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spoIIR spoIIR bofA bofA CA_C0130 CA_C0130 CA_C0186 CA_C0186 csfB csfB CA_C0301 CA_C0301 abrB abrB CA_C0325 CA_C0325 spmA spmA spmB spmB spoVR spoVR CA_C0613 CA_C0613 CA_C0614 CA_C0614 CA_C0686 CA_C0686 splB-2 splB-2 CA_C1232 CA_C1232 SpoIIP SpoIIP CA_C1291 CA_C1291 CA_C1298 CA_C1298 CA_C1335 CA_C1335 tlp tlp CA_C1522 CA_C1522 CA_C1614 CA_C1614 CA_C1620 CA_C1620 sigK sigK spoIIGA spoIIGA sigE sigE sigG sigG CA_C1697 CA_C1697 CA_C1713 CA_C1713 CA_C1740 CA_C1740 CA_C1750 CA_C1750 CA_C1809 CA_C1809 CA_C1817 CA_C1817 CA_C1841 CA_C1841 abrB-2 abrB-2 CA_C2059 CA_C2059 CA_C2068 CA_C2068 spo0A spo0A CA_C2086 CA_C2086 CA_C2087 CA_C2087 CA_C2088 CA_C2088 CA_C2089 CA_C2089 CA_C2090 CA_C2090 CA_C2091 CA_C2091 CA_C2092 CA_C2092 CA_C2093 CA_C2093 CA_C2122 CA_C2122 CA_C2124 CA_C2124 CA_C2177 CA_C2177 CA_C2193 CA_C2193 CA_C2300 CA_C2300 SpoVAE SpoVAE CA_C2303 CA_C2303 SpoVAD SpoVAD SpoVAC SpoVAC spoIIAB spoIIAB spoIIAA spoIIAA sspA sspA CA_C2506 CA_C2506 CA_C2550 CA_C2550 CA_C2615 CA_C2615 cotF cotF CA_C2780 CA_C2780 spoIID spoIID splB splB CA_C2905 CA_C2905 CA_C2906 CA_C2906 CA_C2908 CA_C2908 CA_C2909 CA_C2909 CA_C2910 CA_C2910 CA_C3024 CA_C3024 CA_C3081 CA_C3081 spoIIE spoIIE CA_C3208 CA_C3208 CA_C3209 CA_C3209 CA_C3214 CA_C3214 spoVG spoVG CA_C3264 CA_C3264 CA_C3317 CA_C3317 CA_C3492 CA_C3492 abrB-3 abrB-3 spoVT spoVT hsp18 hsp18 CA_C3718 CA_C3718 soj soj
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
spoIIRStage II sporulation protein R. (221 aa)
bofABofA B.subtilis ortholog, SigmaK-factor processing regulatory protein. (90 aa)
CA_C0130Uncharacterized membrane protein, YTAF B.subtilis ortholog; Probably functions as a manganese efflux pump. (200 aa)
CA_C0186Xre family DNA-binding domain and TPR-repeat-containing protein. (434 aa)
csfBZn-finger containing protein, csfB B.subtilis homolog. (71 aa)
CA_C0301Signal peptidase II (PSP1) homolog, YAAT B.subtilis ortholog. (303 aa)
abrBRegulators of stationary/sporulation gene expression, abrB B.subtilis ortholog. (81 aa)
CA_C0325Uncharacterized membrane protein, homolog of YtaF B.subtilis; Probably functions as a manganese efflux pump. (204 aa)
spmASpore maturation protein A (gene spmA). (191 aa)
spmBSpore maturation protein B (gene spmB). (173 aa)
spoVRStage V sporulation protein R. (460 aa)
CA_C0613Spore coat protein F. (98 aa)
CA_C0614Spore coat protein F. (76 aa)
CA_C0686Spore cortex-lytic enzyme prepeptide; peptodoglycan-binding domain. (234 aa)
splB-2Spore photoproduct lyase, splB; Involved in repair of UV radiation-induced DNA damage during spore germination. Can repair thymine dimer 5-thyminyl-5,6- dihydrothymine (known as spore photoproduct (SP)) by in situ monomerization of SP to two thymines. (336 aa)
CA_C1232Predicted lytic murein transglycosylase (N-term. LysM motif repeat domain). (253 aa)
SpoIIPStage II sporulation protein P. (356 aa)
CA_C1291Uncharacterized protein, YQFD ortholog, related spoIV gene product. (376 aa)
CA_C1298Uncharacterized protein, related to B.subtilis spore coat protein COTS. (355 aa)
CA_C1335Spore coat protein F (COTF) related protein. (189 aa)
tlpUncharacterized protein, similar to TlpA of B.subtilis; Belongs to the Tlp family. (75 aa)
CA_C1522Small acid-soluble spore protein. (66 aa)
CA_C1614Predicted glycosyltransferase. (256 aa)
CA_C1620Small acid-soluble spore protein. (64 aa)
sigKDNA-dependent RNA polymerase sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (234 aa)
spoIIGASigma factor E processing enzyme, SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR (By similarity). Belongs to the peptidase U4 family. (266 aa)
sigEDNA-dependent RNA polymerase sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes (By similarity). (235 aa)
sigGSpecialized DNA-dependent RNA polymerase sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is responsible for the expression of sporulation specific genes. (257 aa)
CA_C1697Uncharacterized conserved protein, YMXH B.subtilis homolog; Belongs to the YlmC/YmxH family. (87 aa)
CA_C1713Coat morphogenesis sporulation protein spoIVA; ATPase. Has a role at an early stage in the morphogenesis of the spore coat. (492 aa)
CA_C1740Uncharcaterized membrane protein, YLBJ B.subtilis homolog. (381 aa)
CA_C1750SpoVS-related protein. (86 aa)
CA_C1809Uncharacterized conserved protein, YLMC B.subtilis ortholog. (91 aa)
CA_C1817Stage V sporulation protein, spoVS. (86 aa)
CA_C1841Uncharacterized protein, related to Spore coat protein CotS. (356 aa)
abrB-2Transcription regulator AbrB. (79 aa)
CA_C2059Uncharacterized protein, YTFJ Bacillus subtilis ortholog. (158 aa)
CA_C2068Sporulation factor spoIIM, uncharacterized membrane protein. (215 aa)
spo0ASpo0A protein, (CheY-like receiver domain and HTH-type DNA binding domain); May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process (By similarity). (281 aa)
CA_C2086Stage III sporulation protein AH, SpoIIIAH. (177 aa)
CA_C2087Stage III sporulation protein AG, SpoIIIAG. (210 aa)
CA_C2088Stage III sporulation protein AF, SpoIIIAF. (193 aa)
CA_C2089Stage III sporulation protein AE, SpoIIIAE. (382 aa)
CA_C2090Stage III sporulation protein AD, SpoIIIAD. (127 aa)
CA_C2091Stage III sporulation protein AC, SpoIIIAC. (65 aa)
CA_C2092Stage III sporulation protein AB, SpoIIIAB. (172 aa)
CA_C2093Stage III sporulation protein AA, SpoIIIAA. (305 aa)
CA_C2122Conserved membrane protein. (246 aa)
CA_C2124Conserved membrane protein. (243 aa)
CA_C2177Ucharacterized protein, CGEB homolog. (456 aa)
CA_C2193Ucharacterized protein, CGEB homolog. (527 aa)
CA_C2300Uncharacterized secreted protein, YunB B.subtilis homolog. (219 aa)
SpoVAEStage V sporulation AE, SpoVAE (fragment). (189 aa)
CA_C2303Stage V sporulation AE, SpoVAE (fragment). (119 aa)
SpoVADStage V sporulation AD, SpoVAD. (342 aa)
SpoVACStage V sporulation AC, SpoVAC. (152 aa)
spoIIABSigma factor F inhibitor spoIIAB (anti-sigma factor); Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. (143 aa)
spoIIAAAnti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. (111 aa)
sspASmall acid-soluble spore protein. (65 aa)
CA_C2506SpoIID-like domain containing protein; peptidoglycan-binding domain. (1042 aa)
CA_C2550Hypothetical protein. (320 aa)
CA_C2615Uncharacterized conserved protein, CotF B.subtilis family. (153 aa)
cotFRelated to spore coat protein F. (93 aa)
CA_C2780Spore coat protein, cotF related. (98 aa)
spoIIDSporulation protein SpoIID. (345 aa)
splBSpore photoproduct lyase, SPL related protein. (347 aa)
CA_C2905Uncharacterized protein, YABG B.subtilis ortholog. (300 aa)
CA_C2906Spore coat protein cotS related. (333 aa)
CA_C2908Spore coat protein cotS related. (344 aa)
CA_C2909Spore coat protein cotS related (diverged). (251 aa)
CA_C2910Spore coat protein cotS related. (335 aa)
CA_C3024acyl-CoA thioesterase family protein. (265 aa)
CA_C3081Spore-cortex-lytic enzyme, SLEB. (194 aa)
spoIIEStage II sporulation protein E, serine phosphatase family. (795 aa)
CA_C3208Uncharacterized protein, YABQ B.subtilis. (127 aa)
CA_C3209Uncharacterized protein, YABP B.subtilis. (98 aa)
CA_C3214Stage V sporulation protein T, AbrB family transcriptional regulator. (183 aa)
spoVGStage V sporulation protein G; Could be involved in septation. (95 aa)
CA_C3264Uncharacterized conserved protein, YTFJ B.subtilis ortholog. (133 aa)
CA_C3317Spore coat protein F (CotF) family protein. (97 aa)
CA_C3492Uncharacterized conserved protein. (290 aa)
abrB-3Transition state regulatory protein AbrB. (81 aa)
spoVTPossible stage V sporulation protein T, transcriptional regulator AbrB homolog. (84 aa)
hsp18Molecular chaperone (small heat shock protein), HSP18; Probable chaperone; Belongs to the small heat shock protein (HSP20) family. (151 aa)
CA_C3718Exopolyphosphatase-like domain and PAS domain containing protein, YYBT B.subtilis ortholog; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. (661 aa)
sojChromosome partitioning MinD-family ATPase, SOJ. (253 aa)
Your Current Organism:
Clostridium acetobutylicum
NCBI taxonomy Id: 272562
Other names: C. acetobutylicum ATCC 824, Clostridium acetobutylicum ATCC 824, Clostridium acetobutylicum DSM 792, Clostridium acetobutylicum str. ATCC 824, Clostridium acetobutylicum strain ATCC 824
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