STRINGSTRING
ddlA ddlA murJ murJ CA_C3069 CA_C3069 murD murD gcaD gcaD murC murC murI murI murA-2 murA-2 CA_C3676 CA_C3676 murA murA murE-2 murE-2 CA_C2802 CA_C2802 CA_C2631 CA_C2631 CA_C2537 CA_C2537 CA_C2438 CA_C2438 CA_C2431 CA_C2431 CA_C2395 CA_C2395 CA_C2321 CA_C2321 CA_C2320 CA_C2320 CA_C2312 CA_C2312 mrcB mrcB murG murG CA_C2172 CA_C2172 CA_C2171 CA_C2171 murE murE murF murF mraY mraY spoVE spoVE dacF-2 dacF-2 CA_C2057 CA_C2057 CA_C1822 CA_C1822 CA_C1756 CA_C1756 CA_C1688 CA_C1688 mltG mltG CA_C1540 CA_C1540 CA_C1434 CA_C1434 CA_C1350 CA_C1350 dacB dacB dacF dacF bacA-2 bacA-2 CA_C0962 CA_C0962 CA_C0961 CA_C0961 CA_C0888 CA_C0888 CA_C0747 CA_C0747 CA_C0605 CA_C0605 murB murB bacA bacA amj amj CA_C0441 CA_C0441 CA_C0352 CA_C0352 CA_C0011 CA_C0011
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ddlAD-alanine-D-alanine ligase; Cell wall formation. (343 aa)
murJUncharacterized membrane protein, putative virulence factor MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (520 aa)
CA_C3069Predicted glycosyltransferase. (299 aa)
murDUDP-N-acetylmuramoylalanine D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (462 aa)
gcaDUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa)
murCUDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (458 aa)
murIPossible glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (256 aa)
murA-2UDP-N-acetylglucosamine enolpyruvyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa)
CA_C3676Uncharacterized conserved protein. (308 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa)
murE-2UDP-N-acetylmuramyl tripeptide synthase, MURE; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (483 aa)
CA_C2802Predicted phosphoglycerol transferase (alkaline phosphatase superfamily), YFNI B.subtilis. (627 aa)
CA_C2631Uncharacterized protein, ErfK family. (229 aa)
CA_C2537Predicted phosphatase. (193 aa)
CA_C2438Predicted phosphatase. (180 aa)
CA_C2431Alkaline phosphatase superfamily enzyme. (634 aa)
CA_C2395Predicted phosphatase, YWOA B.subtilis ortholog. (178 aa)
CA_C2321Predicted glycosyltransferase. (298 aa)
CA_C2320Predicted glycosyltransferase. (254 aa)
CA_C2312Rhamnosyl transferase, rfbQ. (303 aa)
mrcBMembrane carboxypeptidase mrcB; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (809 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase, MurG; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (359 aa)
CA_C2172Predicted glycosyltransferase. (449 aa)
CA_C2171Predicted glycosyltransferase. (299 aa)
murEUDP-N-acetylmuramyl tripeptide synthase, MurE; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (482 aa)
murFUDP-N-acetylmuramyl pentapeptide synthase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide transferase, MraY; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (317 aa)
spoVEStage V sporulation protein E, FtsW/MrdB/SpoVE family; Belongs to the SEDS family. (371 aa)
dacF-2D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (404 aa)
CA_C2057D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (351 aa)
CA_C1822Fused Zn-dependent amidase/peptidase/peptodoglycan-binding domain-containing protein; Fusion of predicted Zn-dependent amidase/peptidase (cell wall hydrolase/DD-carboxypeptidase family) and uncharacterized domain of ErfK family; peptodoglycan-binding domain. (281 aa)
CA_C1756Predicted nucleic acid binding protein, containing KH domain; Belongs to the UPF0109 family. (75 aa)
CA_C1688Penicillin-binding protein. (532 aa)
mltGUncharacterized protein from YceG family; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (339 aa)
CA_C1540Uncharacterized ATP-grasp enzyme. (328 aa)
CA_C1434Alkaline phosphatase superfamily protein. (625 aa)
CA_C1350Hypothetical protein. (101 aa)
dacBD-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (425 aa)
dacFD-alanyl-D-alanine carboxypeptidase (penicilin binding protein); Belongs to the peptidase S11 family. (426 aa)
bacA-2Bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (307 aa)
CA_C0962UDP-N-acetylmuramyl tripeptide synthetase. (435 aa)
CA_C0961Cobyric acid synthase CobQ. (243 aa)
CA_C0888Phosphoglycerol transferase MdoB related protein, alkaline phosphatase superfamily. (606 aa)
CA_C0747Secreted protein containing uncharacterized conserved protein of ErfK family. (466 aa)
CA_C0605Predicted phosphatase. (290 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase (murB); Cell wall formation. (305 aa)
bacABacitracin resistance protein (bacA); Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa)
amjUncharacterized membrane protein, homolog of YDAH B.subtilis; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (269 aa)
CA_C0441Uncharacterized conserved membrane protein of SANA family. (259 aa)
CA_C0352Uncharacterized conserved membrane protein, SANA family. (225 aa)
CA_C0011Uncharacterized conserved of ErfK family. (286 aa)
Your Current Organism:
Clostridium acetobutylicum
NCBI taxonomy Id: 272562
Other names: C. acetobutylicum ATCC 824, Clostridium acetobutylicum ATCC 824, Clostridium acetobutylicum DSM 792, Clostridium acetobutylicum str. ATCC 824, Clostridium acetobutylicum strain ATCC 824
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