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tnpA-5 tnpA-5 gyrB gyrB oprB oprB BPSL1003 BPSL1003 tnpA tnpA amrB amrB amrA amrA amrR amrR tnpA-2 tnpA-2 tnpA-3 tnpA-3 gyrA gyrA tnpA-4 tnpA-4 flhB flhB cheA cheA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tnpA-5Similar to Bordetella parapertussis transposase for insertion sequence element IS1001 TnpA SWALL:TNPA_BORPA (SWALL:Q06126) (406 aa) fasta scores: E(): 6.2e-138, 78.07% id in 406 aa, and to Ralstonia solanacearum ISrso15-transposase protein rsp1547 or rs02103 or rsc2573 or rs00774 SWALL:Q8XFK1 (EMBL:AL646085) (406 aa) fasta scores: E(): 8.5e-161, 91.62% id in 406 aa. (406 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (822 aa)
oprBSimilar to Pseudomonas aeruginosa outer membrane protein OprM precursor pa0427 SWALL:OPRM_PSEAE (SWALL:Q51487) (485 aa) fasta scores: E(): 4.1e-85, 55.67% id in 476 aa, and to Xanthomonas axonopodis outer membrane protein xac2842 SWALL:AAM37687 (EMBL:AE011925) (503 aa) fasta scores: E(): 5.8e-84, 53.72% id in 497 aa. (514 aa)
BPSL1003Putative ornithine decarboxylase; Similar to, although longer in its N-terminal region than, Escherichia coli ornithine decarboxylase, inducible SpeF or b0693 SWALL:DCOS_ECOLI (SWALL:P24169) (732 aa) fasta scores: E(): 4.5e-73, 32.64% id in 680 aa, and to Ralstonia solanacearum probable biodegradative arginine decarboxylase protein rsc2365 or rs01181 SWALL:Q8XWV5 (EMBL:AL646069) (759 aa) fasta scores: E(): 1.1e-198, 79.68% id in 768 aa. (759 aa)
tnpATransposase; Highly similar to to Bordetella parapertussis transposase for insertion sequence element IS1001 TnpA SWALL:TNPA_BORPA (SWALL:Q06126) (406 aa) fasta scores: E(): 2.5e-139, 78.57% id in 406 aa, and to Tnp SWALL:Q9FDC1 (EMBL:AF285635) (386 aa) fasta scores: E(): 1.5e-161, 99.22% id in 386 aa. CDS is extended at the N-terminus in comparison to B. mallei protein. (406 aa)
amrBMultidrug efflux system transporter protein AmrB; Almost identical to previously sequenced Burkholderia pseudomallei putative transporter AmrB SWALL:O87936 (EMBL:AF072887) (1043 aa) fasta scores: E(): 0, 99.8% id in 1043 aa. Similar to Escherichia coli acriflavine resistance protein B AcrB or AcrE or b0462 SWALL:ACRB_ECOLI (SWALL:P31224) (1049 aa) fasta scores: E(): 5.5e-199, 51.79% id in 1033 aa. (1043 aa)
amrAAlmost identical to Burkholderia pseudomallei putative membrane fusion protein AmrA SWALL:O87935 (EMBL:AF072887) (399 aa) fasta scores: E(): 7.7e-133, 99.74% id in 399 aa. Similar to Escherichia coli, and Escherichia coli O157:H7 acriflavine resistance protein A precursor AcrA or MtcA or Lir or b0463 or z0578 or ecs0516 SWALL:ACRA_ECO57 (SWALL:P31223) (397 aa) fasta scores: E(): 3.5e-43, 40.1% id in 384 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (399 aa)
amrRTetR family regulatory protein; Almost identical to Burkholderia pseudomallei regulator AmrR SWALL:O87934 (EMBL:AF072887) (187 aa) fasta scores: E(): 1e-64, 99.42% id in 173 aa. Similar to Ralstonia solanacearum putative AcrAB operon repressor transcription regulator protein AcrR or rsc0012 or rs01834 SWALL:Q8Y3G8 (EMBL:AL646057) (219 aa) fasta scores: E(): 4.2e-21, 38.22% id in 225 aa. Note: This CDS is longer than the previously sequenced AmrR in its C-terminal region, it is possible that the previous sequence submitted to the databases had a sequencing error that led to a frameshift [...] (223 aa)
tnpA-2Transposase; Similar to Bordetella parapertussis transposase for insertion sequence element IS1001 TnpA SWALL:TNPA_BORPA (SWALL:Q06126) (406 aa) fasta scores: E(): 3.6e-138, 78.32% id in 406 aa, and to Burkholderia mallei transposase Tnp SWALL:Q9FDC1 (EMBL:AF285635) (386 aa) fasta scores: E(): 3.8e-162, 99.22% id in 386 aa. CDS is extended at the N-terminus in comparison to B. mallei protein. (406 aa)
tnpA-3Transposase; Similar to Bordetella parapertussis transposase for insertion sequence element IS1001 TnpA SWALL:TNPA_BORPA (SWALL:Q06126) (406 aa) fasta scores: E(): 3.6e-138, 78.32% id in 406 aa, and to Burkholderia mallei transposase Tnp SWALL:Q9FDC1 (EMBL:AF285635) (386 aa) fasta scores: E(): 3.8e-162, 99.22% id in 386 aa. CDS is extended at the N-terminus in comparison to B. mallei protein. (406 aa)
gyrADNA Gyrase, subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (866 aa)
tnpA-4Transposase; Similar to Bordetella parapertussis transposase for insertion sequence element IS1001 TnpA SWALL:TNPA_BORPA (SWALL:Q06126) (406 aa) fasta scores: E(): 3.6e-138, 78.32% id in 406 aa, and to Burkholderia mallei transposase Tnp SWALL:Q9FDC1 (EMBL:AF285635) (386 aa) fasta scores: E(): 3.8e-162, 99.22% id in 386 aa. CDS is extended at the N-terminus in comparison to the B. mallei protein. (406 aa)
flhBFlagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (405 aa)
cheAChemotaxis two-component sensor kinase CheA; Similar to Escherichia coli chemotaxis protein CheA or b1888 SWALL:CHEA_ECOLI (SWALL:P07363) (654 aa) fasta scores: E(): 9.5e-76, 56.14% id in 741 aa. (747 aa)
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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