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purH purH dcd dcd CA_C0090 CA_C0090 tadA tadA CA_C0181 CA_C0181 nagA nagA CA_C0190 CA_C0190 CA_C0282 CA_C0282 CA_C0358 CA_C0358 rocB rocB CA_C0376 CA_C0376 CA_C0436 CA_C0436 CA_C0474 CA_C0474 pyrC pyrC ribD ribD ribA ribA pdxT pdxT adeC adeC hisH hisH hisI_1 hisI_1 CA_C0960 CA_C0960 CA_C0961 CA_C0961 CA_C1037 CA_C1037 CA_C1040 CA_C1040 nadE nadE CA_C1054 CA_C1054 CA_C1359 CA_C1359 PurN PurN CA_C1544 CA_C1544 CA_C1699 CA_C1699 ansA ansA def def CA_C1764 CA_C1764 CA_C1778 CA_C1778 nadE-2 nadE-2 folD folD cheB cheB cheD cheD CA_C2316 CA_C2316 CA_C2383 CA_C2383 CA_C2396 CA_C2396 CA_C2445 CA_C2445 def-2 def-2 CA_C2476 CA_C2476 CA_C2609 CA_C2609 CA_C2678 CA_C2678 CA_C2876 CA_C2876 ctrA ctrA add add CA_C3009 CA_C3009 CA_C3017 CA_C3017 CA_C3092 CA_C3092 CA_C3332 CA_C3332 CA_C3377 CA_C3377 CA_C3497 CA_C3497 mtrA mtrA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purHAICAR transformylase/IMP cyclohydrolase. (499 aa)
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (173 aa)
CA_C0090Xylanase/chitin deacetylase, NodB family. (293 aa)
tadACytosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (147 aa)
CA_C0181Similar to beta-lactamase. (351 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase (gene nagA). (381 aa)
CA_C0190Beta-lactamase. (260 aa)
CA_C0282Cytosine/guanine deaminase related protein. (428 aa)
CA_C0358Predicted xylanase/chitin deacetylase. (266 aa)
rocBArginine degradation protein (gene rocB). (549 aa)
CA_C0376N-dimethylarginine dimethylaminohydrolase (similar to ykgA B.subtilis). (293 aa)
CA_C0436Predicted xylanase/chitin deacetilase, similar to yxkH B.subtilis. (295 aa)
CA_C0474ACT domain containing transcriptional regulators, related to gcvR of E.coli. (976 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (424 aa)
ribDRiboflavin biosynthesis protein RIBD (pirimidine deaminase and pirimidine reductase); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (383 aa)
ribA3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (401 aa)
pdxTGlutamine amidotranspherase (possibly involved in histidine and purine biosinthesis); Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (186 aa)
adeCAdenine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. (570 aa)
hisHGlutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa)
hisI_1Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (115 aa)
CA_C0960Predicted xylanase related protein. (255 aa)
CA_C0961Cobyric acid synthase CobQ. (243 aa)
CA_C1037Predicted xylanase/chitin deacetylase. (261 aa)
CA_C1040Predicted amidohydrolases. (387 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (636 aa)
CA_C1054Arginase; Belongs to the arginase family. (299 aa)
CA_C1359Predicted xylanase/chitin deacetylase. (277 aa)
PurNFolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa)
CA_C1544Cytidine deaminase, cdd; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
CA_C1699Uncharacterized protein, YfiH family; Multicopper oxidase with polyphenol oxidase activity. (237 aa)
ansAL-asparaginase. (331 aa)
defN-formylmethionyl-tRNA deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity). (150 aa)
CA_C1764Predicted glutamine amidotransferase. (241 aa)
CA_C1778Amidase from nicotinamidase family. (216 aa)
nadE-2NH(3)-dependent NAD(+) synthase (nadE) fused to amidohydrolase domain; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (642 aa)
folDTetrahydrofolate dehydrogenase/cyclohydrolase, FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (278 aa)
cheBChemotaxis protein CheB, (CheY-like receiver domain and methylesterase domain); Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (345 aa)
cheDChemotaxis protein CheD; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family. (166 aa)
CA_C2316Polysaccharide deacetylase-like protein; Xylanase/chitin deacetylase family enzyme. (289 aa)
CA_C2383Predicted xylanase/chitin deacetylase. (255 aa)
CA_C2396Predicted xylanase/chitin deacetylase. (280 aa)
CA_C2445AICAR transformylase domain of PurH-like protein. (391 aa)
def-2N-formylmethionyl-tRNA deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (150 aa)
CA_C2476Uncharacterized protein, homolog of Spirochaeta aurantia (gi:152901). (114 aa)
CA_C2609Cytidine deaminase family enzyme. (139 aa)
CA_C2678Hypothetical protein. (666 aa)
CA_C2876Deoxycytidylate deaminase. (162 aa)
ctrACTP synthase (UTP-ammonia lyase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa)
addAdenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (334 aa)
CA_C3009Xylanase/chitin deacetylase family protein. (295 aa)
CA_C3017Predicted xylanase/chitin deacetylase. (282 aa)
CA_C3092Amidase, germination specific (cwlC/cwlD B.subtilis ortholog). (231 aa)
CA_C3332Predicted amidohydrolase (dihydroorothase family). (393 aa)
CA_C3377Xylanase/chitin deacetylase family enzyme. (282 aa)
CA_C3497Hypothetical protein. (137 aa)
mtrAGTP cyclohydrolase I. (195 aa)
Your Current Organism:
Clostridium acetobutylicum
NCBI taxonomy Id: 272562
Other names: C. acetobutylicum ATCC 824, Clostridium acetobutylicum ATCC 824, Clostridium acetobutylicum DSM 792, Clostridium acetobutylicum str. ATCC 824, Clostridium acetobutylicum strain ATCC 824
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