STRINGSTRING
coaX coaX coaD coaD ilvE ilvE BPSL0844 BPSL0844 BPSL0885 BPSL0885 dfp dfp ilvD ilvD panD panD panC panC BPSL1020 BPSL1020 ilvI ilvI ilvH ilvH ilvC ilvC BPSL1399 BPSL1399 BPSL1550 BPSL1550 BPSL2345 BPSL2345 acpS acpS panB panB coaE coaE ilvG ilvG BPSS0305 BPSS0305 BPSS0414 BPSS0414 BPSS0902 BPSS0902 BPSS1466 BPSS1466 ilvE-2 ilvE-2 BPSS1879 BPSS1879 BPSS2266 BPSS2266
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
coaXBordetella pertussis Bvg accessory factor family protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (259 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa)
ilvEPutative branched-chain amino acid aminotransferase IlvE; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
BPSL0844Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (310 aa)
BPSL0885Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (341 aa)
dfpPutative DNA/pantothenate metabolism flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (403 aa)
ilvDSimilar to Lactococcus lactis dihydroxy-acid dehydratase IlvD or ll1223 SWALL:ILVD_LACLA (SWALL:Q02139) (570 aa) fasta scores: E(): 4.6e-100, 49.63% id in 554 aa, and to Ralstonia solanacearum dihydroxy-acid dehydratase IlvD or rsc2412 or rs02706 SWALL:ILVD_RALSO (SWALL:Q8XWR1) (557 aa) fasta scores: E(): 1.2e-186, 86.33% id in 556 aa; Belongs to the IlvD/Edd family. (557 aa)
panDPutative aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (128 aa)
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (279 aa)
BPSL1020Similar to Escherichia coli putative aldehyde dehydrogenase AldH or b1300 SWALL:DHAL_ECOLI (SWALL:P23883) (495 aa) fasta scores: E(): 2.3e-61, 41.12% id in 479 aa, and to Ralstonia solanacearum probable aldehyde dehydrogenase oxidoreductase protein rsc2350 or rs01196 SWALL:Q8XWX0 (EMBL:AL646069) (478 aa) fasta scores: E(): 5.1e-138, 73.31% id in 476 aa. (479 aa)
ilvISimilar to Escherichia coli acetolactate synthase isozyme III large subunit IlvI or b0077 SWALL:ILVI_ECOLI (SWALL:P00893) (574 aa) fasta scores: E(): 9e-132, 57.61% id in 571 aa, and to Ralstonia solanacearum probable acetolactate synthase isozyme III rsc2077 or rs03642 SWALL:Q8XXN6 (EMBL:AL646068) (585 aa) fasta scores: E(): 6.5e-194, 79.38% id in 587 aa. Note: This CDS is longer in its N-terminal region than most of its database matches. (587 aa)
ilvHSimilar to Escherichia coli acetolactate synthase isozyme III small subunit IlvH or BrnP or b0078 SWALL:ILVH_ECOLI (SWALL:P00894) (163 aa) fasta scores: E(): 4.8e-31, 55.82% id in 163 aa, and to Ralstonia solanacearum probable acetolactate synthase isozyme III rsc2076 or rs03641 SWALL:Q8XXN7 (EMBL:AL646068) (163 aa) fasta scores: E(): 9.5e-49, 88.34% id in 163 aa. (163 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
BPSL1399Putative reductase; Similar to Ralstonia solanacearum putative oxidoreductase protein rsc3361 or rs02636 SWALL:Q8XU33 (EMBL:AL646074) (325 aa) fasta scores: E(): 2.4e-50, 51.5% id in 332 aa, and to Rhizobium loti putative 2-dehydropantoate 2-reductase mll6982 SWALL:PANE_RHILO (SWALL:Q987N5) (326 aa) fasta scores: E(): 2.2e-43, 45.59% id in 329 aa. (328 aa)
BPSL1550Similar to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SWALL:DHAB_BACSU (SWALL:P71016) (490 aa) fasta scores: E(): 1.9e-59, 40.33% id in 476 aa, and to Ralstonia solanacearum putative betaine aldehyde dehydrogenase rsc1456 or rs03851 SWALL:Q8XZE5 (EMBL:AL646064) (478 aa) fasta scores: E(): 1.1e-127, 71.3% id in 474 aa. (478 aa)
BPSL2345Hypothetical protein; Weakly similar to Anabaena sp. 4'-phosphopantetheinyl transferase HetI or all5359 SWALL:HETI_ANASP (SWALL:P37695) (237 aa) fasta scores: E(): 9e-12, 31.57% id in 209 aa, and to the N-terminal region of Streptomyces venezuelae phosphopantetheinyl transferase JadM SWALL:Q9L7M4 (EMBL:AF222693) (262 aa) fasta scores: E(): 1.1e-10, 34.89% id in 235 aa. (263 aa)
acpSPutative holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (143 aa)
panBPutative 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (271 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
ilvGSimilar to Escherichia coli acetolactate synthase isozyme II large subunit IlvG or b3767 SWALL:ILVG_ECOLI (SWALL:P00892) (548 aa) fasta scores: E(): 1.7e-45, 30.91% id in 537 aa, and to Brucella melitensis acetolactate synthase large subunit BmeII0351 SWALL:Q8YD26 (EMBL:AE009672) (564 aa) fasta scores: E(): 5.1e-126, 59.56% id in 554 aa; Belongs to the TPP enzyme family. (567 aa)
BPSS0305Similar to Bacillus subtilis ketol-acid reductoisomerase IlvC SWALL:ILVC_BACSU (SWALL:P37253) (342 aa) fasta scores: E(): 7e-27, 36.91% id in 298 aa, and to Neisseria meningitidis ketol-acid reductoisomerase nma1763 SWALL:ILVC_NEIMA (SWALL:Q9JTI3) (337 aa) fasta scores: E(): 9.9e-31, 35.71% id in 322 aa. (351 aa)
BPSS0414Similar to Caulobacter crescentus acetolactate synthase, large subunit cc2100 SWALL:Q9A6J3 (EMBL:AE005883) (582 aa) fasta scores: E(): 3.3e-53, 36.34% id in 575 aa, and to Bacillus subtilis acetolactate synthase large subunit IlvB SWALL:ILVB_BACSU (SWALL:P37251) (573 aa) fasta scores: E(): 7.6e-53, 33.74% id in 572 aa; Belongs to the TPP enzyme family. (570 aa)
BPSS0902Putative thiamine pyrophosphate enzyme; Similar to Pseudomonas aeruginosa probable decarboxylase pa3506 SWALL:Q9HYA3 (EMBL:AE004771) (560 aa) fasta scores: E(): 1.8e-134, 66.13% id in 561 aa. Weakly similar to Escherichia coli acetolactate synthase isozyme I large subunit IlvB SWALL:ILVB_ECOLI (SWALL:P08142) (562 aa) fasta scores: E(): 1.8e-32, 28.57% id in 532 aa; Belongs to the TPP enzyme family. (557 aa)
BPSS1466Putative aldehyde dehydrogenase family protein; Similar to Streptomyces clavuligerus semialdehyde dehydrogenase Pcd SWALL:O85725 (EMBL:AF073895) (512 aa) fasta scores: E(): 2e-120, 66.05% id in 492 aa, and to Ralstonia solanacearum putative transmembrane aldehyde dehydrogenase oxidoreductase protein rsp1591 or rs02148 SWALL:Q8XPP7 (EMBL:AL646085) (504 aa) fasta scores: E(): 9.4e-134, 69.84% id in 504 aa, and to Rhizobium loti aldehyde dehydrogenase mll2867 SWALL:Q98HH4 (EMBL:AP003000) (504 aa) fasta scores: E(): 4.1e-132, 68.93% id in 499 aa. (503 aa)
ilvE-2Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (314 aa)
BPSS1879Similar to Bacillus subtilis acetolactate synthase AlsS SWALL:ILVX_BACSU (SWALL:Q04789) (571 aa) fasta scores: E(): 2.8e-57, 32.78% id in 543 aa, and to Pseudomonas aeruginosa probable acetolactate synthase large subunit pa4180 SWALL:Q9HWK1 (EMBL:AE004834) (547 aa) fasta scores: E(): 3.5e-155, 69.57% id in 539 aa; Belongs to the TPP enzyme family. (546 aa)
BPSS2266Similar to Anabaena sp. 4'-phosphopantetheinyl transferase HetI SWALL:HETI_ANASP (SWALL:P37695) (237 aa) fasta scores: E(): 7.9e-15, 31.5% id in 200 aa, and to Stigmatella aurantiaca MtaA protein SWALL:Q9RFL1 (EMBL:AF188287) (277 aa) fasta scores: E(): 1.5e-37, 43.08% id in 253 aa. (271 aa)
Your Current Organism:
Burkholderia pseudomallei
NCBI taxonomy Id: 272560
Other names: B. pseudomallei K96243, Burkholderia pseudomallei K96243, Burkholderia pseudomallei str. K96243, Burkholderia pseudomallei strain K96243
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.