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cobC cobC cobT cobT cobS cobS cobD cobD BPSL0986 BPSL0986 cobQ cobQ BPSL1723 BPSL1723 BPSL1747 BPSL1747 cobM cobM cobK cobK cbiD cbiD cobL cobL cobH cobH cobI cobI cobJ cobJ BPSL1771 BPSL1771 cobO cobO cobB cobB cobD-2 cobD-2 BPSL2735 BPSL2735 BPSL2785 BPSL2785 BPSL2841 BPSL2841 BPSL3085 BPSL3085 BPSS0361 BPSS0361 BPSS0825 BPSS0825 BPSS1798 BPSS1798
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cobCPutative cobalamin biosynthesis aminotransferase protein; Similar to Pseudomonas denitrificans CobC protein SWALL:COBC_PSEDE (SWALL:P21633) (333 aa) fasta scores: E(): 2.2e-31, 43.06% id in 339 aa, and to Ralstonia solanacearum probable cobalamin biosynthesis protein pyridoxal-phosphate-dependent aminotransferase rsc2393 or rs02729 SWALL:Q8XWS7 (EMBL:AL646069) (350 aa) fasta scores: E(): 2.5e-62, 57.18% id in 341 aa, and to Xanthomonas axonopodis cobalamin biosynthetic protein xac3189 SWALL:AAM38033 (EMBL:AE011964) (327 aa) fasta scores: E(): 1.7e-49, 51.07% id in 327 aa. (350 aa)
cobTPutative nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (352 aa)
cobSPutative cobalamin [5'-phosphate] synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (252 aa)
cobDPutative cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (314 aa)
BPSL0986Putative bifunctional cobalamin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (185 aa)
cobQPutative cobyric acid synthase protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (486 aa)
BPSL1723Hypothetical protein; No significant database matches. (366 aa)
BPSL1747Similar to Pseudomonas aeruginosa hypothetical protein pa1329 SWALL:Q9I415 (EMBL:AE004562) (143 aa) fasta scores: E(): 5.2e-18, 53.73% id in 134 aa, and to Burkholderia sp. RP007 hypothetical 15.7 kDa protein PhnX SWALL:Q9RB84 (EMBL:AF112137) (149 aa) fasta scores: E(): 1.5e-09, 42.33% id in 137 aa. Note: This CDS is shorter in its N-terminal region than most of its database matches. (149 aa)
cobMSimilar to Rhodococcus erythropolis precorrin-4 C11-methyltransferase CobM SWALL:COBM_RHOER (SWALL:Q53138) (249 aa) fasta scores: E(): 3.3e-43, 52.69% id in 241 aa, and to Pseudomonas denitrificans precorrin-4 C11-methyltransferase CobM SWALL:COBM_PSEDE (SWALL:P21922) (253 aa) fasta scores: E(): 1.1e-41, 52.43% id in 246 aa. (241 aa)
cobKSimilar to Rhodococcus erythropolis precorrin-6X reductase CobK SWALL:COBK_RHOER (SWALL:Q53139) (248 aa) fasta scores: E(): 1.2e-30, 45.56% id in 248 aa, and to Streptomyces coelicolor putative precorrin-6X reductase sco3283 or sce39.33C SWALL:Q9X8F6 (EMBL:AL049573) (255 aa) fasta scores: E(): 5.9e-32, 48.81% id in 252 aa. (242 aa)
cbiDPutative cobalamin biosynthesis-related protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (363 aa)
cobLSimilar to Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] cobL SWALL:COBL_PSEDE (SWALL:P21921) (413 aa) fasta scores: E(): 7.9e-67, 49.62% id in 401 aa, and to Brucella melitensis precorrin-6Y C5,15-methyltransferase bmei0716 SWALL:Q8YHT0 (EMBL:AE009513) (401 aa) fasta scores: E(): 1.9e-90, 61.71% id in 397 aa. (408 aa)
cobHSimilar to Pseudomonas denitrificans precorrin-8X methylmutase CobH SWALL:COBH_PSEDE (SWALL:P21638) (210 aa) fasta scores: E(): 3.7e-44, 66.33% id in 202 aa, and to Brucella melitensis precorrin-8X methylmutase bmei0714 SWALL:Q8YHT2 (EMBL:AE009513) (208 aa) fasta scores: E(): 3.5e-55, 75.48% id in 208 aa. (208 aa)
cobIPrecorrin-2 C20-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. (244 aa)
cobJSimilar to Pseudomonas denitrificans precorrin-3b C17-methyltransferase CobJ SWALL:COBJ_PSEDE (SWALL:P21640) (254 aa) fasta scores: E(): 1.1e-35, 52.2% id in 249 aa, and to C-terminal region to Mycobacterium tuberculosis cobalamin biosynthesis protein rv2066 or mt2126 or mtcy49.05 SWALL:COBI_MYCTU (SWALL:Q10677) (508 aa) fasta scores: E(): 1.8e-31, 40% id in 365 aa. (616 aa)
BPSL1771Putative cobalamin biosynthesis related protein; Similar to C-terminal region of Ralstonia solanacearum putative precorrin methylase protein CbiG or rsp0619 or rs03748 SWALL:Q8XS62 (EMBL:AL646079) (254 aa) fasta scores: E(): 4.8e-06, 46.85% id in 143 aa, and to Pseudomonas denitrificans CobE protein SWALL:COBE_PSEDE (SWALL:P21635) (154 aa) fasta scores: E(): 0.36, 31.97% id in 147 aa. Possible gene remnant. (150 aa)
cobOCobalamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (200 aa)
cobBSimilar to Pseudomonas aeruginosa cobyrinic acid A,C-diamide synthase CobB or pa1273 SWALL:COBB_PSEAE (SWALL:Q9I471) (435 aa) fasta scores: E(): 2.8e-48, 49.81% id in 528 aa, and to Bacillus megaterium cobyrinic acid A,C-diamide synthase CobB or CbiA SWALL:COBB_BACME (SWALL:O87698) (460 aa) fasta scores: E(): 4.4e-16, 29.29% id in 536 aa. Note: This CDS contains an unique region from approximately residue 225 to approximately residue 340 that has no similarity to any of the database matches. (535 aa)
cobD-2Putative membrane protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (329 aa)
BPSL2735Putative oxidoreductase; Similar to many including: Ralstonia solanacearum probable oxidoreductase protein rsp0614 or rs03753 SWALL:Q8XS67 (EMBL:AL646079) (216 aa) fasta scores: E(): 7.4e-61, 71.15% id in 208 aa and to Thermus thermophilus NADH dehydrogenase Nox SWALL:NOX_THETH (SWALL:Q60049) (205 aa) fasta scores: E(): 0.00054, 29.7% id in 202 aa. (219 aa)
BPSL2785Putative exported protein; No significant database matches. (390 aa)
BPSL2841Similar to Ralstonia solanacearum hypothetical protein rsc2663 or rs04544 SWALL:Q8XW12 (EMBL:AL646071) (185 aa) fasta scores: E(): 4.8e-55, 80.11% id in 181 aa, and to Xanthomonas campestris hypothetical protein Xcc0796 SWALL:AAM40111 (EMBL:AE012179) (185 aa) fasta scores: E(): 2.8e-38, 60% id in 185 aa, and to Xanthomonas axonopodis hypothetical protein Xac0870 SWALL:AAM35758 (EMBL:AE011718) (185 aa) fasta scores: E(): 1.6e-36, 57.83% id in 185 aa; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
BPSL3085Similar to Ralstonia solanacearum hypothetical protein Rsc3157 or Rs00441 SWALL:Q8XUN0 (EMBL:AL646074) (278 aa) fasta scores: E(): 5e-95, 83.75% id in 277 aa. (298 aa)
BPSS0361Conserved hypothetical protein; Similar to Escherichia coli, and Escherichia coli O6 protein GlcG or b2977 or c3706 SWALL:GLCG_ECOLI (SWALL:P45504) (134 aa) fasta scores: E(): 1.9e-20, 49.24% id in 132 aa, and to Pseudomonas aeruginosa hypothetical protein pa5352 SWALL:Q9HTK6 (EMBL:AE004947) (133 aa) fasta scores: E(): 6.9e-22, 53.38% id in 133 aa. (136 aa)
BPSS0825Hypothetical protein; Poor database matches. C-terminus is similar to the C-terminal region of Rhizobium loti hypothetical protein mlr1181 SWALL:Q98L47 (EMBL:AP002996) (218 aa) fasta scores: E(): 1.8e-12, 34.54% id in 165 aa. Possible alternative translational start site. (235 aa)
BPSS1798Similar to Agrobacterium tumefaciens hypothetical protein atu5140 or agr_pat_202 SWALL:Q8UKG9 (EMBL:AE008938) (238 aa) fasta scores: E(): 9.5e-47, 60.6% id in 231 aa, and to Pseudomonas aeruginosa hypothetical protein pa2034 SWALL:Q9I281 (EMBL:AE004629) (224 aa) fasta scores: E(): 1.4e-16, 38.24% id in 217 aa. (237 aa)
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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