 1.5e-56, 47.23% id in 343 aa. (344 aa)
murBPutative UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (349 aa)
murJMviN-like protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (516 aa)
BPSL1055murein-DD-endopeptidase; Similar to Escherichia coli penicillin-binding protein 7 precursor PbpG or b2134 SWALL:PBP7_ECOLI (SWALL:P33364) (313 aa) fasta scores: E(): 1.8e-32, 44.35% id in 257 aa, and to Ralstonia solanacearum putative D-alanyl-D-alanine-endopeptidase rsc1609 or rs03972 SWALL:Q8XYZ7 (EMBL:AL646065) (375 aa) fasta scores: E(): 7.6e-44, 45.56% id in 338 aa; Belongs to the peptidase S11 family. (378 aa)
uppP1Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (276 aa)
BPSL1512Conserved hypothetical protein; Similar to Ralstonia solanacearum probable transmembrane protein rsc1214 or rs02709 SWALL:Q8Y030 (EMBL:AL646063) (367 aa) fasta scores: E(): 5.1e-17, 34.87% id in 367 aa, and to Escherichia coli hypothetical protein YfgA or b2516 SWALL:YFGA_ECOLI (SWALL:P27434) (337 aa) fasta scores: E(): 3.3e-06, 27.85% id in 341 aa. (362 aa)
BPSL2015Putative membrane attached glycosyl hydrolase; Similar to Alteromonas sp. beta-hexosaminidase A precursor Cht60 SWALL:HEXA_ALTSO (SWALL:P48823) (598 aa) fasta scores: E(): 2.1e-59, 35.98% id in 628 aa, and to Ralstonia solanacearum putative hydrolase glycosidase protein rsc0769 or rs05085 SWALL:Q8Y1C1 (EMBL:AL646060) (734 aa) fasta scores: E(): 3.1e-152, 61.84% id in 684 aa; Belongs to the glycosyl hydrolase 3 family. (682 aa)
BPSL2104Putative penicillin-binding protein; Similar to Ralstonia solanacearum probable penicillin-binding 1 rsc2976 or rs01357 SWALL:Q8XV55 (EMBL:AL646073) (801 aa) fasta scores: E(): 2.2e-183, 61.61% id in 805 aa, and to Neisseria lactamica penicillin-binding protein 1A MrcA or PonA SWALL:PBPA_NEILA (SWALL:O87579) (798 aa) fasta scores: E(): 4.3e-129, 47.4% id in 791 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. (852 aa)
BPSL2297Family S11 unassigned peptidase; Similar to the C-terminus of Escherichia coli penicillin-binding protein 7 precursor PbpG SWALL:PBP7_ECOLI (SWALL:P33364) (313 aa) fasta scores: E(): 6.5e-40, 47.84% id in 278 aa, and to the full length Ralstonia solanacearum putative D-alanyl-D-alanine-endopeptidase rsc1609 or rs03972 SWALL:Q8XYZ7 (EMBL:AL646065) (375 aa) fasta scores: E(): 5.4e-63, 55.52% id in 353 aa. (359 aa)
nagZPutative beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (342 aa)
uppP2Putative undecaprenol kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (276 aa)
wbiHPreviously sequenced as Burkholderia pseudomallei putative undecaprenyl phosphate N-acetylglucosaminyltransferase WbiH SWALL:O69129 (EMBL:AF064070) (336 aa) fasta scores: E(): 1e-130, 100% id in 336 aa. Also similar to Xanthomonas axonopodis lipopolysaccharide core biosynthesis protein rfb303 or xac2294 SWALL:AAM37147 (EMBL:AE011866) (322 aa) fasta scores: E(): 8.6e-23, 34.51% id in 310 aa. (336 aa)
mtgAPutative peptidoglycan biosynthesis-related protein; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (256 aa)
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (494 aa)
ddlBD-alanine--d-alanine ligase B; Cell wall formation. (312 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (465 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (367 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (430 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (496 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (389 aa)
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (468 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (514 aa)
ftsIPeptidoglycan synthetase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (614 aa)
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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