STRINGSTRING
argG argG glmS1 glmS1 BPSL0497 BPSL0497 BPSL0682 BPSL0682 nadB nadB argH argH glmS2 glmS2 carA carA carB carB ansB ansB BPSL1476 BPSL1476 purA purA gabD gabD BPSL1715 BPSL1715 argH-2 argH-2 argG-2 argG-2 BPSL2214 BPSL2214 glnA glnA BPSL2336 BPSL2336 pyrB pyrB BPSL2925 BPSL2925 purB purB glt2 glt2 glt1 glt1 putA putA asnO asnO gabD-2 gabD-2 gabT gabT BPSS0469 BPSS0469 glsA glsA BPSS0677 BPSS0677 ald ald pyrB-2 pyrB-2 BPSS1308 BPSS1308 purF purF glmS3 glmS3 ansA ansA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
argGSimilar to Escherichia coli argininosuccinate synthase ArgG SWALL:ASSY_ECOLI (SWALL:P22767) (446 aa) fasta scores: E(): 1.1e-138, 77.87% id in 443 aa, and to Neisseria meningitidis argininosuccinate synthase nma0303 SWALL:Q9JWM1 (EMBL:AL162752) (447 aa) fasta scores: E(): 1.2e-144, 82.87% id in 438 aa; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (446 aa)
glmS1Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (610 aa)
BPSL0497Putative phosphosugar-binding protein; Similar to Pseudomonas aeruginosa probable aminotransferase pa3759 SWALL:Q9HXN6 (EMBL:AE004794) (340 aa) fasta scores: E(): 1e-70, 65.08% id in 338 aa, and to the C-terminal regions of many glucosamine--fructose-6-phosphate aminotransferases, including of Escherichia coli glucosamine--fructose-6-phosphate aminotransferase [isomerizing] GlmS SWALL:GLMS_ECOLI (SWALL:P17169) (608 aa) fasta scores: E(): 1.8e-09, 28.9% id in 339 aa. (338 aa)
BPSL0682Similar to Escherichia coli asparagine synthetase B [glutamine-hydrolyzing] asnB or b0674 SWALL:ASNB_ECOLI (SWALL:P22106) (553 aa) fasta scores: E(): 7.9e-21, 32.63% id in 524 aa, and to Lactococcus lactis asparagine synthetase B asnB or ll0352 SWALL:Q9CIK5 (EMBL:AE006272) (530 aa) fasta scores: E(): 4.7e-30, 30.04% id in 476 aa, and to Caenorhabditis elegans M02d8.4 protein m02d8.4 SWALL:Q21463 (EMBL:U41034) (567 aa) fasta scores: E(): 6e-28, 30.66% id in 525 aa. (510 aa)
nadBPutative L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (548 aa)
argHSimilar to Escherichia coli argininosuccinate lyase ArgH or b3960 SWALL:ARLY_ECOLI (SWALL:P11447) (457 aa) fasta scores: E(): 9.8e-72, 44.97% id in 458 aa, to Pseudomonas aeruginosa argininosuccinate lyase ArgH or pa5263 SWALL:ARLY_PSEAE (SWALL:P50987) (464 aa) fasta scores: E(): 1.5e-110, 64.51% id in 465 aa, and to Ralstonia solanacearum argininosuccinate lyase rsc2363 or rs01183 SWALL:ARLY_RALSO (SWALL:Q8XWV7) (471 aa) fasta scores: E(): 1.5e-143, 82.09% id in 469 aa. (469 aa)
glmS2Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (633 aa)
carACarbamoyl-phosphate synthase small chain; Similar to Escherichia coli, and Escherichia coli O157:H7 carbamoyl-phosphate synthase small chain CarA or PyrA or b0032 or z0037 or ecs0035 SWALL:CARA_ECOLI (SWALL:P00907) (382 aa) fasta scores: E(): 4.3e-94, 64.87% id in 373 aa, and to Ralstonia solanacearum carbamoyl-phosphate synthase small chain rsc1519 or rs03785 SWALL:CARA_RALSO (SWALL:Q8XZ85) (378 aa) fasta scores: E(): 6.4e-127, 83.28% id in 377 aa; Belongs to the CarA family. (381 aa)
carBSimilar to Escherichia coli carbamoyl-phosphate synthase large chain CarB or PyrA or b0033 SWALL:CARB_ECOLI (SWALL:P00968) (1072 aa) fasta scores: E(): 0, 68.93% id in 1088 aa, and to Ralstonia solanacearum carbamoyl-phosphate synthase large chain rsc1521 or rs03783 SWALL:Q8XZ83 (EMBL:AL646065) (1081 aa) fasta scores: E(): 0, 85.82% id in 1086 aa; Belongs to the CarB family. (1084 aa)
ansBSimilar to Escherichia coli L-asparaginase II precursor AnsB or b2957 SWALL:ASG2_ECOLI (SWALL:P00805) (348 aa) fasta scores: E(): 3.5e-47, 47% id in 334 aa, and to Ralstonia solanacearum probable L-asparaginase II precursor signal peptide protein rsc1306 or rs02828 SWALL:Q8XZT9 (EMBL:AL646063) (367 aa) fasta scores: E(): 3.1e-56, 54.7% id in 351 aa. (347 aa)
BPSL1476Putative aminotransferase; Similar to Ralstonia solanacearum probable aspartate aminotransferase protein rsc1326 or rs02848 SWALL:Q8XZR9 (EMBL:AL646064) (413 aa) fasta scores: E(): 3.1e-130, 76.58% id in 410 aa, and to Escherichia coli probable aminotransferase YfbQ or b2290 SWALL:YFBQ_ECOLI (SWALL:P77727) (405 aa) fasta scores: E(): 6.9e-110, 64.46% id in 408 aa. (412 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (448 aa)
gabDSimilar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or b2661 SWALL:GABD_ECOLI (SWALL:P25526) (482 aa) fasta scores: E(): 2e-126, 66.45% id in 480 aa, and to Pseudomonas aeruginosa succinate-semialdehyde dehydrogenase pa0265 SWALL:Q9I6M5 (EMBL:AE004464) (483 aa) fasta scores: E(): 1e-130, 69.03% id in 478 aa. (486 aa)
BPSL1715Putative bifunctional protein (ligase and argininosuccinate lyase); Similar to full length of Rhizobium loti fusion protein contains putative ligase and probable arginosuccinate lyase msi203 SWALL:CAD31608 (EMBL:AL672113) (899 aa) fasta scores: E(): 5.4e-96, 38.52% id in 911 aa, and C-terminal region similar to Escherichia coli argininosuccinate lyase ArgH or b3960 SWALL:ARLY_ECOLI (SWALL:P11447) (457 aa) fasta scores: E(): 1.2e-25, 32.44% id in 376 aa. (894 aa)
argH-2Similar to Escherichia coli argininosuccinate lyase ArgH or b3960 SWALL:ARLY_ECOLI (SWALL:P11447) (457 aa) fasta scores: E(): 7.9e-63, 43.26% id in 453 aa, and to Bacillus subtilis argininosuccinate lyase ArgH SWALL:ARLY_BACSU (SWALL:O34858) (461 aa) fasta scores: E(): 1.8e-70, 44.13% id in 460 aa. (466 aa)
argG-2Similar to Streptomyces clavuligerus argininosuccinate synthase ArgG SWALL:ASSY_STRCL (SWALL:P50986) (397 aa) fasta scores: E(): 8.4e-49, 35.78% id in 394 aa, and to Thermoanaerobacter tengcongensis argininosuccinate synthase tte2494 SWALL:Q8R7C2 (EMBL:AE013190) (410 aa) fasta scores: E(): 1.9e-70, 44.92% id in 394 aa. (404 aa)
BPSL2214Similar to Rhizobium loti fusion protein contains putative ligase and probable arginosuccinate lyase msi203 SWALL:CAD31608 (EMBL:AL672113) (899 aa) fasta scores: E(): 7.9e-99, 38.19% id in 906 aa, N-terminal region to Rhizobium loti putative ligase/carboxylase protein msi201 SWALL:CAD31606 (EMBL:AL672113) (425 aa) fasta scores: E(): 5.4e-25, 31.08% id in 415 aa and C-terminal region to Rhizobium loti argininosuccinate lyase mll9226 SWALL:Q981V0 (EMBL:AP003015) (927 aa) fasta scores: E(): 4.4e-94, 37.19% id in 898 aa. (898 aa)
glnASimilar to Escherichia coli glutamine synthetase GlnA SWALL:GLNA_ECOLI (SWALL:P06711) (468 aa) fasta scores: E(): 3.4e-133, 65.51% id in 464 aa, and to Ralstonia solanacearum probable glutamine synthetase protein rsc1258 or rs02774 SWALL:Q8XZY7 (EMBL:AL646063) (471 aa) fasta scores: E(): 2e-175, 85.77% id in 471 aa. (471 aa)
BPSL2336Putative glutamine synthetase; Similar to Pseudomonas aeruginosa probable glutamine synthetase pa0298 SWALL:Q9I6J3 (EMBL:AE004467) (452 aa) fasta scores: E(): 1.2e-104, 55.35% id in 448 aa, and to Caulobacter crescentus glutamine synthetase family protein cc3130 SWALL:Q9A3S2 (EMBL:AE005976) (465 aa) fasta scores: E(): 2.5e-109, 61.53% id in 442 aa. BPSS0469, 87.838% identity (87.838% ungapped) in 444 aa overlap. (444 aa)
pyrBSimilar to Ralstonia solanacearum aspartate carbamoyltransferase PyrB or rsc0678 or rs01583 SWALL:PYRB_RALSO (SWALL:Q8Y1L2) (323 aa) fasta scores: E(): 1.7e-105, 88.64% id in 317 aa, and to Pseudomonas aeruginosa aspartate carbamoyltransferase PyrB or pa0402 SWALL:PYRB_PSEAE (SWALL:Q59653) (334 aa) fasta scores: E(): 4e-81, 69.8% id in 308 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (343 aa)
BPSL2925Putative glutamate dehydrogenase; Similar to Bacillus subtilis NAD-specific glutamate dehydrogenase GudB SWALL:GUDB_BACSU (SWALL:P50735) (426 aa) fasta scores: E(): 2.1e-70, 47.51% id in 402 aa, and to Salmonella typhimurium putative homolog of glutamic dehyrogenase stm1795 SWALL:Q8ZP21 (EMBL:AE008780) (441 aa) fasta scores: E(): 2.4e-109, 64.67% id in 419 aa; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (434 aa)
purBAdenylosuccinate lyase; Similar to Escherichia coli, and Escherichia coli O6 adenylosuccinate lyase PurB or b1131 or c1510 SWALL:PUR8_ECOLI (SWALL:P25739) (456 aa) fasta scores: E(): 2.5e-109, 62.55% id in 454 aa, and to Ralstonia solanacearum probable adenylosuccinate lyase protein rsc2720 or rs00002 SWALL:Q8XVV7 (EMBL:AL646071) (457 aa) fasta scores: E(): 9.1e-148, 82.41% id in 455 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. It contains an alternative start codon at residue 22. (483 aa)
glt2Similar to Ralstonia solanacearum probable glutamate synthase GltD or Rsc2964 or Rs01333 SWALL:Q8XV67 (EMBL:AL646072) (487 aa) fasta scores: E(): 2.8e-142, 77.66% id in 488 aa, and to Oryza sativa NADH dependent glutamate synthase precursor SWALL:Q9ZNX7 (EMBL:AB008845) (2166 aa) fasta scores: E(): 6.9e-74, 51.6% id in 500 aa. (506 aa)
glt1Glutamate synthase large subunit; Similar to Synechocystis sp. ferredoxin-dependent glutamate synthase 2 GltS or Sll1499 SWALL:GLTS_SYNY3 (SWALL:P55038) (1556 aa) fasta scores: E(): 0, 43.8% id in 1573 aa, and to Ralstonia solanacearum probable glutamate synthase GltB or Rsc2965 or Rs01332 SWALL:Q8XV66 (EMBL:AL646072) (1582 aa) fasta scores: E(): 0, 83.76% id in 1564 aa. (1567 aa)
putABifunctional PutA protein [includes: proline dehydrogenase (EC 1.5.99.8) (proline oxidase); Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1309 aa)
asnOSimilar to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 3 AsnO SWALL:ASNO_BACSU (SWALL:O05272) (614 aa) fasta scores: E(): 1.6e-68, 42.01% id in 626 aa, and to Streptomyces aureofaciens asparagine synthase homolog TcsG SWALL:Q9FAR2 (EMBL:AB039379) (609 aa) fasta scores: E(): 2.6e-128, 54.76% id in 619 aa. (622 aa)
gabD-2Similar to Escherichia coli succinate-semialdehyde dehydrogenase [NADP+] GabD or b2661 SWALL:GABD_ECOLI (SWALL:P25526) (482 aa) fasta scores: E(): 1.4e-130, 69.7% id in 482 aa, and to Salmonella typhi succinate-semialdehyde dehydrogenase sty2911 SWALL:Q8Z4F8 (EMBL:AL627276) (482 aa) fasta scores: E(): 7.2e-131, 70.12% id in 482 aa. (489 aa)
gabTSimilar to Escherichia coli 4-aminobutyrate aminotransferase GabT or b2662 SWALL:GABT_ECOLI (SWALL:P22256) (426 aa) fasta scores: E(): 4.8e-79, 54.24% id in 424 aa, and to Ralstonia solanacearum probable 4-aminobutyrate aminotransferase protein rsc0029 or rs01852 SWALL:Q8Y3F1 (EMBL:AL646057) (426 aa) fasta scores: E(): 1.5e-108, 71.29% id in 418 aa; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
BPSS0469Similar to Xanthomonas campestris glutamine synthetase GlnA or xcc2346 SWALL:AAM41624 (EMBL:AE012342) (461 aa) fasta scores: E(): 6e-107, 58.63% id in 440 aa, and to Thermotoga maritima glutamine synthetase GlnA or tm0943 SWALL:GLNA_THEMA (SWALL:P36205) (439 aa) fasta scores: E(): 1.9e-29, 28.09% id in 420 aa. (444 aa)
glsASimilar to Rhizobium etli thermolabile glutaminase GlsA SWALL:GLSA_RHIET (SWALL:O87405) (309 aa) fasta scores: E(): 4e-60, 53.44% id in 305 aa, and to Ralstonia solanacearum probable glutaminase A protein rsp1143 or rs05469 SWALL:Q8XQS6 (EMBL:AL646083) (304 aa) fasta scores: E(): 9.9e-96, 78.28% id in 304 aa. (304 aa)
BPSS0677Putative asparagine synthetase; Similar to Burkholderia cepacia genomovar III putative asparagine synthetase SWALL:Q8VP10 (EMBL:AY028431) (656 aa) fasta scores: E(): 6e-206, 74.54% id in 656 aa. N-terminal region is similar to the N-terminal region of Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 2 AsnH SWALL:ASNH_BACSU (SWALL:P42113) (747 aa) fasta scores: E(): 4.6e-23, 27.93% id in 605 aa. (656 aa)
aldSimilar to Vibrio proteolyticus alanine dehydrogenase ald SWALL:O85596 (EMBL:AF070716) (374 aa) fasta scores: E(): 5.5e-77, 63.76% id in 367 aa, and to Vibrio cholerae alanine dehydrogenase vc1905 SWALL:Q9KQU3 (EMBL:AE004266) (374 aa) fasta scores: E(): 3.2e-77, 64.01% id in 364 aa; Belongs to the AlaDH/PNT family. (371 aa)
pyrB-2Similar to Burkholderia cepacia aspartate transcarbamoylase PyrB SWALL:Q9F9H3 (EMBL:AF192346) (431 aa) fasta scores: E(): 1.6e-157, 92.82% id in 432 aa, and to Pisum sativum aspartate carbamoyltransferase 2, chloroplast precursor PyrB2 SWALL:PYB2_PEA (SWALL:Q43087) (385 aa) fasta scores: E(): 2e-42, 43.61% id in 321 aa, and to Pisum sativum aspartate carbamoyltransferase 3, chloroplast precursor PyrB3 SWALL:PYB3_PEA (SWALL:Q43064) (391 aa) fasta scores: E(): 2.3e-42, 42.94% id in 333 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (431 aa)
BPSS1308Asparaginase; Similar to Hordeum vulgare asparaginase SWALL:Q9FUG8 (EMBL:AF308474) (333 aa) fasta scores: E(): 5.1e-26, 39.45% id in 327 aa, and to Ralstonia solanacearum probable L-asparaginase precursor protein rsc1378 or rs04661 SWALL:Q8XZL7 (EMBL:AL646064) (320 aa) fasta scores: E(): 8.2e-30, 62.89% id in 345 aa, and to Oryza sativa putative L-asparaginase h0212b02.5 SWALL:Q9FSS5 (EMBL:AL442007) (333 aa) fasta scores: E(): 1.1e-27, 40.66% id in 332 aa. (348 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (511 aa)
glmS3Putative transposase (fragment); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (605 aa)
ansAL-asparaginase; Similar to Wolinella succinogenes L-asparaginase AnsA SWALL:ASPG_WOLSU (SWALL:P50286) (330 aa) fasta scores: E(): 1.2e-51, 48.32% id in 329 aa, and to Escherichia coli L-asparaginase II precursor AnsB or b2957 SWALL:ASG2_ECOLI (SWALL:P00805) (348 aa) fasta scores: E(): 1.5e-46, 47.23% id in 326 aa. (351 aa)
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.