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| | CA_C0011 | Uncharacterized conserved of ErfK family. (286 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (173 aa) |
| | pyrE | Orotate phosphoribosyltranspherase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (224 aa) |
| | CA_C0086 | Muconate cycloisomerase related protein, ortholog of YKGB B.subtilis. (359 aa) |
| | glmS | Glucoseamine-fructose-6-phosphate aminotransferase (gene glmS); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (608 aa) |
| | CA_C0167 | Possible sigma factor, diverged member of sigF/sigE/sigG family. (228 aa) |
| | murQ | Predicted sugar phosphate isomerase, homolog of eucaryotic glucokinase regulator; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (302 aa) |
| | CA_C0181 | Similar to beta-lactamase. (351 aa) |
| | murK | Transcriptional regulators of NagC/XylR (ROK) family, sugar kinase; Catalyzes the ATP-dependent phosphorylation of both cell wall (peptidoglycan) amino sugars, N-acetylmuramic acid (MurNAc) and N- acetylglucosamine (GlcNAc), at the 6-hydroxyl group. Neither the non-N- acetylated forms of the cell wall sugars, i.e., glucosamine and/or muramic acid, nor epimeric hexoses or 1,6-anhydro-MurNAc are substrates for the enzyme. May have a role in the rescue of the murein sugars GlcNAc and MurNAc released from muropeptides during cell wall turnover in C.acetobutylicum. (306 aa) |
| | nagB | Glucosamine-6-phosphate isomerase (glucosamine-6-phosphate deaminase) (gene nagB); Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (241 aa) |
| | nagA | N-acetylglucosamine-6-phosphate deacetylase (gene nagA). (381 aa) |
| | CA_C0191 | Transcriptional regulator, RpiR family. (283 aa) |
| | CA_C0193 | Uncharacterized conserved membrane protein, affecting LPS biosynthesis. (667 aa) |
| | fruB | 1-phosphofructokinase (fructoso 1-phosphate kinase); Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (309 aa) |
| | CA_C0251 | Uncharacterized Fe-S protein (fragment). (70 aa) |
| | ldh1 | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (313 aa) |
| | CA_C0352 | Uncharacterized conserved membrane protein, SANA family. (225 aa) |
| | CA_C0354 | Uncharacterized membrane protein. (544 aa) |
| | CA_C0397 | Predicted sugar phosphate aminotransferase involved in capsule formation. (182 aa) |
| | CA_C0404 | Serine/threonine protein kinase fused to TPR repeats domain. (657 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (155 aa) |
| | CA_C0441 | Uncharacterized conserved membrane protein of SANA family. (259 aa) |
| | amj | Uncharacterized membrane protein, homolog of YDAH B.subtilis; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (269 aa) |
| | nrdG | Anaerobic ribonucleoside-triphosphate reductase activating protein, gene nrdG; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (153 aa) |
| | bacA | Bacitracin resistance protein (bacA); Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase (murB); Cell wall formation. (305 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | pykA | Pyruvate kinase (pykA). (473 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (424 aa) |
| | CA_C0531 | Transcriptional regulator, RpiR family. (257 aa) |
| | lyc | Autolytic lysozime (1,4-beta-N-acetylmuramidase), family 25 of glycosyl hydrolases; peptodoglycan-binding domain. (324 aa) |
| | CA_C0605 | Predicted phosphatase. (290 aa) |
| | CA_C0642 | Conserved domain seen in the bacterial SpoT. (262 aa) |
| | gapC | Glyceraldehyde 3-phosphate dehydrogenase, gene gapC; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate de [...] (334 aa) |
| | pgk | 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (397 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | pgm | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase gene; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | CA_C0747 | Secreted protein containing uncharacterized conserved protein of ErfK family. (466 aa) |
| | CA_C0776 | NCAIR mutase (PurE)-related protein. (248 aa) |
| | CA_C0794 | Nucleoside-diphosphate-sugar epimerase (UDP-glucose 4-epimerase). (315 aa) |
| | CA_C0827 | Fructose-bisphosphate aldolase. (287 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa) |
| | CA_C0888 | Phosphoglycerol transferase MdoB related protein, alkaline phosphatase superfamily. (606 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa) |
| | CA_C0961 | Cobyric acid synthase CobQ. (243 aa) |
| | CA_C0962 | UDP-N-acetylmuramyl tripeptide synthetase. (435 aa) |
| | bacA-2 | Bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (307 aa) |
| | dacF | D-alanyl-D-alanine carboxypeptidase (penicilin binding protein); Belongs to the peptidase S11 family. (426 aa) |
| | ndk | Probable nucleoside-diphosphate kinase N-terminal domain. (134 aa) |
| | pykA-2 | Pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa) |
| | coaE | P-loop kinase (uridine kinase family); Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (201 aa) |
| | CA_C1100 | Secreted protein, similar to catalytic domain of murein transglycosylase. (183 aa) |
| | CA_C1108 | Lyc gene autolisin (1,4-bets-N-acetylmuramidase), family 25 of glycosyl hydrolases; peptodoglycan-binding domain. (357 aa) |
| | CA_C1183 | Hypothetical protein. (194 aa) |
| | dut | Deoxyuridine 5'triphosphate nucleotidohydrolase (DUPTase); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (157 aa) |
| | CA_C1218 | Phage related protein, YorS B.subtilis homolog; Dephosphorylates nucleoside monophosphates such as the 5' and 2'(3')-phosphates of deoxyribonucleotides in vitro. Belongs to the 5'(3')-deoxyribonucleotidase family. (180 aa) |
| | dacB | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (425 aa) |
| | glpK | Glycerol kinase, GLPK; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (498 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (488 aa) |
| | araA-2 | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (488 aa) |
| | tal | Transaldolase, TAL; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | CA_C1348 | Transketolase, TKT; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | CA_C1350 | Hypothetical protein. (101 aa) |
| | cobC | Alpha-ribazole-5'-phosphate phosphatase, CobC; Belongs to the phosphoglycerate mutase family. (191 aa) |
| | purE | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa) |
| | purC | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (235 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (475 aa) |
| | purM | Phosphoribosylaminoimidazol (AIR) synthetase. (332 aa) |
| | PurN | Folate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa) |
| | purH | AICAR transformylase/IMP cyclohydrolase. (499 aa) |
| | purD | Phosphoribosylamine-glycine ligase. (416 aa) |
| | dut-2 | DUTPase, dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (145 aa) |
| | rpiA | Ribose 5-phosphate isomerase. (227 aa) |
| | CA_C1434 | Alkaline phosphatase superfamily protein. (625 aa) |
| | CA_C1540 | Uncharacterized ATP-grasp enzyme. (328 aa) |
| | CA_C1544 | Cytidine deaminase, cdd; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (215 aa) |
| | deoA | Pyrimidine-nucleoside phosphorylase. (433 aa) |
| | queH | Ncharacterized conserved protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (208 aa) |
| | mltG | Uncharacterized protein from YceG family; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (339 aa) |
| | CA_C1688 | Penicillin-binding protein. (532 aa) |
| | gpsA | Glycerol 3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa) |
| | gmk | Guanylate kinase, YLOD B.subtilis ortholog; Essential for recycling GMP and indirectly, cGMP. (209 aa) |
| | CA_C1720 | Flavoprotein involved in panthothenate metabolism, YLOI B.subtilis ortholog; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (398 aa) |
| | CA_C1730 | Pentose-5-phosphate-3-epimerase, YLOR B.subtilis ortholog; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | kdtB | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (161 aa) |
| | pta | Phosphotransacetylase. (333 aa) |
| | askA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa) |
| | CA_C1756 | Predicted nucleic acid binding protein, containing KH domain; Belongs to the UPF0109 family. (75 aa) |
| | smbA | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (385 aa) |
| | gcpE | GcpE protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (349 aa) |
| | RibC | Riboflavin kinase/FAD synthase; Belongs to the ribF family. (303 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | CA_C1822 | Fused Zn-dependent amidase/peptidase/peptodoglycan-binding domain-containing protein; Fusion of predicted Zn-dependent amidase/peptidase (cell wall hydrolase/DD-carboxypeptidase family) and uncharacterized domain of ErfK family; peptodoglycan-binding domain. (281 aa) |
| | lytB/rpsA | Penicillin tolerance LytB domain/S1 ribosomal protein fusion; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. In the N-terminal section; belongs to the IspH family. (642 aa) |
| | CA_C1850 | Transcriptional regulators, RpiR family. (293 aa) |
| | CA_C1854 | Nudix (MutT) family hydrolase. (172 aa) |
| | lyc-2 | N-acetylmuramidase, autolytic enzyme, family 25 of glycosyl hydrolases; peptodoglycan-binding domain. (351 aa) |
| | CA_C2045 | Secreted protein containing domain of murein hydrolase (MLTA homolog). (626 aa) |
| | CA_C2057 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (351 aa) |
| | dacF-2 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (404 aa) |
| | deoD | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa) |
| | deoB | Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (390 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (619 aa) |
| | pfs | Nucleoside phosphorylase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa) |
| | spoVE | Stage V sporulation protein E, FtsW/MrdB/SpoVE family; Belongs to the SEDS family. (371 aa) |
| | mraY | Phospho-N-acetylmuramoyl-pentapeptide transferase, MraY; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (317 aa) |
| | murF | UDP-N-acetylmuramyl pentapeptide synthase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa) |
| | murE | UDP-N-acetylmuramyl tripeptide synthase, MurE; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (482 aa) |
| | fliI | Flagellar-Type ATPase. (438 aa) |
| | CA_C2168 | Uncharacterized conserved protein. (578 aa) |
| | CA_C2170 | Predicted membrane protein. (161 aa) |
| | CA_C2171 | Predicted glycosyltransferase. (299 aa) |
| | CA_C2172 | Predicted glycosyltransferase. (449 aa) |
| | fcl | Nucleoside-diphosphate-sugar epimerase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (309 aa) |
| | gmd | GDP-D-mannose dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (355 aa) |
| | CA_C2189 | Carbamoylphosphate synthase large subunit, short form. (315 aa) |
| | CA_C2196 | Uncharacterized conserved protein. (544 aa) |
| | CA_C2200 | Uncharacterized conserved protein. (405 aa) |
| | CA_C2202 | Uncharacterized conserved protein. (592 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase, MurG; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (359 aa) |
| | CA_C2250 | UDP-glucose pyrophosphorylase. (287 aa) |
| | CA_C2251 | Uncharacterized conserved membrane protein, affecting LPS biosynthesis. (723 aa) |
| | spoT | RelA/SpoT protein, (p)ppGpp synthetase/pyrophosphohydrolases; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (740 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | tgt | Queuine tRNA-ribosyltransferase, tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to fo [...] (376 aa) |
| | queA | Queuine synthetase, queA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (341 aa) |
| | mrcB | Membrane carboxypeptidase mrcB; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (809 aa) |
| | CA_C2312 | Rhamnosyl transferase, rfbQ. (303 aa) |
| | CA_C2315 | DTDP-4-dehydrorhamnose reductase, rfbD ortholog; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (280 aa) |
| | CA_C2318 | Membrane protein of EXOQ family, involved in exopolysaccharide production. (406 aa) |
| | CA_C2320 | Predicted glycosyltransferase. (254 aa) |
| | CA_C2321 | Predicted glycosyltransferase. (298 aa) |
| | CA_C2331 | DTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa) |
| | spsJ | DTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (351 aa) |
| | CA_C2335 | UTP-glucose-1-phosphate uridylyltransferase. (303 aa) |
| | CA_C2395 | Predicted phosphatase, YWOA B.subtilis ortholog. (178 aa) |
| | CA_C2400 | Serine/threonine kinase related protein, inactivated (HRDL motif absent) (fragment). (177 aa) |
| | CA_C2431 | Alkaline phosphatase superfamily enzyme. (634 aa) |
| | CA_C2438 | Predicted phosphatase. (180 aa) |
| | CA_C2445 | AICAR transformylase domain of PurH-like protein. (391 aa) |
| | CA_C2453 | CBS domain containing protein. (243 aa) |
| | CA_C2469 | Lactoylglutathione lyase (fragment). (57 aa) |
| | CA_C2481 | Predicted kinase from adenilate kinase family, FLAR-like protein. (177 aa) |
| | CA_C2525 | Uncharacterized conserved membrane protein. (822 aa) |
| | CA_C2526 | 6-pyruvoyl-tetrahydropterin synthase related protein. (118 aa) |
| | CA_C2537 | Predicted phosphatase. (193 aa) |
| | CA_C2576 | 6-pyruvoyl-tetrahydropterin synthase related protein. (159 aa) |
| | CA_C2581 | 6-pyruvoyl-tetrahydropterin synthase related domain; conserved membrane protein. (1002 aa) |
| | CA_C2585 | 6-pyruvoyl-tetrahydropterin synthase related domain; conserved membrane protein. (153 aa) |
| | CA_C2592 | 6-pyruvoyl-tetrahydropterin synthase related domain; conserved membrane protein. (993 aa) |
| | CA_C2609 | Cytidine deaminase family enzyme. (139 aa) |
| | CA_C2621 | Cell wall hydrolase (autolysin), family 25 of glycosyl hydrolases; peptodoglycan-binding domain. (325 aa) |
| | CA_C2631 | Uncharacterized protein, ErfK family. (229 aa) |
| | carB | Carbamoylphosphate synthase large subunit. (1065 aa) |
| | carA | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (351 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (298 aa) |
| | pyrZ | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (246 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (286 aa) |
| | pyrB | Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (307 aa) |
| | CA_C2677 | Lytic murein transglycosylase. (237 aa) |
| | CA_C2678 | Hypothetical protein. (666 aa) |
| | pgi | Glucose-6-phosphate isomerase. (450 aa) |
| | guaA | GMP synthase; Catalyzes the synthesis of GMP from XMP. (510 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (243 aa) |
| | CA_C2802 | Predicted phosphoglycerol transferase (alkaline phosphatase superfamily), YFNI B.subtilis. (627 aa) |
| | murE-2 | UDP-N-acetylmuramyl tripeptide synthase, MURE; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (483 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa) |
| | atpC | FoF1-type ATP synthase epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa) |
| | atpD | FoF1-type ATP synthase beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (466 aa) |
| | atpG | FoF1-type ATP synthase gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (282 aa) |
| | atpA | FoF1-type ATP synthase alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (505 aa) |
| | atpH | FoF1-type ATP synthase delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (179 aa) |
| | atpF | FoF1-type ATP synthase B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (159 aa) |
| | atpE | FoF1-type ATP synthase C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa) |
| | atpB | FoF1-type ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (221 aa) |
| | CA_C2874 | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (385 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | ctrA | CTP synthase (UTP-ammonia lyase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa) |
| | ddlA | D-alanine-D-alanine ligase; Cell wall formation. (343 aa) |
| | CA_C2897 | Predicted UDP-glucuronosyltransferase, YPFP B/subtilis ortholog. (384 aa) |
| | CA_C2901 | Predicted membrane protein. (268 aa) |
| | ispE | Isopentenyl monophosphate kinase, IPK; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (280 aa) |
| | lacC | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (308 aa) |
| | gatY | Tagatose-bisphosphate aldolase. (284 aa) |
| | CA_C2988 | Uncharacterized conserved protein, YABE B.subtilis ortholog. (377 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (263 aa) |
| | CA_C3021 | Possible phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (219 aa) |
| | CA_C3027 | Predicted phosphohydrolase. (392 aa) |
| | CA_C3033 | Uncharacterized protein containing conserved domain, related to YABE B.subtilis C-terminal domain. (351 aa) |
| | CA_C3044 | CPSD/CAPA conserved membrane protein of Rol/Cld family. (227 aa) |
| | murJ | Uncharacterized membrane protein, putative virulence factor MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (520 aa) |
| | gmhA | Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (196 aa) |
| | CA_C3061 | CPSD/CAPA conserved membrane protein of Rol/Cld family. (227 aa) |
| | CA_C3064 | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (378 aa) |
| | CA_C3067 | Predicted membrane protein. (439 aa) |
| | CA_C3069 | Predicted glycosyltransferase. (299 aa) |
| | CA_C3074 | Uncharacterized conserved protein. (161 aa) |
| | dacA | Uncharacterized conserved protein, YPPB B.subtilis ortholog; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (281 aa) |
| | CA_C3092 | Amidase, germination specific (cwlC/cwlD B.subtilis ortholog). (231 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa) |
| | CA_C3155 | Uncharacterized conserved protein, THY1 family; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (439 aa) |
| | ispD | 4-diphosphocytidyl-2-methylerithritol synthase (Sugar Nucleotide Phosphorylase family); Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (229 aa) |
| | murD | UDP-N-acetylmuramoylalanine D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (462 aa) |
| | coaX | Predicted transcriptional regulator, homolog of Bvg accessory factor; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (273 aa) |
| | hprT | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | CA_C3212 | Fusion of Uroporphyrinogen-III methylase related protein and MAZG family protein, YABN B.subtilis ortholog. (483 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | gcaD | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (456 aa) |
| | murC | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (458 aa) |
| | comB | Uncharacterized conserved protein, YITC B.subtilis ortholog; Belongs to the ComB family. (235 aa) |
| | murI | Possible glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (256 aa) |
| | nrdB | Ribonucleotide reductase beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (344 aa) |
| | CA_C3287 | Predicted membrane protein. (420 aa) |
| | CA_C3293 | Uncharacterized conserved membrane protein. (487 aa) |
| | CA_C3308 | Glycosyltransferase fused to TPR-repeat domain. (593 aa) |
| | CA_C3340 | Uncharacterized conserved domain seen in the bacterial SpoT. (217 aa) |
| | CA_C3356 | Lactoylglutathione lyase (LGUL) family protein, diverged. (120 aa) |
| | CA_C3379 | Uncharacterized protein, YQFW B.subtilis homolog; Catalyzes the dephosphorylation of nucleotide monophosphates and of different sugar phosphates in vitro. (192 aa) |
| | CA_C3424 | Transcriptional regulator, RpiR family. (235 aa) |
| | CA_C3501 | Predicted phosphosugar isomerase. (336 aa) |
| | murA-2 | UDP-N-acetylglucosamine enolpyruvyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (418 aa) |
| | ldh2 | Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (320 aa) |
| | CA_C3558 | Probable S-layer protein. (439 aa) |
| | accA | Acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (274 aa) |
| | accD | Acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (285 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | fabZ | Hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (141 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | CA_C3624 | 6-pyruvoyl-tetrahydropterin synthase. (136 aa) |
| | queE | Fe-S oxidoreductase of MoaA family; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (221 aa) |
| | queC | PP-loop superfamily ATPase, confers aluminum resistance; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (222 aa) |
| | CA_C3676 | Uncharacterized conserved protein. (308 aa) |
