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BPSL0062 BPSL0062 BPSL0063 BPSL0063 BPSL0371 BPSL0371 BPSL0391 BPSL0391 BPSL0649 BPSL0649 BPSL0650 BPSL0650 BPSL1424 BPSL1424 BPSL1426 BPSL1426 BPSL1488 BPSL1488 phbA phbA BPSL1540 BPSL1540 BPSL2747 BPSL2747 paaF paaF pobA pobA pcaI pcaI pcaJ pcaJ pcaB pcaB BPSS0046 BPSS0046 pcaC pcaC BPSS0939 BPSS0939 pcaH pcaH pcaG pcaG BPSS1791 BPSS1791 mhpE mhpE mhpF mhpF catB catB catA catA catC catC benA benA benB benB benC benC benD benD BPSS2332 BPSS2332
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
BPSL0062Similar to Pseudomonas putida beta-ketoadipyl CoA thiolase PcaF SWALL:PCAF_PSEPU (SWALL:Q51956) (400 aa) fasta scores: E(): 8e-34, 41.8% id in 421 aa, and to Caulobacter crescentus fatty oxidation complex, beta subunit, putative CC0077 SWALL:Q9ABZ3 (EMBL:AE005682) (401 aa) fasta scores: E(): 5.5e-95, 71% id in 400 aa; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
BPSL0063Similar to Pseudomonas fragi fatty oxidation complex alpha subunit [includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3- hydroxybutyryl-CoA epimerase] FaoA SWALL:FAOB_PSEFR (SWALL:P28793) (715 aa) fasta scores: E(): 5e-65, 36.06% id in 721 aa, and to Caulobacter crescentus fatty oxidation complex, alpha subunit CC0076 SWALL:Q9ABZ4 (EMBL:AE005681) (709 aa) fasta scores: E(): 8.9e-130, 55.26% id in 684 aa. (707 aa)
BPSL0371Similar to Alcaligenes eutrophus acetyl-CoA acetyltransferase PhbA SWALL:THIL_ALCEU (SWALL:P14611) (393 aa) fasta scores: E(): 1.5e-65, 48.84% id in 389 aa, and to Ralstonia solanacearum probable acetyl-CoA acetyltransferase rsc0276 or rs03243 SWALL:Q8Y2Q9 (EMBL:AL646058) (393 aa) fasta scores: E(): 6.7e-109, 74.42% id in 391 aa. Similar to BPSL1535, 50.643% identity (51.036% ungapped) in 389 aa overlap; Belongs to the thiolase-like superfamily. Thiolase family. (397 aa)
BPSL0391enoyl-CoA hydratase/isomerase family protein; Similar to Escherichia coli probable enoyl-CoA hydratase PaaG SWALL:PAAG_ECOLI (SWALL:P77467) (262 aa) fasta scores: E(): 1e-14, 30.8% id in 237 aa, and to Ralstonia solanacearum probable enoyl-CoA hydratase protein rsc0304 or rs03271 SWALL:Q8Y2N1 (EMBL:AL646058) (272 aa) fasta scores: E(): 2e-75, 74.26% id in 272 aa; Belongs to the enoyl-CoA hydratase/isomerase family. (275 aa)
BPSL0649Similar to Ralstonia solanacearum putative 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein rsc0474 or rs04421 SWALL:Q8Y262 (EMBL:AL646059) (827 aa) fasta scores: E(): 0, 77.28% id in 810 aa. N-terminal region and to Homo sapiens short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor HADHSC or SCHAD SWALL:HCDH_HUMAN (SWALL:Q16836) (314 aa) fasta scores: E(): 1.6e-20, 34.57% id in 295 aa. R. solanacearum protein is extended at the N-terminus in comparison to CDS. (811 aa)
BPSL0650Similar to Rattus norvegicus 3-ketoacyl-CoA thiolase A, peroxisomal precursor SWALL:THIJ_RAT (SWALL:P21775) (434 aa) fasta scores: E(): 2.6e-55, 46.95% id in 394 aa, and to Ralstonia solanacearum putative acetyl-CoA acyltransferase protein rsc0475 or rs04420 SWALL:Q8Y261 (EMBL:AL646059) (399 aa) fasta scores: E(): 2.5e-124, 83.7% id in 399 aa. R. norvegicus protein is extended at the N-terminus in comparison to CDS; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
BPSL1424Putative fatty acid degradation protein (possibly trifunctional); Similar to Ralstonia solanacearum probable trifunctional: enoyl-CoA hydratase and delta3-cis-delta2-trans-enoyl-CoA isomerase and 3-hydroxyacyl-CoA dehydrogenase oxidoreductase protein rsc1759 or rs02946 SWALL:Q8XYJ9 (EMBL:AL646066) (706 aa) fasta scores: E(): 2.4e-192, 74.6% id in 693 aa, and to Escherichia coli fatty oxidation complex alpha subunit [includes: enoyl-CoA hydratase; delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase; 3-hydroxybutyryl-CoA epimerase] FadB or OldB or b3846 SWALL [...] (694 aa)
BPSL1426Putative thiolase; Similar to Ralstonia solanacearum probable acetyl-CoA acetyltransferase protein rsc1761 or rs02948 SWALL:Q8XYJ7 (EMBL:AL646066) (392 aa) fasta scores: E(): 1.6e-124, 85.2% id in 392 aa, and to Pseudomonas aeruginosa probable acyl-CoA thiolase pa3454 SWALL:Q9HYF2 (EMBL:AE004766) (394 aa) fasta scores: E(): 4.5e-74, 53.69% id in 393 aa; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
BPSL1488Putative decarboxylase; Similar to Methanobacterium thermoautotrophicum gamma-carboxymuconolactone decarboxylase mth234 SWALL:O26336 (EMBL:AE000810) (125 aa) fasta scores: E(): 2.8e-20, 49.59% id in 123 aa, and to Acinetobacter calcoaceticus 4-carboxymuconolactone decarboxylase PcaC SWALL:DC4C_ACICA (SWALL:P20370) (134 aa) fasta scores: E(): 4.1e-09, 35.29% id in 119 aa. Note: N-terminal region overlaps in 17 residues with CDS upstream. (132 aa)
phbASimilar to Alcaligenes eutrophus acetyl-CoA acetyltransferase PhbA SWALL:THIL_ALCEU (SWALL:P14611) (393 aa) fasta scores: E(): 4.9e-117, 85.96% id in 392 aa, and to Burkholderia sp. DSMZ 9242 PhaA SWALL:Q9RB81 (EMBL:AF153086) (393 aa) fasta scores: E(): 9.4e-127, 92.36% id in 393 aa. Note: Also similar to BPSL1540 (418 aa) fasta scores: E(): 6e-62, 52.806% identity in 392 aa overlap and to BPSL0371 (398 aa) fasta scores: E(): 7.2e-59, 50.643% identity in 389 aa overlap; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
BPSL1540Similar to Alcaligenes eutrophus beta-ketothiolase BktB SWALL:O68275 (EMBL:AF026544) (394 aa) fasta scores: E(): 3.2e-114, 79.44% id in 394 aa, and to Alcaligenes eutrophus acetyl-CoA acetyltransferase PhbA SWALL:THIL_ALCEU (SWALL:P14611) (393 aa) fasta scores: E(): 6.3e-67, 52.04% id in 392 aa. Note: Also similar to BPSL1535 (394 aa) fasta scores: E(): 1.8e-61, 52.806% identity in 392 aa overlap; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
BPSL2747Putative glutaryl-CoA dehydrogenase; Similar to Prokaryotic and Eukaryotic dehydrogenases including: Rhizobium meliloti putative glutaryl-CoA dehydrogenase protein rb0847 or smb21181 SWALL:Q92V67 (EMBL:AL603645) (395 aa) fasta scores: E(): 7.9e-118, 72.98% id in 396 aa and to Homo sapiens glutaryl-CoA dehydrogenase, mitochondrial precursor GcdH SWALL:GCDH_HUMAN (SWALL:Q92947) (438 aa) fasta scores: E(): 1.9e-100, 64.6% id in 404 aa. (413 aa)
paaFPutative phenylacetic acid degradation enoyl-CoA hydratase PaaF; Similar to Escherichia coli probable enoyl-CoA hydratase PaaF or b1393 SWALL:PAAF_ECOLI (SWALL:P76082) (255 aa) fasta scores: E(): 4.2e-36, 44.66% id in 253 aa; Belongs to the enoyl-CoA hydratase/isomerase family. (264 aa)
pobASimilar to Pseudomonas aeruginosa p-hydroxybenzoate hydroxylase PobA or pa0247 SWALL:PHHY_PSEAE (SWALL:P20586) (394 aa) fasta scores: E(): 1.7e-84, 55.21% id in 393 aa, and to Ralstonia solanacearum probable 4-hydroxybenzoate 3-monooxygenase oxidoreductase protein rsc2242 or rs01317 SWALL:Q8XX74 (EMBL:AL646069) (410 aa) fasta scores: E(): 2e-111, 69% id in 400 aa. (407 aa)
pcaISimilar to Pseudomonas putida 3-oxoadipate CoA-transferase subunit A PcaI SWALL:PCAI_PSEPU (SWALL:Q01103) (231 aa) fasta scores: E(): 3.5e-63, 75.33% id in 223 aa, and to Ralstonia solanacearum probable 3-oxoadipate coa-transferase subunit A protein rsc2254 or rs01305 SWALL:Q8XX62 (EMBL:AL646069) (229 aa) fasta scores: E(): 2.6e-67, 80.34% id in 229 aa. (237 aa)
pcaJSimilar to Pseudomonas putida 3-oxoadipate CoA-transferase subunit B PcaJ SWALL:PCAJ_PSEPU (SWALL:Q01104) (212 aa) fasta scores: E(): 9.6e-62, 76.55% id in 209 aa, and to Ralstonia solanacearum probable 3-oxoadipate coa-transferase subunit B protein rsc2253 or rs01306 SWALL:Q8XX63 (EMBL:AL646069) (220 aa) fasta scores: E(): 2.7e-62, 77.98% id in 209 aa. (218 aa)
pcaBSimilar to Bradyrhizobium japonicum 3-carboxy-cis,cis-muconate cycloisomerase PcaB SWALL:PCAB_BRAJA (SWALL:O31385) (451 aa) fasta scores: E(): 4.4e-79, 55.95% id in 420 aa, and to Pseudomonas putida 3-carboxy-cis,cis-muconate cycloisomerase PcaB SWALL:PCAB_PSEPU (SWALL:P32427) (407 aa) fasta scores: E(): 2.5e-63, 53.82% id in 366 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. (465 aa)
BPSS0046Putative lactone hydrolase; Similar to Alcaligenes eutrophus 3-oxoadipate enol-lactone hydrolase CatD1 SWALL:Q9EV40 (EMBL:AF042281) (260 aa) fasta scores: E(): 3.8e-44, 47.69% id in 260 aa, and to Ralstonia solanacearum probable b-ketoadipate enol-lactone hydrolase transmembrane protein rsc2250 or rs01309 SWALL:Q8XX66 (EMBL:AL646069) (270 aa) fasta scores: E(): 5.3e-44, 45% id in 260 aa. (261 aa)
pcaCSimilar to Acinetobacter calcoaceticus 4-carboxymuconolactone decarboxylase PcaC SWALL:DC4C_ACICA (SWALL:P20370) (134 aa) fasta scores: E(): 8.8e-29, 57.02% id in 121 aa, and to Ralstonia solanacearum putative 4-carboxymuconolactone decarboxylase protein rsc2249 or rs01310 SWALL:Q8XX67 (EMBL:AL646069) (131 aa) fasta scores: E(): 9e-38, 76.98% id in 126 aa. (128 aa)
BPSS0939Similar to Acinetobacter calcoaceticus 4-carboxymuconolactone decarboxylase PcaC SWALL:DC4C_ACICA (SWALL:P20370) (134 aa) fasta scores: E(): 6.5e-15, 40.47% id in 126 aa, and to Pseudomonas aeruginosa hypothetical protein pa4486 SWALL:Q9HVT5 (EMBL:AE004862) (128 aa) fasta scores: E(): 1.5e-24, 59.2% id in 125 aa. (132 aa)
pcaHSimilar to Burkholderia cepacia protocatechuate 3,4-dioxygenase beta chain PcaH SWALL:PCXB_BURCE (SWALL:P15110) (235 aa) fasta scores: E(): 9.7e-88, 91.06% id in 235 aa, and to Pseudomonas marginata protocatechuate 3,4-dioxygenase beta-subunit PcaH SWALL:Q9ZB85 (EMBL:U33634) (234 aa) fasta scores: E(): 5.5e-87, 88.46% id in 234 aa, and to Acinetobacter lwoffii protocatechuate 3,4-dioxygenase beta subunit PcaH SWALL:Q8KQ86 (EMBL:AY099487) (226 aa) fasta scores: E(): 1.1e-79, 84.51% id in 226 aa. (234 aa)
pcaGSimilar to Burkholderia cepacia protocatechuate 3,4-dioxygenase alpha chain PcaG SWALL:PCXA_BURCE (SWALL:P15109) (197 aa) fasta scores: E(): 4.3e-56, 74.11% id in 197 aa, and to Pseudomonas marginata protocatechuate 3,4-dioxygenase alpha-subunit PcaG SWALL:Q9ZB84 (EMBL:U33634) (196 aa) fasta scores: E(): 1.9e-57, 74.61% id in 197 aa. (197 aa)
BPSS1791Similar to Streptomyces coelicolor hypothetical protein sco1037 or scg20a.17 SWALL:Q9K3M3 (EMBL:AL939107) (133 aa) fasta scores: E(): 4.5e-12, 40.62% id in 128 aa, and to Bacillus subtilis hypothetical protein YrdN SWALL:YRDN_BACSU (SWALL:P94502) (129 aa) fasta scores: E(): 4.6e-11, 34.64% id in 127 aa. (127 aa)
mhpE4-hydroxy-2-oxovalerate aldolase; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (347 aa)
mhpFAcetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (297 aa)
catBSimilar to Acinetobacter lwoffii muconate cycloisomerase I 1 CatB1 SWALL:CTB1_ACILW (SWALL:O33946) (379 aa) fasta scores: E(): 7.3e-80, 62.53% id in 371 aa, and to Burkholderia sp. TH2 cis,cis-muconate lactonizing enzyme CatB2 SWALL:BAC16768 (EMBL:AB035325) (395 aa) fasta scores: E(): 3.5e-92, 73.76% id in 343 aa; Belongs to the mandelate racemase/muconate lactonizing enzyme family. (377 aa)
catASimilar to Acinetobacter lwoffii catechol 1,2-dioxygenase 2 CatA2 SWALL:CTA2_ACILW (SWALL:O33950) (275 aa) fasta scores: E(): 4.6e-84, 81.22% id in 261 aa, and to Burkholderia sp. TH2 catechol 1,2-dioxygenase CatA2 SWALL:BAC16769 (EMBL:AB035325) (300 aa) fasta scores: E(): 3.4e-90, 74.66% id in 300 aa. (300 aa)
catCSimilar to Acinetobacter lwoffii muconolactone delta-isomerase 2 CatC2 SWALL:CTC2_ACILW (SWALL:O33951) (96 aa) fasta scores: E(): 2.9e-32, 80.2% id in 96 aa, and to Pseudomonas putida muconolactone delta-isomerase CatC SWALL:CATC_PSEPU (SWALL:P00948) (96 aa) fasta scores: E(): 4.4e-28, 73.95% id in 96 aa. (96 aa)
benASimilar to Acinetobacter calcoaceticus benzoate 1,2-dioxygenase alpha subunit BenA SWALL:BENA_ACICA (SWALL:P07769) (461 aa) fasta scores: E(): 2.6e-150, 74.65% id in 438 aa, and to Pseudomonas putida benzoate 1,2-dioxygenase large subunit BenA SWALL:Q93SR8 (EMBL:AY026914) (455 aa) fasta scores: E(): 1.8e-142, 73.68% id in 437 aa. (455 aa)
benBSimilar to Acinetobacter calcoaceticus benzoate 1,2-dioxygenase beta subunit BenB SWALL:BENB_ACICA (SWALL:P07770) (169 aa) fasta scores: E(): 1.8e-48, 71.16% id in 163 aa, and to Pseudomonas putida benzoate 1,2-dioxygenase small subunit BenB SWALL:Q93SR7 (EMBL:AY026914) (162 aa) fasta scores: E(): 1.3e-42, 66.45% id in 155 aa. (163 aa)
benCSimilar to Acinetobacter calcoaceticus benzoate 1,2-dioxygenase electron transfer component [includes: ferredoxin; ferredoxin--NAD(+) reductase (EC 1.18.1.3)] BenC SWALL:BENC_ACICA (SWALL:P07771) (348 aa) fasta scores: E(): 3.8e-77, 61.49% id in 335 aa, and to Pseudomonas putida benzoate dioxygenase-ferredoxin reductase BenC SWALL:Q9L7Y3 (EMBL:AF218267) (336 aa) fasta scores: E(): 2.4e-69, 56.25% id in 336 aa. (339 aa)
benDSimilar to Acinetobacter calcoaceticus cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase BenD SWALL:BEND_ACICA (SWALL:P07772) (261 aa) fasta scores: E(): 1.3e-60, 64.45% id in 256 aa, and to Pseudomonas putida cis-diol dehydrogenase BenD SWALL:Q9L7Y2 (EMBL:AF218267) (253 aa) fasta scores: E(): 2.6e-61, 67.57% id in 256 aa; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (264 aa)
BPSS2332Putative membrane protein; No significant database matches. (182 aa)
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
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