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adhC adhC gpmA gpmA pgk pgk pykA pykA cbbA cbbA flhA flhA BPSL1020 BPSL1020 tpiA tpiA pckG pckG BPSL1380 BPSL1380 pgi pgi BPSL1550 BPSL1550 odhL odhL ppsA ppsA eno eno BPSL2299 BPSL2299 pdhB pdhB pdhA pdhA fbp fbp glk glk pgm pgm BPSL2902 BPSL2902 gapA gapA BPSL2964 BPSL2964 acoD acoD pyk pyk acoE acoE BPSS0618 BPSS0618 BPSS1413 BPSS1413 BPSS1466 BPSS1466 aceE aceE BPSS1918 BPSS1918 adhA adhA BPSS1957 BPSS1957 BPSS2067 BPSS2067 lpdV lpdV
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
adhCNADP-dependent alcohol dehydrogenase; Similar to Mycobacterium tuberculosis, and Mycobacterium bovis NADP-dependent alcohol dehydrogenase AdhC or Adh SWALL:ADH_MYCTU (SWALL:P31975) (346 aa) fasta scores: E(): 3.3e-68, 56% id in 350 aa, and to Xylella fastidiosa NADP-alcohol dehydrogenase XF1136 SWALL:Q9PE92 (EMBL:AE003949) (352 aa) fasta scores: E(): 3.9e-72, 58.48% id in 342 aa. (354 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (249 aa)
pgkSimilar to Escherichia coli phosphoglycerate kinase Pgk or b2926 SWALL:PGK_ECOLI (SWALL:P11665) (386 aa) fasta scores: E(): 1.8e-80, 63.7% id in 394 aa, and to Ralstonia solanacearum phosphoglycerate kinase Pgk or rsc0571 or rs04894 SWALL:Q8Y1W6 (EMBL:AL646060) (419 aa) fasta scores: E(): 1.7e-115, 85.64% id in 397 aa. (397 aa)
pykAPutative pyruvate kinase II protein; Similar to Pseudomonas hydrogenothermophila pyruvate kinase Pyk SWALL:Q9LBF0 (EMBL:AB042618) (473 aa) fasta scores: E(): 5.5e-91, 58.82% id in 476 aa, and to Ralstonia solanacearum probable pyruvate kinase II protein rsc0572 or rs04893 SWALL:Q8Y1W5 (EMBL:AL646060) (479 aa) fasta scores: E(): 2.9e-131, 78.49% id in 479 aa. (478 aa)
cbbAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
flhASimilar to Paracoccus denitrificans glutathione-dependent formaldehyde dehydrogenase FlhA SWALL:FADH_PARDE (SWALL:P45382) (375 aa) fasta scores: E(): 1e-108, 75.2% id in 375 aa, and to Ralstonia solanacearum probable bifunctional: glutathione-dependent formaldehyde dehydrogenase and alcohol dehydrogenase class III oxidoreductase protein AdhC1 or rsp0069 or rs02044 SWALL:Q8XTN7 (EMBL:AL646076) (368 aa) fasta scores: E(): 4e-128, 88.04% id in 368 aa; Upstream repeat region (ggcgc)3; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa)
BPSL1020Similar to Escherichia coli putative aldehyde dehydrogenase AldH or b1300 SWALL:DHAL_ECOLI (SWALL:P23883) (495 aa) fasta scores: E(): 2.3e-61, 41.12% id in 479 aa, and to Ralstonia solanacearum probable aldehyde dehydrogenase oxidoreductase protein rsc2350 or rs01196 SWALL:Q8XWX0 (EMBL:AL646069) (478 aa) fasta scores: E(): 5.1e-138, 73.31% id in 476 aa. (479 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
pckGPhosphoenolpyruvate carboxykinase [GTP]; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (621 aa)
BPSL1380Putative acetyl-CoA synthetase; Similar to Bacillus subtilis acetyl-coenzyme A synthetase AcsA SWALL:ACSA_BACSU (SWALL:P39062) (572 aa) fasta scores: E(): 5.7e-54, 34.63% id in 540 aa, and to Rhizobium loti acetyl-CoA synthetase mll6017 SWALL:Q98AG0 (EMBL:AP003008) (562 aa) fasta scores: E(): 8.3e-119, 55.51% id in 553 aa. (555 aa)
pgiGlucose-6-phosphate isomerase; Similar to Escherichia coli, and Escherichia coli O157:H7 glucose-6-phosphate isomerase Pgi or b4025 or z5623 or ecs5008 SWALL:G6PI_ECOLI (SWALL:P11537) (549 aa) fasta scores: E(): 2.5e-100, 49.9% id in 543 aa, and to Deinococcus radiodurans glucose-6-phosphate isomerase dr1742 SWALL:G6PI_DEIRA (SWALL:Q9RTL8) (541 aa) fasta scores: E(): 7.5e-120, 57.22% id in 540 aa. (540 aa)
BPSL1550Similar to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SWALL:DHAB_BACSU (SWALL:P71016) (490 aa) fasta scores: E(): 1.9e-59, 40.33% id in 476 aa, and to Ralstonia solanacearum putative betaine aldehyde dehydrogenase rsc1456 or rs03851 SWALL:Q8XZE5 (EMBL:AL646064) (478 aa) fasta scores: E(): 1.1e-127, 71.3% id in 474 aa. (478 aa)
odhLSimilar to Alcaligenes eutrophus dihydrolipoamide dehydrogenase OdhL SWALL:DLDH_ALCEU (SWALL:P52992) (474 aa) fasta scores: E(): 9.7e-132, 76.93% id in 477 aa, and to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1271 or rs02809 SWALL:Q8XZX4 (EMBL:AL646063) (478 aa) fasta scores: E(): 2.9e-134, 77.35% id in 477 aa. (476 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (799 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
BPSL2299Putative dihydrolipoamide dehydrogenase; C-terminal region is similar to Escherichia coli, Escherichia coli O6, and Escherichia coli O157:H7 dihydrolipoamide dehydrogenase LpdA or Lpd SWALL:DLDH_ECOLI (SWALL:P00391) (473 aa) fasta scores: E(): 1.9e-93, 65.75% id in 473 aa. Full length CDS is similar to Ralstonia solanacearum probable dihydrolipoamide dehydrogenase rsc1603 or rs03965 SWALL:Q8XZ03 (EMBL:AL646065) (594 aa) fasta scores: E(): 2.1e-142, 76.88% id in 597 aa. (589 aa)
pdhBDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (546 aa)
pdhAPyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (898 aa)
fbpSimilar to Alcaligenes eutrophus fructose-1,6-bisphosphatase, chromosomal CbbfC or cfxF SWALL:F16P_ALCEU (SWALL:P19911) (364 aa) fasta scores: E(): 1.2e-79, 60.41% id in 341 aa, and to Pseudomonas aeruginosa fructose-1,6-bisphosphatase Fbp or pa5110 SWALL:Q9HU73 (EMBL:AE004923) (336 aa) fasta scores: E(): 4.9e-96, 72.23% id in 335 aa. (338 aa)
glkGlucokinase; Similar to Escherichia coli, and Escherichia coli O157:H7 glucokinase Glk or b2388 or z3654 or ecs3268 SWALL:GLK_ECOLI (SWALL:P46880) (321 aa) fasta scores: E(): 9e-49, 46.2% id in 316 aa and to Neisseria meningitidis glucokinase Glk or nma1607 or nmb1390 SWALL:GLK_NEIMA (SWALL:Q9JQX3) (328 aa) fasta scores: E(): 4.6e-57, 49.54% id in 327 aa; In the N-terminal section; belongs to the bacterial glucokinase family. (641 aa)
pgmPhosphoglucomutase; Similar to Neisseria meningitidis phosphoglucomutase Pgm or nmb0790 SWALL:PGMU_NEIMB (SWALL:P40391) (460 aa) fasta scores: E(): 1.2e-98, 56% id in 466 aa and to Ralstonia solanacearum putative phosphomannomutase or phosphoglucomutase protein rsc0691 or rs01596 SWALL:Q8Y1J9 (EMBL:AL646060) (461 aa) fasta scores: E(): 1.6e-123, 68.46% id in 463 aa. (464 aa)
BPSL2902Putative phosphoglycerate mutase; Similar to Escherichia coli, Escherichia coli O157:H7, and Shigella flexneri probable phosphoglycerate mutase GpmB or b4395 or z5997 or ecs5353 or sf4427 SWALL:GPMB_ECOLI (SWALL:P36942) (215 aa) fasta scores: E(): 1.7e-12, 36.19% id in 221 aa, and to Ralstonia solanacearum putative phosphoglycerate mutase 2 protein rsc0499 or rs05023 SWALL:Q8Y237 (EMBL:AL646059) (227 aa) fasta scores: E(): 1.8e-33, 46.84% id in 222 aa. (229 aa)
gapASimilar to Bacillus subtilis glyceraldehyde 3-phosphate dehydrogenase 1 AapA or Gap SWALL:G3P1_BACSU (SWALL:P09124) (334 aa) fasta scores: E(): 2.7e-71, 60.06% id in 333 aa, and to Alcaligenes eutrophus glyceraldehyde 3-phosphate dehydrogenase, plasmid CbbGP SWALL:G3PP_ALCEU (SWALL:P50322) (336 aa) fasta scores: E(): 5.1e-112, 84.52% id in 336 aa; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
BPSL2964Putative epimerase; Similar to Ralstonia solanacearum hypothetical protein rsc2754 or rs00100 SWALL:Q8XVS5 (EMBL:AL646071) (296 aa) fasta scores: E(): 9.1e-52, 49.31% id in 292 aa, and to Rhizobium loti hypothetical protein mlr7196 SWALL:Q986V3 (EMBL:AP003011) (308 aa) fasta scores: E(): 4.7e-33, 35.83% id in 293 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. (327 aa)
acoDSimilar to Alcaligenes eutrophus acetaldehyde dehydrogenase II AcoD SWALL:DHA2_ALCEU (SWALL:P46368) (506 aa) fasta scores: E(): 5.2e-172, 81.02% id in 506 aa. (506 aa)
pykPyruvate kinase; Similar to Bacillus stearothermophilus pyruvate kinase Pyk SWALL:KPYK_BACST (SWALL:Q02499) (587 aa) fasta scores: E(): 1.7e-60, 41.27% id in 470 aa, and to Pseudomonas aeruginosa pyruvate kinase I PykF or pa1498 SWALL:Q9I3L4 (EMBL:AE004578) (477 aa) fasta scores: E(): 1.5e-83, 55.57% id in 466 aa. (484 aa)
acoEAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
BPSS0618AMP-binding enzyme; Similar to Ralstonia solanacearum probable acetyl-coenzyme A synthetase rsp0651 or rs05571 SWALL:Q8XS30 (EMBL:AL646080) (567 aa) fasta scores: E(): 2.8e-165, 75.22% id in 561 aa, and to Streptomyces coelicolor putative acetyl-coenzyme A synthetase SCO6195 or SC2G5.16 SWALL:Q9Z5A7 (EMBL:AL939126) (558 aa) fasta scores: E(): 1.1e-118, 58.46% id in 561 aa. (567 aa)
BPSS1413Putative hydrolase protein; Similar to Bradyrhizobium japonicum Bll1358 protein SWALL:BAC46623 (EMBL:AP005939) (271 aa) fasta scores: E(): 5.4e-28, 44.33% id in 203 aa, and to Xanthomonas axonopodis hydrolase xac3428 SWALL:Q8PH32 (EMBL:AE011989) (205 aa) fasta scores: E(): 4.7e-16, 36.31% id in 201 aa. (204 aa)
BPSS1466Putative aldehyde dehydrogenase family protein; Similar to Streptomyces clavuligerus semialdehyde dehydrogenase Pcd SWALL:O85725 (EMBL:AF073895) (512 aa) fasta scores: E(): 2e-120, 66.05% id in 492 aa, and to Ralstonia solanacearum putative transmembrane aldehyde dehydrogenase oxidoreductase protein rsp1591 or rs02148 SWALL:Q8XPP7 (EMBL:AL646085) (504 aa) fasta scores: E(): 9.4e-134, 69.84% id in 504 aa, and to Rhizobium loti aldehyde dehydrogenase mll2867 SWALL:Q98HH4 (EMBL:AP003000) (504 aa) fasta scores: E(): 4.1e-132, 68.93% id in 499 aa. (503 aa)
aceEPyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (907 aa)
BPSS1918Putative alcohol dehydrogenase; Similar to Ralstonia solanacearum probable alcohol dehydrogenase-like oxidoreductase protein rsc1505 or rs03800 SWALL:Q8XZ99 (EMBL:AL646064) (334 aa) fasta scores: E(): 4.3e-81, 66.26% id in 329 aa, and to Bacillus stearothermophilus alcohol dehydrogenase SWALL:ADH3_BACST (SWALL:P42328) (339 aa) fasta scores: E(): 8.8e-32, 34.02% id in 338 aa. (328 aa)
adhASimilar to Rhizobium meliloti alcohol dehydrogenase AdhA or ra0704 or sma1296 SWALL:ADHA_RHIME (SWALL:O31186) (340 aa) fasta scores: E(): 3e-84, 64.37% id in 334 aa, and to Brucella melitensis alcohol dehydrogenase bmei1746 SWALL:Q8YEY1 (EMBL:AE009608) (373 aa) fasta scores: E(): 4.7e-95, 72.35% id in 340 aa. (341 aa)
BPSS1957Similar to Escherichia coli 6-phosphofructokinase isozyme 2 PfkB or b1723 SWALL:K6P2_ECOLI (SWALL:P06999) (309 aa) fasta scores: E(): 1.8e-31, 39.48% id in 309 aa, and to Salmonella typhimurium 6-phosphofructokinase II Pfkb or stm1326 SWALL:Q8ZPT5 (EMBL:AE008757) (310 aa) fasta scores: E(): 7e-32, 39.15% id in 309 aa; Belongs to the carbohydrate kinase PfkB family. (313 aa)
BPSS2067Putative aldose 1-epimerase; Similar to Rhizobium meliloti hypothetical protein ra0037 or sma0077 SWALL:Q931A7 (EMBL:AE007198) (295 aa) fasta scores: E(): 1.8e-46, 44.33% id in 291 aa, and to Rhizobium loti hypothetical protein mll7370 SWALL:Q986G3 (EMBL:AP003011) (299 aa) fasta scores: E(): 3.6e-39, 40.97% id in 288 aa. (298 aa)
lpdVSimilar to Pseudomonas putida dihydrolipoamide dehydrogenase LpdV SWALL:DLD1_PSEPU (SWALL:P09063) (459 aa) fasta scores: E(): 9.9e-115, 69.09% id in 466 aa, and to Pseudomonas aeruginosa lipoamide dehydrogenase-Val pa2250 SWALL:Q9I1L9 (EMBL:AE004650) (464 aa) fasta scores: E(): 2.6e-123, 71.24% id in 466 aa. (466 aa)
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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